American journal of cardiovascular disease最新文献

{"title":"Long-term survival and complications of Fontan patients: where do we stand?","authors":"Adam Najm, Fayez Yassine, Assyl Amhaz, Fadi Bitar, Mariam Arabi","doi":"10.62347/IHTH5044","DOIUrl":"https://doi.org/10.62347/IHTH5044","url":null,"abstract":"<p><p>Single ventricle disease (SVD) is a rare but severe form of congenital heart disease (CHD) which requires surgical palliation through the Fontan procedure. This operation, which was pioneered in 1971, has become the final part of a surgical pathway after the Norwood and Glenn procedures. The pathway aims to reduce the load on the functional ventricle whilst improving systemic blood oxygenation. Advances in surgical technique and the modern era have shifted the approach from addressing mortality concerns to offering a lifeline to patients in need. With improved survival, the Fontan population grows which requires an emphasis on the lifelong complications that these individuals face along with specific risk factors that predispose them to these issues allowing for risk stratification and systematic monitoring. This narrative review aims to summarize the recent cohort studies on Fontan patients to identify long-term outcomes of the procedure along with their associated risk factors. The literature review was conducted till December 2025 using PubMed, Scopus, and Google Scholar, the procedure itself is not curative. I has numerous morbidities including arrhythmia, heart failure, neurocognitive delays, protein-losing enteropathy, renal dysfunction, and Fontan-associated liver disease (FALD). FALD specifically may affect over half of Fontan patients within 35 years and the seriousness of FALD sequelae including cirrhosis and hepatocellular carcinoma underscores the need to prioritize early and systematic monitoring. Preoperatively, demographic, surgical, and biomarker risk factors have been shown to be predictors of postoperative complications/mortality. Overall, Fontan patients tend to have excellent survival rates over both the short and long terms compared to prior surgical eras. As postoperative concerns now shift from early mortality to long-term complications, our healthcare system must adapt to ensure lifelong follow-up and a systematic approach for early detection.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"16 1","pages":"30-49"},"PeriodicalIF":1.3,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Watchman device implantation in atrial fibrillation patients contraindicated for long-term anticoagulation: a single-center experience.","authors":"Ghulam Mujtaba Ghumman, Sidra Kalsoom, Fnu Salman, Anas Noman, Tarif Kanaan, Chandramohan Meenakshisundaram, Mohammed Alo, Fnu Zafrullah, Sinan Alo, Syed Sohail Ali, Mohammed Taleb","doi":"10.62347/GIFT9764","DOIUrl":"https://doi.org/10.62347/GIFT9764","url":null,"abstract":"<p><strong>Background: </strong>Left atrial appendage occlusion (LAAO) using the Watchman device is an established strategy for stroke prevention in atrial fibrillation (AF) patients at high thromboembolic risk who cannot tolerate long-term oral anticoagulation (OAC).</p><p><strong>Objectives: </strong>To evaluate short-term clinical and echocardiographic outcomes of Watchman implantation in AF patients with contraindications to long-term OAC.</p><p><strong>Methods: </strong>We conducted a retrospective single-center study of AF patients who underwent Watchman implantation between September 01, 2023, and March 01, 2025. Baseline demographics, comorbidities, procedural characteristics, complications, antithrombotic strategies, and 45-day outcomes were analyzed. Outcomes were compared between patients with and without follow-up TEE. Data were analyzed using SAS v9.4. All tests were two-tailed, and a <i>p</i>-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>Among 10,078 AF patients, 120 underwent Watchman implantation; 105 met the inclusion criteria. The mean age was 75.8±7.8 years, and 46.7% were female. Implant success was 100%. Pericardial effusion occurred in 11 patients (10.5%, 95% CI 5.4-18.0%), including tamponade requiring pericardiocentesis in 2 patients (1.9%). Vascular access complications occurred in 3 patients (2.9%, 95% CI 0.6-8.1%). No device embolizations, device-related thrombi, or periprocedural strokes were observed. Most patients (88.5%) were discharged on dual antiplatelet therapy, while 3.8% received single antiplatelet therapy. At 45 days, 89 patients (84.8%) completed TEE; device position was stable in all. One patient (1.1%, 95% CI 0.03-6.1%) had a significant peridevice leak (>5 mm), and none had device-related thrombus. Clinical outcomes included one hemorrhagic stroke (1.1%) and eight rehospitalizations (7.6%, 95% CI 3.4-14.5%), unrelated to the device. No ischemic strokes were observed.