{"title":"Diverse roles for axon guidance pathways in adult tissue architecture and function.","authors":"Kaitlin M Laws, Greg J Bashaw","doi":"10.1002/ntls.20220021","DOIUrl":"10.1002/ntls.20220021","url":null,"abstract":"<p><p>Classical axon guidance ligands and their neuronal receptors were first identified due to their fundamental roles in regulating connectivity in the developing nervous system. Since their initial discovery, it has become clear that these signaling molecules play important roles in the development of a broad array of tissue and organ systems across phylogeny. In addition to these diverse developmental roles, there is a growing appreciation that guidance signaling pathways have important functions in adult organisms, including the regulation of tissue integrity and homeostasis. These roles in adult organisms include both tissue-intrinsic activities of guidance molecules, as well as systemic effects on tissue maintenance and function mediated by the nervous and vascular systems. While many of these adult functions depend on mechanisms that mirror developmental activities, such as regulating adhesion and cell motility, there are also examples of adult roles that may reflect signaling activities that are distinct from known developmental mechanisms, including the contributions of guidance signaling pathways to lineage commitment in the intestinal epithelium and bone remodeling in vertebrates. In this review, we highlight studies of guidance receptors and their ligands in adult tissues outside of the nervous system, focusing on <i>in vivo</i> experimental contexts. Together, these studies lay the groundwork for future investigation into the conserved and tissue-specific mechanisms of guidance receptor signaling in adult tissues.</p>","PeriodicalId":74244,"journal":{"name":"Natural sciences (Weinheim, Germany)","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346896/pdf/nihms-1830702.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9821498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scents from the past: Lineage history and terminal identity in the olfactory system.","authors":"Sriivatsan G Rajan, Ankur Saxena","doi":"10.1002/ntls.20220037","DOIUrl":"https://doi.org/10.1002/ntls.20220037","url":null,"abstract":"The development of the vertebrate nose depends upon the interaction and intermingling of multiple progenitor subtypes, giving rise to olfactory epithelia that detect sensory information and transmit it to the brain.1,2 The olfactory epithelium is a dense and complex structure that houses numerous specialized cell types, including olfactory sensory neurons (OSNs) and, additionally, is thought to be the origin of migratory gonadotropin-releasing hormone (GnRH) neurons.2–4","PeriodicalId":74244,"journal":{"name":"Natural sciences (Weinheim, Germany)","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9746709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10363087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Thompson, D. Muth, Sebastian Anhäuser, D. Bischof, M. Gerhard, G. Witte, E. Malic
{"title":"Singlet‐exciton optics and phonon‐mediated dynamics in oligoacene semiconductor crystals","authors":"J. Thompson, D. Muth, Sebastian Anhäuser, D. Bischof, M. Gerhard, G. Witte, E. Malic","doi":"10.1002/ntls.20220040","DOIUrl":"https://doi.org/10.1002/ntls.20220040","url":null,"abstract":"Organic semiconductor crystals stand out as an efficient, cheap and diverse platform for realising optoelectronic applications. The optical response of these crystals is governed by a rich tapestry of exciton physics. So far, little is known on the phonon-driven singlet exciton dynamics in this class of materials. In this joint theory-experiment work, we combine the fabrication of a high-quality oligoacene semiconductor crystal and characterization via photoluminescence measurements with a sophisticated approach to the microscopic modeling in these crystals. This allows us to investigate singlet exciton optics and dynamics. We predict phonon-bottleneck effects in pentacene crystals, where we find dark excitons acting as crucial phonon-mediated relaxation scattering channels. While the efficient singlet fission in pentacene crystals hampers the experimental observation of this bottleneck effect, we reveal both in theory and experiment a distinct polarisation- and temperature-dependence in absorption and photoluminescence spectra of tetracene crystals, including microscopic origin of exciton linewidths, the activation of the higher Davydov states at large temperatures, and polarisation-dependent quenching of specific exciton resonances. Our joint theory-experiment study represents a significant advance in microscopic understanding of singlet exciton optics and dynamics in oligoacene crystals.","PeriodicalId":74244,"journal":{"name":"Natural sciences (Weinheim, Germany)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89850738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Förstel, Nima‐Noah Nahvi, Kai Pollow, T. Studemund, Alice E. Green, A. Fielicke, S. Mackenzie, O. Dopfer
{"title":"The impact of optical excitation on the binding in complexes of the cationic gold dimer: Au2+N2${rm{Au}_{2}^{+}} {rm{N}_{2}} $ and Au2+N2O${rm{Au}_{2}^{+}} {rm{N}_{2}{rm{O}}} $","authors":"M. Förstel, Nima‐Noah Nahvi, Kai Pollow, T. Studemund, Alice E. Green, A. Fielicke, S. Mackenzie, O. Dopfer","doi":"10.1002/ntls.20220023","DOIUrl":"https://doi.org/10.1002/ntls.20220023","url":null,"abstract":"","PeriodicalId":74244,"journal":{"name":"Natural sciences (Weinheim, Germany)","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75596075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Krüger, Jake Wilson, M. Wietzoreck, B. A. Bandowe, G. Lammel, B. Schmidt, U. Pöschl, T. Berkemeier
{"title":"Convolutional neural network prediction of molecular properties for aerosol chemistry and health effects","authors":"Matteo Krüger, Jake Wilson, M. Wietzoreck, B. A. Bandowe, G. Lammel, B. Schmidt, U. Pöschl, T. Berkemeier","doi":"10.1002/ntls.20220016","DOIUrl":"https://doi.org/10.1002/ntls.20220016","url":null,"abstract":"","PeriodicalId":74244,"journal":{"name":"Natural sciences (Weinheim, Germany)","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86698787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The road toward imaging a black hole: A personal perspective","authors":"H. Falcke","doi":"10.1002/ntls.20220031","DOIUrl":"https://doi.org/10.1002/ntls.20220031","url":null,"abstract":"The images of the supermassive black holes Sgr A* and M87* by the Event Horizon Telescope (EHT) collaboration mark a special milestone in the history of the subject. For the first time we are able to see the shadow of black holes, testing basic predictions of the theory of general relativity. We are also now learning more about the fundamental astrophysical processes close to the event horizon that help to shape entire galaxies and even parts of our cosmos. The ultimate result was only possible due to a large collaborative effort of scientists and institutions around the world. The road towards these images was the result of a long sociological and scientific process. It started with early pathfinder experiments and a few simple ideas that were remarkably successful in predicting the basic observational signatures to look for. This was based on the premise that black holes are inherently simple objects. Here I describe this journey and some lessons learned from a personal perspective.","PeriodicalId":74244,"journal":{"name":"Natural sciences (Weinheim, Germany)","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90428995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}