Adam M. Ostrovsky BS, Joshua R. Chen BS, Vishal N. Shah DO, Babak Abai MD
{"title":"Performance of 5 Prominent Large Language Models in Surgical Knowledge Evaluation: A Comparative Analysis","authors":"Adam M. Ostrovsky BS, Joshua R. Chen BS, Vishal N. Shah DO, Babak Abai MD","doi":"10.1016/j.mcpdig.2024.05.022","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.05.022","url":null,"abstract":"","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 348-350"},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000579/pdfft?md5=4ab21ee50f30d05ffdd5242c3c0f5bb9&pid=1-s2.0-S2949761224000579-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141479361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominique du Crest MBE , Monisha Madhumita MD , Wendemagegn Enbiale MD, MPH, PhD , Alexander Zink MD, MPH, PhD , Art Papier MD , Gaone Matewa BBA , Harvey Castro MD, MBA , Hector Perandones MD , Josef De Guzman OD-OPS , Misha Rosenbach MD , Tu-Anh Duong MD, PhD , Yu-Chuan Jack Li MD, PhD , Hugues Cartier MD , Benjamin Ascher MD , Sebastien Garson MD , Alessandra Haddad MD, PhD , Daniel Z. Liu MD , Diala Haykal MD , Jane Yoo MD, MPP , Nav Paul MBBS, MRCP , Lilit Garibyan MD, PhD
{"title":"Skin and Digital–The 2024 Narrative","authors":"Dominique du Crest MBE , Monisha Madhumita MD , Wendemagegn Enbiale MD, MPH, PhD , Alexander Zink MD, MPH, PhD , Art Papier MD , Gaone Matewa BBA , Harvey Castro MD, MBA , Hector Perandones MD , Josef De Guzman OD-OPS , Misha Rosenbach MD , Tu-Anh Duong MD, PhD , Yu-Chuan Jack Li MD, PhD , Hugues Cartier MD , Benjamin Ascher MD , Sebastien Garson MD , Alessandra Haddad MD, PhD , Daniel Z. Liu MD , Diala Haykal MD , Jane Yoo MD, MPP , Nav Paul MBBS, MRCP , Lilit Garibyan MD, PhD","doi":"10.1016/j.mcpdig.2024.05.008","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.05.008","url":null,"abstract":"<div><p>The global burden of skin diseases affects over 3 billion individuals, posing important public health challenges worldwide, with profound impacts in both high-income and low-income and middle-income countries. These challenges are exacerbated by widespread disparities in access to dermatologic care and the prevalence of misinformation. This article, derived from the Skin and Digital Summit at the International Master Course on Aging Science critically evaluates how digital technologies such as artificial intelligence, teledermatology, and large language models can bridge these access gaps. It explores practical applications and case studies demonstrating the impact of these technologies in various settings, with a particular focus on adapting solutions to meet the diverse needs of low-income and middle-income countries. In addition, the narrative highlights the ongoing conversation within the dermatologic community about the role of digital advances in health care, emphasizing that this discussion is dynamic and the one that is continuously evolving. Dermatologists play an essential role in this transition, integrating digital tools into mainstream care to complement a patient-centered, culturally sensitive approach. The article advocates for a globally coordinated digital response that not only addresses current disparities in skin health care but also promotes equitable access to digital health resources, making dermatologic care more representative of all skin types and accessible worldwide.</p></div>","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 322-330"},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000439/pdfft?md5=ef5fd4a5427d12cc5a17c3fd6d54330b&pid=1-s2.0-S2949761224000439-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Waldemar E. Wysokinski MD, PhD, Ryan A. Meverden PA-C, Francisco Lopez-Jimenez MD, MBA, David M. Harmon MD, Betsy J. Medina Inojosa MD, Abraham Baez Suarez PhD, MS, Kan Liu PhD, Jose R. Medina Inojosa MD, Ana I. Casanegra MD, Robert D. McBane MD, Damon E. Houghton MD, MS
