Kidney and dialysis最新文献_第4页

Renal Mechanisms of Diuretic Resistance in Congestive Heart Failure 充血性心力衰竭患者利尿剂抵抗的肾脏机制

Kidney and dialysis Pub Date : 2023-01-05 DOI: 10.3390/kidneydial3010005

N. Lameire

引用次数: 1

Chronic Kidney Disease—Mineral and Bone Disorder (CKD-MBD), from Bench to Bedside 慢性肾脏疾病-矿物质和骨骼疾病(CKD-MBD)，从实验室到床边

Kidney and dialysis Pub Date : 2023-01-04 DOI: 10.3390/kidneydial3010004

K. Nitta, N. Hanafusa, K. Akiyama, Yuki Kawaguchi, Ken Tsuchiya

引用次数: 1

The Age–Stiffness Relationships of Elastic and Muscular Arteries in a Control Population and in End-Stage Renal Disease Patients 对照人群和终末期肾病患者弹性动脉和肌肉动脉的年龄-僵硬关系

Kidney and dialysis Pub Date : 2023-01-03 DOI: 10.3390/kidneydial3010003

G. London, M. Safar, B. Pannier

{"title":"The Age–Stiffness Relationships of Elastic and Muscular Arteries in a Control Population and in End-Stage Renal Disease Patients","authors":"G. London, M. Safar, B. Pannier","doi":"10.3390/kidneydial3010003","DOIUrl":"https://doi.org/10.3390/kidneydial3010003","url":null,"abstract":"Arterial dysfunction is major risk factor for cardiovascular complications, and arterial stiffness is an independent risk factor in end-stage renal disease patients. As the distance from the heart increases, arterial stiffness (pulse wave velocity) becomes progressively more marked. This generates a centrifugal stiffness gradient, which leads to partial, continuous local wave reflections, which in turn attenuate the transmission of pulsatile pressure into the microcirculation, thus limiting the potentially deleterious outcomes both upstream (on the heart: left-ventricular hypertrophy and coronary perfusion) and downstream (on the renal and cerebral microcirculation: reduced glomerular filtration and impaired cognitive functions). The impact of arterial aging is greater on the aorta and central capacitive arteries, and it is characterized by a loss or reversal of the physiological stiffness gradient between central and peripheral arteries. Recently, however, in contrast to observations on the aorta, several studies have shown less pronounced, absent, or even negative associations between muscular peripheral arteries and age–stiffness relationships, which may be associated with a decrease in or reversal of the stiffness gradient. These findings point to a potential benefit of assessing the muscular peripheral arteries to predict the risk of cardiovascular disease and suggest that reversal of the stiffness gradient may be an independent risk factor for all-cause mortality.","PeriodicalId":74038,"journal":{"name":"Kidney and dialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49196206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prevalence and Lived Experience of Pain in People Undertaking Dialysis 透析患者疼痛的患病率和生活经验

Kidney and dialysis Pub Date : 2023-01-01 DOI: 10.3390/kidneydial3010002

Ivy Moore, P. Byrne, N. Ilic, Jenny Heng-Chen Chen, K. Lambert

{"title":"The Prevalence and Lived Experience of Pain in People Undertaking Dialysis","authors":"Ivy Moore, P. Byrne, N. Ilic, Jenny Heng-Chen Chen, K. Lambert","doi":"10.3390/kidneydial3010002","DOIUrl":"https://doi.org/10.3390/kidneydial3010002","url":null,"abstract":"(1) Background: Pain is a prevalent and debilitating symptom associated with kidney failure. However, the impact of pain on quality of life remains unclear. We aimed to identify the prevalence, severity and characteristics of people undertaking dialysis impacted by pain and explore the lived experience of pain (2) Methods: A cross-sectional survey was administered to people undertaking haemodialysis or via telephone to those undertaking peritoneal and home haemodialysis in a single tertiary centre. Open-ended questions were analysed using thematic analysis. (3) Results: Responses were received from 131 participants (response rate 66.8%). Most were undergoing haemodialysis (87.0%). Pain was present in 92% (n = 121) of patients with 62% (n = 81) reporting pain as severe to excruciating. Common sites of pain were joints, muscle cramps, headaches, fistula pain, non-specific back pain and neuropathy. The overarching theme from the thematic analysis was that pain was a “debilitating and accepted burden” (4) Conclusions: Pain is highly prevalent, severe and debilitating in those on dialysis. There is a need for health care providers to be proactive and attentive to the management of pain. More research is needed to identify effective treatment approaches to decrease pain burden and improve the quality of life in those with kidney failure.","PeriodicalId":74038,"journal":{"name":"Kidney and dialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46618425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifaceted Nutritional Disorders in Elderly Patients Undergoing Dialysis 老年透析患者的多方面营养失调

