Tumelo Muyenga, Dominion Samuel K Bamitale, Dan Kibuule, C. Hikaambo, Mutenta N Nyambe, Christian Ezeala
{"title":"Antidiabetic, and radical scavenging activity of Kigelia africana fruit fractions.","authors":"Tumelo Muyenga, Dominion Samuel K Bamitale, Dan Kibuule, C. Hikaambo, Mutenta N Nyambe, Christian Ezeala","doi":"10.55320/mjz.50.1.376","DOIUrl":"https://doi.org/10.55320/mjz.50.1.376","url":null,"abstract":"Background: Traditional medicine is gaining traction in Africa. 92.1% of diabetes patients at the University Teaching Hospital in Zambia use herbal medicine. Kigelia africana is a botanical species used in traditional medicine for diabetes due to its phytochemical composition. This study aimed to determine the phytoconstituents, radical scavenging activities, total flavonoid concentration, and total phenolic content of the antidiabetic bioactive Kigelia africana fruit fractions. \u0000Methods: Using UV spectrophotometer we determined the total phenolic content (TPC), total flavonoid content (TFC) and free radical scavenging activity. Alloxan-induced diabetes rat models were used to determine the antidiabetic effect in vivo. Phytoconstituent analysis was via gas-chromatography Mass spectrophotometry (GC-MS) \u0000Results: The ethyl acetate fraction demonstrated superior antidiabetic activity, reducing blood glucose levels from 28.42±2.7 mmol/l to 8.16±4.4 mmol/l. Statistical analysis showed no significant difference between the ethyl acetate fraction and Glibenclamide,(p=0.152). Although the ethyl acetate fraction had a higher reading, there was no statistically significant difference found in Total Phenolic content (TPC) (p=0.3) and Total Flavonoid content (TFC) (p=0.06). IC50 values for DPPH were 0.05330 (chloroform), 0.05352 (ethyl acetate), and 0.4013 (butanol). GC-MS analysis revealed the presence of important fatty acids, methyl furfural, furan carboxylic acid and 4-pyran-4-one derivatives. \u0000Conclusion: The GC-MS fingerprint of the antidiabetic fractions revealed important fatty acids and phenolic compounds that could be attributed to the observed antidiabetic activity.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"49 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew Chisanga, Evans Mpabalwani, Aaron Nyirenda, D. Banda, C. Chabala
{"title":"Evaluation of Fine Needle Aspiration for diagnosis of Tuberculous Lymphadenitis in Children using the Xpert MTB/RIF Ultra at the University Teaching Hospitals Children’s Hospital, Lusaka, Zambia","authors":"Andrew Chisanga, Evans Mpabalwani, Aaron Nyirenda, D. Banda, C. Chabala","doi":"10.55320/mjz.49.4.387","DOIUrl":"https://doi.org/10.55320/mjz.49.4.387","url":null,"abstract":"Background: Tuberculous Lymphadenitis (TBL) is the commonest form of Extra Pulmonary TB and poses diagnostic challenges in setting with no access to Histopathology. Our goal was to evaluate the diagnostic yield of Xpert MTB Ultra performed on lymph node aspirate obtained using Fine Needle Aspiration (FNA) in children with suspected TBL. Methods: This was a cross-sectional study conducted at a tertiary and main referral hospital in Zambia. Children aged 6 months to 15 years with lymphadenopathy and presumed TBL were enrolled. FNA was performed and lymph node aspirate samples were analysed using XPERT MTB/RIF ULTRA. Data was collected and analysed as frequencies and percentages. Logistic regression was used to measure the odds of testing positive for MTB. Results: Sixty one children were enrolled in the study, 34(55.7%) were males and a median age of 6 years (IQR: 3-11 years). Sixteen (26%) were diagnosed with TB, 7 on clinical basis while, one was positive on gastric lavage, five (31%) were positive for TB on lymph node FNA using Xpert MTB/RIF Ultra. Then, 3 were positive Histopathology, with one also positive on XPERT MTB/RIF Ultra. Alternative diagnosis included malignancies like lymphomas and acute Leukemias. While non malignant lymphadenopathy included, benign reactive lymphadenopathy and HIV associated lymphadenopathy. The prevalence of HIV among the children diagnosed with TB was 37.5% (6/16). Thirty one percent (5/16) of children with TB had a close contact with TB, OR=9.0 (95% CI: 1.3-77, p-value (<0.05). Conclusion: TBL is not uncommon in children presenting with Lymphadenopathy. FNA is a less invasive, inexpensive technique and coupled with use of Xpert MTB/RIF Ultra has potential for early diagnosis of TBL, in a low resource setting with limited Histopathology services.