{"title":"A narrative review of curcuminoids from various Curcuma species in Indonesia as potential antidiabetic agents","authors":"K. T. A. Priyangga, C. P. Sagita, L. Yuliati","doi":"10.21037/lcm-21-9","DOIUrl":"https://doi.org/10.21037/lcm-21-9","url":null,"abstract":"Objective: To discuss the potential of curcuminoids from various Curcuma plants in Indonesia as the antidiabetic agent for diabetes mellitus treatment. Background: Natural bioactive compounds are very attractive for medical applications, owing to their abundant availability, as well as safe and non-toxic properties for human body. One of the promising bioactive compounds is curcuminoids. Curcuminoids may consist of three main components, which are curcumin, demethoxycurcumin, and bisdemethoxycurcumin, and generally can be found in Curcuma species. Various types of Curcuma species can be found in various locations in Indonesia, i.e., Curcuma longa, Curcuma heyneana, Curcuma zanthorrhiza , and Curcuma mangga . The Curcuma plants have been reported to show antidiabetic activity, which can be a great potential source for diabetes therapy. Method: The narrative review is written based on the published literature retrieved from search engines in internet databases, limiting the discussion on the diabetes mellitus and antidiabetic potentials of curcuminoids extracted from the Curcuma species in Indonesia. Conclusion: As compared to the commercial drugs such as metformin, acarbose, and glibenclamide for diabetes mellitus type 2, the antidiabetic property of curcuma extracts was found to be at a similar level and in several cases were found to give better activity. The different antidiabetic activity of curcuma extract was strongly affected by the Curcuma species, extracting solvents, and the location where the Curcuma species grow as it would be related to the composition of curcuminoids. Even though the high antidiabetic capacity and activity can be observed, the stability and bioavailability of the curcuma extracts still need to be improved. 15 a traditional The Curcuma zanthorrhiza was reported to contain several active compounds, such as curcuminoids, xanthorrhizol, champhor, zerumbone, geranyl acetate curcumene, and zingiberene (43). It was also found that Curcuma zanthorrhiza extract contains 16.64% xanthorrizhol as its bioactive compound. The potential antidiabetic activity of the Curcuma zanthorrhiza obtained from Jakarta was examined by the in - vivo method using high fat diet-induced obese mice. The plant rhizome was extracted in ethanol solvent. Both the crude Curcuma zanthorrhiza extract and purified xanthorrhizol from the plant extracts were investigated to study their antidiabetic activities. The purified xanthorrhizol at 10 and 25 mg/kg/day exhibited a decrease in the fasting blood glucose level up to 21.8 and 33%, respectively. Meanwhile, the Curcuma zanthorrhiza extract at 50 or 100 mg/kg BW/day gave the value of 28.5% and 31.2%, respectively. From the results, both the Curcuma zanthorrhiza extract and purified xanthorrhizol from the extract showed their higher activity as the antidiabetic agent when compared to the standard of metformin at a dose of 100 mg/kg BW/day. This finding suggested that the antidiabetic activity of Curcuma zanth","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42923176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case report on integrative medicine management of suspected Sjogren’s syndrome","authors":"M. Jolicoeur, G. Chu, K. Hui","doi":"10.21037/lcm-21-61","DOIUrl":"https://doi.org/10.21037/lcm-21-61","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43612706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"History and regulation of traditional Chinese medicine in Hungary","authors":"A. Eőry","doi":"10.21037/lcm-21-40","DOIUrl":"https://doi.org/10.21037/lcm-21-40","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42354705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haimeng Zhao, Xiaoming Tang, Bo Li, Li-li Guan, W. Cai, Tianjiao Wang, Hainan Liu, Nannan Liu, Nagarajan Ma, Fan Zhang