</p><p><strong>Conclusion: </strong>Watchman implantation achieved a 100% success rate with low complication rates and favorable short-term clinical and echocardiographic outcomes in AF patients contraindicated for long-term anticoagulation.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"16 1","pages":"63-72"},"PeriodicalIF":1.3,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung ultrasound versus lung auscultation to detect pulmonary congestion in patients with advanced heart failure before discharge.","authors":"Hamayak Sisakian, Cecilia Linde, Sama Shamyar, Shant H Mahrokhian, Magdaghine Stamboltsyan, Syuzanna Shahnazaryan","doi":"10.62347/CZZS9228","DOIUrl":"https://doi.org/10.62347/CZZS9228","url":null,"abstract":"<p><strong>Background: </strong>Residual lung congestion is common in patients discharged after an acute heart failure (HF) hospitalization and represents a risk for HF rehospitalization. The aim of this study was to compare the diagnostic accuracy of B-lines on lung ultrasound and lung auscultation to detect residual congestion. We hypothesized that lung ultrasound would be more sensitive than physical examination.</p><p><strong>Methods: </strong>In this observational study of consecutive chronic HF patients discharged after an acute HF exacerbation, auscultation performed by two cardiologists and ultrasound examination performed by one experienced sonographer were compared at discharge. Residual congestion was defined by the presence of B-lines in all four zones and/or pleural effusion.</p><p><strong>Results: </strong>The study compared one hundred patients with severe heart failure (mean left ventricular (LV) ejection fraction 26%), mean age 70 years. Among the patients with signs of pulmonary congestion by lung auscultation, 31 zones were positive on lung ultrasound. Using positive ultrasound as reference, the accuracy of lung auscultation was 89.5%, with 52.5% sensitivity and 95.9% specificity. The positive and negative predictive values of lung auscultation were 68.9% and 92.1%, respectively.</p><p><strong>Conclusion: </strong>Lung auscultation has a moderate sensitivity and high specificity for detecting residual lung congestion in patients with chronic HF before discharge compared to lung ultrasound. These findings suggest, that lung ultrasound should be implemented as part of the discharge exam for the detection of residual congestion.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"16 1","pages":"73-79"},"PeriodicalIF":1.3,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric nutritional risk index predicts all-cause mortality in patients with heart failure: an updated systematic review and meta-analysis.","authors":"Alireza Gholami, Fateme Kazemi, Delaram Nourmohammadi, Reza Behfar, Fatemeh Nouroozi, Fateme Skandary, Nima Zabihi, Yeganeh Ghobadi, Siamand Abdolghaderi, Aida Bakhshi, Mohammad Hossein Shafieyoun, Yaser Khakpour, Mahdyieh Naziri, Mohamad Javad Bay","doi":"10.62347/JFZM5494","DOIUrl":"https://doi.org/10.62347/JFZM5494","url":null,"abstract":"<p><strong>Objectives: </strong>The role of malnutrition in heart failure (HF) patients is unclear. We assessed the correlation between the Geriatric Nutritional Risk Index (GNRI) and all-cause mortality in HF.</p><p><strong>Methods: </strong>PubMed, Scopus, and Web of Science were searched for observational studies reporting the correlation between GNRI and all-cause mortality in HF patients (up to January 26, 2025). Titles, abstracts, and full texts were screened. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used to assess study quality. Data were synthesized via random-effects meta-analysis using the restricted maximum likelihood (REML) method. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.</p><p><strong>Results: </strong>Nineteen observational studies with 9,982 subjects were included. A low-risk GNRI group was correlated with raised all-cause mortality in HF patients (hazard ratio (HR) 1.77, 95% CI 1.38-2.16; P < 0.0001). Results were consistent across sensitivity analyses. Heterogeneity was high (I² = 99.5%), and meta-regression explained 18.9% of the variance. Egger's test demonstrated possible publication bias (P = 0.0305). The high GNRI subgroup (5 studies, 2,193 patients) had a pooled HR of 3.15 (95% CI 0.93-5.37; P = 0.0055). The CI included 1.0, indicating some uncertainty.