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139273724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence, Awareness And Adverse Outcomes Of Breast Ironing Among Cameroonian Women In Buea Health District","authors":"Mela Fotabong, Gbolahan Obajimi, Temitayo Lawal, Imran Morhason-Bello","doi":"10.55320/mjz.49.4.391","DOIUrl":"https://doi.org/10.55320/mjz.49.4.391","url":null,"abstract":"Background: Breast ironing, also known as breast flattening, is a practice that involves the use of an object to massage, press, or pound the breast. This practice is usually performed on girls, between the ages of 9 and 15 years The known effects of breast ironing are self-reported symptoms or signs of breast ironing by the victims. This study aims to investigate the prevalence, awareness, and adverse outcomes of Cameroonian women towards breast ironing. Methods: A mixed method design involving qualitative and cross-sectional study among women aged 18years and above. The primary outcome variable was previous experience of breast ironing. Log-binomial model was used to determine effects of breast-ironing on selected reproductive health outcomes. Results: Of 160 women interviewed, 22 (14%) had experienced breast ironing. The mean age was 26±4.62 years. All participants were aware of breast ironing. There were significant associations between being a victim of breast ironing and parity, breast symmetry, nipple anatomy, breast pain, milk quantity during lactation, breast sagging. The risk of reporting breast ironing was higher among women who experienced breast sagging earlier than expected, women who reported breast pain and women whose breasts had marked asymmetry. Conclusion: Breast ironing is prevalent in the Buea health district of Cameroon, and victims are more likely to experience adverse breast outcomes. Health education and introduction of legislation against breast ironing will go a long way to eliminate this harmful traditional practice. More studies will help to further understand drivers of breast ironing in other regions of Cameroon.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139274511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mad Dogs and Englishmen - A case of fatal hyperthermia in military personnel","authors":"Dr K Saasa, K. Saasa¹, Mss Patel²","doi":"10.55320/mjz.49.4.394","DOIUrl":"https://doi.org/10.55320/mjz.49.4.394","url":null,"abstract":"A case of fatal hyperthermia in a military personnel is reported. It highlights the health hazards of over exposure to hot temperatures. A clinico-pathological aspect of the topic is discussed.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139275136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Danladi, Y. Aremu-Kasumu, Kabiru B. Sada, Olaniyi T. Fasanu, Sikiru A. Yusuf
{"title":"Gestational Diabetes Mellitus among women attending antenatal clinic in a Tertiary Hospital in Northern Nigeria","authors":"A. Danladi, Y. Aremu-Kasumu, Kabiru B. Sada, Olaniyi T. Fasanu, Sikiru A. Yusuf","doi":"10.55320/mjz.49.4.389","DOIUrl":"https://doi.org/10.55320/mjz.49.4.389","url":null,"abstract":"Introduction: Women with gestational diabetes mellitus (GDM) are at an increased risk of adverse perinatal and maternal morbidities and mortalities. Hence, early detection and management of this condition is vital to ensure a good outcome for both mother and baby. Aim: The aim of the study is to determine the prevalence and associated risk factors for GDM among antenatal attendees in Federal Medical Centre Gusau (FMCG), Zamfara state, Nigeria. Methods: A descriptive cross-sectional study was carried out. Screening was done between 24 and 28-weeks gestational age with a 75g oral glucose tolerance test (OGTT). Plasma glucose measurements was performed using the glucose oxidase method. GDM was diagnosed according to the 2013 WHO diagnostic criteria. Data were collected using a proforma and analyzed using the Statistical Package for Social Sciences (SPSS) Version 26. Descriptive data were presented in frequency tables. Statistical testing using Chi-square, and multivariate analysis (Odd ratio and CI) were carried out with a level of significance set as P< 0.05. Results: One hundred and thirty-six women between the gestational ages of 24-28 weeks were recruited. The mean age of the participants was 25.9±5.4 years. The prevalence of GDM was found to be 16.9%. Fasting blood glucose alone correctly diagnosed 87% of the patients. Previous history of macrosomic babies (≥4kg) and history of GDM in previous pregnancies were significantly associated with GDM. Conclusion: The prevalence of GDM is high among antenatal attendees in Federal Medical center, Gusau.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"47 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139271530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olakunle Olawole Oloko, O. Ogunbode, Gbolahan Obajimi, Ayodele Arowojolu
