American journal of cardiovascular disease最新文献

{"title":"An updated meta-analysis on the association between celiac disease and cardiovascular diseases.","authors":"Mahdi Faraji, Reza Khademi, Maede Maleki, Fatemeh Jafari, Ensiyeh Olama, Mohammad Sadra Saghafi, Anita Fatehi, Elnaz Olama, Danial Abasi Dehkordi, Aydin Hassanpour Adeh, Seyyed Kiarash Sadat Rafiei, Komeil Aghazadeh-Habashi, Amin Magsudy, Pegah Refahi, Niloofar Deravi, Zahra Keyhanifar, Mahsa Asadi Anar","doi":"10.62347/WNAK3699","DOIUrl":"10.62347/WNAK3699","url":null,"abstract":"<p><strong>Objectives: </strong>Research on the relationship between celiac disease (CD) and cardiovascular disease (CVD) is still ongoing, and different studies have reported contradictory findings. To carry out a meta-analysis and systematic review to look into the connection between CD and CVD risk.</p><p><strong>Methods: </strong>A thorough search was conducted in PubMed, Scopus, and Google Scholar databases up to February 19, 2024. Relevant articles were extracted, and the titles, abstracts, and full texts of the related articles were screened. The quality of the studies was assessed using the Joanna Briggs Institute critical appraisal tools.</p><p><strong>Results: </strong>Nine cohort and one case-control studies involving 49,621,333 individuals were included in the meta-analysis. The pooled analysis revealed a 7% increased risk of CVD in CD patients compared to controls (OR: 1.07, 95% CI: 1.03-1.10, P < 0.05). Significant heterogeneity was observed among studies (I² = 76%, P < 0.001).</p><p><strong>Conclusion: </strong>This meta-analysis provides evidence of a modest but significant increase in CVD risk in patients with CD. The results highlight the importance of considering cardiovascular health in CD treatment and the need for further research to elucidate the mechanisms underlying this association and to develop targeted prevention strategies.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 3","pages":"181-194"},"PeriodicalIF":1.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative clinical outcomes and mortality risk in coronary artery bypass grafting, valve surgeries, and percutaneous interventions.","authors":"Sanam Faizabadi, Amirali Farshid, Parisa Alsadat Dadkhah, Shayan Yaghoubi, Reza Khademi, Shakiba Zebardast Khorrami, Alireza Asadi, Arta Garmsiri, Nima Zabihi, Sareh Khazaei Pool, Niki Talebian, Mahdi Falah Tafti, Alaleh Alizadeh, Mahsa Asadi Anar, Niloofar Deravi","doi":"10.62347/TYLZ6475","DOIUrl":"10.62347/TYLZ6475","url":null,"abstract":"<p><strong>Objectives: </strong>Coronary artery disease and valvular heart disease are leading causes of mortality globally. This study aimed to investigate the correlation between expected mortality rates (EMRs) and observed mortality rates (OMRs) for common cardiac interventions using recent national data on percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), and cardiac valve surgeries.</p><p><strong>Methods: </strong>This multi-institutional, retrospective observational study analyzed in-hospital/30-day mortality outcomes for 106,836 patients who underwent PCI, CABG, or cardiac valve procedures across 64 non-federal hospitals in New York State between December 2012 and November 2015. The procedures included emergency and non-emergency PCI, CABG, valve or valve-CABG surgeries, and transcatheter aortic valve replacement (TAVR).</p><p><strong>Results: </strong>Among the 106,836 patients, a 3.21% 30-day mortality rate was observed (n=3,436). To assess the disparity between OMR and EMR, a one-sample t-test was performed. Effect sizes were determined using Cohen's d and Hedges' correction. With a 95% confidence interval, the t-value for the OMR (mean difference =2.037±1.728, CI: 1.95-2.12) was 47.270, whereas the EMR (mean difference =1.930±1.284, CI: 1.86-1.99) yielded a t-value of 60.279. The OMR was significantly greater than the EMR (P<0.001).</p><p><strong>Conclusion: </strong>The OMR was significantly greater than the EMR across all cardiac procedures, suggesting potential influences from patient demographics, comorbidities, and variations in hospital practices. Further research is needed to understand these factors and improve the quality of cardiac care.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 3","pages":"195-211"},"PeriodicalIF":1.