JU open plus最新文献_第6页

Editorial Comment: Case Report: Sacral Neuromodulation with Suspected Neuromuscular Blockade Secondary to a Butyrylcholinesterase (BCHE) Variant 编辑评论病例报告：丁酰胆碱酯酶（BCHE）变异引起的骶神经调节与疑似神经肌肉阻滞

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000085

J. Kikuchi

引用次数: 0

Case Report: Sacral Neuromodulation with Suspected Neuromuscular Blockade Secondary to Butyrylcholinesterase Variant 病例报告：疑因丁酰胆碱酯酶变异而导致神经肌肉阻滞的骶神经调节术

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000083

Nadia Megahed, Prapti Singh, Yaseen Maleki, Rachel A. High, Julie Stewart

引用次数: 1

Editorial Comment: Postoperative Oral Care Pathways Are Not Required at the Time of Buccal Mucosa Harvest 编辑评论：颊黏膜采集时不需要术后口腔护理路径

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000086

Ryan Terlecki, Ethan Matz, Connor Policastro

引用次数: 0

Reply to Editorial Comment: Pelvic Floor Dysfunction: A Common Cause of Chronic Orchialgia 回复编辑评论：盆底功能障碍：慢性睾丸炎的常见病因

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000091

Amy Zheng, Susan M. MacDonald

引用次数: 0

JU Open Plus: Updates on the American Urological Association Family of Journals JU Open Plus：美国泌尿外科协会期刊家族的最新动态

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000099

John W. Davis

引用次数: 0

Editorial Comment: Microbiomes in Post-DRE Urine Samples Are Linked to Prostate Cancer Risk 社论评论：DRE后尿液样本中的微生物组与前列腺癌风险有关

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000084

Michael A. Liss

引用次数: 0

Microbiomes in Post–Digital Rectal Exam Urine Samples are Linked to Prostate Cancer Risk 数字直肠检查后尿液样本中的微生物组与前列腺癌风险有关

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000082

E. D. Crawford, R. Martin, Caleb D. Phillips, Whitney N. Stanton, A. van Bokhoven, M. S. Lucia, Paul Arangua, Francisco G. La Rosa, Zachary Grasmick, Ryan Terlecki, Margaret F. Meagher, Daisaku Hirano, J. C. Nickel, P. Werahera

{"title":"Microbiomes in Post–Digital Rectal Exam Urine Samples are Linked to Prostate Cancer Risk","authors":"E. D. Crawford, R. Martin, Caleb D. Phillips, Whitney N. Stanton, A. van Bokhoven, M. S. Lucia, Paul Arangua, Francisco G. La Rosa, Zachary Grasmick, Ryan Terlecki, Margaret F. Meagher, Daisaku Hirano, J. C. Nickel, P. Werahera","doi":"10.1097/ju9.0000000000000082","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000082","url":null,"abstract":"\u0000 \u0000 \u0000 Bacterial species including Cutibacterium acnes (C. acnes) have been associated with different inflammatory and neoplastic conditions in prostate cancer (PCa) tissue samples, but their clinical impact is unknown. Using next-generation sequencing (NGS)–based clinical reports, we investigated the differential abundance and incidence of microbiomes in post–digital rectal exam (DRE) urine samples from patients with PCa and a matched control group at low risk of PCa.\u0000 \u0000 \u0000 \u0000 A total of 200 post-DRE urine samples were analyzed, 100 from patients with histopathologically confirmed PCa and 100 from men at very low risk of PCa with PSA <1.5 ng/mL as controls. Bacterial and fungal communities were characterized by NGS of 16S and internal transcribed spacer (ITS) loci, respectively, with species' relative abundances provided on physicians' clinical reports. The differential abundance and incidence of species between cancer and control groups were evaluated.\u0000 \u0000 \u0000 \u0000 Microbes were reported in 39% and 56% of PCa and control group samples, respectively. C. acnes had a significantly higher relative abundance in patients with PCa vs controls (P < .05), and C. acnes incidence rates were also nominally higher in patients with PCa as compared with controls (12.82% and 7.27%, respectively). By contrast, Finegoldia magna (F. magna) had a significantly higher relative abundance (P < .05) and incidence rate (P < .05) in controls as compared with patients with PCa.\u0000 \u0000 \u0000 \u0000 \u0000 C. acnes was among the most prevalent bacterial species in PCa urine samples. F. magna identified in the low-risk group is responsible for production of equol, a soy metabolite associated with lowering risk of PCa, suggesting a role in prostate cancer chemoprevention.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":" 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138619754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Uropathogenic Dysbiosis Pattern is Associated With Urethral Fibrosis 尿道致病性菌群失调模式与尿道纤维化有关