{"title":"A Comparative Review of the Efficacy of 24-HourVersus 48-Hour Dose Regimen of Amoxicillin/Clavulanic Acid Prophylaxis forpostoperative infections following elective Caesarean Section at the University College Hospital, Ibadan, Nigeria: A Randomized Clinical Trial","authors":"Olakunle Olawole Oloko, O. Ogunbode, Gbolahan Obajimi, Ayodele Arowojolu","doi":"10.55320/mjz.49.4.388","DOIUrl":"https://doi.org/10.55320/mjz.49.4.388","url":null,"abstract":"Objectives: To compare the efficacy of 24hour versus 48hour prophylaxis of amoxicillin/clavulanic acid in the prevention of postoperative infections. Study Design: This study was a randomized controlled clinical trial conducted in a tertiary hospital in Ibadan, Nigeria. Two hundred and fifty -two pregnant women scheduled for elective caesarean section were randomly assigned into two groups. After the initial pre-incision antibiotic administration, group A received the Amoxicillin/Clavulanic Acid for 24 hours while group B received the same drug for 48hours. Main Outcomes: Participants were examined on the 3rd, 10th and 17th post-operative days for evidence of infections. All entry and analysis of data was by computer using the Statistical Package for Social Sciences version 22 (IBM, New York). Statistically significant differences were determined at p value of < 0.05. Results: The incidence of postoperative wound infection, postoperative fever and endometritis in this study was 5.2%, 9.1% and 5.6% respectively. There was no significant differences in the incidence of postoperative wound infection, postoperative fever and endometritis between the two regimens of antibiotics. Conclusion: A 24-hour prophylactic regimen of amoxicillin/clavulanic acid is adequate following caesarean section and prolonged use of antibiotics is generally unnecessary, costly and inadvertently increases antibiotics resistance","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139274569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Bwanga, Ernest Chanda, Edward Mwansa, Billy Nkoloma
{"title":"Changing Roles of a Radiographer in Fluoroscopy:","authors":"O. Bwanga, Ernest Chanda, Edward Mwansa, Billy Nkoloma","doi":"10.55320/mjz.49.4.393","DOIUrl":"https://doi.org/10.55320/mjz.49.4.393","url":null,"abstract":"Fluoroscopic imaging services in Zambia have been available since 1972 when the first equipment was installed at the University Teaching Hospital (UTH). However, there is limited fluoroscopy equipment use due to a critical shortage of radiologists who are traditionally trained to carry out this role. Radiologists work alongside radiographers who provide technical support and patient care. To address the shortage of radiologists, radiographers in the United Kingdom (UK) have explicitly expanded their scope of practice and started performing and reporting on fluoroscopic examinations such as barium swallow, barium meal, small bowel follow-through, barium enema, and videofluoroscopy after undergoing appropriate training. Literature from the UK shows that gastrointestinal (GI) radiographers’ performance is of a high-quality standard. The initiative has been very effective and made a significant contribution to the delivery of fluoroscopic services in that country. Therefore, the aim of this article was to review the literature on role extension for GI radiographers to guide the development and practice of fluoroscopic studies in Zambia. It is anticipated that this article will bring awareness to stakeholders such as the Ministry of Health (MOH), Schools of Radiography, the Radiological Society of Zambia (RSZ), and the Zambia Medical Association (ZMA) on this important subject.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"32 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139274223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Patient’s Satisfaction with Use of Spinal Anaesthesia for Day-Case gynaecological procedures","authors":"Nweze Onochie Uchenna, Ebirim Longinus Ndubuisi, Alagbe-Briggs OlubusolaTemitope","doi":"10.55320/mjz.49.4.392","DOIUrl":"https://doi.org/10.55320/mjz.49.4.392","url":null,"abstract":"Background: Patient Satisfaction is defined as the individual’s positive evaluation of a distinct dimension of care. Satisfaction is positive when the perception of the care given meets pateints’ level of expectation. The ideal anaesthesia for ambulatory procedures should provide a rapid and smooth onset of action, good intraoperative analgesia, good operating condition, short recovery time free from side effect and high level of patient satisfaction. Patient satisfaction is a vital part of assessing quality of care, and different instruments have been developed to measure it without a consensus on an ideal one. Achieving high satisfaction among patients that undergo day case gynaecological procedures under spinal would promote the acceptance of this anaesthetic technique in our locality. Method: This was an observational prospective study in which ninety (90) patients aged 18 – 45 years with ASA class I or II scheduled for day case gynaecological procedures were recruited. Spinal anaesthesia was given in sitting position using a range of 7.5mg to 10mg of 0.5% hyperbaric