Scents from the past: Lineage history and terminal identity in the olfactory system.

Abstract

The development of the vertebrate nose depends upon the interaction and intermingling of multiple progenitor subtypes, giving rise to olfactory epithelia that detect sensory information and transmit it to the brain.1,2 The olfactory epithelium is a dense and complex structure that houses numerous specialized cell types, including olfactory sensory neurons (OSNs) and, additionally, is thought to be the origin of migratory gonadotropin-releasing hormone (GnRH) neurons.2–4