Advances in wound care最新文献

{"title":"Integrating Regenerative Therapies and Artificial Intelligence for Precision Management of Diabetic Foot Ulcers.","authors":"Hsiu-Jung Liao, Tzu-Chi Liao, Yu-Feng Wu","doi":"10.1177/21621918261422388","DOIUrl":"https://doi.org/10.1177/21621918261422388","url":null,"abstract":"<p><strong>Significance: </strong>Diabetic foot ulcers (DFUs) represent one of the most devastating complications of diabetes, leading to high rates of amputation and mortality. Their multifactorial pathogenesis-including neuropathy, ischemia, infection, and immune dysfunction-creates a chronic inflammatory microenvironment that impairs tissue repair and regeneration.</p><p><strong>Recent advances: </strong>Emerging regenerative strategies using stem cells and extracellular vesicles (EVs) have demonstrated potential to restore vascularization and modulate inflammation. In particular, miRNA-enriched EVs regulate key wound-healing pathways such as angiogenesis, extracellular matrix remodeling, and oxidative stress response. Meanwhile, small-molecule drugs targeting hypoxia and inflammatory cascades are being explored to enhance re-epithelialization and fibroblast migration. Parallel advances in artificial intelligence (AI) and optical sensing-using visible, infrared, or hyperspectral imaging-enable automated wound detection, tissue classification, and healing prediction with high accuracy.</p><p><strong>Critical issues: </strong>Despite these developments, translation remains limited by unstable therapeutic efficacy, variable biomarker expression, and the absence of standardized evaluation systems. AI-based wound assessment requires robust datasets and clinical validation to ensure reliability across diverse populations.</p><p><strong>Future directions: </strong>Integrating molecular-targeted therapies with AI-assisted diagnostic platforms could establish a next-generation DFU management framework-combining precise molecular intervention, automated wound monitoring, and personalized treatment planning-to achieve reliable, real-time, and patient-centered wound care.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261422388"},"PeriodicalIF":5.6,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vivo</i>, Label-Free Multiphoton Microscopy Is Sensitive to Altered Metabolism and Structure in Aged Skin.","authors":"Marcos R Rodriguez, Alan E Woessner, Kyle P Quinn","doi":"10.1177/21621918261421628","DOIUrl":"10.1177/21621918261421628","url":null,"abstract":"<p><strong>Objective: </strong>The expected increase in age-related health care costs over the coming decades underscores the need to characterize the effects of biological aging in our cells and tissues. Our objective is to use <i>in vivo</i> multiphoton microscopy (MPM) to find endogenous biomarkers of skin aging.</p><p><strong>Approach: </strong>MPM was performed on the skin of 2- and 21-month-old mice to measure the autofluorescence of metabolic cofactors, nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD), and second-harmonic generation signal from collagen. A suite of quantitative biomarkers with sensitivity to age-related changes in bioenergetic demands, mitochondrial organization, and collagen composition and organization was evaluated using these optical sources of contrast.</p><p><strong>Results: </strong>An optical redox ratio of FAD/(NADH + FAD) autofluorescence, NADH fluorescence lifetime imaging, and mitochondrial fractal dimension measurements indicated that aged keratinocytes have more fragmented mitochondria that undergo less catabolism of carbon substrates. Analysis of the dermal regions indicated that aged collagen has more nonenzymatic cross-links and has a more fragmented organization.</p><p><strong>Innovation: </strong>This study identifies a suite of biomarkers from label-free MPM sensitive to intrinsic aging and provides the first <i>in vivo</i> demonstration of sensitivity to age-dependent metabolic changes in skin through multiple independent optical parameters.</p><p><strong>Conclusion: </strong>Our results demonstrate that surrogate markers of metabolic function, mitochondrial organization, collagen cross-linking, and fiber organization are sensitive to a loss of homeostasis with advanced age and may be used in future studies to longitudinally assess the progression of aging.