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Neuromethods最新文献

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The Effects of Antidepressants on Neurotransmission: Translational Insights from In Vivo Electrophysiological Studies 抗抑郁药对神经传递的影响:来自体内电生理研究的转化见解
Neuromethods Pub Date : 2022-01-01 DOI: 10.1007/978-1-0716-2083-0_9
M. Amidfar, Yong-Ku Kim
{"title":"The Effects of Antidepressants on Neurotransmission: Translational Insights from In Vivo Electrophysiological Studies","authors":"M. Amidfar, Yong-Ku Kim","doi":"10.1007/978-1-0716-2083-0_9","DOIUrl":"https://doi.org/10.1007/978-1-0716-2083-0_9","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51714146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring Mouse Somatosensory Reflexive Behaviors with High-speed Videography, Statistical Modeling, and Machine Learning. 用高速摄像、统计建模和机器学习测量小鼠体感反射行为。
Neuromethods Pub Date : 2022-01-01 Epub Date: 2022-05-27 DOI: 10.1007/978-1-0716-2039-7_21
Ishmail Abdus-Saboor, Wenqin Luo
{"title":"Measuring Mouse Somatosensory Reflexive Behaviors with High-speed Videography, Statistical Modeling, and Machine Learning.","authors":"Ishmail Abdus-Saboor,&nbsp;Wenqin Luo","doi":"10.1007/978-1-0716-2039-7_21","DOIUrl":"10.1007/978-1-0716-2039-7_21","url":null,"abstract":"<p><p>Objectively measuring and interpreting an animal's sensory experience remains a challenging task. This is particularly true when using preclinical rodent models to study pain mechanisms and screen for potential new pain treatment reagents. How to determine their pain states in a precise and unbiased manner is a hurdle that the field will need to overcome. Here, we describe our efforts to measure mouse somatosensory reflexive behaviors with greatly improved precision by high-speed video imaging. We describe how coupling sub-second ethograms of reflexive behaviors with a statistical reduction method and supervised machine learning can be used to create a more objective quantitative mouse \"pain scale.\" Our goal is to provide the readers with a protocol of how to integrate some of the new tools described here with currently used mechanical somatosensory assays, while discussing the advantages and limitations of this new approach.</p>","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"178 ","pages":"441-456"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249079/pdf/nihms-1702641.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9525481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pou4f3DTR Mice Enable Selective and Timed Ablation of Hair Cells in Postnatal Mice Pou4f3DTR小鼠能够选择性和定时消融出生后小鼠的毛细胞
Neuromethods Pub Date : 2022-01-01 DOI: 10.1007/978-1-0716-2022-9_1
J. Stone, E. Rubel, M. Warchol
{"title":"Pou4f3DTR Mice Enable Selective and Timed Ablation of Hair Cells in Postnatal Mice","authors":"J. Stone, E. Rubel, M. Warchol","doi":"10.1007/978-1-0716-2022-9_1","DOIUrl":"https://doi.org/10.1007/978-1-0716-2022-9_1","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51711194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ribosomal Pulldown Assays and Their Use to Analyze Gene Expression in Multiple Inner Ear Cell Types 核糖体下拉试验及其在多种内耳细胞类型基因表达分析中的应用
Neuromethods Pub Date : 2022-01-01 DOI: 10.1007/978-1-0716-2022-9_8
Maggie S. Matern, B. Milon, R. Elkon, R. Hertzano
{"title":"Ribosomal Pulldown Assays and Their Use to Analyze Gene Expression in Multiple Inner Ear Cell Types","authors":"Maggie S. Matern, B. Milon, R. Elkon, R. Hertzano","doi":"10.1007/978-1-0716-2022-9_8","DOIUrl":"https://doi.org/10.1007/978-1-0716-2022-9_8","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51711504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning Paradigms and Genetic Tools for the Study of Cerebellum-Dependent Learning and Memory 小脑依赖性学习和记忆研究的学习范式和遗传工具
