Molecular psychology最新文献

{"title":"A review of ethical and regulatory issues in the clinical application of stem cell-derived tissue constructs","authors":"Alexander R. Harris, Patrick McGivern, F. Gilbert","doi":"10.12688/molpsychol.17522.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17522.1","url":null,"abstract":"The potential of organoids and other stem cell-derived tissue constructs (SCTC) to be used for clinical applications is developing rapidly.  Subsequently, there is an increasing need to understand and address the ethical, legal and regulatory issues around their use.  There are a range of health, ethical, regulatory and legal issues associated with SCTCs that will evolve as the technology develops and they become more accepted for clinical use.  SCTCs can be used for drug screening, phenotypic disease screening and regenerative medicine applications.  Each clinical application has different issues and requirements, there is no perfect, one size fits all SCTC that will cover all applications, even where these different applications assess the same treatment, patient or disease.  Currently, there is minimal guidance on the use of SCTCs in clinical applications, but the regulatory requirements will depend on the particular application.  There is a tension between population based and personalised SCTCs for drug screening, phenotypic disease screening and regenerative medicine applications; whether experimental trials and subsequent delivery of safe and effective treatments for small or individual patient groups can be developed and their financial viability.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45697326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Of looping kinds and unruly objects: the conceptual making of organoids","authors":"O. Altınok","doi":"10.12688/molpsychol.17527.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17527.1","url":null,"abstract":"Although the traditional approach within ELSA (Ethical, Legal and Social Aspects) initiatives is to have certain kinds of objects “set” or ready to be governed within bioethics, I will claim that the established regime of bioethics and bio law act as governance while influencing the conceptualization of the entities at play, in this example, the organoids. As a small contrast case to making organoids, I will use the regulation and categorization of embryonic research as a more “natural kind” entity research compared to conceptually synthetic research, where the objects to be regulated are shaped by existing practices of language and material alike. While analyzing the conceptual making of the organoids, I will follow the general methodological framework of Ian Hacking in Social Construction of What? (1999) from philosophy of science, particularly his understanding of “looping kinds”. And since Hacking’s understanding of looping kinds is in a relatively vague formulation, I will supply with different structures within co – productionist account of science and technology studies, most notably of works of Jasonoff (2015) of co-productionist accounts and Bensaude – Vincent’s concept of “buzzword coalitions” (2014) in the making of conceptual coalition around organoids. I will use the structure of scientific objects to assign different uses of parts of concepts in the making.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49504709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-canonical odor representation and learning in Dipteran brains","authors":"Michael J Rauscher, G. Wolff","doi":"10.12688/molpsychol.17525.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17525.1","url":null,"abstract":"For decades, the vinegar fly Drosophila melanogaster has provided a window into the structure and function of the insect olfactory system, revealing a remarkable organizational correspondence between insects and vertebrates. In both clades, olfactory sensory neurons expressing the same class of sensory receptor proteins exclusively target a dedicated neuropil known as a glomerulus. Here, we review recent evidence from Drosophila and other Dipteran taxa that challenges this canonical view, showing widespread co-expression of olfactory sensory proteins within the same neurons. We discuss the consequences of co-expression for early sensory processing in the insect olfactory system. In addition, we situate these findings within the broader framework of olfactory learning, highlighting recent findings that suggest a wider importance of the antennal lobe than has been previously appreciated.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46720555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The welfare of brain organoids","authors":"Heather Browning, W. Veit","doi":"10.12688/molpsychol.17523.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17523.1","url":null,"abstract":"One of the most urgent challenges arising in bioethics has been the ethical assessment of the use of brain organoids, largely because of the possibility of sentience and the potential that if they can feel, then they might suffer. But while there is a growing literature on the possibility of sentience in brain organoids and why we should take a precautionary approach towards them, there is very little guidance on what it would mean to protect their welfare. In this paper, we address this omission by exploring the question of what the welfare of an organoid might be like, and how we could scientifically assess this question. As we will show, these are difficult questions to answer, given the current lack of empirical data on many of the important features of brain organoids, but we will provide some principled empirically-informed speculation on possible answers, as well as suggestions for future research directions.