American journal of cardiovascular disease最新文献

{"title":"Association of nocturnal blood pressure and left ventricular hypertrophy in Iranian hypertensive patients.","authors":"Shideh Anvari, Ehsan Noroozi, Mohammad Amin Karimi, Reza Khademi, Seyyed Kiarash Sadat Rafiei, Samira Pirzad, Nima Zabihi, Niloofar Deravi, Arezou Soltanattar, Fariba Samadian, Elham Keikha","doi":"10.62347/HQQX9117","DOIUrl":"10.62347/HQQX9117","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertension is a prevalent risk factor for cardiovascular mortality and morbidity, often leading to left ventricular hypertrophy (LVH). As ambulatory blood pressure monitoring (ABPM) gains prominence in hypertension management, it is crucial to explore its association with LVH occurrence to enhance clinical understanding and treatment strategies. This study aims to investigate the correlation between nocturnal blood pressure patterns and presence of LVH in hypertensive patients, offering insights into optimizing hypertension management strategies.</p><p><strong>Methods: </strong>Fifty-four patients with confirmed hypertension were included in this study. All participants underwent transthoracic echocardiography within two days of admission and 48-hour ABPM within one week of admission. Based on the presence of LVH, patients were categorized into LVH and non-LVH groups. Nocturnal systolic/diastolic BP were compared between the two groups using the appropriate statistical tests.</p><p><strong>Results: </strong>Among the 54 hypertensive patients, those with LVH (n = 22) demonstrated a significantly higher nocturnal average SBP (124.04 ± 11.92 mmHg) and DBP (76.24 ± 9.76) compared to those without LVH (n = 32, SBP = 116.78 ± 13.92 mmHg, DBP = 72.45 ± 9.76, P < 0.001).</p><p><strong>Conclusion: </strong>This research shows a significant association between nocturnal BP patterns and the presence of LVH in hypertensive individuals. Nocturnal SBP and DBP were identified as independent risk factors for LVH. Further research, particularly on the timing of antihypertensive medication, is warranted to confirm causal relationships and improve management strategies.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"108-114"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the link: social determinants of health, quality of life, and burden of treatment in heart failure patients.","authors":"Inderpreet Singh, Rubina Shah, Madison Stoms, Charlotte Fowler, Ammar Vohra, Laverne Yip, Chee Yao Lim, Kenneth Johan, Gustavo E Garcia-Franceschini, Alexander Mandadjiev, Alejandrina Cuello Ramirez, Aurelia Hernandez, Moiz Kasubhai, Vihren Dimitrov, Shavy Nagpal, Ying Wei, Vidya Menon","doi":"10.62347/VCZP1725","DOIUrl":"10.62347/VCZP1725","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Black and Hispanic American patients have seen an increase in heart failure (HF) rates, with higher rates of hospitalizations and age-adjusted mortality. Our study aims to examine the associations between Social Determinants of Health (SDoH), difficulties associated with the workload assigned to the patients by healthcare providers/healthcare system measured as Burden of Treatment (BoT), and Quality of Life (QoL) in a predominantly minority, low income population of patients with heart failure in the South Bronx.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We included 265 patients hospitalized for HF decompensation. They were administered questionnaires to evaluate SDoH, QoL (EQ-5D), and BoT (Patient Experience with Treatment and Self-management-PETS questionnaire) at baseline. We fitted 10 zero-inflated negative binomial models to determine associations between total SDOH and total QoL with each BoT domain. We modelled the likelihood that a patient reports no burden on a given domain as well as the severity of the burden among patients who report burden.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The mean age of our cohort was 63.7 years, with 66% male, 50% Hispanic ethnicity and 48% Black. Spanish was the predominant primary language of communication. Their mean Charlson Comorbidity Index was 5.32 (SD = 2.6). Heart failure with reduced ejection fraction (HFrEF) was present in 72% of our participating patients. The mean composite SDoH score was 3.4 (SD = 1.9), with 31% of the cohort reporting problems paying their bills, 28% with food insecurity, and 35% requiring public assistance. Among the 5 domains measured by EQ-5D for evaluating QoL, moderate to severe difficulty was experienced by 88% of our cohort in at least one of the five domains, and severe difficulty in at least one of the five domains was reported in 23% of our patients. Of