Neuromethods Pub Date : 2022-01-01 DOI: 10.1007/978-1-0716-2026-7_6
A. Katoh
{"title":"Learning Paradigms and Genetic Tools for the Study of Cerebellum-Dependent Learning and Memory","authors":"A. Katoh","doi":"10.1007/978-1-0716-2026-7_6","DOIUrl":"https://doi.org/10.1007/978-1-0716-2026-7_6","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51712170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcranial Direct Current Stimulation for the Treatment of Major Depressive Disorder 经颅直流电刺激治疗重度抑郁症
Neuromethods Pub Date : 2022-01-01 DOI: 10.1007/978-1-0716-2083-0_16
Lucas Borrione, Laís B. Razza, A. Moffa, A. Brunoni
{"title":"Transcranial Direct Current Stimulation for the Treatment of Major Depressive Disorder","authors":"Lucas Borrione, Laís B. Razza, A. Moffa, A. Brunoni","doi":"10.1007/978-1-0716-2083-0_16","DOIUrl":"https://doi.org/10.1007/978-1-0716-2083-0_16","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51713187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressants, Sexual Behavior, and Translational Models for Male Sexual Dysfunction: Development of Animal Models, Pharmacology, and Genetics 抗抑郁药、性行为和男性性功能障碍的转化模型:动物模型、药理学和遗传学的发展
Neuromethods Pub Date : 2022-01-01 DOI: 10.1007/978-1-0716-2083-0_20
J. Olivier, J. Janssen, T. Pattij, Stephen de Prêtre, B. Olivier
{"title":"Antidepressants, Sexual Behavior, and Translational Models for Male Sexual Dysfunction: Development of Animal Models, Pharmacology, and Genetics","authors":"J. Olivier, J. Janssen, T. Pattij, Stephen de Prêtre, B. Olivier","doi":"10.1007/978-1-0716-2083-0_20","DOIUrl":"https://doi.org/10.1007/978-1-0716-2083-0_20","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51713363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Correlative Light and Electron Microscopy (CLEM): Bringing Together the Best of Both Worlds to Study Neuronal Autophagy 相关光学和电子显微镜(CLEM):结合两个世界的最好的研究神经元自噬
Neuromethods Pub Date : 2021-08-20 DOI: 10.1007/978-1-0716-1589-8_10
J. Kriel, D. Lumkwana, L. Joubert, Martin L. Jones, C. Peddie, L. Collinson, B. Loos, L. Engelbrecht
{"title":"Correlative Light and Electron Microscopy (CLEM): Bringing Together the Best of Both Worlds to Study Neuronal Autophagy","authors":"J. Kriel, D. Lumkwana, L. Joubert, Martin L. Jones, C. Peddie, L. Collinson, B. Loos, L. Engelbrecht","doi":"10.1007/978-1-0716-1589-8_10","DOIUrl":"https://doi.org/10.1007/978-1-0716-1589-8_10","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51709219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Measuring 测量
Neuromethods Pub Date : 2021-08-20 DOI: 10.1007/978-1-0716-1589-8_6
Andrea Du Toit, J. S. Hofmeyr, Benjamin Loos
{"title":"Measuring","authors":"Andrea Du Toit, J. S. Hofmeyr, Benjamin Loos","doi":"10.1007/978-1-0716-1589-8_6","DOIUrl":"https://doi.org/10.1007/978-1-0716-1589-8_6","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41516682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantification of the Neurofilament Light Chain Protein by Single Molecule Array (Simoa) Assay 单分子阵列(Simoa)法测定神经丝轻链蛋白
Neuromethods Pub Date : 2021-01-01 DOI: 10.1007/978-1-0716-1319-1_13
C. Barro, Sarah Storz, S. Gröbke, Z. Michalak, J. Kuhle
{"title":"Quantification of the Neurofilament Light Chain Protein by Single Molecule Array (Simoa) Assay","authors":"C. Barro, Sarah Storz, S. Gröbke, Z. Michalak, J. Kuhle","doi":"10.1007/978-1-0716-1319-1_13","DOIUrl":"https://doi.org/10.1007/978-1-0716-1319-1_13","url":null,"abstract":"","PeriodicalId":74285,"journal":{"name":"Neuromethods","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51707516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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