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The zero calcium score paradox and multivessel obstructive disease: a case report of a patient with zero CAC score.","authors":"Azad Mojahedi, Hal Skopicki, Tahmid Rahman, Arman Soltani, Michael Park, Mandeep Kainth, On Chen","doi":"10.62347/GLVD7571","DOIUrl":"10.62347/GLVD7571","url":null,"abstract":"<p><p>A coronary artery calcium (CAC) score of 0 is generally indicative of a low risk for both all-cause mortality and cardiovascular events, often serving as a basis for excluding obstructive coronary artery disease (CAD). Although isolated cases of coronary involvement have been reported in patients with a CAC score of 0, the incidence of extensive multivessel disease under these circumstances is exceedingly rare. A 48-year-old man with diabetes and hypercholesterolemia presented with atypical non-exertional left-sided chest pain. Despite a nonspecific ECG, a HEART score of 3, and a zero CAC score on echocardiography, coronary computed tomography angiography (CCTA) revealed multiple non-calcified plaques in the right coronary artery (RCA), right posterior descending coronary artery (RPDA), and left circumflex artery (LCX). The patient underwent staged percutaneous coronary intervention with drug-eluting stents, resulting in complete resolution of the stenosis. At the one-month follow-up, he remained symptom-free and tolerated the medication regimen well. This case report demonstrates that a zero CAC score should not preclude further evaluation in high-risk symptomatic patients. Extensive non-calcified plaques causing significant luminal obstruction underscore the limitations of CAC scoring, highlighting the need for additional imaging modalities, such as CCTA, to achieve timely and accurate diagnoses and appropriate therapeutic interventions.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 3","pages":"175-180"},"PeriodicalIF":1.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between serum copeptin levels and non-invasive endothelial function indicators in dipper and non-dipper hypertensive patients.","authors":"Huseyin Kandemir, Mehmet Tolga Dogru, Selcuk Ozturk, Muhammed Karadeniz, Caglar Alp, Ucler Kisa","doi":"10.62347/TSLN4765","DOIUrl":"10.62347/TSLN4765","url":null,"abstract":"<p><strong>Objective: </strong>Pathological changes in the endothelium are the earliest determinants of endothelial dysfunction and atherosclerosis in hypertension (HT). The diagnostic and prognostic role of copeptin in various diseases is well-recognized. This study aims to investigate the relationship between serum copeptin levels and non-invasive endothelial function indicators determined by flow-mediated dilation (FMD) and pulse wave analysis (PWA) in dipper and non-dipper HT patients.</p><p><strong>Methods: </strong>In this study, 30 dipper HT, 31 non-dipper HT patients and 30 healthy control subjects were included. Blood samples were taken for copeptin level determination. All participants underwent detailed cardiovascular and transthoracic echocardiography examinations and measurements of FMD and PWA.</p><p><strong>Results: </strong>Copeptin levels of the non-dipper HT group were significantly higher than the control group and dipper HT groups (P=.001, P=.010, respectively). No significant difference was found between the dipper and non-dipper HT groups regarding FMD and PWA measurements, and both groups significantly differed from the control group. In the whole group evaluation by partial correlation analysis, a significant correlation was found between serum copeptin levels and reflection index (RI) after adjustment for age and body mass index (r=0.24, P=.039). Stepwise linear regression analysis revealed RI as an independent predictor of copeptin (β=0.285, P=.015).</p><p><strong>Conclusion: </strong>The correlation between copeptin levels and RI in HT patients, especially in the non-dipper HT group, suggests that copeptin can be used as a biomarker to indicate endothelial dysfunction in hypertensive patients.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 3","pages":"156-165"},"PeriodicalIF":1.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and demographic disparities in heart failure mortality rates in non-alcoholic fatty liver disease: a population-based retrospective study in the United States from 1999 to 2020.","authors":"Ryan D Plunkett, Faizan Ahmed, Alexander Thomas, Hayden Rotramel, Tehmasp Rehman Mirza, Nicholas Philip, Chaitanya Rojulpote, Deana Mikhalkova, Kamran Qureshi, Chien-Jung Lin","doi":"10.62347/MCPC3010","DOIUrl":"10.62347/MCPC3010","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to analyze two decades heart failure (HF) mortality data in Non-Alcoholic Fatty Liver Disease (NAFLD), now known as Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), in the United States (US), identifying patterns and disparities in mortality rates.