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261421628"},"PeriodicalIF":5.7,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13621446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair.","authors":"Bing Zhu, Yaojun Lu, Xinyue Kang, Lihua Hui, Yongkang Ding, Lu Liang, Zhigang Yang","doi":"10.1089/wound.2024.0243","DOIUrl":"10.1089/wound.2024.0243","url":null,"abstract":"<p><p>Wound healing is a dynamic process involving multiple cell types and signaling pathways. Dermal sheath cells (DSCs), residing surrounding hair follicles, play a critical role in tissue repair, yet their regulatory mechanisms remain unclear. This study used single-cell proteomics with the <i>Acan^CreER;R26^{LSL-tdTomato-DTR}</i> mouse model to explore DSC function across different healing stages. All animal procedures were conducted in accordance with the Animal Research: Reporting of In Vivo Experiments guidelines. Gene set enrichment analysis (GSEA) and temporal clustering (Mfuzz) were employed to reveal dynamic functional shifts. GSEA identified enriched gene sets related to interferon-gamma response, inflammatory response, ultraviolet response, myogenesis, and xenobiotic metabolism. Temporal clustering revealed eight distinct clusters: clusters associated with the early contracting and proliferative phases were linked to metabolic activation and oxidative stress, while clusters from the later remodeling phase emphasized extracellular matrix remodeling and structural reorganization. The dynamic expression of epithelial-mesenchymal transition-related genes and keratins supported DSCs' dual epithelial and mesenchymal traits. Additionally, keratins, collagens, integrins, and actin proteins emerged as promising markers or signature molecules for DSCs. This study reveals DSCs' dual traits during wound repair, providing a basis for therapies to enhance healing.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"116-133"},"PeriodicalIF":5.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Reconstituted High-Density Lipoproteins Elicit Anti-Inflammatory Effects in Diabetic Wounds.","authors":"Zahra Lotfollahi, Joanne T M Tan, Victoria A Nankivell, Lauren Sandeman, Sanuri Liyanage, Emma L Solly, Liam Stretton, Anna E Williamson, Joseph Dawson, Stephen J Nicholls, Peter J Psaltis, Robert Fitridge, Christina A Bursill","doi":"10.1089/wound.2023.0162","DOIUrl":"10.1089/wound.2023.0162","url":null,"abstract":"<p><strong>Objective: </strong>Reconstituted high-density lipoproteins (rHDL) improve wound healing in diabetes. We aimed to determine if rHDL elicit anti-inflammatory effects in diabetic wounds, as a mechanism to explain their wound healing benefits.</p><p><strong>Approach: </strong>Diabetes was induced using streptozotocin in C57Bl6/J mice. Two full-thickness wounds were placed on the subflanks of diabetic and nondiabetic (ND) mice. Phosphate-buffered saline (PBS) or rHDL (50 µg/wound/day) were applied topically. Wound closure was assessed daily. Inflammatory gene transcripts were measured by qPCR and proteins by Western blotting and enzyme-linked immunosorbent assay in wounds collected at baseline, 24 h, and 3 days postwounding. Wound macrophages were assessed by flow cytometry 7 days postwounding. The fate of fluorescent 3,3-dioctadecyloxacarbocyanine, perchlorate (DiO)-labeled rHDL was tracked by flow cytometry, fluorescent imaging, and microscopy.</p><p><strong>Results: </strong>In diabetic mice, rHDL increased wound closure rates at days 6 (+288%, p < 0.01) and 7 (+639%, p < 0.0001) postwounding, compared with PBS controls. After 3 days, rHDL-treated diabetic wounds had lower <i>Rela</i> (-65%) and C-C motif chemokine ligand 2 (<i>Ccl2</i>) (-59%) mRNA levels and CCL2 protein (29%) than PBS controls, p < 0.05 for all. Wound macrophage content was higher in diabetic than ND wounds, but rHDL did not change macrophage content or polarity. DiO-rHDL were taken up by key wound cells including fibroblasts, macrophages, keratinocytes and endothelial cells, and retained in wounds for at least 48 h.</p><p><strong>Innovation: </strong>rHDL exerts anti-inflammatory effects in diabetic wounds early postwounding, which may contribute to its wound healing properties.</p><p><strong>Conclusion: </strong>The anti-inflammatory properties of rHDL in diabetic wounds present topical rHDL as a novel treatment option for improving healing in patients with diabetic foot ulcers. [Figure: see text].</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"91-106"},"PeriodicalIF":5.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Measurement of Transepidermal Water Loss.","authors":"Dibyasankha Kundu, Anant Jayaraman, Chandan K Sen","doi":"10.1089/wound.2024.0148","DOIUrl":"10.1089/wound.2024.0148","url":null,"abstract":"<p><strong>Significance: </strong>Recent reports recognize transepidermal water loss (TEWL) as a critical objective parameter measuring clinical wound healing endpoint. At the site of wound repair, TEWL measures functional wound closure as marked by re-establishment of barrier function at the wound site. This review article addresses recent developments in clinical TEWL measurement in the context of human skin health and wound care. To that end, emphasis is placed on the review of registered clinical studies reported in ClinicalTrials.gov for which TEWL results have been posted or published.