the ten domains evaluated for Burden of Treatment (BoT), the highest median scores obtained from our cohort were for difficulty with medical expenses, role and social activity limitations, difficulty with accessing healthcare services, difficulty with medical information, and physical and mental exhaustion due to self-care. Zero-inflated models identified a significant association between higher SDoH scores and having some burden of treatment in 6 of the 10 domains, particularly in the domains of difficulty with healthcare expenses and difficulty with self-care interfering with social/daily activities. Additionally, high SDoH scores were also associated with greater severity of burden in 7 of the 10 domains, particularly relating to understanding medical information and difficulty with healthcare expenses. Poor QoL was associated with increased BoT in 6 of the 10 domains. QoL was strongly associated with the burdens of physical and mental exhaustion and difficulty with medical appointments.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Our findings highlight the interplay of SDoH, QoL and BoT in driving health di","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"69-84"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significant deviation between reported wedge pressure and diastolic pulmonary arterial pressure found during right heart catheterization in patients undergoing cardiac transplant evaluation.","authors":"Mohammad Reza Movahed, Ashkan Bahrami, Reza Eshraghi","doi":"10.62347/NEDV9140","DOIUrl":"10.62347/NEDV9140","url":null,"abstract":"<p><strong>Objectives: </strong>Diastolic pulmonary arterial pressure should be the same as wedge pressure in patients with cardiomyopathy without a known history of pulmonary vein occlusive disease. The goal of this study was to study the correlation between reported wedge pressure and pulmonary arterial diastolic pressure in patients with end-stage cardiomyopathy to evaluate the accuracy of right heart pressure reporting.</p><p><strong>Methods: </strong>Pre-cardiac transplant patients who underwent cardiac catheterization before their heart transplantation at our institution between 2003 and 2005 (n = 159) were retrospectively reviewed. Reported diastolic pulmonary arterial pressure was correlated with reported wedge pressure.</p><p><strong>Results: </strong>The correlation between reported diastolic pulmonary arterial pressure with wedge pressure was modest with r² = 0.75. There was wide variation with some division up to 40 mmHg. Most discrepancies occurred in the lower and higher-pressure measurements.</p><p><strong>Conclusions: </strong>Among patients referred for heart transplant evaluation, a correlation between reported diastolic pulmonary pressure and wedge pressure is only modest suggesting a significant error in the reporting or measuring right-sided pressures during right heart catheterization warranting further investigation to reduce errors.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"100-107"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac magnetic resonance imaging in myocardial infarction with non-obstructed coronary arteries: diagnostic and prognostic value.","authors":"Farshad Riahi, Seyed-Hamed Tooyserkani, Azad Mojahedi, Seyed-Amirhossein Dormiani-Tabatabaei, Shahin Fesharaki, Sara Azizollahi, Armin Sourani, Mahmoud Khansari, Maryam Alaei, Mohamad Ghazanfari-Hashemi, Milad Vakili-Zarch, Amirhossein Sadeghian, Sahar Hosseini, Seyedeh-Nooshin Miratashi-Yazdi","doi":"10.62347/FCDC4114","DOIUrl":"10.62347/FCDC4114","url":null,"abstract":"<p><p>Myocardial infarction with non-obstructed coronary arteries (MINOCA) occurs when patients experience a heart attack without significant coronary artery blockage despite showing acute coronary syndrome symptoms. Unlike stable atherosclerosis, MINOCA involves acute myocardial infarction (MI) without obstructive coronary artery disease (CAD). The diagnostic criteria included meeting the universal MI definition, non-obstructive coronary arteries on angiography (< 50% stenosis), and no apparent cause of the acute event. The causes include coronary, cardiac, and extracardiac origins, such as plaque rupture, coronary spasm, myocarditis, or pulmonary embolism. MINOCA affects 5-6% of patients with acute MI undergoing angiography, with variations based on demographic factors. Although MINOCA was initially believed to have a favorable outcome, recent findings have indicated that MINOCA patients have a worse prognosis than the general population. Current guidelines strongly advocate the use of cardiac magnetic resonance imaging (CMR) to evaluate suspected MINOCA cases. However, multiple studies have demonstrated that CMR may fail to detect some instances of MINOCA, particularly in cases of mild inflammation or minor infractions. This could lead to a false-negative diagnosis requiring further testing. This review aimed to evaluate the diagnostic and prognostic value of CMR in patients with potential MINOCA.