Allergy proceedings : the official journal of regional and state allergy societies最新文献_第8页

Management of inflammation in allergic asthma (IRINE symposium). Immunology Research Institute of New England. 过敏性哮喘的炎症管理(国际哮喘学会学术研讨会)。新英格兰免疫学研究所。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816553

L M DuBuske

{"title":"Management of inflammation in allergic asthma (IRINE symposium). Immunology Research Institute of New England.","authors":"L M DuBuske","doi":"10.2500/108854194778816553","DOIUrl":"https://doi.org/10.2500/108854194778816553","url":null,"abstract":"Allergic inflammation as a cause of asthma is now well recognized. New methods of identification of allergen-specific IgE including improved in vitro technologies will require optimization of the lowest threshold for the detection of allergen-specific IgE in order to maximize sensitivity without loss of specificity, thus allowing for significant enhancement in a clinical setting for determination of allergen-specific IgE levels. New concepts of allergic inflammation include the recognition that significant histologic changes may occur even in the mildest allergic patients. Thus, early intervention with antiinflammatory therapies including corticosteroids or inhaled nedrocromil sodium appears clearly warranted based on these early pathological changes occurring in asthmatic individuals. Inhaled corticosteroids have been demonstrated to prevent pathological changes that otherwise occur in asthmatic patients whose sole therapy is use of inhaled B2 agonist. Corticosteroids have also been noted to be successful in the prevention of progression of pathological changes including the development of bronchiectasis in asthmatic patients with allergic bronchopulmonary fungoses. Allergen-specific immunotherapy may be successfully used in selective asthmatic patients allergic to pollen, dust mite, or certain mold allergens including Alternaria. Immunotherapy appears to be most useful in those patients who are allergic to one rather than many allergens and whose asthma is not associated with other significant precipitating factors such as chronic rhinosinusitis or aspirin sensitivity. The risk of systemic reactions to allergen immunotherapy in the asthmatic patient is significant.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":7423,"journal":{"name":"Allergy proceedings : the official journal of regional and state allergy societies","volume":"15 6","pages":"313-8"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854194778816553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18723014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diagnosis and management of allergic bronchopulmonary aspergillosis. 过敏性支气管肺曲霉病的诊断与治疗。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816463

P A Greenberger

{"title":"Diagnosis and management of allergic bronchopulmonary aspergillosis.","authors":"P A Greenberger","doi":"10.2500/108854194778816463","DOIUrl":"https://doi.org/10.2500/108854194778816463","url":null,"abstract":"Early diagnosis and treatment is essential for patients afflicted with bronchopulmonary aspergillosis (ABPA). Inflammatory damage to the airways may be significantly reduced through use of corticosteroids. Without treatment, bronchiectasis causing permanent anatomic alteration of the airways may occur. ABPA should be considered in any asthmatic who requires oral corticosteroids and has recurrent pulmonary infiltrates. Evaluation should include determination of total serum IgE, which generally exceeds 1000 ng/mL in patients with ABPA. Disease categorization of ABPA patients may be made according to radiographic and clinical considerations into five stages. The treatment choice for ABPA is prednisone, although inhaled corticosteroids including beclomethasone dipropionate may also be used in long-term asthma management. Successful therapy of ABPA is typically associated with a decline in total serum IgE, subsequent exacerbations often being associated with elevation in total serum IgE. Allergen avoidance is essential for the ABPA patient, as exposure to heavy concentrations of fungi may precipitate disease exacerbation.","PeriodicalId":7423,"journal":{"name":"Allergy proceedings : the official journal of regional and state allergy societies","volume":"15 6","pages":"335-9"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854194778816463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18723576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 155

Detection limits and receiver operating characteristic curve analysis in the evaluation of specific IgE assays. 特异性IgE检测评价的检出限及受试者工作特征曲线分析。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816508

W K Dolen

引用次数: 9

Variables in allergy skin testing. 过敏皮肤试验中的变量。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816490

H S Nelson

引用次数: 33

Pathology of asthma. 哮喘病理。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816436