Kidney and dialysis Pub Date : 2022-12-22 DOI: 10.3390/kidneydial3010001

K. Mori, M. Kurajoh, M. Inaba, M. Emoto

{"title":"Multifaceted Nutritional Disorders in Elderly Patients Undergoing Dialysis","authors":"K. Mori, M. Kurajoh, M. Inaba, M. Emoto","doi":"10.3390/kidneydial3010001","DOIUrl":"https://doi.org/10.3390/kidneydial3010001","url":null,"abstract":"Advances in medicine have resulted in increased longevity, which has consequently led to unexpected geriatric syndromes, such as frailty and sarcopenia. Patients with end-stage kidney disease, especially those receiving dialysis treatment, often show characteristic reductions in body protein and energy storage, termed protein energy wasting (PEW). Therefore, maintenance of nutritional condition has a key role in defending against both geriatric syndromes and PEW, which share several components in elderly individuals undergoing hemodialysis. To counteract the development of an undesirable condition, nutritional evaluation is indispensable. In addition to simple measurements of body mass index, and serum albumin and creatinine, a composite nutritional assessment including a malnutrition inflammation score is useful, although subjective elements are included and a well-trained examiner is required. On the other hand, the geriatric nutritional risk index and nutritional risk index for Japanese hemodialysis patients (NRI-JH) are objective tools, and easy to use in clinical settings. Undernutrition is closely related to infectious events and the results of an infection are often serious in elderly patients, even those with survival, with large medical costs incurred. Together with appropriate nutritional evaluation, it is necessary to clarify the underlying relationship of PEW with infection for improvement of prognosis in affected elderly individuals.","PeriodicalId":74038,"journal":{"name":"Kidney and dialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47454457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Carfilzomib-Induced Thrombotic Microangiopathy Treated with Eculizumab: A Case Report and Rapid Literature Review 依曲单抗治疗卡非佐米诱发的血栓性微血管病:1例报告和快速文献回顾

Kidney and dialysis Pub Date : 2022-12-12 DOI: 10.3390/kidneydial2040056

F. Pallotti, Claire Queffeulou, M. Bellal, Bastien Jean-Jacques, A. Gac, V. Châtelet, A. Boyer, V. Gueutin

{"title":"Carfilzomib-Induced Thrombotic Microangiopathy Treated with Eculizumab: A Case Report and Rapid Literature Review","authors":"F. Pallotti, Claire Queffeulou, M. Bellal, Bastien Jean-Jacques, A. Gac, V. Châtelet, A. Boyer, V. Gueutin","doi":"10.3390/kidneydial2040056","DOIUrl":"https://doi.org/10.3390/kidneydial2040056","url":null,"abstract":"Background: Thrombotic microangiopathies (TMAs) can be induced by drugs. Recent works have indicated proteasome inhibitors, including carfilzomib, as a possible new causative agent. Although the physiopathology and management of carfilzomib-induced TMA are still unknown, eculizumab seems to be efficient. Results: We report a clinical case of TMA during carfilzomib treatment for multiple myeloma, possibly triggered by a concomitant influenza infection, suggesting a multi-hit process. Histologic analysis of the kidney biopsy proved renal TMA. Eculizumab allowed rapid and long-lasting renal and hematologic recovery. We enriched our work with a systemic review of published cases of carfilzomib-induced TMA treated by eculizumab. Twelve patients were included, all of whom presented acute renal failure and nine of them required hemodialysis. Eculizumab led to TMA resolution in eleven patients and complete renal recovery with hemodialysis withdrawal for seven of them within a month. One patient died from multiple myeloma progression. Two patients presented inter-current viral infection. Soluble complement fragment Bb and C5b9s were found in two patients and genetic benign variant of Factor H (CFH3–CFH1) in four. Conclusion: Our results suggest that eculizumab is effective in carfilzomib-induced TMA, which could support its inclusion as a treatment option. Further studies are required to clarify its physiopathology, complement role, and management.","PeriodicalId":74038,"journal":{"name":"Kidney and dialysis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42266828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular Calcification in Diabetic Kidney Disease 糖尿病肾病的血管钙化

Kidney and dialysis Pub Date : 2022-12-01 DOI: 10.3390/kidneydial2040054

O. Phan, N. Joki

引用次数: 0

Cell-Matrix Interactions in Renal Fibrosis. 肾脏纤维化中细胞与基质的相互作用

Kidney and dialysis Pub Date : 2022-12-01 Epub Date: 2022-12-07 DOI: 10.3390/kidneydial2040055

Kristin P Kim, Caitlin E Williams, Christopher A Lemmon