Molecular biomedicine最新文献_第10页

Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification. RNA结合蛋白47的下调可预测患者的低生存率，并通过RNA稳定性修饰促进肾细胞恶性肿瘤的发展。

IF 6.3

Molecular biomedicine Pub Date : 2023-11-14 DOI: 10.1186/s43556-023-00148-w

Cheng Wang, Weiquan Li, Xiangui Meng, Hongwei Yuan, Tiexi Yu, Wei Yang, Dong Ni, Lei Liu, Wen Xiao

{"title":"Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification.","authors":"Cheng Wang, Weiquan Li, Xiangui Meng, Hongwei Yuan, Tiexi Yu, Wei Yang, Dong Ni, Lei Liu, Wen Xiao","doi":"10.1186/s43556-023-00148-w","DOIUrl":"10.1186/s43556-023-00148-w","url":null,"abstract":"RNA binding proteins (RBPs) are crucial for cell function, tissue growth, and disease development in disease or normal physiological processes. RNA binding motif protein 47 (RBM47) has been proven to have anti-tumor effects on many cancers, but its effect is not yet clear in renal cancer. Here, we demonstrated the expression and the prognostic role of RBM47 in public databases and clinical samples of clear cell renal carcinoma (ccRCC) with bioinformatics analysis. The possible mechanism of RBM47 in renal cancer was verified by gene function prediction and in vitro experiments. The results showed that RBM47 was downregulated in renal cancers when compared with control groups. Low RBM47 expression indicated poor prognosis in ccRCC. RBM47 expression in renal cancer cell lines was reduced significantly when compared to normal renal tubular epithelial cells. Epithelial-mesenchymal transition (EMT) and transforming growth factor-β signaling pathway was associated with RBM47 in ccRCC by Gene set enrichment analysis. RBM47 expression had a positive correlation with e-cadherin, but a negative correlation with snail and vimentin. RBM47 overexpression could repress the migration, invasion activity, and proliferation capacity of renal cancer cells, while RBM47 inhibition could promote the development of the malignant features through EMT signaling by RNA stability modification. Therefore, our results suggest that RBM47, as a new molecular biomarker, may play a key role in the cancer development of ccRCC.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"41"},"PeriodicalIF":6.3,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92158051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions. 炎症和应激相关疾病中的JAK-STAT信号传导：对治疗干预的影响。

IF 4

Molecular biomedicine Pub Date : 2023-11-08 DOI: 10.1186/s43556-023-00151-1

Alexey Sarapultsev, Evgenii Gusev, Maria Komelkova, Irina Utepova, Shanshan Luo, Desheng Hu

{"title":"JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions.","authors":"Alexey Sarapultsev, Evgenii Gusev, Maria Komelkova, Irina Utepova, Shanshan Luo, Desheng Hu","doi":"10.1186/s43556-023-00151-1","DOIUrl":"10.1186/s43556-023-00151-1","url":null,"abstract":"The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves as a cornerstone in cellular signaling, regulating physiological and pathological processes such as inflammation and stress. Dysregulation in this pathway can lead to severe immunodeficiencies and malignancies, and its role extends to neurotransduction and pro-inflammatory signaling mechanisms. Although JAK inhibitors (Jakinibs) have successfully treated immunological and inflammatory disorders, their application has generally been limited to diseases with similar pathogenic features. Despite the modest expression of JAK-STAT in the CNS, it is crucial for functions in the cortex, hippocampus, and cerebellum, making it relevant in conditions like Parkinson's disease and other neuroinflammatory disorders. Furthermore, the influence of the pathway on serotonin receptors and phospholipase C has implications for stress and mood disorders. This review expands the understanding of JAK-STAT, moving beyond traditional immunological contexts to explore its role in stress-related disorders and CNS function. Recent findings, such as the effectiveness of Jakinibs in chronic conditions such as rheumatoid arthritis, expand their therapeutic applicability. Advances in isoform-specific inhibitors, including filgotinib and upadacitinib, promise greater specificity with fewer off-target effects. Combination therapies, involving Jakinibs and monoclonal antibodies, aiming to enhance therapeutic specificity and efficacy also give great hope. Overall, this review bridges the gap between basic science and clinical application, elucidating the complex influence of the JAK-STAT pathway on human health and guiding future interventions.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"40"},"PeriodicalIF":4.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71489685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SARS-CoV-2 RNA persists in the central nervous system of non-human primates despite clinical recovery. 严重急性呼吸系统综合征冠状病毒2型核糖核酸在非人类灵长类动物的中枢神经系统中持续存在，尽管临床上已经康复。