</p><p><strong>Conclusion: </strong>GNRI is a reliable nutritional tool predicting all-cause mortality in HF patients. Our study suggests GNRI should be considered for evaluating long-term prognosis in this population.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"16 1","pages":"17-29"},"PeriodicalIF":1.3,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the association between marital status and hypertension: evaluating the impact of age and gender.","authors":"Mohammad Amin Karimi, Ali Moradi, Mehregan Shahrokhi, Reyhaneh Alikhani, Seyed Amirhossein Mazhari, Fateme Hamzavi, Rosa Azad, Faezeh Jadidian, Elika Sohrabi, Aida Rabiei Nezhad, Arezu Karimzadeh, Arezou-Sadat Razavi, Sourena Mohammad Hashem, Vida Hafezi, Reza Khademi, Mahdyieh Naziri, Mohammad Ali Hatamian","doi":"10.62347/FBJS1513","DOIUrl":"https://doi.org/10.62347/FBJS1513","url":null,"abstract":"<p><strong>Objectives: </strong>Hypertension is a risk factor for cardiovascular diseases and is more prevalent in the elderly. Due to the aging population, it is crucial to know the risk factors of hypertension to prevent it and its complications. One potential risk factor is marital status; therefore, this study investigates the impact of marital status on hypertension risk, considering the variables of gender and age.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, Scopus, and Google Scholar until August 27, 2023. Study selection and data extraction were performed precisely. The pooled effect size for various marital status, age, and gender subgroups was calculated.</p><p><strong>Results: </strong>The overall effect size of the association between marital status and HTN was 32.01 (95% CI = [38.93, 35.09]). Single, married, divorced, and widowed subgroups showed an effect size of 17.67 (95% CI = [19.23, 19.12]), 54.89 (45.05, 64,13]), 16.11 (95% CI = [14.00, 18.23]), and 27.46 (95% CI = [23.63, 31.29]), respectively. The analysis based on age revealed an effect size of 0.52 (95% CI = [0.38, 0.65]) and 0.38 (95% CI = [0.24, 0.52]). For those aged above 40 and below 40, respectively. Finally, males and females were associated with HTN, with effect sizes of 0.38 (95% CI = [0.33, 0.43]) and 0.45 (95% CI = [0.39, 0.51]), respectively.</p><p><strong>Conclusion: </strong>Our findings revealed that married and divorced status is associated with the highest and the lowest incidence of hypertension, respectively. In terms of gender and age, males aged < 40 were related to lower hypertension risk compared to females and those aged ≥ 40. However, more extensive cohort studies are needed to further support our findings.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"16 1","pages":"1-16"},"PeriodicalIF":1.3,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of a novel traction balloon technique for guide-extension advancement in complex coronary interventions: a case series.","authors":"Abhishek P Raval, Kamal Sharma, Sharad Jain, Anand Shukla, Jayal Shah, Amanpreet Singh Wasir","doi":"10.62347/AZRJ4340","DOIUrl":"https://doi.org/10.62347/AZRJ4340","url":null,"abstract":"<p><p><i>Background:</i> Severe coronary tortuosity and calcification frequently result in difficult device delivery during percutaneous coronary intervention (PCI). Conventional techniques for guide-extension (GE) insertion have reported success rates of 88-98.7% with complication rates of 1.6-5.9%. We aimed to evaluate the feasibility and safety of a novel traction balloon technique (TBT) to facilitate GE insertion to overcome these limitations and achieve reasonable procedural outcomes in complex coronary anatomy. <i>Methods:</i> We conducted a retrospective single-center case-series of consecutive patients who underwent GE-assisted PCI with TBT between December, 2020 and September, 2025. PCI cases in which, conventional methods of coronary device-delivery and/or GE insertion were unsuccessful were evaluated for GE-assisted PCI using TBT. The technique enables passive tracking of the GE through active traction to a large anchor-balloon inflated distally. Clinical characteristics, procedural-details, efficacy and safety endpoints were analyzed. <i>Results:</i> A total of 225 vessels from 214 patients (mean age 62.24 ± 9.8 years) underwent GE-assisted PCI using TBT. Clinical presentations included acute coronary syndrome (n=182, 85.05%), effort-angina (n=25, 11.68%), and heart-failure (n=7, 3.27%). Mean lesion-length was 52.15 ± 22.7 mm. All lesions were American College of Cardiology/American Heart Association type-C (n=225); and Society of Cardiovascular Angiography and