</p><p><strong>Recent advances: </strong>The U.S. Food and Drug Administration (FDA) defines complete wound closure as the achievement of 100% re-epithelialization of the wound surface, with no detectable exudate, drainage, or need for wound dressing, as verified during two sequential clinical assessments conducted at least 14 days apart. Clinically, wounds may meet this current FDA-recommended clinical criteria for wound closure, yet not achieve functional wound closure which requires the re-establishment of barrier function at the site of repair. Such wounds are likely to recur. High TEWL posthealing predicts wound recurrence. Thus, TEWL measurement at the site of repair posthealing is emerging as a significant measurement of wound healing endpoint.</p><p><strong>Critical issues: </strong>Appropriate clinical measurement of TEWL requires a basic understanding of the related technologies and their appropriate use. Such understanding will help achieve the necessary rigor and reproducibility in clinical measurement.</p><p><strong>Future directions: </strong>Recent reports on the critical significance of TEWL in wound care open new horizons wherein TEWL is likely to have broader applications involving altered skin barrier functions, such as during aging and other factors that determine skin health. Evidence to support revisiting the FDA definition of wound closure to include restoration of barrier function at the site of closure is strong. Widespread adoption of TEWL in wound care practices to determine functional wound closure is anticipated. [Figure: see text].</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"73-90"},"PeriodicalIF":5.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Evaluation of Vitamin C, Vitamin D, and Zinc Deficiencies in Patients with Active Foot Ulceration.","authors":"Nada Bechara, Peta Tehan, Jenny E Gunton","doi":"10.1089/wound.2024.0063","DOIUrl":"10.1089/wound.2024.0063","url":null,"abstract":"<p><strong>Objective: </strong>This prospective cohort study aimed to determine the relationship between serum vitamin C, D, and zinc on foot wound healing and compare time to healing in individuals who are deficient versus those who have adequate levels.</p><p><strong>Approach: </strong>One hundred adults with foot wounds were recruited from Blacktown high-risk foot service with a follow-up period of 12 months. Serum vitamin C, D, and zinc as well as routine baseline blood testing was undertaken. Wounds were measured using a three-dimensional wound camera and classified using the Wound Ischemia and Foot Infection system at regular intervals.</p><p><strong>Results: </strong>Vitamin C deficiency was present in 75% of participants, 50% had vitamin D deficiency, and 38% had zinc deficiency. Diabetes was present in 91% of participants, and 50% had a history of previous amputation. Wound chronicity (<i>p</i> = 0.03) and toe pressures (<i>p</i> = 0.04) were predictive of wound healing. Serum vitamin C, D, and zinc were not associated with significant differences in wound healing or time to wound healing.</p><p><strong>Innovation: </strong>Deficiencies in vitamin C, D, and zinc were highly prevalent in participants with active foot ulceration. Wound chronicity was predictive of healing outcomes, highlighting the importance of rapid access to best practice care.</p><p><strong>Conclusion: </strong>This cohort had high deficiency rates of vitamin C, D, and zinc consistent with previous literature; however, there was no relationship between these deficiencies and wound healing or time to heal. Large randomized controlled trials are required to comprehensively determine if adequate levels of these nutrients improve wound healing outcomes. [Figure: see text].</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"107-115"},"PeriodicalIF":5.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141465473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Human Amniotic Membrane for Chronic Wounds: A Systematic Review and Meta-Analysis of Clinical Trials.","authors":"Chengcheng Zheng, Weiwei Tang, Xingwu Ran","doi":"10.1177/21621918251411808","DOIUrl":"10.1177/21621918251411808","url":null,"abstract":"<p><strong>Objective: </strong>The meta-analysis was performed to evaluate the efficacy and safety associated with the application of human amniotic membrane (HAM) in individuals with chronic nonhealing wounds.