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000089

Michael Witthaus, Saager Chawla, Dhruvi Puri, Kyoko Sakamoto, Jill Buckley, Aaron Miller, Mahadevan Rajasekaran

{"title":"Uropathogenic Dysbiosis Pattern is Associated With Urethral Fibrosis","authors":"Michael Witthaus, Saager Chawla, Dhruvi Puri, Kyoko Sakamoto, Jill Buckley, Aaron Miller, Mahadevan Rajasekaran","doi":"10.1097/ju9.0000000000000089","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000089","url":null,"abstract":"Cellular mechanisms of stricture progression after repeated transurethral interventions are unclear. We hypothesize that urethral injury and mechanical stretch cause tears on the urethral epithelial cell lining leading to leaking epithelium and urine extravasation. Urinary bacteria traverse the epithelial lining and may promote fibrogenesis through inflammation due to microbial activity. Our objective was to perform a case-control study of the urobiome from patients with urethral stricture disease or healthy controls using 16S rRNA and shotgun metagenomic sequencing profiling to elucidate the clinical relevance of the urobiome in urinary stricture progression.\u0000 \u0000 \u0000 \u0000 First catch urine samples from patients and healthy volunteers were collected and pelleted urine was used for DNA extraction, followed by high throughput 16S rRNA and shotgun metagenomic sequencing. Sequencing data were used to determine microbial taxa and functions associated with urethral stricture disease.\u0000 \u0000 \u0000 \u0000 Sequencing results revealed that the lower urinary tract urobiome was significantly different between urethral stricture disease cases and healthy controls. In particular, taxonomic and metabolic profiles point toward anaerobic biofilm formation by antibiotic-resistant species of Klebsiella, which is a known uropathogen. Importantly, no patients in the study exhibited signs or symptoms of clinical infection.\u0000 \u0000 \u0000 \u0000 Our findings suggest a role for biofilm formation by uropathogens such as Klebsiella spp. in developing an inflammatory environment and consequent fibrosis progression. Future studies will elucidate specific mechanisms of Klebsiella-induced fibrosis. Our data suggest that targeting specific bacteria or biofilm formation may be beneficial for urethral stricture disease detection and prevention of progression.","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"125 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138608918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Metastatic Renal Cell Carcinoma to the Maxillary Sinus Initially Presenting as Recurrent Epistaxis 一例转移至上颌窦的肾细胞癌，最初表现为复发性鼻衄

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000072

Justin P. Mehr, Kyle A. Blum, William S. Jones, Neha Maithel, Martin J. Citardi, Steven Canfield

引用次数: 1

Utilization of Instagram by Urology Residency Programs for Applicant Recruitment 泌尿科住院医师计划利用 Instagram 招募申请人

JU open plus Pub Date : 2023-12-01 DOI: 10.1097/ju9.0000000000000088

Oscar Li, Aurora Grutman, Matthew Rabinowitz, Marisa Clifton

{"title":"Utilization of Instagram by Urology Residency Programs for Applicant Recruitment","authors":"Oscar Li, Aurora Grutman, Matthew Rabinowitz, Marisa Clifton","doi":"10.1097/ju9.0000000000000088","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000088","url":null,"abstract":"\u0000 \u0000 To assess Instagram content and trends by urology residency programs.\u0000 \u0000 \u0000 \u0000 A cross-sectional analysis of urology residency program Instagram accounts was completed after data collection between October 1 and 20, 2022. Included accounts were reviewed and descriptive details were recorded, such as number of followers, those followed, and post content. All posts were then coded on a predetermined list of 7 categories: (1) resident promotion; (2) faculty/departmental promotion; (3) activities outside medicine; (4) research, presentation, or awards; (5) urology match/application-related promotion; (6) “urology in general”; and (7) other.\u0000 \u0000 \u0000 \u0000 Overall, 66 of 147 (44.9%) programs had an account at the time of analysis. About half (31 of 66, 47%) of accounts were created between June and December 2020. Accounts had a median of 633 followers (IQR: 254,844) and 39 posts (IQR: 18,64). Of the 3236 posts analyzed, the majority featured residents or activities outside medicine; video posts were least used. Posts promoting residents had significantly higher average likes per post compared with all other categories except posts about “urology in general.”\u0000 \u0000 \u0000 \u0000 To our knowledge, this is the first study analyzing the use of Instagram by urology residency programs for recruitment. Our study describes an increasing number of urology residency program Instagram accounts for showcasing residents and life outside of medicine to engage with followers.\u0000","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"114 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1