Interventions type-2 (n=161, 71.56%) or type-4 (n=64, 28.44%) lesions. Median tortuosity-score was 2 (1-3) with extreme tortuosity in 75.56% of cases. Median calcification-grade was 2 (1-4) with heavy calcification in 40% of cases. Procedures were performed via upper-limb (n=194, 86.22%) or femoral (n=31, 13.78%) access. The indications for GE included distal delivery of balloons (n=195), stents (n=222) and others (n=199). The balloon-to-artery diameter ratio was 0.91 ± 0.1. The GE was inserted a median of 2 (1-6) times/vessel, achieving a mean maximum depth of 55.32 ± 17.9 mm. A total of 351 stents were deployed in 31 (12-131) minutes, with 100% procedural success. Complications included transient bradycardia and/or hypotension (n=2) and non-flow-limiting dissection (n=2). At a median follow-up of 22 (1-58) months, all patients remained asymptomatic, except for three patients who died. <i>Conclusion:</i> TBT-assisted GE insertion is a feasible and safe technique for device delivery during complex PCI, with high procedural success.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"16 1","pages":"50-62"},"PeriodicalIF":1.3,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning models for predicting heart disease risk using the UCI database: methods, performance, and clinical context.","authors":"Reza Khademi, Golnaz Yazdanpanah, Ghazaleh Rouhparvarzamin, Vida Hafezi, Shayesteh Haghighi, Parham Panahi, Aida Bakhshi, Bita Faridnia, Ramin Ahangar-Sirous, Yasaman Tavakoli, Mohammad Amin Karimi, Farzad Sheikhzadeh, Ata Akhtari Kohnehshahri, Amir Abdi, Shekoufeh Safarbeiranvand, Mahsa Asadi Anar, Parisa Alsadat Dadkhah","doi":"10.62347/CEBK2916","DOIUrl":"10.62347/CEBK2916","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and evaluate deep learning models for predicting heart disease using the University of California, Irvine (UCI) heart disease dataset, and to contextualize model performance against classical machine learning approaches.</p><p><strong>Method: </strong>Data were extracted from the University of California Irvine (UCI) heart disease dataset, including information from Cleveland, Hungary, Switzerland, and Long Beach V, collected in 1988. The dataset comprises 1,025 patients and 14 key attributes. Deep learning models were used to analyze the data and predict heart disease risk.</p><p><strong>Results: </strong>The deep learning models demonstrated high accuracy in predicting heart disease risk. The Random Forest model achieved an accuracy of 99%. Significant predictors included exercise-induced angina and downsloping ST segments. The data revealed that 72% of females and 42% of males experienced heart attacks. There was a 79% chance that atypical angina and a 77% chance that non-anginal pain would lead to a heart attack. Exercise-induced angina had a 67% chance of resulting in a heart attack, while downsloping of the peak exercise ST segment had a 72% chance. Additionally, a 71% chance was observed for heart attacks in patients with no major coronary artery blockage (ca=0), and a 75% chance for those with a potentially reversible thalassemia-related defect (thal=2). Age groups 40-44 and 50-54 had a 76% and 61% risk of heart attacks, respectively.</p><p><strong>Conclusion: </strong>Deep learning models can significantly enhance heart disease risk prediction, leading to improved treatment strategies. These findings can aid in early diagnosis and timely interventions, improving clinical outcomes for heart disease patients.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 6","pages":"374-386"},"PeriodicalIF":1.3,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitination-mediated protein homeostasis in cardiovascular diseases: molecular mechanisms and therapeutic opportunities.","authors":"Yanfei Wang, Xuesong Liu, Yong Hu, Hongfan Li, Zhaoyu Li, Hui Xu, Lu Cheng, Qian Qiao, Xuerui Ye, Haoling Zhang, Zhijing Song, Wei Wang, Jingjing Zhang","doi":"10.62347/ZQVK5365","DOIUrl":"10.62347/ZQVK5365","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) remain one of the leading causes of death worldwide. Although the well-known risk factors include hypertension, hyperglycemia, dyslipidemia and obesity, the latest studies implicate involvement of pathological mechanisms at the molecular level. Various cellular processes, including oxidative stress, inflammatory response, mitochondrial dysfunction, and ferroptosis, are regarded as contributors to the initiation and progression of CVDs. Ubiquitination, a post-translational modification essential for the maintenance of protein homeostasis, influences