{"title":"Electrocardiogram Signal Analysis With a Machine Learning Model Predicts the Presence of Pulmonary Embolism With Accuracy Dependent on Embolism Burden","authors":"Waldemar E. Wysokinski MD, PhD, Ryan A. Meverden PA-C, Francisco Lopez-Jimenez MD, MBA, David M. Harmon MD, Betsy J. Medina Inojosa MD, Abraham Baez Suarez PhD, MS, Kan Liu PhD, Jose R. Medina Inojosa MD, Ana I. Casanegra MD, Robert D. McBane MD, Damon E. Houghton MD, MS","doi":"10.1016/j.mcpdig.2024.03.009","DOIUrl":"10.1016/j.mcpdig.2024.03.009","url":null,"abstract":"<div><h3>Objective</h3><p>To develop an artificial intelligence deep neural network (AI-DNN) algorithm to analyze 12-lead electrocardiogram (ECG) for detection of acute pulmonary embolism (PE) and PE categories.</p></div><div><h3>Patients and Methods</h3><p>A cohort of patients seen between January 1, 1999, and December 31, 2020, from across the Mayo Clinic Enterprise with computed tomography pulmonary angiogram (CTPA) and ECG performed ±6 hours was identified. Natural language processing algorithms were applied to radiology reports to determine the diagnosis of acute PE, acute right ventricular strain pulmonary embolism (RVSPE), saddle pulmonary embolism (SADPE), or no PE. Diagnostic performance parameters of the AI-DNN reported were area under the receiver operating characteristics curve (AUROC), sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).</p></div><div><h3>Results</h3><p>A cohort of patients with CTPA report and ECG consisted of 79,894 patients including 7423 (9.3%) with acute PE, among whom 1138 patients had RVSPE or SADPE. Artificial intelligence deep neural network predicted acute PE with a modest accuracy of AUROC of 0.69 (95% CI, 0.68-0.71), sensitivity of 63.5%, specificity of 64.7%, PPV of 15.6%, and NPV of 94.5%. The AI-DNN prediction using the same algorithm for RVSPE or SADPE was higher (AUROC, 0.84; 95% CI, 0.81-0.86) with a sensitivity of 80.8%, specificity of 64.7.8%, PPV of 3.5%, and NPV of 99.5%.</p></div><div><h3>Conclusion</h3><p>An AI-based analysis of 12-lead ECG shows modest detection power for acute PE in patients who underwent CTPA, with higher accuracy for high-risk PE. Moreover, with the high NPV, it has the clinical potential to exclude high-risk PE quickly and correctly.</p></div>","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 453-462"},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000336/pdfft?md5=37397978693133143ba8101acf52268a&pid=1-s2.0-S2949761224000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amy Bucher PhD, E. Susanne Blazek PhD, Christopher T. Symons PhD
{"title":"How are Machine Learning and Artificial Intelligence Used in Digital Behavior Change Interventions? A Scoping Review","authors":"Amy Bucher PhD, E. Susanne Blazek PhD, Christopher T. Symons PhD","doi":"10.1016/j.mcpdig.2024.05.007","DOIUrl":"10.1016/j.mcpdig.2024.05.007","url":null,"abstract":"<div><p>To assess the current real-world applications of machine learning (ML) and artificial intelligence (AI) as functionality of digital behavior change interventions (DBCIs) that influence patient or consumer health behaviors. A scoping review was done across the EMBASE, PsycInfo, PsycNet, PubMed, and Web of Science databases using search terms related to ML/AI, behavioral science, and digital health to find live DBCIs using ML or AI to influence real-world health behaviors in patients or consumers. A total of 32 articles met inclusion criteria. Evidence regarding behavioral domains, target real-world behaviors, and type and purpose of ML and AI used were extracted. The types and quality of research evaluations done on the DBCIs and limitations of the research were also reviewed. Research occurred between October 9, 2023, and January 20, 2024. Twenty-three DBCIs used AI to influence real-world health behaviors. Most common domains were cardiometabolic health (n=5, 21.7%) and lifestyle interventions (n=4, 17.4%). The most common types of ML and AI used were classical ML algorithms (n=10, 43.5%), reinforcement learning (n=8, 34.8%), natural language understanding (n=8, 34.8%), and conversational AI (n=5, 21.7%). Evidence was generally positive, but had limitations such as inability to detect causation, low generalizability, or insufficient study duration to understand long-term outcomes. Despite evidence gaps related to the novelty of the technology, research supports the promise of using AI in DBCIs to manage complex input data and offer personalized, contextualized support for people changing real-world behaviors. Key opportunities are standardizing terminology and improving understanding of what ML and AI are.