IF 4

Molecular biomedicine Pub Date : 2023-11-07 DOI: 10.1186/s43556-023-00153-z

Hailong Li, Kristen A McLaurin, Charles F Mactutus, Jay Rappaport, Prasun K Datta, Rosemarie M Booze

引用次数: 0

Phosphopeptides P140 cause oxidative burst responses of pulmonary macrophages in an imiquimod-induced lupus model. 在咪喹莫特诱导的狼疮模型中，磷酸肽P140引起肺巨噬细胞的氧化爆发反应。

IF 4

Molecular biomedicine Pub Date : 2023-11-03 DOI: 10.1186/s43556-023-00149-9

Jianghong Zhong, Chanyu Zheng, Zhongheng Chen, Hangqi Yue, Haiqiang Gao, Yunfan Jiang, Hui Hui, Jie Tian

{"title":"Phosphopeptides P140 cause oxidative burst responses of pulmonary macrophages in an imiquimod-induced lupus model.","authors":"Jianghong Zhong, Chanyu Zheng, Zhongheng Chen, Hangqi Yue, Haiqiang Gao, Yunfan Jiang, Hui Hui, Jie Tian","doi":"10.1186/s43556-023-00149-9","DOIUrl":"10.1186/s43556-023-00149-9","url":null,"abstract":"Recent studies challenge the dogma that a 21-mer phosphopeptide P140 protects against direct cell damage in the phase-III clinical trial (NCT02504645) for lupus, involving reactive oxygen species (ROS)-dependent release of citrullinated histone H3 (H3cit)-linked neutrophil extracellular traps. An open question is the cellular location of ROS production and H3cit formation in lupus. In this study, we examined the effects of P140 peptides on ROS production and H3cit location in lupus with in vivo and situ fluorescence imaging with subcellular resolution. We developed a mouse model of the B6 strain harbouring a bioluminescent reporter under the control of the Lysozyme M promoter. Based on the imiquimod-induced disease model of B6 mice, we used bioluminescent imaging, flow cytometry analysis, and immunohistology staining to study the effects of P140 peptides in lupus. We found a profound accumulation of CX3CR1-positive macrophages in the lungs of lupus mice after the application of P140, accompanied by lung fibrosis formation. The defined P140-mediated macrophage responses were associated with an increase of H3cit in the cytosol, interleukin-1 receptor type 1 on the extracellular membrane, and intracellular production of ROS. Of interest, the disease of imiquimod-induced lupus was prevented with an antioxidant drug apocynin. This study shows that P140 peptides play a role in aggravated murine lupus in a manner dependent on ROS production and H3cit upregulation through pulmonary macrophages.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"38"},"PeriodicalIF":4.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71435016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncogene SCARNA12 as a potential diagnostic biomarker for colorectal cancer. 癌基因SCARNA12作为癌症的潜在诊断生物标志物。

IF 4

Molecular biomedicine Pub Date : 2023-11-01 DOI: 10.1186/s43556-023-00147-x

Hong Zhang, Xin Liu, Wencheng Zhang, Jiarong Deng, Chuxian Lin, Zhenhua Qi, Yaqiong Li, Yongqing Gu, Qi Wang, Liping Shen, Zhidong Wang

{"title":"Oncogene SCARNA12 as a potential diagnostic biomarker for colorectal cancer.","authors":"Hong Zhang, Xin Liu, Wencheng Zhang, Jiarong Deng, Chuxian Lin, Zhenhua Qi, Yaqiong Li, Yongqing Gu, Qi Wang, Liping Shen, Zhidong Wang","doi":"10.1186/s43556-023-00147-x","DOIUrl":"https://doi.org/10.1186/s43556-023-00147-x","url":null,"abstract":"Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive system, and represents a severe threat to the life and health of individuals. Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) as critical regulatory gene in cancer development. Small Cajal body-specific RNAs (scaRNAs), a subtype of snoRNAs, are named for their subcellular localization within Cajal bodies. SCARNA12, which located at the intronic region of PHB2 in chromosome 12p13.31 with 270 nucleotides (nt) in length. It has been reported function as a diagnostic marker for cervical cancer. However, its biological functions and molecular mechanisms in CRC have yet to be elucidated. In this study, bioinformatics analysis revealed that SCARNA12 was highly expressed in CRC and positively correlated with poor prognosis in CRC patients. Additionally, SCARNA12 showed upregulated expression in CRC cell lines and clinical CRC tissue samples. Moreover, SCARNA12 overexpression in SW620 cells accelerated cell proliferation, suppressed the apoptosis rate, and enhanced tumorigenesis in vivo. The knockdown of SCARNA12 expression in HCT116 and HT29 cells resulted in contrasting effects. The functioning of SCARNA12 is mechanically independent of its host gene PHB2. Notably, the overexpression of SCARNA12 activated PI3K/AKT pathway in SW620 cells, and the malignancy degree of CRC cells was attenuated after treatment with MK2206 (a specific AKT inhibitor). Our findings demonstrated that SCARNA12 plays an oncogenic role in CRC progression and can be used as a potential diagnostic biomarker for CRC.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"37"},"PeriodicalIF":4.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dengue virus infection induces myocarditis in IFNα/β receptor deficient mice. 登革热病毒感染诱导IFNα/β受体缺陷小鼠心肌炎。