the pathogenesis of CVD through regulating protein degradation, signal transduction and cellular functionality. The enzymes E1, E2 and several E3 ligases (e.g., TRAF6, TRIM21, TRIM35) participate in autophagy, inflammation and cardiac remodelling, while deubiquitinating enzymes (DUBs) (e.g., USP25, OTUB1) modulate cardiac function by stabilizing calcium pumps or regulating key signalling molecules. For example, ubiquitination of TRPC3 Ca²⁺ channels prevents them from functioning closely with phospholipase C; excessive accumulation of TRPC3 lowers cardiac contractility. On the other hand, new protein degradation technologies like Proteolysis-Targeting Chimera (PROTAC) are promising for precise selective down-regulation of disease-related proteins. This study will systematically summarize the molecular mechanisms of ubiquitination in CVDs and its potential therapeutics to provide theoretical support for mechanistic research and the development of new targeted drugs.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 6","pages":"442-476"},"PeriodicalIF":1.3,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-transplant hemodynamic profiles of patients with ischemic vs. non-ischemic cardiomyopathy: insights from a retrospective single-center study.","authors":"Mohammad Reza Movahed, Shiva Aminnia","doi":"10.62347/JHDW8386","DOIUrl":"10.62347/JHDW8386","url":null,"abstract":"<p><strong>Objectives: </strong>Heart transplantation remains the last resort for patients with end-stage heart failure. The clinical and hemodynamic profiles of these patients may differ depending on the underlying etiology of cardiomyopathy. This study aimed to evaluate pre-transplant hemodynamic characteristics in patients with ischemic versus non-ischemic cardiomyopathy.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 170 adult patients who underwent orthotopic heart transplantation at a single center. Patients were categorized based on the etiology of heart failure as either ischemic or non-ischemic cardiomyopathy. Preoperative hemodynamic and echocardiographic parameters were compared between the groups.</p><p><strong>Results: </strong>Of the 170 patients, 45.2% had ischemic cardiomyopathy. These patients were significantly older than those with non-ischemic cardiomyopathy (53.2 vs. 46.7 years, P<0.01). However, no significant differences were observed between the two groups in pulmonary capillary wedge pressure (17.9 ± 8.0 vs. 17.4 ± 9.5 mmHg), mean pulmonary artery pressure (29.4 ± 10.9 vs. 27.3 ± 12.6 mmHg), or left ventricular ejection fraction (21.4 ± 10.8% vs. 23.3 ± 12.5%).</p><p><strong>Conclusion: </strong>While ischemic cardiomyopathy patients were older, their preoperative hemodynamic and echocardiographic profiles were closely similar to those with non-ischemic cardiomyopathy.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 6","pages":"366-373"},"PeriodicalIF":1.3,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of external magnetic and electric fields on blood flow and drug transport in a cardiovascular tube.","authors":"Binyam Zigta Teferi","doi":"10.62347/RYQF6012","DOIUrl":"10.62347/RYQF6012","url":null,"abstract":"<p><p>Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, and efficient drug delivery (DD) is critical for treatment success. The use of external electric (EF) and magnetic fields (MF) offers a promising approach to enhance targeted drug transport in vascular systems. This study investigates the effect of combined electric and magnetic fields (EMF) on blood flow and drug delivery (DD) in a cardiovascular tube model. The governing equations for momentum, energy, and concentration were formulated using magneto-hydrodynamics (MHD) theory with slip boundary conditions and external electromagnetic forces (EEF). Similarity transformations reduced the equations to ordinary differential form (ODEs), which were solved numerically using MATLAB code. Increasing magnetic field strength reduced flow resistance while improving drug penetration, whereas the electric field (EF) enhanced solute dispersion via electro-osmotic effects (EOE). The combined effect significantly improved concentration profiles along the tube. Conclusion: The findings suggest that external electromagnetic fields (EEF) can optimize drug delivery (DD) efficiency, providing a theoretical framework for advanced cardiovascular therapies.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 6","pages":"395-404"},"PeriodicalIF":1.3,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12816775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}