Life metabolism最新文献_第2页

Potential therapeutic strategies for MASH: from preclinical to clinical development MASH 的潜在治疗策略：从临床前研究到临床开发

Life metabolism Pub Date : 2024-07-06 DOI: 10.1093/lifemeta/loae029

Zhifu Xie, Yufeng Li, Long Cheng, Yidan Huang, Wanglin Rao, Honglu Shi, Jingya Li

引用次数: 0

BAT-tling oxidative stress through BCAA catabolism.

Life metabolism Pub Date : 2024-06-28 eCollection Date: 2024-10-01 DOI: 10.1093/lifemeta/loae028

Maria Delgado-Martin, Qiaoqiao Zhang, Lawrence Kazak

引用次数: 0

The FTO variant conferring enhanced UCP1 expression is linked to human migration out of Africa.

Life metabolism Pub Date : 2024-06-22 eCollection Date: 2024-12-01 DOI: 10.1093/lifemeta/loae027

Nan Yin, Dan Zhang, Jiqiu Wang

引用次数: 0

Phytic acid-based nanomedicine against mTOR represses lipogenesis and immune response for metabolic dysfunction-associated steatohepatitis therapy.

Life metabolism Pub Date : 2024-06-18 eCollection Date: 2024-12-01 DOI: 10.1093/lifemeta/loae026

Fenghua Xu, Shoujie Zhao, Yejing Zhu, Jun Zhu, Lingyang Kong, Huichen Li, Shouzheng Ma, Bo Wang, Yongquan Qu, Zhimin Tian, Junlong Zhao, Lei Liu

{"title":"Phytic acid-based nanomedicine against mTOR represses lipogenesis and immune response for metabolic dysfunction-associated steatohepatitis therapy.","authors":"Fenghua Xu, Shoujie Zhao, Yejing Zhu, Jun Zhu, Lingyang Kong, Huichen Li, Shouzheng Ma, Bo Wang, Yongquan Qu, Zhimin Tian, Junlong Zhao, Lei Liu","doi":"10.1093/lifemeta/loae026","DOIUrl":"10.1093/lifemeta/loae026","url":null,"abstract":"Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common chronic liver diseases and is mainly caused by metabolic disorders and systemic inflammatory responses. Recent studies have indicated that the activation of the mammalian (or mechanistic) target of rapamycin (mTOR) signaling participates in MASH progression by facilitating lipogenesis and regulating the immune microenvironment. Although several molecular medicines have been demonstrated to inhibit the phosphorylation or activation of mTOR, their poor specificity and side effects limit their clinical application in MASH treatment. Phytic acid (PA), as an endogenous and natural antioxidant in the liver, presents significant anti-inflammatory and lipid metabolism-inhibiting functions to alleviate MASH. In this study, considering the unique phosphate-rich structure of PA, we developed a cerium-PA (CePA) nanocomplex by combining PA with cerium ions possessing phosphodiesterase activity. CePA intervened in the S2448 phosphorylation of mTOR through the occupation effect of phosphate groups, thereby inhibiting the inflammatory response and mTOR-sterol regulatory element-binding protein 1 (SREBP1) regulation axis. The in vivo experiments suggested that CePA alleviated MASH progression and fat accumulation in high-fat diet-fed mice. Mechanistic studies validated that CePA exerts a liver-targeted mTOR repressive function, making it a promising candidate for MASH and other mTOR-related disease treatments.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"3 6","pages":"loae026"},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immuno-electron microscopy localizes Caenorhabditis elegans vitellogenins along the classic exocytosis route 免疫电子显微镜确定秀丽隐杆线虫卵黄原蛋白的经典外渗路线

Life metabolism Pub Date : 2024-06-13 DOI: 10.1093/lifemeta/loae025

Chao Zhai, Nan Zhang, Xixia Li, Xue-Ke Tan, Fei Sun, Meng-Qiu Dong

{"title":"Immuno-electron microscopy localizes Caenorhabditis elegans vitellogenins along the classic exocytosis route","authors":"Chao Zhai, Nan Zhang, Xixia Li, Xue-Ke Tan, Fei Sun, Meng-Qiu Dong","doi":"10.1093/lifemeta/loae025","DOIUrl":"https://doi.org/10.1093/lifemeta/loae025","url":null,"abstract":"\u0000 Vitellogenins (VITs) are the most abundant proteins in adult hermaphrodite Caenorhabditis elegans. VITs are synthesized in the intestine, secreted to the pseudocoelom, matured into yolk proteins, and finally deposited in oocytes as nutrients for progeny developme nt. How VITs are secreted out of the intestine remains unclear. Using immuno-electron microscopy (immuno-EM), we localize intestinal VITs along an exocytic pathway consisting of the rough endoplasmic reticulum (ER), the Golgi, and the lipid bilayer-bounded VIT vesicles (VVs). This suggests that the classic exocytotic pathway mediates the secretion of VITs from the intestine to the pseudocoelom. We also show that pseudocoelomic yolk patches (PYPs) are membrane-less and amorphous. The different VITs/yolk proteins are packed as a mixture into the above structures. The size of VVs can vary with the VIT levels and the age of the worm. On adult day 2 (AD 2), intestinal VVs (~200 nm in diameter) are smaller than gonadal yolk organelles (YOs, ~500 nm in diameter). VVs, PYPs, and YOs share a uniform medium electron density by conventional EM. The morphological profiles documented in this study serve as a reference for future studies of VITs/yolk proteins.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141346708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protecting liver health with microbial-derived succinylated bile acids 用微生物提取的琥珀酰化胆汁酸保护肝脏健康

