American Journal of Kidney Diseases最新文献

{"title":"Longitudinal Change in Small Solute Clearance Measurement in Patients Receiving Peritoneal Dialysis.","authors":"Jack Kit-Chung Ng,Winston Wing-Shing Fung,Gordon Chun-Kau Chan,Phyllis Mei-Shan Cheng,Wing-Fai Pang,Kai-Ming Chow,Cheuk-Chun Szeto","doi":"10.1053/j.ajkd.2025.02.608","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.02.608","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"17 1","pages":""},"PeriodicalIF":13.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Multifocal Leukoencephalopathy in Kidney Transplant Recipients: A Retrospective Multicenter Nationwide Case Series.","authors":"Adélaïde Sanson,Yannis Lombardi,Rebecca Sberro-Soussan,François Provôt,Léonard Golbin,Samir Boudjeltia,Romain Pszczolinski,Christophe Masset,Anne-Sophie Vasseur,Jean-François Augusto,Hannah Kaminski,Eric Daugas,Sophie Caillard,Jean-Michel Rebibou,Valérie Moal,Moglie Le Quintrec,Renaud Snanoudj,Marie Matignon,Giovanna Melica,Julien Zuber,Laurent Mesnard,Nacera Ouali,Yosu Luque,Camille Petit-Hoang,Arnaud Del Bello,Nassim Kamar,Hélène François","doi":"10.1053/j.ajkd.2025.02.606","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.02.606","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"258 1","pages":""},"PeriodicalIF":13.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LB-02 Re-Defining Carboplatin Dosage Using EGFR-Creatinine-Cystatin C Compared to Cockcroft Gault and Impact on Platinum-Associated Adverse Events","authors":"","doi":"10.1053/j.ajkd.2025.03.006","DOIUrl":"10.1053/j.ajkd.2025.03.006","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"85 5","pages":"Page 668"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LB-07 Patients (PTS) in Duplex Achieved Partial or Complete Remission of Proteinuria Earlier and more Often with Sparsentan (SPAR) vs Irbesartan (IRB): Implications for Slowing Progression to Kidney Failure (KF) in Focal Segmental Glomerulosclerosis (FSGS)","authors":"","doi":"10.1053/j.ajkd.2025.03.011","DOIUrl":"10.1053/j.ajkd.2025.03.011","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"85 5","pages":"Page 670"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malpighi's Forgotten Drawings of Renal Glomeruli.","authors":"Roberto F Nicosia,Paolo Cassoli","doi":"10.1053/j.ajkd.2025.01.026","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.01.026","url":null,"abstract":"Marcello Malpighi (1628-1694) is universally recognized for his pioneering work in microscopic anatomy. His groundbreaking studies of human, animal, and plant anatomy laid the foundation for modern histology, embryology, comparative anatomy, entomology, botany, and biology. Among his many contributions is the discovery of renal glomeruli, which he described as minimae glandulae (very small glands), attributing to them the production of urine. His treatise De renibus contained a detailed description of glomeruli but no images. A drawing of glomeruli by Malpighi appeared many years later on an illustrated manuscript sheet containing a plate with different types of glands, including the kidney's minimae glandulae. While examining Malpighi's handwritten scientific diary, kept at the Biblioteca Universitaria di Bologna, we found unpublished drawings of his kidney observations, including one that may represent his earliest extant depiction of glomeruli. This paper reviews Malpighi's groundbreaking discovery of glomeruli, focusing on his kidney drawings and their historical significance.","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"17 1","pages":""},"PeriodicalIF":13.