Livers最新文献_第9页

Non-Coding RNAs in Hepatocellular Carcinoma 肝细胞癌中的非编码rna

Livers Pub Date : 2022-09-02 DOI: 10.3390/livers2030017

Mascha Korsch, A. Margetts, C. Wahlestedt, I. Lohse

{"title":"Non-Coding RNAs in Hepatocellular Carcinoma","authors":"Mascha Korsch, A. Margetts, C. Wahlestedt, I. Lohse","doi":"10.3390/livers2030017","DOIUrl":"https://doi.org/10.3390/livers2030017","url":null,"abstract":"Liver cancer ranks as the fourth leading cause of cancer-related deaths. Despite extensive research efforts aiming to evaluate the biological mechanisms underlying hepatocellular carcinoma (HCC) development, little has been translated towards new diagnostic and treatment options for HCC patients. Historically, the focus has been centered on coding RNAs and their respective proteins. However, significant advances in sequencing and RNA detection technologies have shifted the research focus towards non-coding RNAs (ncRNA), as well as their impact on HCC development and progression. A number of studies reported complex post-transcriptional interactions between various ncRNA and coding RNA molecules. These interactions offer insights into the role of ncRNAs in both the known pathways leading to oncogenesis, such as dysregulation of p53, and lesser-known mechanisms, such as small nucleolar RNA methylation. Studies investigating these mechanisms have identified prevalent ncRNA changes in microRNAs, snoRNAs, and long non-coding RNAs that can both pre- and post-translationally regulate key factors in HCC progression. In this review, we present relevant publications describing ncRNAs to summarize the impact of different ncRNA species on liver cancer development and progression and to evaluate recent attempts at clinical translation.","PeriodicalId":74083,"journal":{"name":"Livers","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43719556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue-Recent Advances in Acetaminophen Hepatotoxicity. 对乙酰氨基酚肝毒性:不像人们想象的那么简单!对乙酰氨基酚肝毒性研究进展特刊导论。

Livers Pub Date : 2022-09-01 Epub Date: 2022-07-01 DOI: 10.3390/livers2030008

Hartmut Jaeschke

引用次数: 2

Percutaneous Gallbladder Biopsy: Indications, Technique and Complications 经皮胆囊活检：适应证、技术和并发症

Livers Pub Date : 2022-09-01 DOI: 10.3390/livers2030016

A. Posa, L. Steri, Valentina Longo, Giulia Mazza, Pierluigi Barbieri, R. Iezzi

引用次数: 1

Established Liver Cell Lines: Are You Sure to Have the Right Ones? 已建立的肝细胞系:你确定有正确的肝细胞系吗?

Livers Pub Date : 2022-09-01 DOI: 10.3390/livers2030015

R. Weiskirchen

引用次数: 4

Protein Catabolism and the Dysregulation of Energy Intake-Related Hormones May Play a Major Role in the Worsening of Malnutrition in Hospitalized Cirrhotic Patients 蛋白质代谢和能量摄入相关激素的失调可能在住院肝硬化患者营养不良恶化中起主要作用

Livers Pub Date : 2022-08-18 DOI: 10.3390/livers2030014

E. Gangitano, L. Gnessi, M. Merli

{"title":"Protein Catabolism and the Dysregulation of Energy Intake-Related Hormones May Play a Major Role in the Worsening of Malnutrition in Hospitalized Cirrhotic Patients","authors":"E. Gangitano, L. Gnessi, M. Merli","doi":"10.3390/livers2030014","DOIUrl":"https://doi.org/10.3390/livers2030014","url":null,"abstract":"Malnutrition in cirrhotic patients is extremely common and has a multifactorial aetiology, whose constitutive elements have not been completely elucidated yet. Protein depletion is particularly important and an imbalance of hormones regulating hunger and satiety may be an important additive factor. The diagnosis and treatment of malnutrition are extremely important since malnutrition is associated with higher complication rates and mortality. Our observational study aimed to study protein status and energy intake-related hormone levels in a cohort of hospitalized cirrhotic patients. We enrolled 50 hospitalized and clinically stable cirrhotic patients and assessed their nutritional status with anthropometric measurements and nitrogen balance. In a subgroup of 16 patients and 10 healthy controls, circulating ghrelin and leptin levels were studied. We observed that 60% of our patients were malnourished on the basis of the mid-arm muscle circumference values; the recorded daily protein intake was tendentially insufficient (mean protein intake of 0.7 ± 0.5 g protein/Kg vs. recommended intake of 1.2–1.5 g of protein/Kg/die). Cirrhotic patients had lower circulating levels of both ghrelin and leptin compared to healthy controls. In conclusion, hospitalized cirrhotic patients face a catabolic state and an imbalance in hormones regulating food intake and satiety, and these elements may play a major role in the genesis and/or the worsening of malnutrition.","PeriodicalId":74083,"journal":{"name":"Livers","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41936692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet γ -谷维醇对高糖/高脂饮食动物非酒精性脂肪肝相关生理病理过程的预防作用

Livers Pub Date : 2022-08-10 DOI: 10.3390/livers2030013

F. V. Francisqueti-Ferron, J. Silva, J. Garcia, A. Ferron, H. Kano, C. C. V. A. Silva, M. R. Costa, G. A. Nai, F. Moreto, C. Corrêa

