{"title":"Platelet closure time in anesthetized Greyhounds with hemorrhagic shock treated with hydroxyethyl starch 130/0.4 or 0.9% sodium chloride infusions.","authors":"D. McBride, G. Hosgood, A. Raisis, L. Smart","doi":"10.1111/vec.12468","DOIUrl":"https://doi.org/10.1111/vec.12468","url":null,"abstract":"OBJECTIVE\u0000To measure platelet closure time (PCT) in dogs during controlled hemorrhagic shock and after fluid resuscitation with hydroxyethyl starch (HES) 130/0.4 or 0.9% sodium chloride.\u0000\u0000\u0000DESIGN\u0000Experimental interventional study.\u0000\u0000\u0000SETTING\u0000University veterinary teaching hospital.\u0000\u0000\u0000ANIMALS\u0000Eleven healthy Greyhounds.\u0000\u0000\u0000INTERVENTIONS\u0000Dogs were anesthetized and had 48 mL/kg of blood removed to induce hemorrhagic shock. Dogs received 20 mL/kg of HES 130/0.4 (n = 6) or 80 mL/kg of 0.9% sodium chloride (NaCl; n = 5) intravenously over 20 minutes. PCT was measured using the Platelet Function Analyzer-100 with collagen and adenosine-diphosphate cartridges at: T0 = 60 minutes after induction of anesthesia prior to hemorrhage, T1 = during hemorrhagic shock, and T2 = 40 minutes after completion of fluid bolus. Packed cell volume and platelet count were concurrently measured.\u0000\u0000\u0000MEASUREMENT AND MAIN RESULTS\u0000Hemorrhagic shock did not significantly change PCT, with no difference between T0 and T1. Both the HES 130/0.4 and 0.9% NaCl group had a significantly increased mean PCT at T2 of 91.4 seconds (95% CI 69.3-113.4) and 95.5 seconds (95% CI 78.2-112.8), respectively, compared to T1. The magnitude of change was significantly greater for the 0.9% NaCl group than the HES 130/0.4 group. There was no difference in the magnitude of change in PCV and platelet count between the 2 groups. The PCV and platelet count were >25% and >100,000/μL, respectively, in all dogs, except for dogs in the HES 130/0.4 group at T2 where platelet counts were <100,000/μL.\u0000\u0000\u0000CONCLUSION\u0000Controlled hemorrhagic shock in Greyhounds under anesthesia did not cause a significant change in PCT. Both HES 130/0.4 and 0.9% NaCl administration after induction of shock increased PCT. These results do not support that HES 130/0.4 causes relevant platelet dysfunction beyond hemodilution.","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63497861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jill S Manion, John M Thomason, Vernon C Langston, Andrew K Claude, Marjory B Brooks, Andrew J Mackin, Kari V Lunsford
{"title":"Anticoagulant effects of inhaled unfractionated heparin in the dog as determined by partial thromboplastin time and factor Xa activity.","authors":"Jill S Manion, John M Thomason, Vernon C Langston, Andrew K Claude, Marjory B Brooks, Andrew J Mackin, Kari V Lunsford","doi":"10.1111/vec.12344","DOIUrl":"https://doi.org/10.1111/vec.12344","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the anticoagulant effects of inhaled heparin in dogs.</p><p><strong>Design: </strong>This study was conducted in 3 phases. In phase 1, bronchoalveolar lavage fluid (BALf) was collected to generate an in vitro calibration curve to relate heparin concentration to the activated partial thromboplastin time (aPTT). In phase 2, heparin was administered via nebulization to determine the threshold dose needed to prolong systemic aPTT. In phase 3, the local anticoagulant activity of inhaled heparin was determined by measurement of BALf anti-Xa activity and aPTT.</p><p><strong>Setting: </strong>University teaching hospital.</p><p><strong>Animals: </strong>Six healthy intact female Walker Hounds were used in this study. Two dogs were used for each phase.</p><p><strong>Interventions: </strong>Inhaled unfractionated sodium heparin was administered in doses ranging from 50,000 to 200,000 IU.</p><p><strong>Results: </strong>In vitro addition of heparin to BALf caused a prolongation in aPTT. Inhaled heparin at doses as high as 200,000 IU failed to prolong systemic aPTT, and a threshold dose could not be determined. No significant local anticoagulant effects were detected.</p><p><strong>Conclusions: </strong>Even at doses higher than those known to be effective in people, inhaled heparin appears to have no detectable local or systemic anticoagulant effects in dogs with the current delivery method.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12344","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33921367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective comparison of early- versus late-insulin therapy regarding effect on time to resolution of diabetic ketosis and ketoacidosis in dogs and cats: 60 cases (2003-2013).","authors":"Jillian DiFazio, D. Fletcher","doi":"10.1111/vec.12415","DOIUrl":"https://doi.org/10.1111/vec.12415","url":null,"abstract":"OBJECTIVE To determine whether early insulin administration (≤6 h after admission) results in more rapid resolution of diabetic ketosis (DK) and ketoacidosis (DKA), shorter duration of hospitalization, and higher incidence of complications, and whether more severe ketonuria is associated with longer time to resolution of DK/DKA. DESIGN Retrospective study (January 1, 2003-March 1, 2013). SETTING University teaching hospital. ANIMALS Sixty dogs and cats with DK or DKA receiving short-acting insulin therapy. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Medical records were reviewed and data recorded including signalment; previous history of diabetes; intake temperature, blood pressure, blood glucose, pH, base excess, and degree of ketonuria; time to short-acting insulin therapy and resolution of DK/DKA; length of hospitalization; and complications. Insulin was initiated ≤6 hours in the early group and >6 hours in the late group after hospital admission. Early group patients had more rapid resolution of DK/DKA after starting short-acting insulin therapy (36.4 ± 22.6 vs. 55.4 ± 26.6 h, P = 0.014). There was no difference in duration of hospitalization or complications. More severe ketonuria resulted in longer time to resolution of DK/DKA after initiation of short-acting insulin (severe: 50.9 ± 24.2; moderate: 29.6 ± 19; mild: 23.4 ± 21.9 h, P = 0.005, all individual pairwise comparisons P < 0.05). CONCLUSIONS Early insulin administration is associated with more rapid resolution of DK/DKA without an associated increase in complication rates. DK/DKA took longer to resolve with more severe ketonuria. Prospective studies are warranted to identify specific time targets for insulin administration in DK/DKA patients.","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12415","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63496900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Boller, D. Fletcher, B. Brainard, S. Haskins, K. Hopper, V. Nadkarni, P. Morley, M. McMichael, R. Nishimura, J. Robben, E. Rozanski, E. Rudloff, J. Rush, A. Shih, Sean D. Smarick, Luis H Tello
{"title":"Utstein-style guidelines on uniform reporting of in-hospital cardiopulmonary resuscitation in dogs and cats. A RECOVER statement.","authors":"M. Boller, D. Fletcher, B. Brainard, S. Haskins, K. Hopper, V. Nadkarni, P. Morley, M. McMichael, R. Nishimura, J. Robben, E. Rozanski, E. Rudloff, J. Rush, A. Shih, Sean D. Smarick, Luis H Tello","doi":"10.1111/vec.12436","DOIUrl":"https://doi.org/10.1111/vec.12436","url":null,"abstract":"OBJECTIVE To provide recommendations for reviewing and reporting clinical in-hospital cardiopulmonary resuscitation (CPR) events in dogs and cats and to establish nonambiguous operational definitions for CPR terminology. DESIGN Consensus guidelines. SETTING International, academia, referral practice, general practice, and human medicine. METHODS An international veterinary Utstein task force was convened in April 2013 in San Francisco to determine the scope of the project, the variables to be reported, their definitions, and a reporting template. Factors that were essential for meaningful data reporting and were amenable to accurate collection (ie, core variables) and additional variables useful for research projects and hypothesis generation (ie, supplemental variables) were defined. Consensus on each item was either achieved during that meeting or during the subsequent online modified Delphi process and dialogue between task force members. RESULTS Variables were defined and categorized as hospital, animal, event (arrest), and outcome variables. This report recommends a template for standardized reporting of veterinary in-hospital CPR studies involving dogs or cats. Core elements include the suspected cause(s) and location of arrest, first rhythm identified, the occurrence of return of spontaneous circulation (ROSC) of more than 30 seconds (any ROSC) or more than 20 minutes (sustained ROSC), survival to discharge, and functional capacity at discharge. If CPR is discontinued or the patient is euthanized by owner request, a reason is reported. The task force suggests a case report form to be used for individual resuscitation events. CONCLUSIONS The availability of these veterinary small animal CPR reporting guidelines will encourage and facilitate high-quality veterinary CPR research, improve data comparison between studies and across study sites, and serve as the foundation for veterinary CPR registries.","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63497552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"VETERINARY EMERGENCY & CRITICAL CARE SOCIETY 2016 MEMBERSHIP APPLICATION.","authors":"","doi":"10.1111/vec.12443","DOIUrl":"https://doi.org/10.1111/vec.12443","url":null,"abstract":"","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63497693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bari R Morris, Armelle deLaforcade, Joyce Lee, Joseph Palmisano, Dawn Meola, Elizabeth Rozanski