IF 4

Molecular biomedicine Pub Date : 2023-10-31 DOI: 10.1186/s43556-023-00150-2

Chongzhi Bai, Ruoyu Wang, Qiuxia Xiong, Qian Yang, Pengcheng Han

引用次数: 0

Activation and induction of antigen-specific T follicular helper cells play a critical role in recombinant SARS-CoV-2 RBD vaccine-induced humoral responses. 抗原特异性T卵泡辅助细胞的激活和诱导在重组严重急性呼吸系统综合征冠状病毒2型RBD疫苗诱导的体液反应中起着关键作用。

IF 4

Molecular biomedicine Pub Date : 2023-10-19 DOI: 10.1186/s43556-023-00145-z

Songhao Yang, Liangwei Duan, Chan Wang, Cuiying Zhang, Siyu Hou, Hao Wang, Jiahui Song, Tingting Zhang, Zihua Li, Mingxia Wang, Jing Tang, Qianqian Zheng, Hui Wang, Qi Wang, Wei Zhao

{"title":"Activation and induction of antigen-specific T follicular helper cells play a critical role in recombinant SARS-CoV-2 RBD vaccine-induced humoral responses.","authors":"Songhao Yang, Liangwei Duan, Chan Wang, Cuiying Zhang, Siyu Hou, Hao Wang, Jiahui Song, Tingting Zhang, Zihua Li, Mingxia Wang, Jing Tang, Qianqian Zheng, Hui Wang, Qi Wang, Wei Zhao","doi":"10.1186/s43556-023-00145-z","DOIUrl":"10.1186/s43556-023-00145-z","url":null,"abstract":"The role of follicular T helper (Tfh) cells in humoral response has been considered essential in recent years. Understanding how Tfh cells control complex humoral immunity is critical to developing strategies to improve the efficacy of vaccines against SARS-CoV-2 and other emerging pathogens. However, the immunologic mechanism of Tfh cells in SARS-CoV-2 receptor binding domain (RBD) vaccine strategy is limited. In this study, we expressed and purified recombinant SARS-CoV-2 RBD protein in Drosophila S2 cells for the first time and explored the mechanism of Tfh cells induced by RBD vaccine in humoral immune response. We mapped the dynamic of Tfh cell in lymph node and spleen following RBD vaccination and revealed the relationship between Tfh cells and humoral immune response induced by SARS-CoV-2 RBD vaccine through correlation analysis, blocking of IL-21 signaling pathway, and co-culture of Tfh with memory B cells. Recombinant RBD protein elicited a predominant Tfh1 and Tfh1-17 subset response and strong GC responses in spleen and lymph nodes, especially to enhanced vaccination. IL-21 secreted by Tfh cells affected the development and differentiation of B cells and played a key role in the humoral immune response. These observations will help us further understand the mechanism of protective immune response induced by COVID-19 vaccine and has guiding significance for the development of vaccines against newly emerging mutants.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"34"},"PeriodicalIF":4.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular calcification: from the perspective of crosstalk. 血管钙化：从串扰的角度来看。