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"56-68"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular outcomes of chagas-induced non-ischemic cardiomyopathy versus other nonischemic cardiomyopathies: a regression matched national cohort analysis.","authors":"Omar Al Wahadneh, Sivaram Neppala, Sahithi Sharma, Krutarth Pandya, Harshith Thyagaturu, Karthik Gonuguntla, Nazam Sattar Kokhar, Waleed Alruwaili, Muhammad Abdullah Naveed, Himaja Dutt Chigurupati, Tarique Ahmed, Yasar Sattar","doi":"10.62347/APJC3998","DOIUrl":"10.62347/APJC3998","url":null,"abstract":"<p><strong>Objectives: </strong>Chagas disease, caused by Trypanosoma cruzi, is a parasitic infection endemic to Latin America and is increasingly prevalent in the United States. This study examines mortality, heart failure, arrhythmias, cardiogenic shock, and the need for heart transplantation in Chagas patients over five years in the United States.</p><p><strong>Methods: </strong>We selected all non-ischemic cardiomyopathy (NICM) patients from the National Inpatient Sample Database from 2016 to 2020 and compared them to Chagas-induced NICM.</p><p><strong>Results: </strong>A total of 783,535 patients had non-ischemic cardiomyopathy (NICM), with 250 cases being secondary to Chagas disease. Chagas NICM was predominantly seen in the Hispanic population. Patients with Chagas NICM have significantly higher odds of receiving a heart transplant (OR 15.48; P<0.05), particularly in the context of a high incidence of cardiogenic shock due to end-stage heart failure or severe myocarditis (OR 2.7; P<0.05). Furthermore, these patients demonstrate a higher incidence of ventricular fibrillation (OR 4.87; P<0.05) and pericardial effusion (OR 3.75; P<0.05) compared to other forms of NICM. They are frequently associated with the need for pacemaker placement (OR 2.80; P<0.05), likely due to ventricular fibrillation and conduction blocks. The odds of in-hospital mortality were similar between patients with Chagas NICM and those with other NICM patients.</p><p><strong>Conclusion: </strong>Patients with Chagas cardiomyopathy are more likely to experience cardiogenic shock, ventricular fibrillation, and pericardial effusion. They also face an increased risk of needing an ICD and heart transplant. Further research is necessary on this subject.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"139-148"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of obesity on outcomes of transcatheter aortic valve implantation in patients with aortic stenosis: a systematic review and meta-analysis of real-world data.","authors":"Farah Yasmin, Abdul Moeed, Farwa Zaidi, Mariam Adil, Salim Surani, M Chadi Alraies","doi":"10.62347/VTYE4110","DOIUrl":"10.62347/VTYE4110","url":null,"abstract":"<p><p>Most recent large-scale global analyses on transcatheter aortic valve implantation (TAVI) for aortic stenosis (AS) showed favorable survival outcomes in patients with high body mass index (BMI). We performed a meta-analysis pooling all clinical studies to assess the validity of improved post-TAVI prognosis in obese patients. MEDLINE and Scopus were queried till January 2023 to identify studies comparing AS patients with BMI≥30 kg/m², and BMI 18.5 to <25 undergoing TAVI. Data were analyzed using a random-effects model to derive odds ratios (ORs) for all outcomes, and hazard ratios (HRs) for long-term overall survival with 95% confidence intervals. The primary outcomes of interest included 30-day all-cause mortality and long-term overall survival while secondary outcomes consisted of myocardial infarction (MI), major bleeding, major vascular events and acute kidney injury (AKI). A total of 24 studies comprising 38,743 patients were included in this meta-analysis. All-cause mortality at 30-days was significantly reduced in patients with BMI>30 kg/m² (OR 0.71, P<0.0001) vs. normal BMI. Every 1 kg/m² increase in BMI was associated with better overall survival (HR 0.96, P<0.0001). Obese patients had greater long-term overall survival (HR 0.87, P<0.00001) compared with non-obese patients. No significant differences in MI (OR 0.84, 95% CI 0.52-1.34), major bleeding (OR 0.94, 95% CI 0.72-1.21), major vascular events (OR 1.18, 95% CI 0.97-1.43) and AKI (OR 1.17, 95% CI 0.87-1.56) were observed between the two groups. Obese AS patients might have similar procedural complications, but reduced mortality, and increased overall survival in comparison with normal weight individuals.