</p><p><strong>Approach: </strong>The research conducted a comprehensive search of nine electronic databases from their inception to August 1, 2024, aiming to identify randomized controlled trials (RCTs) that evaluated the efficacy of HAM compared with conventional management alone in individuals suffering from chronic wounds. The risk of bias of included studies and the certainty of the evidence in the meta-analysis were evaluated by two investigators and confirmed by a third. The meta-analysis was performed using RevMan 5.4 software.</p><p><strong>Results: </strong>We identified 14 RCTs encompassing a total of 1,056 participants. The potential risk of bias was determined to be moderate. HAM therapy demonstrated significantly greater efficacy than conventional treatment alone in achieving complete wound healing among patients with chronic ulcers (relative risk [RR] = 1.82; 95% confidence interval [CI]: 1.48-2.24; moderate-quality evidence). In patients with diabetic foot ulcers, HAM reduced the mean time to complete healing by 22 days compared with standard care alone (mean difference = -22.09 days; 95% CI: -39.13 to -5.05; low-quality evidence) and increased the rate of complete healing at 6 weeks (RR = 3.02; 95% CI: 2.04-4.47; moderate-quality evidence) and at 12 weeks (RR = 1.74; 95% CI: 1.37-2.21; low-quality evidence). Similarly, in patients with venous leg ulcers, HAM was associated with more than twice the likelihood of complete healing (RR = 2.03; 95% CI: 1.45-2.86; moderate-quality evidence). No statistically significant differences were noted in the incidence of adverse events among patients with chronic ulcers (moderate-quality evidence).</p><p><strong>Innovation: </strong>Our study suggests that HAM represents a promising and viable therapeutic strategy for the management of chronic wounds, including lower-extremity diabetic ulcers and venous ulcers.</p><p><strong>Conclusion: </strong>The application of HAM provides a safer and more effective therapeutic approach compared with conventional management alone for patients suffering from chronic refractory ulcers.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918251411808"},"PeriodicalIF":5.6,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Imbalance Drives Keloid Pathogenesis: Emerging Targets for Precision Immunotherapy.","authors":"Qilei Chen, Shujun Wan, Yuanyuan Duan, Jing Yan, Min Zhang","doi":"10.1177/21621918261417702","DOIUrl":"https://doi.org/10.1177/21621918261417702","url":null,"abstract":"<p><strong>Significance: </strong>Keloids represent a persistent clinical challenge, with recurrence rates approaching 100% after conventional surgical excision. Historically viewed as fibroblast-driven scars, emerging evidence positions immune dysregulation as a central driver of keloid pathogenesis, reshaping diagnostic and therapeutic paradigms.</p><p><strong>Recent advances: </strong>Multi-omics and single-cell analyses reveal profound alterations in immune cell populations and cytokine networks within keloid tissue. M2 macrophages, mast cells, Th2 and Th17 subsets, and dendritic cells dominate the inflammatory microenvironment, sustaining fibroblast activation and excessive extracellular matrix deposition. Key signaling axes-including transforming growth factor-β (TGF-β)/Smad, IL-4/IL-13, IL-6/JAK-STAT-3, and PI3K/AKT/mTOR-intersect with mechanical stress pathways, creating a self-perpetuating fibrotic loop. Notably, soluble human leukocyte antigen-E emerges as a predictive biomarker for disease progression and recurrence, while tissue-resident memory T cells may underlie postoperative relapse.</p><p><strong>Therapeutic implications: </strong>Beyond corticosteroids and silicone gel, immune-targeted strategies are gaining traction. Dupilumab (IL-4/IL-13 blockade) demonstrates clinical efficacy in reducing keloid burden and pruritus. Experimental approaches targeting TGF-β signaling (Fresolizumab, AVID200), NKG2A/CD94 checkpoints (Monalizumab), IL-6 (Tocilizumab), and TSLP (Tezepelumab) hold promise for precision immunotherapy. Localized delivery and combination regimens may optimize outcomes while minimizing systemic toxicity.</p><p><strong>Critical issues and future directions: </strong>The absence of validated keloid models and large-scale trials limits translation. Future research must integrate immune profiling, biomarker validation, and mechanistic modeling to enable personalized interventions. Immune dysregulation is not merely an epiphenomenon-it is the Achilles' heel of keloids, offering unprecedented opportunities for targeted therapy and recurrence prevention.