Kidney and dialysis最新文献_第6页

Is HIF-PHI the Answer to Tackle ESA Hyporesponsiveness in the Elderly? HIF-PHI是解决老年人ESA低反应性的答案吗？

Kidney and dialysis Pub Date : 2022-08-04 DOI: 10.3390/kidneydial2030040

Henry H. L. Wu, R. Chinnadurai, R. Walker

{"title":"Is HIF-PHI the Answer to Tackle ESA Hyporesponsiveness in the Elderly?","authors":"Henry H. L. Wu, R. Chinnadurai, R. Walker","doi":"10.3390/kidneydial2030040","DOIUrl":"https://doi.org/10.3390/kidneydial2030040","url":null,"abstract":"Anemia in chronic kidney disease (CKD) has become an important clinical issue with the increased prevalence of elderly patients living with CKD progressing to kidney failure. The causes of anemia in elderly individuals tend to be multifactorial, exacerbated by the physiological effects of aging, frailty and declining kidney function. Erythropoiesis-stimulating agents (ESAs) are the conventional therapeutic option for anemia in CKD. However, ESA hyporesponsiveness is a commonly observed issue in clinical practice and an issue that is more challenging to resolve in elderly patients living with frailty, kidney disease, and multi-morbidities. Following the emergence of oral hypoxia-induced factor prolyl-hydroxylase inhibitors (HIF-PHI) in recent years, there is discussion on whether it is a solution to the conundrum of ESA hyporesponsiveness, as HIF-PHI treats anemia via an alternative physiological pathway. There remains uncertainty on the suitability of HIF-PHI use in elderly patients, given a lack of data on its safety over long-term follow-up for the elderly population. Further study is needed to provide answers, considering the clinical significance of this issue within a public-health scale.","PeriodicalId":74038,"journal":{"name":"Kidney and dialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48570380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cephalad Migration of Tunneled-Cuffed Catheter: The Importance of Post Procedure Imaging 隧道式Cuffed导管的头位偏移：术后成像的重要性

Kidney and dialysis Pub Date : 2022-08-03 DOI: 10.3390/kidneydial2030039

Asheesh Kumar, Ramjeewan Singh

引用次数: 0

The Epidemiology of Diabetic Kidney Disease 糖尿病肾病的流行病学

Kidney and dialysis Pub Date : 2022-08-01 DOI: 10.3390/kidneydial2030038

E. Hoogeveen

引用次数: 24

Association of High-Density Lipoprotein Cholesterol, Renal Function, and Metabolic Syndrome: An Assessment of the 2013–2018 National Health and Nutrition Examination Surveys 高密度脂蛋白胆固醇、肾功能和代谢综合征的相关性：对2013-2018年全国健康和营养检查调查的评估

Kidney and dialysis Pub Date : 2022-07-12 DOI: 10.3390/kidneydial2030037

K. Richardson, Luke T. Richardson, R. Bowden

{"title":"Association of High-Density Lipoprotein Cholesterol, Renal Function, and Metabolic Syndrome: An Assessment of the 2013–2018 National Health and Nutrition Examination Surveys","authors":"K. Richardson, Luke T. Richardson, R. Bowden","doi":"10.3390/kidneydial2030037","DOIUrl":"https://doi.org/10.3390/kidneydial2030037","url":null,"abstract":"Previous findings assessing the relationship between high-density lipoprotein cholesterol (HDL-c) and kidney function have demonstrated contradictory results including positive, negative, and U-shaped relationships. Many prior studies in this area have been conducted in healthy populations, but few have considered the influence of metabolic health status. In the present study, a cross-sectional analysis was conducted using complex survey sample weighting in the assessment of 6455 subjects from the 2013–2018 National Health and Nutrition Examination Surveys (NHANES), representative of 94,993,502 United States citizens. Subjects were classified as metabolically healthy or unhealthy and linear regression analyses were performed to evaluate the influence of HDL-c on estimated glomerular filtration rate (eGFR). HDL-c was found to be negatively associated with eGFR in the metabolically healthy, unhealthy, and combined groups (B = −0.16, p < 0.0001, B = −0.21, p < 0.0001, and B = −0.05, p = 0.0211, respectively). This relationship persisted after adjustment for confounding variables (B = −0.24, p < 0.0001, B = −0.17, p < 0.001, and B = −0.18, p < 0.0001, respectively). The relationship between HDL-c and eGFR was found to be a negative linear association, rather than a U-shaped association, and it persisted in all models tested, despite statistical adjustment for confounding variables. After controlling the samples for outliers, the negative relationship between HDL-c and eGFR was attenuated in the healthy and total groups but remained significant in the MetS group, indicating a stronger relationship between HDL-c and eGFR in those with poorer health.","PeriodicalId":74038,"journal":{"name":"Kidney and dialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42854909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Resonance Imaging to Diagnose and Predict the Outcome of Diabetic Kidney Disease—Where Do We Stand? 磁共振成像诊断和预测糖尿病肾病预后的研究进展如何?