</p><p><strong>Methods: </strong>A retrospective analysis was conducted using mortality data from the CDC WONDER database spanning 1999-2020. Age-adjusted mortality rates (AAMRs) per 1,000,000 persons were calculated, and trends were assessed using Average Annual Percentage Change (AAPC) and Annual Percent Change (APC) using Joinpoint 5.0.2. Data were stratified by year, sex, race/ethnicity, urbanization, and census regions.</p><p><strong>Results: </strong>From 1999-2020, 68,436 HF-related deaths occurred among US adults with NAFLD. The overall AAMR increased from 12.49 in 1999 to 24.30 in 2020, with an AAPC of 3.05 (95% CI: 2.80 to 3.31, P < 0.001), with a steep rise in AAMR from 2017-2020 and an APC of 12.35 (95% CI: 9.71 to 15.99). American Indian or Alaskan natives had the highest AAMRs (28.63), followed by Hispanics (20.05), and African Americans or Blacks (14.51). The highest mortality regionally was in the Southern region (AAMR: 16.05) and nonmetropolitan areas had higher AAMRs than metropolitan areas (16.63 vs. 13.76).</p><p><strong>Conclusions: </strong>This analysis demonstrated increasing mortality rates from HF in NAFLD, with a sharper increase in recent years. This also showed nonmetropolitan areas, the Southern region of the US, and minority populations had higher mortality rates, which highlights at-risk populations and opportunities for important public health interventions.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 3","pages":"166-174"},"PeriodicalIF":1.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of nocturnal blood pressure and left ventricular hypertrophy in Iranian hypertensive patients.","authors":"Shideh Anvari, Ehsan Noroozi, Mohammad Amin Karimi, Reza Khademi, Seyyed Kiarash Sadat Rafiei, Samira Pirzad, Nima Zabihi, Niloofar Deravi, Arezou Soltanattar, Fariba Samadian, Elham Keikha","doi":"10.62347/HQQX9117","DOIUrl":"10.62347/HQQX9117","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertension is a prevalent risk factor for cardiovascular mortality and morbidity, often leading to left ventricular hypertrophy (LVH). As ambulatory blood pressure monitoring (ABPM) gains prominence in hypertension management, it is crucial to explore its association with LVH occurrence to enhance clinical understanding and treatment strategies. This study aims to investigate the correlation between nocturnal blood pressure patterns and presence of LVH in hypertensive patients, offering insights into optimizing hypertension management strategies.</p><p><strong>Methods: </strong>Fifty-four patients with confirmed hypertension were included in this study. All participants underwent transthoracic echocardiography within two days of admission and 48-hour ABPM within one week of admission. Based on the presence of LVH, patients were categorized into LVH and non-LVH groups. Nocturnal systolic/diastolic BP were compared between the two groups using the appropriate statistical tests.</p><p><strong>Results: </strong>Among the 54 hypertensive patients, those with LVH (n = 22) demonstrated a significantly higher nocturnal average SBP (124.04 ± 11.92 mmHg) and DBP (76.24 ± 9.76) compared to those without LVH (n = 32, SBP = 116.78 ± 13.92 mmHg, DBP = 72.45 ± 9.76, P < 0.001).</p><p><strong>Conclusion: </strong>This research shows a significant association between nocturnal BP patterns and the presence of LVH in hypertensive individuals. Nocturnal SBP and DBP were identified as independent risk factors for LVH. Further research, particularly on the timing of antihypertensive medication, is warranted to confirm causal relationships and improve management strategies.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"108-114"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the link: social determinants of health, quality of life, and burden of treatment in heart failure patients.","authors":"Inderpreet Singh, Rubina Shah, Madison Stoms, Charlotte Fowler, Ammar Vohra, Laverne Yip, Chee Yao Lim, Kenneth Johan, Gustavo E Garcia-Franceschini, Alexander Mandadjiev, Alejandrina Cuello Ramirez, Aurelia Hernandez, Moiz Kasubhai, Vihren Dimitrov, Shavy Nagpal, Ying Wei, Vidya Menon","doi":"10.62347/VCZP1725","DOIUrl":"10.62347/VCZP1725","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Black and Hispanic American patients have seen an increase in heart failure (HF) rates, with higher rates of hospitalizations and age-adjusted mortality. Our study aims to examine the associations between Social Determinants of Health (SDoH), difficulties associated with the workload assigned to the patients by healthcare providers/healthcare system measured as Burden of Treatment (BoT), and Quality of Life (QoL) in a predominantly minority, low income population of patients with heart failure in the South Bronx.