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"21621918261417702"},"PeriodicalIF":5.6,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation Between Wound Bed Preparation and Wound Closure in Venous Leg Ulcers: A <i>Post Hoc</i> Analysis of the ChronEx Multicenter Randomized Controlled Trial.","authors":"Marissa J Carter, Robert J Snyder, Keren David Zarbiv, Yael Katz-Levy, Asi Haviv, Ety Klinger, Ofra Barnett-Griness, Chaviva Peretz-Rozenblum, Yaron Shoham, John C Lantis","doi":"10.1177/21621918251366644","DOIUrl":"10.1177/21621918251366644","url":null,"abstract":"<p><strong>Objective: </strong>This <i>post hoc</i> analysis determined the correlation between wound bed preparation (WBP), defined as complete debridement of nonviable tissue and complete granulation tissue coverage, and wound closure, using data from a published, Consolidated Standards of Reporting Trials (CONSORT)-compliant randomized controlled trial that evaluated bromelain-based enzymatic debridement (BBD) compared with a placebo gel vehicle (GV) or nonsurgical standard of care (NSSOC) in patients with chronic venous leg ulcers (VLUs).</p><p><strong>Approach: </strong>Patients with chronic VLUs were randomized (3:3:2 ratio) to daily treatment with BBD, GV, or NSSOC for up to 2 weeks and followed up weekly with NSSOC for 12 weeks. Wound closure incidence was compared between those who did and did not achieve WBP by 14 days or anytime during the study.</p><p><strong>Results: </strong>Data were analyzed from 119 VLUs. Among 80 wounds that achieved WBP anytime during the study, 42% healed; among 39 wounds without WBP, only 10.3% healed (relative risk [RR] = 4.1, <i>p</i> = 0.0004, negative predictive value [NPV] = 90%). Among 37 wounds that achieved WBP by 14 days, 54% healed; among 78 wounds that did not achieve WBP by 14 days, only 22% healed (NPV = 78%). Wounds were 2.4 times more likely to achieve closure anytime during the study, if they achieved WBP by 14 days (RR = 2.4, <i>p =</i> 0.0005).</p><p><strong>Innovation: </strong>This landmark analysis confirms that WBP status is an early predictive variable of wound closure.</p><p><strong>Conclusion: </strong>WBP of chronic VLUs significantly increased the likelihood of wound closure and is a critical, though not sufficient, condition for healing.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"32-40"},"PeriodicalIF":5.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Getting Started on Artificial Intelligence in Health Care and Clinical Research: Includes Rigor Checklist for Authors and Reviewers.","authors":"Chandan K Sen, Deeptankar DeMazumder","doi":"10.1177/21621918251380217","DOIUrl":"10.1177/21621918251380217","url":null,"abstract":"<p><p>Artificial intelligence (AI) is rapidly transforming biomedical research and health care, offering new paradigms for discovery, diagnosis, and decision-making. This article provides a roadmap for researchers, clinicians, and reviewers seeking to understand and apply AI with rigor and relevance. It begins with a historical anchor: the birth of AI in health care at the University of Pittsburgh in the 1970s, where the INTERNIST-1 system pioneered diagnostic reasoning through symbolic logic, a milestone that laid the foundation for today's intelligent systems.Structured into three tiers-foundations, core techniques, and applications-the article addresses the full spectrum of biomedical AI. It introduces foundational concepts such as data engineering and preprocessing, knowledge representation and reasoning, and symbolic AI, which together enable structured, interpretable intelligence. Core techniques including expert systems, machine learning, deep learning, and explainable AI are presented with clinical examples, highlighting their role in wound care, image analysis, and predictive modeling. The applications tier showcases natural language processing, non-machine learning computer vision, robotics and automation, and distributed AI/multi-agent systems, demonstrating how AI integrates into real-world workflows. Ethical considerations and bias mitigation strategies are addressed with emphasis on Institutional Review Board oversight and fairness frameworks.Crucially, the article emphasizes that successful AI adoption begins not with technology, but with people. It outlines a systematic approach to building a biomedical AI workforce from within, empowering clinicians, researchers, and staff to become AI-literate contributors and leaders. With rigor checklists, practical guidance, and a vision for human-AI collaboration, this article invites readers to move beyond hype and toward responsible, transformative innovation in health care and biomedical science.</p>","PeriodicalId":7413,"journal":{"name":"Advances in wound care","volume":" ","pages":"1-31"},"PeriodicalIF":5.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}