JU open plus最新文献

{"title":"Erratum: Posterior Approach to Endopelvic Neurovascular Total Sparing Robotic-Assisted Radical Prostatectomy Improves Recovery of Erectile Function: Erratum.","authors":"Gal Wald, Lina Posada, Evan Suzman, John Lama, Joshua Winograd, May Ting, Catherine Pothier, Judy Zhong, Keith J Kowalczyk, Jim C Hu","doi":"10.1097/JU9.0000000000000420","DOIUrl":"10.1097/JU9.0000000000000420","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1097/JU9.0000000000000394.].</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"4 1","pages":"e00011"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12825769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146055443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Urine pH in Postmenopausal Women With a Current, a History of, or No History of Uncomplicated Urinary Tract Infection.","authors":"Philippe Zimmern, Anjana Shah, Feras Alhalabi, Alana Christie, Michael Neugent, Nikki Koonjbearry, Nicole De Nisco","doi":"10.1097/JU9.0000000000000396","DOIUrl":"10.1097/JU9.0000000000000396","url":null,"abstract":"<p><strong>Introduction: </strong>Owing to its mechanism of action, Hiprex should be preferentially administered to those with stable urine pH 6 or less. Consequently, we sought to determine the common range of urine pH in a population of postmenopausal (PM) women affected by recurrent urinary tract infections (rUTIs) to understand the relevance of Hiprex for long-term rUTI management.</p><p><strong>Methods: </strong>Following Internal Review Board approval, a large, prospective database of PM women with uncomplicated rUTI was reviewed for concurrent data on urine pH and urine culture (UC) with bacterial species. Three groups were compared: a history of rUTI, current UTI, and no history of UTI (control). A χ² test analyzed association between a median pH of 6 or less by group. Urinary pH was also examined by bacterial species.</p><p><strong>Results: </strong>The final UC analysis included a total of 345 women (median age 70 years) who provided 1276 UCs (median 3 UCs). The rate of urine pH ≤ 6 was 76% (94/123) and 77% (255/332) in those with current UTI and a history of UTI, respectively. In the control group, urine pH was measured longitudinally (4 times) in 26 PM women (median age 70.5) and 65% (17/26) had a urine pH ≤ 6 (χ² <i>P</i> = .4). Minimal association was noted between low pH and bacterial species.</p><p><strong>Conclusions: </strong>Three-quarters of women with a history of uncomplicated rUTI, whether symptomatic at the time of the UC or not, had a urine pH ≤ 6. More than half of women with no history of UTI fell in that same category.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"4 1","pages":"e00001"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12788754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder wall-embedded bacteria associated with increased risk of recurrence after electrofulguration in women with antibiotic-recalcitrant urinary tract infection.","authors":"Jashkaran G Gadhvi, Parker R M Kenee, Kevin C Lutz, Fatima Khan, Qiwei Li, Philippe E Zimmern, Nicole J De Nisco","doi":"10.1097/ju9.0000000000000315","DOIUrl":"10.1097/ju9.0000000000000315","url":null,"abstract":"<p><strong>Purpose: </strong>Antibiotic-recalcitrant recurrent urinary tract infection (rUTI) is increasingly observed in postmenopausal women. When standard therapies fail, some elect electrofulguration (EF) of areas of chronic cystitis detected on office cystoscopy. EF is thought to remove tissue-resident bacteria within the bladder walls of women with rUTI. We hypothesized that increased bladder wall bacterial burden may be associated with incomplete rUTI resolution following EF.</p><p><strong>Materials and methods: </strong>Following IRB approval, bladder biopsies were obtained from 34 consenting menopausal women electing EF for the advanced management of rUTI. 16S rRNA FISH was performed using both universal and <i>Escherichia</i> probes and tissue-resident bacterial load was quantified. Time to UTI relapse after EF was recorded during a six-month follow-up period and the association of bladder wall bacterial burden and clinical covariates with UTI relapse was assessed.</p><p><strong>Results: </strong>We observed bladder wall-embedded <i>Escherichia</i> in 52% of all participants and in 92% of participants with recent <i>E. coli</i> UTI. Time-to-relapse analysis revealed that women with high bladder wall bacterial burden as detected by the universal probe had a significantly (<i>p</i>=0.035) higher risk of UTI within six months of EF (HR=3.15, 95% CI: 1.09-9.11). Interestingly, bladder wall-resident <i>Escherichia</i> was not significantly associated (<i>p</i>=0.26) with a higher risk of UTI relapse (HR= 2.14, 95% CI: 0.58-7.90).</p><p><strong>Conclusions: </strong>We observed that total bladder wall bacterial burden was associated with a 3.1x increased risk of rUTI relapse within six months. Continued analysis of the relationship between bladder-embedded bacteria and rUTI outcomes may provide insight into the management of these challenging patients.