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We included 265 patients hospitalized for HF decompensation. They were administered questionnaires to evaluate SDoH, QoL (EQ-5D), and BoT (Patient Experience with Treatment and Self-management-PETS questionnaire) at baseline. We fitted 10 zero-inflated negative binomial models to determine associations between total SDOH and total QoL with each BoT domain. We modelled the likelihood that a patient reports no burden on a given domain as well as the severity of the burden among patients who report burden.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The mean age of our cohort was 63.7 years, with 66% male, 50% Hispanic ethnicity and 48% Black. Spanish was the predominant primary language of communication. Their mean Charlson Comorbidity Index was 5.32 (SD = 2.6). Heart failure with reduced ejection fraction (HFrEF) was present in 72% of our participating patients. The mean composite SDoH score was 3.4 (SD = 1.9), with 31% of the cohort reporting problems paying their bills, 28% with food insecurity, and 35% requiring public assistance. Among the 5 domains measured by EQ-5D for evaluating QoL, moderate to severe difficulty was experienced by 88% of our cohort in at least one of the five domains, and severe difficulty in at least one of the five domains was reported in 23% of our patients. Of the ten domains evaluated for Burden of Treatment (BoT), the highest median scores obtained from our cohort were for difficulty with medical expenses, role and social activity limitations, difficulty with accessing healthcare services, difficulty with medical information, and physical and mental exhaustion due to self-care. Zero-inflated models identified a significant association between higher SDoH scores and having some burden of treatment in 6 of the 10 domains, particularly in the domains of difficulty with healthcare expenses and difficulty with self-care interfering with social/daily activities. Additionally, high SDoH scores were also associated with greater severity of burden in 7 of the 10 domains, particularly relating to understanding medical information and difficulty with healthcare expenses. Poor QoL was associated with increased BoT in 6 of the 10 domains. QoL was strongly associated with the burdens of physical and mental exhaustion and difficulty with medical appointments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our findings highlight the interplay of SDoH, QoL and BoT in driving health di","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"69-84"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant deviation between reported wedge pressure and diastolic pulmonary arterial pressure found during right heart catheterization in patients undergoing cardiac transplant evaluation.","authors":"Mohammad Reza Movahed, Ashkan Bahrami, Reza Eshraghi","doi":"10.62347/NEDV9140","DOIUrl":"10.62347/NEDV9140","url":null,"abstract":"<p><strong>Objectives: </strong>Diastolic pulmonary arterial pressure should be the same as wedge pressure in patients with cardiomyopathy without a known history of pulmonary vein occlusive disease. The goal of this study was to study the correlation between reported wedge pressure and pulmonary arterial diastolic pressure in patients with end-stage cardiomyopathy to evaluate the accuracy of right heart pressure reporting.</p><p><strong>Methods: </strong>Pre-cardiac transplant patients who underwent cardiac catheterization before their heart transplantation at our institution between 2003 and 2005 (n = 159) were retrospectively reviewed. Reported diastolic pulmonary arterial pressure was correlated with reported wedge pressure.</p><p><strong>Results: </strong>The correlation between reported diastolic pulmonary arterial pressure with wedge pressure was modest with r² = 0.75. There was wide variation with some division up to 40 mmHg. Most discrepancies occurred in the lower and higher-pressure measurements.</p><p><strong>Conclusions: </strong>Among patients referred for heart transplant evaluation, a correlation between reported diastolic pulmonary pressure and wedge pressure is only modest suggesting a significant error in the reporting or measuring right-sided pressures during right heart catheterization warranting further investigation to reduce errors.