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41567704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Political and ethical landscape of brain organoid research","authors":"Eric Schneider, L. Samsa, Veljko Dubljević","doi":"10.12688/molpsychol.17521.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17521.1","url":null,"abstract":"Human cerebral organoids (hCOs), produced in labs through directed cell culture of embryonic or induced pluripotent stem cells, closely replicate the 3-dimensional architecture of the human brain on a micro scale. This technology has been used to model neurological disease and shows promise to complement or supplant animal subjects in preclinical therapeutic investigation. However, attention must be paid by researchers and institutions to the various ethical concerns associated with hCO development. Human-animal chimeras produced through the grafting of hCOs have shown integration of neurological function, calling into question the moral status of both the animal chimeras and the organoid itself. Sensationalist reporting on such acts may also prompt public backlash, potentially jeopardizing hCO research and the promised benefits thereof. Moreover, concerns arise over privacy and consent for past and prospective donors of stem cells used to produce organoids. Genetic information may be considered privileged to the public domain and disrupted trust can reduce the supply of willing donors. Though hCOs are believed thus far to lack the capacity for consciousness and cognitive function, consideration must be given to their potential status as moral agents with further development or enhancement. Boundaries concerning organoids adhered to by researchers have been largely voluntary and informal to this point. By edict or by the power of the purse, governmental regulatory agencies ought to formalize necessary guidelines to ensure compliance with ethical principles and the adequate representation of all affected stakeholders in future decisions.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42314968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased hippocampal microglial cell activation by methanolic extract from the leaves of Mallotus oppositifolius (Geiseler) Müll. Arg contributes to its antidepressant-like effect","authors":"K. E. Kukuia, Ferka Yaw Takyi, George J. Dugbartey, Patrick Amoateng, W. Kudzi, S. Amponsah, A. Koomson, Frimpong Appiah, Ofosua Adi-Dako, E. Ameyaw, K. Adutwum-Ofosu","doi":"10.12688/molpsychol.17508.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17508.1","url":null,"abstract":"Background: Natural remedies with neuroprotective effect are useful in neuroinflammation-associated depression. Although Mallotus oppositifolius extract (MOE) has previously demonstrated antidepressant and anti-inflammatory properties, its neuroprotective effect remains unknown. Thus, the study evaluated the effect of MOE on lipopolysaccharide (LPS)-induced neuroinflammation-associated depression in mice. Methods: Antidepressant-like effect of MOE (10 - 100 mg/kg), fluoxetine (20 mg/kg) and minocycline (50 mg/kg) was established in naïve Institute of Cancer Research (ICR) mice using the forced swim (FST), tail suspension (TST) and open-space swim (OSST) tests. In a separate experiment, FST and TST were used to assess the effect of an 11-day pre-treatment with MOE (10 - 100 mg/kg) or minocycline (50 mg/kg) on LPS (1 mg/kg) neuroinflammation at 6 and 24 hours post LPS. Following these tests, mice were sacrificed and their hippocampi isolated to evaluate their resting and activated microglial cells using Golgi-Cox staining technique. Open-field test was used to assess locomotor activity. Results: MOE, fluoxetine and minocycline significantly reduced immobility in FST, TST and OSST compared to vehicle (p < 0.05), confirming their antidepressant-like effect. Interestingly, MOE’s antidepressant-like effect was faster than fluoxetine and minocycline. Conversely, LPS treatment increased immobility behavior at 6 and 24 hours, suggestive of neuroinflammation-induced depression. Compared to vehicle group, pre-treatment with MOE and minocycline ameliorated LPS-induced hippocampal microglial activation and reversed increased immobility behavior without affecting locomotor activity (p < 0.05).  Resting microglial cell count was significantly increased by MOE pre-treatment in the OSST-challenged mice compared to vehicle group (p < 0.01). Similarly, MOE pre-treatment reversed LPS-induced reduction in resting microglial count, and restored resting microglial count to normal levels compared to LPS naive vehicle group. Conclusions: Collectively, the results suggest that MOE exerts neuroprotective effect against LPS-induced neuroinflammation by decreasing the activation of microglia and increasing resting microglial count. This contributes to its antidepressant-like effect.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45533568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural mechanisms for spatial cognition across vertebrates","authors":"Ehud Vinepinsky, R. Segev","doi":"10.12688/molpsychol.17503.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17503.1","url":null,"abstract":"The ability to navigate the world is a critical cognitive skill that most animals use to find food, shelter, and mates. Understanding the neural basis of navigation requires probing how the brain encodes spatial information through the study of the activity of single neurons and neuronal populations. Classically in vertebrates, studies have centered on the rodent hippocampal formation, which led to the discovery of place, grid, head direction and other cell types. However, since navigation skills are essential to almost all vertebrates, spatial cognition in different species also needs to be explored. In recent years, as a result of advances in technology, new data have emerged on the ways in which space is represented during navigation in the brains of vertebrates other than rodents, including