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"3 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population-Specific Radiomics From Biparametric Magnetic Resonance Imaging Improves Prostate Cancer Risk Stratification in African American Men.","authors":"Abhishek Midya, Sreeharsha Tirumani, Leonardo Kayat Bittencourt, Sena Azamat, Siddharth Balakrishnan, Amogh Hiremath, Sarah Wido, Pingfu Fu, Lee Ponsky, Anant Madabhushi, Rakesh Shiradkar","doi":"10.1097/ju9.0000000000000310","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000310","url":null,"abstract":"<p><strong>Purpose: </strong>To quantify population-specific differences in prostate cancer (PCa) presentation between African American (AA) and White (W) men on MRI using radiomics.</p><p><strong>Materials and methods: </strong>We identified N = 149 men with PCa who underwent 3T MRI, a confirmatory biopsy and for whom self-reported race was available. Patient studies were partitioned into training (D_Tr) and hold-out test set (D_Te). Three hundred radiomic features quantifying textural patterns were extracted from radiologist delineated PCa regions of interest (ROI) on biparametric MRI. Features with significant differences (<i>P</i> < .05) between clinically significant (csPCa) and insignificant (ciPCa) PCa were identified. Machine learning models were trained separately for AA and W men (C_AA, C_W) on D_Tr to distinguish csPCa and ciPCa. Validation on D_Te was assessed for AUC and compared against a population agnostic model (C_PA) in combination with clinical parameters (age, PSA, Prostate Imaging Reporting and Diagnostic System and tumor volume).</p><p><strong>Results: </strong>Radiomic features from PCa ROIs on biparametric MRI associated with csPCa were observed to be different in AA compared with W men, especially in the peritumoral region. Population-specific radiomic models outperformed similarly trained C_PA models (AUC = 0.84, 0.57 with C_AA, C_PA; <i>P</i> < .05) in AA men on D_Te. Similar findings were observed for W men (AUC = 0.71, 0.60 with C_W, C_PA; <i>P</i> < .05). Integrating clinical and radiomics further improved the risk stratification for AA men (AUC = 0.90) and W men (AUC = 0.75).</p><p><strong>Conclusions: </strong>Accounting for population-specific differences in radiomics may enable improved PCa risk stratification at MRI among AA men compared with a population agnostic approach.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"3 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JUOP April 2025: Report on the Third Annual CUReS Symposium-Collaborative Urology Research Symposium at Houston Methodist.","authors":"Zachary B Kahlenberg, Johnny Su, Raj Satkunasivam, Betsy H Salazar, Jennifer M Taylor, Steven E Canfield, Joseph Sonstein, Patrick Lowry, John W Davis, Rose Khavari","doi":"10.1097/ju9.0000000000000309","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000309","url":null,"abstract":"<p><p>For our monthly editorial series, we are featuring highlights of key academic meetings as a potential review topic, and the editorial board is planning additional content that will feature and illustrate key AUA guidelines into presentation quality formats. For this month, we received this excellent write up of a recent collaborative symposium (basically all authors listed except me) and include it with minimal edits below.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drive Time to Physicians and Outcomes for Bladder Cancer.","authors":"Sruthi L Muluk, Coleman Drake, Zhaojun Sun, Manisha Bhattacharya, Bruce L Jacobs, Lindsay M Sabik","doi":"10.1097/ju9.0000000000000273","DOIUrl":"10.1097/ju9.0000000000000273","url":null,"abstract":"<p><strong>Purpose: </strong>For patients with muscle-invasive bladder cancer (MIBC), time to cystectomy and receipt of neoadjuvant chemotherapy are associated with improved survival. Travel burden may be an important barrier to timely guideline-concordant treatment.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional study of patients in Pennsylvania with a first lifetime cancer diagnosis of MIBC who underwent radical cystectomy at non-federal short-term general hospitals identified in 2010-2016 Pennsylvania Cancer Registry linked to Pennsylvania Healthcare Cost Containment Council (PHC4) inpatient data through 2018. Physician location came from the Centers for Medicare and Medicaid Services.</p><p><strong>Results: </strong>Mean (standard deviation) drive time to nearest oncologist was 17.1 (11.4) minutes and to nearest urologist was 13.9 (9.2) minutes. A 30-minute increase in drive time to the urologist was associated with a 12.5 percentage point lower likelihood of undergoing cystectomy within 90 days (95% CI: -24.3 to -0.6), with greater effects for more socioeconomically disadvantaged areas (18.7 percentage point lower [95% CI: -33.1 to -4.3]). A 30-minute increase to the oncologist was associated with an 11.9 percentage point lower likelihood of receiving neoadjuvant chemotherapy (95% CI: -23.4 to -0.4). Drive time was not significantly associated with 90-day mortality or readmission.</p><p><strong>Conclusions: </strong>Drive time to oncologists and urologists is associated with timely receipt of guideline-recommended care for patients with MIBC. Understanding the impact of geographic access on clinical outcomes for patients with cancer who require multispecialty care can inform providers and policymakers in efforts to improve cancer care access and outcomes.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Analysis of Telemedicine Use Among Urban and Rural Patients With Urologic Malignancies.","authors":"Zeynep G Gul, Michael G Stencel, Kimberly J Rak, Benjamin J Davies, Bruce L Jacobs","doi":"10.1097/ju9.0000000000000249","DOIUrl":"10.1097/ju9.0000000000000249","url":null,"abstract":"<p><strong>Purpose: </strong>To better understand patient perceptions on utilizing telemedicine for the management of urologic malignancies.