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"85-99"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the prevalence, in-hospital mortality and readmission rates amongst pulmonary vs cardiac sarcoidosis patients: insights from a nationwide registry.","authors":"Shivang Chaudhary, Kaushik Gokul, Simran Bhimani, Anand Maligireddy, Nirav Arora, Lolita Golemi, Adam Kilian, Ravi Nayak, Deana Mikhalkova, Chaitanya Rojulpote, Chien-Jung Lin","doi":"10.62347/WJWP6904","DOIUrl":"10.62347/WJWP6904","url":null,"abstract":"<p><strong>Objectives: </strong>Sarcoidosis is a multisystem granulomatous disorder, with pulmonary sarcoidosis (PS) affecting approximately 90% of patients and cardiac sarcoidosis (CS) being less common but associated with severe clinical implications. While PS is primarily characterized by respiratory symptoms, CS can lead to serious complications like heart failure and arrhythmias, contributing to sarcoidosis-related mortality. This study aims to compare the prevalence, in-hospital mortality, 30-day readmission rates, and healthcare costs between PS and CS patients using data from the Nationwide Readmissions Database (NRD).</p><p><strong>Methods: </strong>Data were extracted from the NRD for adult patients diagnosed with PS or CS from January 2016 to December 2020. Baseline demographics, comorbidities, in-hospital outcomes, and 30-day readmission rates were analyzed. Statistical comparisons were made using appropriate tests for categorical and continuous variables.</p><p><strong>Results: </strong>Among 101,365 patients, 96,905 had PS and 4,460 had CS. CS patients experienced significantly higher rates of cardiovascular complications, such as heart failure (77.1% vs. 31.1%) and arrhythmias (75.8% vs. 27.7%), and incurred higher hospital charges ($59,520 vs. $40,249; P < 0.001). In-hospital mortality was similar between groups (CS: 2.4% vs. PS: 2.8%; P = 0.090). The 30-day readmission rate was comparable (CS: 12.9% vs. PS: 11.9%; P = 0.400), but PS patients were more likely to be readmitted for respiratory complications, while CS patients were readmitted primarily for heart failure.</p><p><strong>Conclusions: </strong>This study underscores the distinct clinical profiles of PS and CS. Although CS is less prevalent, it is associated with a higher cardiovascular burden and healthcare costs. Both groups exhibited similar mortality and readmission rates, though their readmission causes differed. These findings highlight the need for targeted management strategies for PS and CS to optimize patient outcomes and resource utilization.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"149-155"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impacts of armed conflict on outcomes of coronary angiography: report from Sudan's hot war zone 2023-2024.","authors":"Eldisugi Hassan Mohammed Humida, Salah Mohamed Ibrahim Mohamed, Abdelsalam Mohamed Hamad Elfaki, Khalid Me Eltalib, Amal Khalil Yousif Mohammed, Rayan Eissa Elbadwi Alhaj, Hussain Gadelkarim Ahmed","doi":"10.62347/IJAI8338","DOIUrl":"10.62347/IJAI8338","url":null,"abstract":"<p><strong>Objectives: </strong>Coronary angiography and emergency coronary revascularizations are critical for decreasing morbidity and mortality linked to coronary artery disease. Establishing and maintaining this service in armed conflict and on the battlefield poses challenges; however, it remains achievable. This study aimed to evaluate the results of coronary angiography in Sudan amid the armed conflict of 2023-2024.</p><p><strong>Methods: </strong>This study utilized a retrospective descriptive analysis conducted at El-Obeid International Hospital (Aldaman) in North Kordofan State, Sudan. Patient data was obtained from the hospital for the period spanning April 15, 2023, to April 30, 2024.</p><p><strong>Results: </strong>Out of 314 diagnostic coronary angiograms, 32% had PCI with DES implantation, 18% showed normal coronary arteries, and the other 50% were treated with medication and advice from heart surgeons (CTC). Among the 100 patients who underwent PCI, 64% were male and 36% were female. The predominant age group was 50-59 years, succeeded by 60-69 years, under 50 years, and over 60 years, with incidence rates of 30%, 29.9%, 20.3%, and 18.2%, respectively.</p><p><strong>Conclusions: </strong>The offering of cardiac catheterization laboratory services amid armed conflict poses challenges but is nonetheless feasible. Despite the tragedy, constrained resources, and the impact of wartime conditions, our findings were consistent with prior reports both locally and globally.