bupivacaine. The procedures lasted less than one (1) hour, during which the haemodynamic parameters (SBP, DBP MAP Pulse rate, and Spo2) were monitored continually. Patients were discharged home on the same day of procedure. Two days following the procedure, a structured questionnaire on patient’s satisfaction level was administered via phone call and data collected included satisfaction with explanation of the anaesthesia for the procedure, postoperative complications and overall level of satisfaction, and acceptance of spinal anaesthesia in the future. Results: Outcome showed that 88 patients (97.8%) were overall satisfied with the use of spinal anaesthesia for Day case gynaecological procedures and 2 patients (2.2%) were not satisfied with the anaesthetic technique used for the procedure. All the patients accepted to use spinal anaesthesia for similar procedure in the future.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"185 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139272463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Aspiration of Barium Contrast by a Geriatric Patient with Gastroparesis","authors":"Shamiso Sharon Chitemamwise, B. Chinene","doi":"10.55320/mjz.49.3.358","DOIUrl":"https://doi.org/10.55320/mjz.49.3.358","url":null,"abstract":"Complications due to aspiration of barium contrast occur rarely during studies of the digestive tract. While lung tissue can tolerate small amounts of Barium large quantities can exceed the lung’s capacity and consequently lead to death especially, in geriatric patients. Barium contrast can affect pulmonary ventilation and perfusion function, causing dyspnoea, hypoxemia and respiratory failure. We herein report a barium swallow case in which an 82-year-old woman aspirated barium on the first swallow and was diagnosed with Gastroparesis. The history, procedure and patient management are discussed. The purpose of the case report is to add to the existing literature on aspiration cases during barium swallow studies and the outcomes after the aspiration. Furthermore, this case report also highlights a need for extra care when attending to senior patients with dysphagia during barium studies.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80005190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Nyirenda, Gershom B. Lwanga, K. Muzandu, D. Chuba, G. Sijumbila
{"title":"In vivo Anti-anaemic Effect of an Aqueous Root Extract of Phyllanthus muellerianus (Kuntze) Exell in Model Rats","authors":"J. Nyirenda, Gershom B. Lwanga, K. Muzandu, D. Chuba, G. Sijumbila","doi":"10.55320/mjz.49.3.357","DOIUrl":"https://doi.org/10.55320/mjz.49.3.357","url":null,"abstract":"Background: Anaemia is a very serious condition in Zambia. One of the plants that has been used traditionally is Phyllanthus muellerianus where different parts of shrub are used to treat a number of diseases in Zambian folklore medicine. Earlier studies have investigated medicinal properties of its aqueous root extracts. This study evaluated the effect of P. muellerianus roots on the haematological indices of albino rats and determined its phytochemical profile. In order to prove this, we carried out phytochemical screening of the root extract and assessed the anti-anaemic effect of the aqueous extract on laboratory rats with tail-bled induced anaemia.\u0000Materials and Methods: Thirty-six male albino rats placed in six groups were used for the study. The groups comprised the 100, 200, and 400 mg/kg plant extract, Ranferon (200 mg/kg positive control), anaemic (non-treated control) and a normal (non-anaemic control) groups. Anaemia, induced through bleeding of the rats, was defined as haemoglobin (Hb) levels less than 12 g/dL. The anti-anaemic potential of the plant was determined by comparing its effect on the haematological parameters of rats on treatment to that of the control group.\u0000Results: Phytochemical screening revealed positive results for alkaloids, flavonoids, saponins, glycosides, steroids, triterpenoids and tannins with varying amounts. After treatment, rats on the 400 mg/kg plant extract dose showed the greatest increase in the mean values for Hb, Packed cell volume (PCV) and RBC count were 43.31.2%, 15.40.3 g/dL and 6.30.3 x106 /L respectively, when compared to the negative control group (P < 0.05).\u0000Conclusions: The aqueous root extract of P. muellerianus was efficacious against anaemia in a dose-dependent manner. The phytochemical compositions seem to be responsible for its haematopoietic properties. Thus, the root decoction of P. muellerianus is useful in alleviating anaemia and the results lend credence to its use in traditional medicine in the management of anaemia.","PeriodicalId":74149,"journal":{"name":"Medical journal of Zambia","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74454075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}