</p><p><strong>Materials and methods: </strong>Semistructured interviews were conducted with patients with bladder, prostate, or kidney cancer. Interviews were conducted by phone, audio-recorded, transcribed, and deidentified. A thematic analysis was performed to examine patients' perceptions of telemedicine and its role in their care. We compared the experiences of rural and urban patients to better understand the impact that telemedicine could have and urban-rural disparities in urologic oncology.</p><p><strong>Results: </strong>We conducted 40 patient interviews. Seventy percent of patients lived in urban areas, and 30% lived in rural areas. Three primary themes were identified: (1) the benefit of telemedicine, primarily convenience, (2) variable appropriateness of telemedicine, and (3) concerns over possible impacts of telemedicine on care quality. Patients had a generally favorable telemedicine experience and appreciated that it was convenient and reduced the travel time and burden associated with getting care. However, they thought it was only appropriate in certain situations, such as routine follow-ups and to supplement in-person visits and if used incorrectly could affect care quality.</p><p><strong>Conclusions: </strong>Telemedicine has a valuable role in the care of patients with urologic malignancies. It reduces the burden of receiving care for rural patients, and optimizing its use may help reduce urban-rural disparities in outcomes. Future studies should study the impact that telemedicine has on quality.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flourine-18 Prostate-Specific Membrane Antigen-1007 Positron Emission Tomography Imaging in Staging of Primary and Secondary Prostate Cancer-A Retrospective Observational Cohort Study.","authors":"Matthew H V Byrne, Nithesh Ranasinha, Abhishek Sharma, Claudia Mercader, Mutie Raslan, Ganesh Sathanapally, Francesca Lewis, Stefanos Gorgoraptis, Ana Catarina Lopes Vieira, Jedrzej Golebka, Bryony Peiris, J Francisco Lopez, Tom Leslie, Richard C Bell, Saiful Miah, Mark Tuthill, Andrew Protheroe, Philip Camilleri, Ami Sabharwal, Gerard Andrade, Freddie C Hamdy, Ruth Macpherson, Fergus Gleeson, Richard J Bryant, Alastair D Lamb","doi":"10.1097/JU9.0000000000000206","DOIUrl":"10.1097/JU9.0000000000000206","url":null,"abstract":"<p><strong>Background: </strong>Detection of metastatic disease is important to inform prostate cancer management.</p><p><strong>Objectives: </strong>Evaluate local and distant staging by initial ¹⁸F-PSMA-1007 PET in primary and secondary prostate cancer.</p><p><strong>Design setting and participants: </strong>We retrospectively identified a consecutive series of ¹⁸F-PSMA-1007 PET scans from the date of introduction of ¹⁸F-PSMA-1007 PET in September 2019 until April 2022 at a single UK tertiary referral center. Our protocol was registered in advance (OSF registration ID: KTE3R).</p><p><strong>Results: </strong>We identified 1335 PSMA-PET scans, from 1220 men. Across 623 initial scans for primary staging, we observed PSMA-PET avidity in 97.6% cases positive for local disease, 29.5% for nodal disease, and 26.5% for metastatic disease. PSMA-PET identified a 13.2% absolute increase in nodal lesions compared with MRI and a 24.0% absolute increase in metastatic lesions compared with MRI marrow. The sensitivity for detection of local disease among 79 patients who had radical prostatectomy was 96.2% for PSMA-PET vs 89.4% for multiparametric MRI. Across 612 scans for secondary staging, we observed PSMA-PET positive avidity in 51.2% of cases for local recurrence, 46.6% for nodal disease, and 43.0% for metastatic disease. When evaluated by the PSA range for patients receiving secondary staging, using the PSA values of 0.2 to 0.49, 0.5 to 0.99, 1 to 1.99, and ≥ 2 ng/mL, PSMA-PET scans were positive in 57.8%, 75.0%, 83.8%, and 95.5% of cases, respectively. PSMA-PET identified a 26.2% absolute increase in metastatic lesions compared with MRI marrow or other skeletal MRI (n = 61) and a 14.7% absolute increase in metastatic lesions compared with the bone scan (n = 42).</p><p><strong>Conclusion: </strong>¹⁸F-PSMA-1007 PET identifies a higher number of nodal and metastatic lesions compared with conventional cross-sectional imaging. However, the high number of indeterminate lesions and stage migration necessitates discussion of ¹⁸F-PSMA-1007 PET imaging within a multidisciplinary team and places a higher burden on these teams.</p>","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"2 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7618851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Reductions in Prostate-Specific Antigen Screening During the COVID-19 Pandemic in a Universally Insured American Health System","authors":"Daisy Obiora, Bruce L. Jacobs","doi":"10.1097/ju9.0000000000000160","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000160","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"56 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: Telehealth in Urology Beyond COVID-19","authors":"K. Kieran","doi":"10.1097/ju9.0000000000000168","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000168","url":null,"abstract":"","PeriodicalId":74033,"journal":{"name":"JU open plus","volume":"261 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}