</p></div>","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 375-404"},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000427/pdfft?md5=6c9780a76948435fb6c91a05b2e3b023&pid=1-s2.0-S2949761224000427-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transforming Health Care With Artificial Intelligence: Redefining Medical Documentation","authors":"Archana Reddy Bongurala MD , Dhaval Save MD , Ankit Virmani MSc , Rahul Kashyap MBBS","doi":"10.1016/j.mcpdig.2024.05.006","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.05.006","url":null,"abstract":"","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 342-347"},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000415/pdfft?md5=65848adacb29206aec465218a9902c5c&pid=1-s2.0-S2949761224000415-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Austin T. Gregg BS , Lisa Soleymani Lehmann MD, PhD
{"title":"Privacy and Consent in Mobile Health: Solutions for Balancing Benefits and Risks","authors":"Austin T. Gregg BS , Lisa Soleymani Lehmann MD, PhD","doi":"10.1016/j.mcpdig.2024.05.005","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.05.005","url":null,"abstract":"","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 331-334"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000403/pdfft?md5=93292ffce6526ded18455eb6f74ff7ad&pid=1-s2.0-S2949761224000403-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Loor-Torres MD , Mayra Duran MD , David Toro-Tobon MD , Maria Mateo Chavez MD , Oscar Ponce MD , Cristian Soto Jacome MD , Danny Segura Torres MD , Sandra Algarin Perneth MD , Victor Montori BA , Elizabeth Golembiewski PhD, MPH , Mariana Borras Osorio MD , Jungwei W. Fan PhD , Naykky Singh Ospina MD , Yonghui Wu PhD , Juan P. Brito MD, MS
{"title":"A Systematic Review of Natural Language Processing Methods and Applications in Thyroidology","authors":"Ricardo Loor-Torres MD , Mayra Duran MD , David Toro-Tobon MD , Maria Mateo Chavez MD , Oscar Ponce MD , Cristian Soto Jacome MD , Danny Segura Torres MD , Sandra Algarin Perneth MD , Victor Montori BA , Elizabeth Golembiewski PhD, MPH , Mariana Borras Osorio MD , Jungwei W. Fan PhD , Naykky Singh Ospina MD , Yonghui Wu PhD , Juan P. Brito MD, MS","doi":"10.1016/j.mcpdig.2024.03.007","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.03.007","url":null,"abstract":"<div><p>This study aimed to review the application of natural language processing (NLP) in thyroid-related conditions and to summarize current challenges and potential future directions. We performed a systematic search of databases for studies describing NLP applications in thyroid conditions published in English between January 1, 2012 and November 4, 2022. In addition, we used a snowballing technique to identify studies missed in the initial search or published after our search timeline until April 1, 2023. For included studies, we extracted the NLP method (eg, rule-based, machine learning, deep learning, or hybrid), NLP application (eg, identification, classification, and automation), thyroid condition (eg, thyroid cancer, thyroid nodule, and functional or autoimmune disease), data source (eg, electronic health records, health forums, medical literature databases, or genomic databases), performance metrics, and stages of development. We identified 24 eligible NLP studies focusing on thyroid-related conditions. Deep learning-based methods were the most common (38%), followed by rule-based (21%), and traditional machine learning (21%) methods. Thyroid nodules (54%) and thyroid cancer (29%) were the primary conditions under investigation. Electronic health records were the dominant data source (17/24, 71%), with imaging reports being the most frequently used (15/17, 88%). There is increasing interest in NLP applications for thyroid-related studies, mostly addressing thyroid nodules and using deep learning-based methodologies with limited external validation. However, none of the reviewed NLP applications have reached clinical practice. Several limitations, including inconsistent clinical documentation and model portability, need to be addressed to promote the evaluation and implementation of NLP applications to support patient care in thyroidology.</p></div>","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 2","pages":"Pages 270-279"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000270/pdfft?md5=a263fb1467469ab6d8333b257365a8ec&pid=1-s2.0-S2949761224000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atefeh Ghorbanzadeh MD , Naresh Prodduturi MS , Ana I. Casanegra MD, MS , Robert McBane MD , Paul Wennberg MD , Thom Rooke MD , David Liedl RN , Dennis Murphree PhD , Damon E. Houghton MD, MS