Life metabolism Pub Date : 2024-06-13 DOI: 10.1093/lifemeta/loae023

H. Demagny, A. Perino, Kristina Schoonjans

引用次数: 0

Cholesin, a new hormone bridges intestinal cholesterol absorption and hepatic synthesis 胆固醇素--一种连接肠道胆固醇吸收和肝脏合成的新激素

Life metabolism Pub Date : 2024-06-07 DOI: 10.1093/lifemeta/loae024

Peter U Amadi, Da-wei Zhang

引用次数: 0

Downregulation of RhoA/ROCK1/YAP/F-actin causing decreased aortic smooth muscle cell stiffness promotes aortic dissection formation RhoA/ROCK1/YAP/F-actin 的下调导致主动脉平滑肌细胞硬度下降，从而促进主动脉夹层的形成

Life metabolism Pub Date : 2024-06-03 DOI: 10.1093/lifemeta/loae022

Wei Zhang, Mengxiao Wang, Enci Wang, Wei Lu, Zengxia Li, Yuchong Zhang, Gaofei Hu, Qi Zhang, Wenxin Shan, Yongjun Dang, Zhe Zhao, Lemin Zheng, Weiguo Fu, Lixin Wang

引用次数: 0

The energetics of cellular life transitions. 细胞生命转换的能量学。

Life metabolism Pub Date : 2024-06-01 Epub Date: 2023-12-27 DOI: 10.1093/lifemeta/load051

Anna S Monzel, Michael Levin, Martin Picard

引用次数: 0

Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.

Life metabolism Pub Date : 2024-05-31 eCollection Date: 2024-12-01 DOI: 10.1093/lifemeta/loae021

Wuxiyar Otkur, Yiran Zhang, Yirong Li, Wenjun Bao, Tingze Feng, Bo Wu, Yaolu Ma, Jing Shi, Li Wang, Shaojun Pei, Wen Wang, Jixia Wang, Yaopeng Zhao, Yanfang Liu, Xiuling Li, Tian Xia, Fangjun Wang, Di Chen, Xinmiao Liang, Hai-Long Piao

{"title":"Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.","authors":"Wuxiyar Otkur, Yiran Zhang, Yirong Li, Wenjun Bao, Tingze Feng, Bo Wu, Yaolu Ma, Jing Shi, Li Wang, Shaojun Pei, Wen Wang, Jixia Wang, Yaopeng Zhao, Yanfang Liu, Xiuling Li, Tian Xia, Fangjun Wang, Di Chen, Xinmiao Liang, Hai-Long Piao","doi":"10.1093/lifemeta/loae021","DOIUrl":"10.1093/lifemeta/loae021","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disease that can progress to metabolic dysfunction-associated steatohepatitis (MASH), cirrhosis, and cancer. The zonal distribution of biomolecules in the liver is implicated in mediating the disease progression. Recently, G-protein-coupled receptor 35 (GPR35) has been highlighted to play a role in MASLD, but the precise mechanism is not fully understood, particularly, in a liver-zonal manner. Here, we aimed to identify spatially distributed specific genes and metabolites in different liver zonation that are regulated by GPR35 in MASLD, by combining lipid metabolomics, spatial transcriptomics (ST), and spatial metabolomics (SM). We found that GPR35 influenced lipid accumulation, inflammatory and metabolism-related factors in specific regions, notably affecting the anti-inflammation factor ELF4 (E74 like E-twenty six (ETS) transcription factor 4), lipid homeostasis key factor CIDEA (cell death-inducing DNA fragmentation factor alpha (DFFA)-like effector A), and the injury response-related genes SAA1/2/3 (serum amyloid A1/2/3), thereby impacting MASLD progression. Furthermore, SM elucidated specific metabolite distributions across different liver regions, such as C10H11N4O7P (3',5'-cyclic inosine monophosphate (3',5'-IMP)) for the central vein, and this metabolite significantly decreased in the liver zones of GPR35-deficient mice during MASLD progression. Taken together, GPR35 regulates hepatocyte damage repair, controls inflammation, and prevents MASLD progression by influencing phospholipid homeostasis and gene expression in a zonal manner.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":"3 6","pages":"loae021"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0