{"title":"Effects of in vitro hemodilution with crystalloids, colloids, and plasma on canine whole blood coagulation as determined by kaolin-activated thromboelastography.","authors":"Bari R Morris, Armelle deLaforcade, Joyce Lee, Joseph Palmisano, Dawn Meola, Elizabeth Rozanski","doi":"10.1111/vec.12345","DOIUrl":"https://doi.org/10.1111/vec.12345","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of in vitro hemodilution with lactated Ringers solution (LRS), hetastarch (HES), and fresh frozen plasma (FFP) on whole blood coagulation in dogs as assessed by kaolin-activated thromboelastography.</p><p><strong>Design: </strong>In vitro experimental study.</p><p><strong>Setting: </strong>University teaching hospital.</p><p><strong>Animals: </strong>Six healthy client-owned dogs.</p><p><strong>Interventions: </strong>Whole blood was collected and diluted in vitro at a 33% and 67% dilution with either LRS, HES, or FFP.</p><p><strong>Measurements and main results: </strong>Kaolin-activated thromboelastography was performed on each sample as well as a control. Thromboelastographic parameters R (min), alpha (deg), K (min), and MA (mm) were measured and compared to the sample control for each dilution using mixed model methodology. Prolongation in coagulation times were seen at both dilutions with LRS and HES. There was no significant difference in R times at the 33% dilution, but R time was significantly prolonged at the 67% dilution with HES (P = 0.004). MA was significantly decreased for LRS at both dilutions (P = 0.013, P < 0.001) and more profoundly decreased for HES (P < 0.001, P = 0.006). No significant difference in any parameter was found for FFP.</p><p><strong>Conclusions: </strong>In vitro hemodilution of whole blood with both LRS and HES but not FFP resulted in significant effects on coagulation with HES having a more profound effect. In vivo evaluation of changes in coagulation with various resuscitation fluids is warranted and may be clinically relevant.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33943314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IVECCS News.","authors":"","doi":"10.1111/vec.12446","DOIUrl":"https://doi.org/10.1111/vec.12446","url":null,"abstract":"","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12446","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63497792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"UPCOMING VECCS CE PROGRAMS.","authors":"","doi":"10.1111/vec.12447","DOIUrl":"https://doi.org/10.1111/vec.12447","url":null,"abstract":"","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63497834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carrie R White, Cathy Langston, Ann E Hohenhaus, Kenneth Lamb, Susan Hackner, Philip R Fox
{"title":"Evaluation of the relationship between clinical variables and thromboelastographic findings in dogs with protein-losing nephropathy.","authors":"Carrie R White, Cathy Langston, Ann E Hohenhaus, Kenneth Lamb, Susan Hackner, Philip R Fox","doi":"10.1111/vec.12409","DOIUrl":"https://doi.org/10.1111/vec.12409","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether hypercoagulability in proteinuric dogs, defined by thromboelastography (TEG), is related to the degree of proteinuria, presence of systemic arterial hypertension, presence of hypoalbuminemia, or reduced antithrombin activity.</p><p><strong>Design: </strong>Prospective study of client-owned dogs. Data collected from each patient included signalment, body weight, urine protein-to-creatinine ratio (UPC), serum albumin concentration, TEG values, noninvasive arterial blood pressure, and AT activity. Hypercoagulability was diagnosed by TEG and odds ratios for other measurements were assessed by univariate logistic regression.</p><p><strong>Setting: </strong>Urban referral center and teaching hospital.</p><p><strong>Animals: </strong>Seventy-six dogs with protein-losing nephropathy (PLN) based on UPC, diagnosed between Oct 2009 and Oct 2012.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>The prevalence of hypercoagulability was 89%. No statistically significant associations were detected between hypercoagulability and UPC, serum albumin, noninvasive blood pressure, or AT activity (all P > 0.05). The prevalence of thromboembolism was 6.6%.</p><p><strong>Conclusions: </strong>Hypercoagulability was prevalent in dogs with PLN but could not be predicted based upon the presence or degree of proteinuria, systemic arterial hypertension, hypoalbuminemia, or low AT activity. The prevalance of thromboembolism was low in this population with PLN.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12409","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34079746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}