{"title":"一项最新的关于乳糜泻和心血管疾病之间关系的荟萃分析。","authors":"Mahdi Faraji, Reza Khademi, Maede Maleki, Fatemeh Jafari, Ensiyeh Olama, Mohammad Sadra Saghafi, Anita Fatehi, Elnaz Olama, Danial Abasi Dehkordi, Aydin Hassanpour Adeh, Seyyed Kiarash Sadat Rafiei, Komeil Aghazadeh-Habashi, Amin Magsudy, Pegah Refahi, Niloofar Deravi, Zahra Keyhanifar, Mahsa Asadi Anar","doi":"10.62347/WNAK3699","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Research on the relationship between celiac disease (CD) and cardiovascular disease (CVD) is still ongoing, and different studies have reported contradictory findings. To carry out a meta-analysis and systematic review to look into the connection between CD and CVD risk.</p><p><strong>Methods: </strong>A thorough search was conducted in PubMed, Scopus, and Google Scholar databases up to February 19, 2024. Relevant articles were extracted, and the titles, abstracts, and full texts of the related articles were screened. The quality of the studies was assessed using the Joanna Briggs Institute critical appraisal tools.</p><p><strong>Results: </strong>Nine cohort and one case-control studies involving 49,621,333 individuals were included in the meta-analysis. The pooled analysis revealed a 7% increased risk of CVD in CD patients compared to controls (OR: 1.07, 95% CI: 1.03-1.10, P < 0.05). Significant heterogeneity was observed among studies (I<sup>2</sup> = 76%, P < 0.001).</p><p><strong>Conclusion: </strong>This meta-analysis provides evidence of a modest but significant increase in CVD risk in patients with CD. The results highlight the importance of considering cardiovascular health in CD treatment and the need for further research to elucidate the mechanisms underlying this association and to develop targeted prevention strategies.</p>","PeriodicalId":7427,"journal":{"name":"American journal of cardiovascular disease","volume":"15 3","pages":"181-194"},"PeriodicalIF":1.3000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267083/pdf/","citationCount":"0","resultStr":"{\"title\":\"An updated meta-analysis on the association between celiac disease and cardiovascular diseases.\",\"authors\":\"Mahdi Faraji, Reza Khademi, Maede Maleki, Fatemeh Jafari, Ensiyeh Olama, Mohammad Sadra Saghafi, Anita Fatehi, Elnaz Olama, Danial Abasi Dehkordi, Aydin Hassanpour Adeh, Seyyed Kiarash Sadat Rafiei, Komeil Aghazadeh-Habashi, Amin Magsudy, Pegah Refahi, Niloofar Deravi, Zahra Keyhanifar, Mahsa Asadi Anar\",\"doi\":\"10.62347/WNAK3699\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Research on the relationship between celiac disease (CD) and cardiovascular disease (CVD) is still ongoing, and different studies have reported contradictory findings. To carry out a meta-analysis and systematic review to look into the connection between CD and CVD risk.</p><p><strong>Methods: </strong>A thorough search was conducted in PubMed, Scopus, and Google Scholar databases up to February 19, 2024. Relevant articles were extracted, and the titles, abstracts, and full texts of the related articles were screened. The quality of the studies was assessed using the Joanna Briggs Institute critical appraisal tools.</p><p><strong>Results: </strong>Nine cohort and one case-control studies involving 49,621,333 individuals were included in the meta-analysis. The pooled analysis revealed a 7% increased risk of CVD in CD patients compared to controls (OR: 1.07, 95% CI: 1.03-1.10, P < 0.05). Significant heterogeneity was observed among studies (I<sup>2</sup> = 76%, P < 0.001).</p><p><strong>Conclusion: </strong>This meta-analysis provides evidence of a modest but significant increase in CVD risk in patients with CD. The results highlight the importance of considering cardiovascular health in CD treatment and the need for further research to elucidate the mechanisms underlying this association and to develop targeted prevention strategies.</p>\",\"PeriodicalId\":7427,\"journal\":{\"name\":\"American journal of cardiovascular disease\",\"volume\":\"15 3\",\"pages\":\"181-194\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-06-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267083/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of cardiovascular disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.62347/WNAK3699\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of cardiovascular disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.62347/WNAK3699","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的：关于乳糜泻（CD）与心血管疾病（CVD）关系的研究仍在进行中，不同的研究报告了相互矛盾的结果。进行荟萃分析和系统评价，以了解CD和CVD风险之间的联系。方法：全面检索截至2024年2月19日的PubMed、Scopus和谷歌Scholar数据库。提取相关文章，筛选相关文章的标题、摘要和全文。研究的质量是用乔安娜布里格斯研究所的关键评估工具来评估的。结果：荟萃分析纳入了9项队列研究和1项病例对照研究，涉及49,621,333人。合并分析显示，与对照组相比，CD患者发生CVD的风险增加7% （OR: 1.07, 95% CI: 1.03-1.10, P < 0.05）。研究间存在显著异质性（I2 = 76%, P < 0.001）。结论：本荟萃分析提供了CD患者心血管疾病风险适度但显著增加的证据。结果强调了在CD治疗中考虑心血管健康的重要性，以及进一步研究阐明这种关联的机制和制定有针对性的预防策略的必要性。
An updated meta-analysis on the association between celiac disease and cardiovascular diseases.
Objectives: Research on the relationship between celiac disease (CD) and cardiovascular disease (CVD) is still ongoing, and different studies have reported contradictory findings. To carry out a meta-analysis and systematic review to look into the connection between CD and CVD risk.
Methods: A thorough search was conducted in PubMed, Scopus, and Google Scholar databases up to February 19, 2024. Relevant articles were extracted, and the titles, abstracts, and full texts of the related articles were screened. The quality of the studies was assessed using the Joanna Briggs Institute critical appraisal tools.
Results: Nine cohort and one case-control studies involving 49,621,333 individuals were included in the meta-analysis. The pooled analysis revealed a 7% increased risk of CVD in CD patients compared to controls (OR: 1.07, 95% CI: 1.03-1.10, P < 0.05). Significant heterogeneity was observed among studies (I2 = 76%, P < 0.001).
Conclusion: This meta-analysis provides evidence of a modest but significant increase in CVD risk in patients with CD. The results highlight the importance of considering cardiovascular health in CD treatment and the need for further research to elucidate the mechanisms underlying this association and to develop targeted prevention strategies.
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