IF 4

Molecular biomedicine Pub Date : 2023-10-18 DOI: 10.1186/s43556-023-00146-y

Shiqi Yang, Zhaolin Zeng, Qing Yuan, Qian Chen, Zuo Wang, Hui Xie, Jianghua Liu

{"title":"Vascular calcification: from the perspective of crosstalk.","authors":"Shiqi Yang, Zhaolin Zeng, Qing Yuan, Qian Chen, Zuo Wang, Hui Xie, Jianghua Liu","doi":"10.1186/s43556-023-00146-y","DOIUrl":"10.1186/s43556-023-00146-y","url":null,"abstract":"Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and mortality, but anti-VC treatment remains an area to be tackled due to the ill-defined molecular mechanisms. Regardless of the type of VC, it does not depend on a single cell but involves multi-cells/organs to form a complex cellular communication network through the vascular microenvironment to participate in the occurrence and development of VC. Therefore, focusing only on the direct effect of pathological factors on vascular smooth muscle cells (VSMCs) tends to overlook the combined effect of other cells and VSMCs, including VSMCs-VSMCs, ECs-VMSCs, Macrophages-VSMCs, etc. Extracellular vesicles (EVs) are a collective term for tiny vesicles with a membrane structure that are actively secreted by cells, and almost all cells secrete EVs. EVs docked on the surface of receptor cells can directly mediate signal transduction or transfer their contents into the cell to elicit a functional response from the receptor cells. They have been proven to participate in the VC process and have also shown attractive therapeutic prospects. Based on the advantages of EVs and the ability to be detected in body fluids, they may become a novel therapeutic agent, drug delivery vehicle, diagnostic and prognostic biomarker, and potential therapeutic target in the future. This review focuses on the new insight into VC molecular mechanisms from the perspective of crosstalk, summarizes how multi-cells/organs interactions communicate via EVs to regulate VC and the emerging potential of EVs as therapeutic methods in VC. We also summarize preclinical experiments on crosstalk-based and the current state of clinical studies on VC-related measures.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"35"},"PeriodicalIF":4.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10584806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mechanism of ferroptosis and its related diseases. 脱铁性贫血的发病机制及其相关疾病。

IF 4

Molecular biomedicine Pub Date : 2023-10-16 DOI: 10.1186/s43556-023-00142-2

Shijian Feng, Dan Tang, Yichang Wang, Xiang Li, Hui Bao, Chengbing Tang, Xiuju Dong, Xinna Li, Qinxue Yang, Yun Yan, Zhijie Yin, Tiantian Shang, Kaixuan Zheng, Xiaofang Huang, Zuheng Wei, Kunjie Wang, Shiqian Qi

{"title":"The mechanism of ferroptosis and its related diseases.","authors":"Shijian Feng, Dan Tang, Yichang Wang, Xiang Li, Hui Bao, Chengbing Tang, Xiuju Dong, Xinna Li, Qinxue Yang, Yun Yan, Zhijie Yin, Tiantian Shang, Kaixuan Zheng, Xiaofang Huang, Zuheng Wei, Kunjie Wang, Shiqian Qi","doi":"10.1186/s43556-023-00142-2","DOIUrl":"10.1186/s43556-023-00142-2","url":null,"abstract":"Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"33"},"PeriodicalIF":4.0,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10577123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial transcriptomics in development and disease. 发育和疾病中的空间转录组学。

IF 6.3

Molecular biomedicine Pub Date : 2023-10-09 DOI: 10.1186/s43556-023-00144-0

Ran Zhou, Gaoxia Yang, Yan Zhang, Yuan Wang

{"title":"Spatial transcriptomics in development and disease.","authors":"Ran Zhou, Gaoxia Yang, Yan Zhang, Yuan Wang","doi":"10.1186/s43556-023-00144-0","DOIUrl":"10.1186/s43556-023-00144-0","url":null,"abstract":"The proper functioning of diverse biological systems depends on the spatial organization of their cells, a critical factor for biological processes like shaping intricate tissue functions and precisely determining cell fate. Nonetheless, conventional bulk or single-cell RNA sequencing methods were incapable of simultaneously capturing both gene expression profiles and the spatial locations of cells. Hence, a multitude of spatially resolved technologies have emerged, offering a novel dimension for investigating regional gene expression, spatial domains, and interactions between cells. Spatial transcriptomics (ST) is a method that maps gene expression in tissue while preserving spatial information. It can reveal cellular heterogeneity, spatial organization and functional interactions in complex biological systems. ST can also complement and integrate with other omics methods to provide a more comprehensive and holistic view of biological systems at multiple levels of resolution. Since the advent of ST, new methods offering higher throughput and resolution have become available, holding significant potential to expedite fresh insights into comprehending biological complexity. Consequently, a rapid increase in associated research has occurred, using these technologies to unravel the spatial complexity during developmental processes or disease conditions. In this review, we summarize the recent advancement of ST in historical, technical, and application contexts. We compare different types of ST methods based on their principles and workflows, and present the bioinformatics tools for analyzing and integrating ST data with other modalities. We also highlight the applications of ST in various domains of biomedical research, especially development and diseases. Finally, we discuss the current limitations and challenges in the field, and propose the future directions of ST.","PeriodicalId":74218,"journal":{"name":"Molecular biomedicine","volume":"4 1","pages":"32"},"PeriodicalIF":6.3,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41124864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0