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"100-107"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac magnetic resonance imaging in myocardial infarction with non-obstructed coronary arteries: diagnostic and prognostic value.","authors":"Farshad Riahi, Seyed-Hamed Tooyserkani, Azad Mojahedi, Seyed-Amirhossein Dormiani-Tabatabaei, Shahin Fesharaki, Sara Azizollahi, Armin Sourani, Mahmoud Khansari, Maryam Alaei, Mohamad Ghazanfari-Hashemi, Milad Vakili-Zarch, Amirhossein Sadeghian, Sahar Hosseini, Seyedeh-Nooshin Miratashi-Yazdi","doi":"10.62347/FCDC4114","DOIUrl":"10.62347/FCDC4114","url":null,"abstract":"<p><p>Myocardial infarction with non-obstructed coronary arteries (MINOCA) occurs when patients experience a heart attack without significant coronary artery blockage despite showing acute coronary syndrome symptoms. Unlike stable atherosclerosis, MINOCA involves acute myocardial infarction (MI) without obstructive coronary artery disease (CAD). The diagnostic criteria included meeting the universal MI definition, non-obstructive coronary arteries on angiography (< 50% stenosis), and no apparent cause of the acute event. The causes include coronary, cardiac, and extracardiac origins, such as plaque rupture, coronary spasm, myocarditis, or pulmonary embolism. MINOCA affects 5-6% of patients with acute MI undergoing angiography, with variations based on demographic factors. Although MINOCA was initially believed to have a favorable outcome, recent findings have indicated that MINOCA patients have a worse prognosis than the general population. Current guidelines strongly advocate the use of cardiac magnetic resonance imaging (CMR) to evaluate suspected MINOCA cases. However, multiple studies have demonstrated that CMR may fail to detect some instances of MINOCA, particularly in cases of mild inflammation or minor infractions. This could lead to a false-negative diagnosis requiring further testing. This review aimed to evaluate the diagnostic and prognostic value of CMR in patients with potential MINOCA.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"56-68"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular outcomes of chagas-induced non-ischemic cardiomyopathy versus other nonischemic cardiomyopathies: a regression matched national cohort analysis.","authors":"Omar Al Wahadneh, Sivaram Neppala, Sahithi Sharma, Krutarth Pandya, Harshith Thyagaturu, Karthik Gonuguntla, Nazam Sattar Kokhar, Waleed Alruwaili, Muhammad Abdullah Naveed, Himaja Dutt Chigurupati, Tarique Ahmed, Yasar Sattar","doi":"10.62347/APJC3998","DOIUrl":"10.62347/APJC3998","url":null,"abstract":"<p><strong>Objectives: </strong>Chagas disease, caused by Trypanosoma cruzi, is a parasitic infection endemic to Latin America and is increasingly prevalent in the United States. This study examines mortality, heart failure, arrhythmias, cardiogenic shock, and the need for heart transplantation in Chagas patients over five years in the United States.</p><p><strong>Methods: </strong>We selected all non-ischemic cardiomyopathy (NICM) patients from the National Inpatient Sample Database from 2016 to 2020 and compared them to Chagas-induced NICM.</p><p><strong>Results: </strong>A total of 783,535 patients had non-ischemic cardiomyopathy (NICM), with 250 cases being secondary to Chagas disease. Chagas NICM was predominantly seen in the Hispanic population. Patients with Chagas NICM have significantly higher odds of receiving a heart transplant (OR 15.48; P<0.05), particularly in the context of a high incidence of cardiogenic shock due to end-stage heart failure or severe myocarditis (OR 2.7; P<0.05). Furthermore, these patients demonstrate a higher incidence of ventricular fibrillation (OR 4.87; P<0.05) and pericardial effusion (OR 3.75; P<0.05) compared to other forms of NICM. They are frequently associated with the need for pacemaker placement (OR 2.80; P<0.05), likely due to ventricular fibrillation and conduction blocks. The odds of in-hospital mortality were similar between patients with Chagas NICM and those with other NICM patients.</p><p><strong>Conclusion: </strong>Patients with Chagas cardiomyopathy are more likely to experience cardiogenic shock, ventricular fibrillation, and pericardial effusion. They also face an increased risk of needing an ICD and heart transplant. Further research is necessary on this subject.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"139-148"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}