{"title":"Experience of traditional Chinese medicine nursing staff from Beijing assisting Hubei in the treatment of patients with COVID-19: a qualitative study","authors":"Haimeng Zhao, Xiaoming Tang, Bo Li, Li-li Guan, W. Cai, Tianjiao Wang, Hainan Liu, Nannan Liu, Nagarajan Ma, Fan Zhang","doi":"10.21037/lcm-21-28","DOIUrl":"https://doi.org/10.21037/lcm-21-28","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42706223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. T. Atayoğlu, Serhat Korhan, Erkan Temizkan, Mehmet Bora Emenli, H. Koç, D. Uçar, Amine Atac, M. Turan, Muharrem Guner
{"title":"Short-term efficacy of spinal manipulation in addition to pharmacological treatment of acute low back pain in the emergency department: a randomized controlled trial","authors":"A. T. Atayoğlu, Serhat Korhan, Erkan Temizkan, Mehmet Bora Emenli, H. Koç, D. Uçar, Amine Atac, M. Turan, Muharrem Guner","doi":"10.21037/lcm-21-11","DOIUrl":"https://doi.org/10.21037/lcm-21-11","url":null,"abstract":"Family Medicine Department, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey; Traditional & Complementary Medicine Department, Istanbul Medipol University, Istanbul, Turkey; Scientific Office, U-merge Ltd., London, Athens, Dubai; Family Medicine Department, Mega Hospital, Istanbul Medipol University, Istanbul, Turkey; Emergency Department, Istanbul Medipol University, Istanbul, Turkey; Physical Therapy and Rehabilitation Department, Istanbul Medipol University, Istanbul, Turkey; Turkish Holistic & Integrative Medicine Association, Istanbul, Turkey Contributions: (I) Conception and design: AT Atayoglu; (II) Administrative support: E Temizkan; (III) Provision of study materials or patients: AT Atayoglu, A Atac, M Turan, M Guner; (IV) Collection and assembly of data: AT Atayoglu, S Korhan, MB Emenli, H Koc; (V) Data analysis and interpretation: AT Atayoglu, E Temizkan; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. U-merge Ltd. (Urology for Emerging Countries) is an academic urological & medical platform dedicated to facilitate knowledge transfer on all levels from developed to emerging countries. U-merge Ltd. is registered with the Companies House in London/UK. www.U-merge.com. Correspondence to: Ali Timucin Atayoglu, MD. U-merge scientific Office, 1, Menandrou Street, Athens 14561, Greece. Email: scientific-Office@u-merge.com; atatayoglu@medipol.edu.tr.","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47612797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuanfang Kan, Chengfu Su, Zhou Zhu, Jia Liu, Xin Guan, A. Iyaswamy, K. Cheung, Yuan-Yuan Zhang, Juxian Song, Min Li
{"title":"Neuroprotective activities of icariin in rodent models of Alzheimer’s disease: a systematic review and meta-analysis","authors":"Yuanfang Kan, Chengfu Su, Zhou Zhu, Jia Liu, Xin Guan, A. Iyaswamy, K. Cheung, Yuan-Yuan Zhang, Juxian Song, Min Li","doi":"10.21037/lcm-21-50","DOIUrl":"https://doi.org/10.21037/lcm-21-50","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42187243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Soy in benign prostate hyperplasia and prostate cancer: a literature review","authors":"A. Trinchieri","doi":"10.21037/lcm-21-36","DOIUrl":"https://doi.org/10.21037/lcm-21-36","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44701289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ella Man-Wai Un, Eva Siu-Yung Chan, Kai-Heng Lam, Lin Li, SimonMing-Yuen Lee
{"title":"Cinnabar is a naturally occurring mercuric sulfide that induces cardiotoxicity in zebrafish larvae","authors":"Ella Man-Wai Un, Eva Siu-Yung Chan, Kai-Heng Lam, Lin Li, SimonMing-Yuen Lee","doi":"10.21037/lcm-21-44","DOIUrl":"https://doi.org/10.21037/lcm-21-44","url":null,"abstract":"","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42335555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulations of traditional Chinese medicine in Argentina","authors":"Marcelo Mariano Biolatto","doi":"10.21037/LCM-2021-002","DOIUrl":"https://doi.org/10.21037/LCM-2021-002","url":null,"abstract":"Traditional Chinese medicine (TCM) has steadily spread and gained followers due to its efficacy not only in treating illnesses but also in preventing them. The theories, which it is based on, have been perfected over time, as it can be proved in the vast bibliography we can find on the subject. In recent decades, acupuncture and TCM have spread throughout the world, which has led to the improvement