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"131-138"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender in post-cardiac transplant patients has no effect on the occurrence of death, major cardiovascular events or development of cardiac allograft vasculopathy.","authors":"Nishant Satapathy, Mohammad Reza Movahed","doi":"10.62347/LPLW4777","DOIUrl":"10.62347/LPLW4777","url":null,"abstract":"<p><strong>Objectives: </strong>The effect of gender on outcome in post-cardiac transplant morbidity and mortality including the occurrence of transplant vasculopathy is not well established. The goal of this study was to evaluate adverse post-transplant outcomes based on gender with a focus on cardiac allograft vasculopathy (CAV).</p><p><strong>Methods: </strong>Using our post-transplant database at the University of Arizona, the effect of gender after heart transplantation on death, major adverse cardiac events (MACE defined as the combined occurrence of myocardial infarction, percutaneous coronary intervention, coronary bypass surgery, re-transplantation, and death) and the occurrence of CAV was evaluated retrospectively over 3 years.</p><p><strong>Results: </strong>A total of 149 patients were evaluated in our database. Over the study period after the first year post-transplantation, a total of 4,7% deaths occurred. There were no differences in death between males and females (4.3% vs 6.1%, p = ns). MACE occurred in similar degrees between males and females (7.8% vs 9.1%, p = ns). Furthermore, the occurrence of an abnormal coronary angiogram or significant intima thickening seen during intracoronary ultrasound studies was similar between the genders for every year studied.</p><p><strong>Conclusions: </strong>Gender does not effect on the occurrence of CAV at any year's post-cardiac transplantation. Furthermore, it has no effect on MACE and mortality.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"115-122"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous coronary intervention in elderly patients: clinical benefits and challenges from single center experience.","authors":"Ani A Rapyan, Armine S Chopikyan, Zinaida T Jndoyan, Ani R Tavaratsyan, Ani S Kocharyan, Shant H Mahrokhian, Hamayak S Sisakian","doi":"10.62347/DGQV8894","DOIUrl":"10.62347/DGQV8894","url":null,"abstract":"<p><strong>Objectives: </strong>Elderly patients who present with acute myocardial infarction are at increased risk for adverse outcomes owing to higher comorbidity burden and complicated coronary anatomy. We evaluated the three-year outcomes following coronary revascularization compared to conservative management among elderly patients presenting with acute myocardial infarction.</p><p><strong>Methods: </strong>155 patients over 75 years of age who were admitted for acute myocardial infarction underwent invasive treatment with coronary angioplasty (n=58) or only medical treatment (n=97). The Kaplan-Meier log rank test was used to compare 3-year survival and rehospitalization probability and the Mantel-Cox log rank test was used to compare mean survival time between groups.</p><p><strong>Results: </strong>In the Invasive treatment group (ITG) cohort, 3-year survival probability was 74.1% as compared to 29.9% in the Conservative treatment group (CTG) cohort (P<0.001). Mean survival time at 3 years of follow-up was 31.50 (95% CI 29.35-33.65) months among ITG patients versus 24.65 (95% CI 22.71-26.59) months among CTG patients (P<0.001). Mean time to rehospitalization at 3 years was 34.05 (95% CI 32.37-35.72) in the ITG cohort compared to 30.03 (95% CI 28.13-31.93) in the CTG cohort (P=0.004).</p><p><strong>Conclusion: </strong>Coronary revascularization among elderly patients with acute myocardial infarction reduces both all-cause mortality and cardiovascular events at 3-year follow-up. However, rates of rehospitalizations remain statistically similar between groups. Moreover, invasive treatment imparted improved rehospitalization probability compared to conservative treatment. This observation can be partially explained by a reduction in the frequency of myocardial infarction among those who underwent invasive treatment. While a thorough clinical assessment is required prior to treatment determination among elderly patients with acute myocardial infarction, coronary revascularization should be strongly considered as an intervention that likely improves overall survival probability.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 2","pages":"123-130"},"PeriodicalIF":1.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}