Kidney and dialysis Pub Date : 2022-07-11 DOI: 10.3390/kidneydial2030036

M. Pruijm, Ibtisam Aslam, B. Milani, W. Brito, M. Burnier, N. Selby, J. Vallée

引用次数: 2

Should We Still Use Therapeutic Plasma Exchange for Rapidly Progressive Glomerulonephritis in ANCA Associated Vasculitis? 急性进展性肾小球肾炎合并ANCA相关性血管炎是否仍应使用血浆置换治疗?

Kidney and dialysis Pub Date : 2022-07-05 DOI: 10.3390/kidneydial2030035

A. Kaplan, W. Szpirt

引用次数: 2

Cardiorenal Crosstalk in Patients with Heart Failure 心力衰竭患者的心肾串扰

Kidney and dialysis Pub Date : 2022-06-23 DOI: 10.3390/kidneydial2030033

S. Schukraft, R. Hullin

引用次数: 0

Choosing A Dialysate Sodium Concentration for Hemodialysis Patients 血液透析患者透析液钠浓度的选择

Kidney and dialysis Pub Date : 2022-06-13 DOI: 10.3390/kidneydial2020031

A. Davenport

引用次数: 0

Effects of Diet and Exercise on Metabolic Parameters and Health in Moderate to Advanced Kidney Disease 饮食和运动对中晚期肾病患者代谢参数和健康的影响

Kidney and dialysis Pub Date : 2022-06-10 DOI: 10.3390/kidneydial2020030

Lale A. Ertuglu, T. A. Ikizler

引用次数: 1

Physical Activity Behaviour in Solid Organ Transplant Recipients: Proposal of Theory-Driven Physical Activity Interventions 实体器官移植受者的身体活动行为:理论驱动的身体活动干预建议

Kidney and dialysis Pub Date : 2022-06-07 DOI: 10.3390/kidneydial2020029

S. Leunis, M. Vandecruys, V. Cornelissen, A. V. Van Craenenbroeck, S. D. De Geest, D. Monbaliu, S. De Smet

{"title":"Physical Activity Behaviour in Solid Organ Transplant Recipients: Proposal of Theory-Driven Physical Activity Interventions","authors":"S. Leunis, M. Vandecruys, V. Cornelissen, A. V. Van Craenenbroeck, S. D. De Geest, D. Monbaliu, S. De Smet","doi":"10.3390/kidneydial2020029","DOIUrl":"https://doi.org/10.3390/kidneydial2020029","url":null,"abstract":"Physical inactivity is highly prevalent after solid organ transplantation and leads to unfavourable outcomes. This review aimed to understand posttransplant physical activity behaviour and propose physical activity interventions. Michie’s Behavioural Change Wheel was applied, in which the Context and Implementation of Complex Interventions framework, the Capability-Opportunity-Motivation and Behaviour model, and the Theoretical Domains Framework were embedded. Various contextual factors were found to modulate physical activity behaviour. Promising strategies to promote long-term physical activity included (i) tailoring of physical activity programs to patients’ abilities and preferences; (ii) incitement of intrinsic and autonomous motivation to change; (iii) SMART goals setting (e.g., Specific, Measurable, Achievable, Realistic, Timebound), (iv) autonomy-supportive co-design of action plans; (v) foster new habit formation; (vi) self-monitoring of physical activity; (vii) follow-up opportunities for evaluation and adjustment; (viii) education of transplant recipients, healthcare providers, and the patients’ social network; (iv) improvement of self-efficacy through incremental successes, verbal persuasion, peer modelling, and awareness of exercise-related bodily signals; (x) providing physical activity opportunity within patients’ social and environmental setting; (xi) encouragement and support from patients’ social network and healthcare providers; and (xii) governmental action that alleviates financial barriers and restructures the physical environment to promote physical activity. These new insights may contribute to physical activity program development for transplantation recipients.","PeriodicalId":74038,"journal":{"name":"Kidney and dialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46709089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4