{"title":"Machine Learning Analysis of Facial Photographs for Predicting Bicuspid Aortic Valve","authors":"Atefeh Ghorbanzadeh MD , Naresh Prodduturi MS , Ana I. Casanegra MD, MS , Robert McBane MD , Paul Wennberg MD , Thom Rooke MD , David Liedl RN , Dennis Murphree PhD , Damon E. Houghton MD, MS","doi":"10.1016/j.mcpdig.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.05.002","url":null,"abstract":"","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 319-321"},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000373/pdfft?md5=323ed4c1e00b694f865a70ffa47c077d&pid=1-s2.0-S2949761224000373-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reinforcing Stereotypes in Health Care Through Artificial Intelligence–Generated Images: A Call for Regulation","authors":"Hannah van Kolfschooten LLM , Astrid Pilottin LLM","doi":"10.1016/j.mcpdig.2024.05.004","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.05.004","url":null,"abstract":"","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 335-341"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000397/pdfft?md5=6c14744f6113830d0aee54966003b0f0&pid=1-s2.0-S2949761224000397-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gioacchino D. De Sario Velasquez MD , Sahar Borna MD , Michael J. Maniaci MD , Jordan D. Coffey MBA , Clifton R. Haider PhD , Bart M. Demaerschalk MSc, MD , Antonio Jorge Forte MD, PhD
{"title":"Economic Perspective of the Use of Wearables in Health Care: A Systematic Review","authors":"Gioacchino D. De Sario Velasquez MD , Sahar Borna MD , Michael J. Maniaci MD , Jordan D. Coffey MBA , Clifton R. Haider PhD , Bart M. Demaerschalk MSc, MD , Antonio Jorge Forte MD, PhD","doi":"10.1016/j.mcpdig.2024.05.003","DOIUrl":"https://doi.org/10.1016/j.mcpdig.2024.05.003","url":null,"abstract":"<div><p>The objective of this study is to explore the current state of research concerning the cost-effectiveness of wearable health technologies, excluding hearing aids, owing to extensive previous investigation. A systematic review was performed using PubMed, EMBASE/MEDLINE, Google Scholar, and Cumulated Index to Nursing and Allied Health Literature to search studies evaluating the cost-effectiveness of wearable health devices in terms of quality-adjusted life years and incremental cost-effectiveness ratio. The search was conducted on March 28, 2023, and the date of publication did not limit the search. The search yielded 10 studies eligible for inclusion. These studies, published between 2012 and 2023, spanned various locations globally. The studies used data from hypothetical cohorts, existing research, randomized controlled trials, and meta-analyses. They covered a diverse range of wearable technologies applied in different health care settings, including respiratory rate monitors, pedometers, fall-prediction devices, hospital-acquired pressure injury prevention monitors, seizure detection devices, heart rate monitors, insulin therapy sensors, and wearable cardioverter defibrillators. The time horizons in the cost-effectiveness analyses ranged from less than a year to a lifetime. The studies indicate that wearable technologies can increase quality-adjusted life years and be cost-effective and potentially cost-saving. However, the cost-effectiveness depends on various factors, such as the type of device, the health condition being addressed, the specific perspective of the health economic analysis, local cost and payment structure, and willingness-to-pay thresholds. The use of wearables in health care promises improving outcomes and resource allocation. However, more research is needed to fully understand the long-term benefits and to strengthen the evidence base for health care providers, policymakers, and patients.</p></div>","PeriodicalId":74127,"journal":{"name":"Mayo Clinic Proceedings. Digital health","volume":"2 3","pages":"Pages 299-317"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949761224000385/pdfft?md5=dcc6804bc580088be603b0023cca6ac3&pid=1-s2.0-S2949761224000385-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141424582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}