A Laitinen, L A Laitinen

{"title":"Pathology of asthma.","authors":"A Laitinen, L A Laitinen","doi":"10.2500/108854194778816436","DOIUrl":"https://doi.org/10.2500/108854194778816436","url":null,"abstract":"Appreciation of the early damage that occurs to the respiratory epithelium has been limited by the use of autopsy specimens from fatally stricken asthmatics as a source of representative specimens. The use of bronchoscopy to obtain specimens from patients early in the course of their asthma has allowed a new understanding of the evolution of pathological changes that occur in asthma. Newly diagnosed, mild asthmatics have been shown to have bronchial goblet cell hyperplasia in addition to increased numbers of mast cells and eosinophils in the respiratory epithelium, and increased eosinophil granule protein deposition within the lamina propria. Endothelial gaps in postcapillary venules are greater in asthmatic airways, suggesting that increased plasma transudation may contribute to the known epithelial cell shedding characteristic of asthma attacks. Asthmatic inflammation, even early in the course of the disease, includes vascular permeability changes, inflammatory cell infiltration, epithelial cell shedding, and goblet cell hyperplasia, replacing the normal ciliated epithelium. Current investigation evaluating the effects of asthmatic inflammation on epithelial cell attachment to each other and to the extracellular matrix molecules regulated by adhesion glycoproteins will likely enhance further the understanding of the pathological changes that occur within the asthmatic airway.","PeriodicalId":7423,"journal":{"name":"Allergy proceedings : the official journal of regional and state allergy societies","volume":"15 6","pages":"323-8"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854194778816436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18723011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The beta-2 adrenergic receptor and its agonists. -2肾上腺素能受体及其激动剂。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816454

W K Dolen

引用次数: 3

Active immunization: how many shots should a child endure? 主动免疫:儿童应接种多少针?

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816481

J A Bellanti

引用次数: 0

Human mast cell heterogeneity. 人肥大细胞异质性。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816472

A M Irani, L B Schwartz

{"title":"Human mast cell heterogeneity.","authors":"A M Irani, L B Schwartz","doi":"10.2500/108854194778816472","DOIUrl":"https://doi.org/10.2500/108854194778816472","url":null,"abstract":"Mast cell neutral proteases are the most precise markers of heterogeneity among human mast cells. Two types of human mast cells have been recognized. MCTC cells contain tryptase together with chymase, cathepsin-G like protease, and mast cell carboxypeptidase; MCT cells contain tryptase, but lack the other neutral proteases present in MCTC cells. All mast cells develop from hemopoietic stem cells. In vitro procedures for studying mast cell growth have been developed, using the major human mast cell growth factor, stem cell factor (SCF, also called Kit-ligand). Cultures of hemopoietic progenitor cells in the presence of SCF alone result in selective differentiation to mast cells. The same progenitor cells can be induced to differentiate into other lineages when SCF is used with various lineage-specific colony-stimulating factors such as erythropoietin for erythrocytes. Mast cell development from hematopoietic progenitors may represent a \"default pathway,\" occurring optimally in a permissive microenvironment such as skin, bowel, and lung. The presence or absence of certain cytokines in blood and bone marrow may create a non-permissive environment, thus the absence of granulated mast cells in such locations.","PeriodicalId":7423,"journal":{"name":"Allergy proceedings : the official journal of regional and state allergy societies","volume":"15 6","pages":"303-8"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/108854194778816472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18724983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 149

Therapeutic indications and rationale for theophylline in the management of asthma. 茶碱治疗哮喘的适应症和基本原理。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-11-01 DOI: 10.2500/108854194778816517

M Weinberger

引用次数: 2

Drug allergy and protocols for management of drug allergies. 药物过敏和药物过敏管理方案。

Allergy proceedings : the official journal of regional and state allergy societies Pub Date : 1994-09-01 DOI: 10.2500/108854194778700713

R Patterson, R D DeSwarte, P A Greenberger, L C Grammer, J E Brown, A C Choy

引用次数: 12