of these therapies through studies from the medical approach using modern research systems. The World Health Organization (WHO) not only encourages countries to find and classify effective solutions and harmless practices to apply in public and private health services but also supports them with research. In Argentina, there is a number of schools teaching acupuncture and TCM and also many therapists using it as its first o complementary choice in treatment of different illnesses. However, Argentina has no clear regulations for the practice or the training of acupuncture as a healing activity. These two situations coexist and intermingle in the end. In the last years, two drafts have been passed but they have not been approved yet. What is more, lately many countries have improved the theoretical and practical aspects of acupuncture. The need to regulate these practices cannot be delayed anymore. So, we really hope authorities will find the way to regulate this practice, always with the help of the experts.","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46606113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gizem Ors Kumoglu, A. Şendemir, M. B. Tanyolaç, B. Bilir, O. Kucuk, Y. Missirlis
{"title":"Epigenetic mechanisms in cancer","authors":"Gizem Ors Kumoglu, A. Şendemir, M. B. Tanyolaç, B. Bilir, O. Kucuk, Y. Missirlis","doi":"10.21037/lcm-21-59","DOIUrl":"https://doi.org/10.21037/lcm-21-59","url":null,"abstract":": This review aims to give a brief summary of the most common epigenetic mechanisms, and their possible relations with cancer initiation and progression, focusing on the possible physico-chemical factors that might control these epigenetic mechanisms, and giving examples of the epigenetic therapy approaches. Original and review articles encompassing epigenetics and inflammation were screened from major databases including PubMed, Medline, Science Direct, Scopus, etc. in English and analyzed for the writing of this review paper. The importance of epigenetics in linking the effects of environmental factors to changes in gene expression is gaining acceptance more and more in recent years. It is becoming more evident that epigenetics plays an important role in health and disease, cancer being no exception. Although effects of environmental factors on cancer initiation and progression have been known for decades, the exact mechanisms that control these interactions are yet to be discovered. The breakthrough that most epigenetic alterations are reversible brings out a new exciting target for cancer therapeutics. Cancer initiation and progression are controlled by both genetic and epigenetic events. Unlike genetic changes, epigenetic modulations are potentially reversible. Epigenetic drugs that inhibit DNA methylation or histone deacetylation enable reactivation of tumor suppressor genes and suppression of cancer cell growth. Taking advantage of these situations allows the reduction of malignant cell clusters. In addition, clinical results, such as epigenetic drugs targeting specific enzymes for cancer treatment and re-sensitizing cells that do not respond to treatment are promising as cancer therapeutics. To date, numerous epigenetic agents have been developed, several DNA methyltransferase (DNMT) and histone deacetylase (HDAC) inhibitors have been definitively approved by regulatory agencies. Combined multidrug approaches for cancer treatment have overcome the limitations of single-agent epigenetic therapies, increased antitumor effects, and reduced drug resistance. It is evident that as our knowledge on epigenetic mechanisms expand, epigenomics-targeted treatments will become more common in cancer therapy, either as primary therapy or as complementary and alternative treatment options to increase the efficacy of conventional treatments for cancer patients, and epigenetics will maintain its increasing importance for cancer diagnostic, prognostic and therapeutic studies for many years to come. with and these epigenetic approaches. Research published were examined using integrative methodology.","PeriodicalId":74086,"journal":{"name":"Longhua Chinese medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41614236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}