teleost fish, birds, and other mammal species. Here, we review the state of the art on the neural representation of an animal’s position and motion across vertebrates at the level of single neurons. We argue that it is time to pool information across vertebrates to identify the underlying algorithms that lead to successful navigation. Although rodent-based data are important, findings in rodents are unlikely to cover the full spectrum of neural computations supporting navigation strategies in the vertebrate kingdom. Studying other species can shed light on length scales such as in large environments, and different scenarios such as naturalistic environments that are hard to carry out in rodents. In addition, a rodent-centric view may neglect the fact that different species are likely to represent positions in the world in ways that do not exist in mammals. Finally, we provide an outlook for the future which includes prediction about findings in unexplored species, and the opportunities for discoveries and understanding in this field.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42720418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What do mammals have to say about the neurobiology of acoustic communication?","authors":"Angeles Salles, Joshua Neunuebel","doi":"10.12688/molpsychol.17539.1","DOIUrl":"10.12688/molpsychol.17539.1","url":null,"abstract":"<p><p>Auditory communication is crucial across taxa, including humans, because it enables individuals to convey information about threats, food sources, mating opportunities, and other social cues necessary for survival. Comparative approaches to auditory communication will help bridge gaps across taxa and facilitate our understanding of the neural mechanisms underlying this complex task. In this work, we briefly review the field of auditory communication processing and the classical champion animal, the songbird. In addition, we discuss other mammalian species that are advancing the field. In particular, we emphasize mice and bats, highlighting the characteristics that may inform how we think about communication processing.</p>","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42721239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early life stress and the role of environmental and molecular moderators in the ontology of pathological and resilient behavioral phenotypes","authors":"Nicholas J. Collins, Taylor S. Campbell, Katelyn M. Donoghue, Urmi Ghosh, Jessica N. Smith, Maeve C. O'Shea, C. Nelson, Olivia K. Bigham, T. Roth","doi":"10.12688/molpsychol.17482.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17482.1","url":null,"abstract":"Early life stress (ELS) in the form of trauma or caregiver abuse and neglect is often associated with psychopathology. However, not everyone exposed to ELS develops a pathology; others display resilience, or the ability to adapt and persevere despite ongoing adversity. Several molecular moderator variables between ELS and behavioral phenotypes have been proposed, including single nucleotide polymorphisms (SNPs) and epigenetic markers. Specifically, several SNPs and aberrant methylation or expression of genes associated with neurotransmitter systems and brain-derived neurotrophic factor have been associated with anxiety, depression or schizophrenia. The present review seeks to explore the relationship between SNPs, epigenomics and disease, and offer data to suggest several SNPs may also predict specific treatment efficacy and psychological resilience. Due to this discrepancy in the literature, it is critical that environmental moderators be equally considered in determining the ontology of resilient or pathological phenotypes; this includes the infant-caregiver relationship, and the degree of control, magnitude, and type of the stressor experienced. Finally, we will offer evidence to suggest that several intervention strategies, including drug treatment, environmental enrichment, or exercise can ameliorate many of the psychological, biological, and molecular consequences of ELS exposure, and help shift one toward a resilient phenotype.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45789102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25 Years of Molecular Psychology: The best is yet to come","authors":"T. Canli","doi":"10.12688/molpsychol.17419.1","DOIUrl":"https://doi.org/10.12688/molpsychol.17419.1","url":null,"abstract":"This editorial defines the scope of the field of Molecular Psychology, which refers to the study of behavior and its underlying neural systems using the toolset of molecular biology, particularly molecular genetics and epigenetics. It is related to other well-established fields that use molecular tools in animal model organisms (Behavioral Neuroscience; Neuroethology) or that focus on molecular mechanisms of human mental health and disease (Molecular Psychiatry; Health Psychology), but extends beyond these fields by its inclusion of broad domains of human behavior; the precise molecular mechanisms by which environmental exposure and experiences modify gene expression; and the ethical, legal, and social implications (ELSI) of these discoveries. Considering the first 25 years of studies that included candidate gene and genome-wide association studies, I suggest a roadmap for the next decade of work. On the launch of F1000 Molecular Psychology: Brain, Behavior & Society, I hope this publication platform will become instrumental in growing this field by promoting a spirit of support and community among its practitioners, embracing transparency and rigor, and publishing novel ideas and studies ranging from pilot and proof-of-concept first steps to gold-standard definitive milestones.","PeriodicalId":74223,"journal":{"name":"Molecular psychology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41948942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}