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LB-04 Association Between Baseline Serum Creatinine/Cystatin C (SCR/CYS) Ratio and Adverse Events in Patients Receiving Cisplatin or Carboplatin: A Prospective Cohort Study","authors":"","doi":"10.1053/j.ajkd.2025.03.008","DOIUrl":"10.1053/j.ajkd.2025.03.008","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"85 5","pages":"Page 669"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Kidney Dysfunction With Weight Loss: A Quiz","authors":"Niveditha Girimaji, Emmanuel A. Adomako, Kerri McGreal, Duncan B. Johnstone","doi":"10.1053/j.ajkd.2024.10.011","DOIUrl":"10.1053/j.ajkd.2024.10.011","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"85 5","pages":"Pages A14-A16"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143852361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Kidney Foundation 2025 Spring Clinical Meeting Late-Breaking Abstracts April 9-13, 2025","authors":"","doi":"10.1053/j.ajkd.2025.03.003","DOIUrl":"10.1053/j.ajkd.2025.03.003","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"85 5","pages":"Page 667"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LB-06 Impact of Kidneyintelx on Targeted use of SGLT2I","authors":"","doi":"10.1053/j.ajkd.2025.03.010","DOIUrl":"10.1053/j.ajkd.2025.03.010","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"85 5","pages":"Pages 669-670"},"PeriodicalIF":9.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study.","authors":"Simon B Ascher,Ronit Katz,Michelle M Estrella,Rebecca Scherzer,Teresa K Chen,Pranav S Garimella,Alexander L Bullen,Stein I Hallan,Nicholas Wettersten,Alfred Cheung,Michael G Shlipak,Joachim H Ix","doi":"10.1053/j.ajkd.2025.02.607","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.02.607","url":null,"abstract":"RATIONALE & OBJECTIVESerum creatinine elevations in the ambulatory setting frequently occur during antihypertensive treatment and complicate clinical management, but few tools are available to distinguish whether kidney function will recover in this setting. This study evaluated if urine biomarkers of glomerular and tubular health are associated with subsequent recovery of eGFR after acute kidney injury (AKI) occurred in the ambulatory setting during blood pressure treatment.STUDY DESIGNLongitudinal analysis of clinical trial participants.SETTING & PARTICIPANTS652 participants in the Systolic Blood Pressure Intervention Trial (SPRINT) who developed AKI in the ambulatory setting, defined as a rise in serum creatinine of ≥0.3 mg/dL from baseline detected at the 1-year or 2-year study visits.EXPOSUREEight urine biomarkers measured at baseline and at the study visit when ambulatory AKI was detected.OUTCOME<50% recovery in eGFR (\"non-recovery\") at 12-months.ANALYTICAL APPROACHMultivariable logistic regression models, stratified by randomization arm, to evaluate biomarker associations with the odds of non-recovery in eGFR.RESULTSMean age was 70 ±10 years; eGFR at baseline was 62 ± 25 mL/min/1.73 m2, and eGFR at the time of serum creatinine elevation was 42 ± 12 mL/min/1.73 m2. Among biomarkers measured at the time ambulatory AKI was detected, higher urine albumin (OR per 1-SD higher: 1.72; 95% CI: 1.10, 2.70) and lower epidermal growth factor (OR 0.46; 95% CI: 0.26, 0.79) were associated with non-recovery in the standard BP treatment arm; higher urine α-1 microglobulin (OR 1.45; 1.09, 1.92), lower epidermal growth factor (OR 0.62; 95% CI: 0.46, 0.83) and lower kidney injury molecule-1 (OR 0.75; 95% CI: 0.59, 0.96) were associated with non-recovery of eGFR in the intensive BP treatment arm.LIMITATIONSPersons with diabetes and proteinuria >1 g/d were excluded.CONCLUSIONSAmong adults enrolled in a BP treatment trial who developed ambulatory AKI, urine biomarkers reflecting glomerular injury and tubular dysfunction may help to distinguish whether kidney function will subsequently recover.PLAIN-LANGUAGE SUMMARYElevations in serum creatinine can occur when treating hypertension and complicate clinical management, but there are few tools available to distinguish whether an individual's kidney function will subsequently recover. In this study, we investigated the association of kidney biomarkers measured in the urine with subsequent kidney function among individuals in the outpatient setting who develop a rise in serum creatinine. We found that biomarkers reflecting worse glomerular injury and tubular dysfunction are associated with the risk of an individual's kidney function not recovering. These results suggest that a broader assessment of kidney health when serum creatinine increases in the outpatient setting may help distinguish subsequent trajectories in kidney function.","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"7 1","pages":""},"PeriodicalIF":13.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}