{"title":"Preventive Effect of Gamma-Oryzanol on Physiopathological Process Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High Sugar/Fat Diet","authors":"F. V. Francisqueti-Ferron, J. Silva, J. Garcia, A. Ferron, H. Kano, C. C. V. A. Silva, M. R. Costa, G. A. Nai, F. Moreto, C. Corrêa","doi":"10.3390/livers2030013","DOIUrl":"https://doi.org/10.3390/livers2030013","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including unsaturated fats and sweetened beverages, which are able to lead to inflammation and oxidative stress, conditions associated with progression and severity of NAFLD. Gamma-oryzanol (γOz) is a nutraceutical obtained from rice brain oil with many benefits to health, from immunological to metabolic. The aim of this study is to test the preventive effect of γOz on the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to high sugar/fat diet. Male Wistar rats (±187 g) were randomly divided into four experimental groups to receive: control diet (C, n = 6), control diet plus γOz (C + γOz, n = 6), high sugar/fat diet (HSF, n = 6), or high sugar/fat diet plus γOz (HSF + γOz, n = 6) during 30 weeks. HSF groups also received water plus sucrose (25%). γOz was added to diets to reach 0.5% of final concentration. The HSF group presented MetS, liver inflammation and oxidative stress, and micro and macrovesicular steatosis. HSF plus γOz was protected against these changes. It is possible to conclude that gamma-oryzanol was effective in modulating the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to a high sugar/fat diet.","PeriodicalId":74083,"journal":{"name":"Livers","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46500783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Therapeutic Potential of Human Microbiome-Based Short-Chain Fatty Acids and Bile Acids in Liver Disease 基于微生物群的短链脂肪酸和胆汁酸在肝病中的治疗潜力

Livers Pub Date : 2022-08-03 DOI: 10.3390/livers2030012

Raja Ganesan, K. Suk

{"title":"Therapeutic Potential of Human Microbiome-Based Short-Chain Fatty Acids and Bile Acids in Liver Disease","authors":"Raja Ganesan, K. Suk","doi":"10.3390/livers2030012","DOIUrl":"https://doi.org/10.3390/livers2030012","url":null,"abstract":"Microbiome-derived short chain fatty acids (SCFAs: acetate, propionate, and butyrate) and bile acids (BAs: primary BAs and secondary BAs) widely influence liver metabolic inflammation, immune responses, and carcinogenesis. In recent literature, the role of SCFAs and BAs in various liver diseases has been discussed. SCFAs and BAs are two types of microbiome-derived metabolites and they have been shown to have immunoregulatory ability in autoimmunity, inflammation, and liver-cancer microcellular environments. SCFAs and BAs are dependent on dietary components. The numerous regulatory processes in lymphocytes and non-immune cells that underpin both the positive and harmful effects of microbial metabolites include variations in metabolic signaling and epigenetic states. As a result, histone deacetylase (HDAC) inhibitors, SCFAs, and BAs, which are powerful immunometabolism modulators, have been explored. BAs have also been shown to alter the microbiome as well as adaptive and innate immune systems. We therefore emphasize the important metabolites in liver disease for clinical therapeutic applications. A deep understanding of SCFAs and Bas, as well as their molecular risk, could reveal more about certain liver-disease conditions.","PeriodicalId":74083,"journal":{"name":"Livers","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48874280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A Comprehensive Review on the Use of Herbal Dietary Supplements in the USA, Reasons for Their Use, and Review of Potential Hepatotoxicity 在美国使用草药膳食补充剂的综合综述，其使用的原因，并审查潜在的肝毒性

Livers Pub Date : 2022-08-02 DOI: 10.3390/livers2030011

Adnan Khan, Kashyap Chauhan, Heather Ross, N. Parra, John Magagna, Makala Wang, Patrick Zhu, Ryan Erwin, D. Halegoua-DeMarzio

引用次数: 3

Inflammaging, a Common Factor in the Development of Sarcopenia and Metabolic-Associated Liver Disease (MAFLD) 炎症，一种发展为肌肉萎缩和代谢相关肝病（MAFLD）的常见因素

Livers Pub Date : 2022-08-01 DOI: 10.3390/livers2030010

Gonzalo Jorquera, F. Cubero

引用次数: 1

Seroprevalence of Hepatitis E Virus Antibodies (IgG) in the Community of Rawalpindi 拉瓦尔品第社区戊型肝炎病毒抗体（IgG）的血清流行率

Livers Pub Date : 2022-07-27 DOI: 10.3390/livers2030009

Muhammad-Awais Farooqi, A. Ahsan, S. Yousuf, Noman Shakoor, H. Farooqi

{"title":"Seroprevalence of Hepatitis E Virus Antibodies (IgG) in the Community of Rawalpindi","authors":"Muhammad-Awais Farooqi, A. Ahsan, S. Yousuf, Noman Shakoor, H. Farooqi","doi":"10.3390/livers2030009","DOIUrl":"https://doi.org/10.3390/livers2030009","url":null,"abstract":"Knowledge regarding the prevalence of the hepatitis E virus (HEV) in the general population can indicate public health and personal hygiene practices in a community. HEV spreads through the fecal-oral route and contaminates drinking water through sewage. Moreover, poverty also contributes to its prevalence in developing countries, including Pakistan. A cross-sectional study was conducted on 650 blood samples taken from suspected patients of HEV in the Rawalpindi cantonment area (Pakistan) from April to November 2019 at the Department of Virology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan. Out of them, 444 (68.15%) were male and 206 (31.85%) were female; the detection of anti-HEV IgG antibodies was carried out using a commercial Anti-Hepatitis E virus antibody (IgG) ELISA Kit. The overall anti-HEV IgG prevalence percentages were 19.23% and 4.77% in males and females, respectively. Patients were categorized into eight groups with ages ranging between 1 and 90 years. HEV IgG seroprevalence was the highest in ages 31–40 (6.46%). The study concluded that males aged 40 or above were susceptible and infected with hepatitis E.","PeriodicalId":74083,"journal":{"name":"Livers","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42560086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5