{"title":"A suspected anaphylactoid reaction to intravenous administration of mannitol in a dog.","authors":"Kathleen Seddon, Georgina Stewart, Íde Gillespie","doi":"10.1111/vec.13440","DOIUrl":"10.1111/vec.13440","url":null,"abstract":"<p><strong>Objective: </strong>To describe a case of a suspected anaphylactoid reaction to mannitol in a dog.</p><p><strong>Case summary: </strong>A 1-year-old, neutered female French Bulldog was anesthetized for a T12-T13 dorsal laminectomy surgery for a previously diagnosed spinal arachnoid diverticulum. Perioperatively, the spinal cord appeared grossly edematous, and IV mannitol administration was elected. Midway through administration of mannitol, peracute erythema and angioedema were noted around the patient's tongue, muzzle, and paws. The dog's tongue grew to approximately twice its normal size. All vital parameters remained within normal limits. The dog was treated intravenously with dexamethasone and intramuscularly with mepyramine maleate. The remainder of the anesthetization was uneventful. The swelling completely resolved during the 2-hour recovery period, but careful management of the enlarged tongue was required to prevent airway occlusion.</p><p><strong>New or unique information provided: </strong>This is the first reported case of a suspected anaphylactoid reaction to IV administration of mannitol in a dog.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142669901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jillian M Haines, Thandeka R Ngwenyama, Linda G Martin, K Jane Wardrop
{"title":"Development and implementation of a hemovigilance program at a university veterinary teaching hospital.","authors":"Jillian M Haines, Thandeka R Ngwenyama, Linda G Martin, K Jane Wardrop","doi":"10.1111/vec.13179","DOIUrl":"https://doi.org/10.1111/vec.13179","url":null,"abstract":"<p><strong>Objective: </strong>To describe the development and implementation of a small animal hemovigilance program at a university veterinary teaching hospital.</p><p><strong>Design: </strong>Retrospective observational descriptive study performed between October 2014 and March 2019.</p><p><strong>Setting: </strong>University teaching hospital.</p><p><strong>Animals: </strong>Dogs and cats receiving blood product transfusions .</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong> A hemovigilance working group composed of veterinary specialists in clinical pathology, internal medicine, and emergency and critical care was established. This group developed evidence-based definitions of transfusion reactions, reaction classification systems, and a transfusion reaction reporting form. The reporting form contained sections for patient information, transfusion information, administration details, and reaction details. Reaction events were classified by reaction type, severity grade, and imputability to the transfusion. Following implementation of the hemovigilance program, transfusion reaction data were collected and examined for the period spanning October 2014 and March 2019. During the study period, 718 canine transfusions (4 whole blood, 400 packed RBC [pRBC], 300 fresh frozen plasma [FFP], 7 platelet rich plasma, and 7 cryoprecipitate) and 124 feline transfusions (5 whole blood, 95 pRBC, and 24 FFP) were administered. There were 32 total reactions (27 canine and 5 feline), with the most common reaction being febrile nonhemolytic transfusion reactions (19/32; 59%). The incidence rate of transfusion reactions was found to be 3.8% in dogs and 4.0% in cats. For the confirmed reactions, classification criteria for case definition, reaction severity grade, and imputability were able to be determined and recorded. This allowed targeted interventions to be implemented in order to potentially reduce future reactions.</p><p><strong>Conclusions: </strong>A hemovigilance program can be instituted successfully in a veterinary hospital setting and once developed, standardized reporting tools could be utilized by multiple hospitals and provide the basis for more widespread reaction reporting in veterinary medicine.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":"32 3","pages":"315-321"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39912254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah M Gradilla, Anusha Balakrishnan, Deborah C Silverstein, Chap L Pratt, Daniel J Fletcher, Jacob M Wolf
{"title":"Owner experiences with and perceptions of owner-witnessed CPR in veterinary medicine.","authors":"Sarah M Gradilla, Anusha Balakrishnan, Deborah C Silverstein, Chap L Pratt, Daniel J Fletcher, Jacob M Wolf","doi":"10.1111/vec.13180","DOIUrl":"https://doi.org/10.1111/vec.13180","url":null,"abstract":"<p><strong>Objective: </strong>To examine owner experiences with and perceptions of owner-witnessed resuscitation (OWR) in veterinary medicine and to determine if previous experience with family-witnessed resuscitation (FWR) influenced perceptions.</p><p><strong>Design: </strong>Multicenter survey.</p><p><strong>Setting: </strong>Two academic and 2 private practice referral hospitals in the United States.</p><p><strong>Subjects: </strong>Four hundred and seven clients presenting their small animal or exotic pet to the emergency service, or owners of patients hospitalized in the small animal ICU, April 1 to May 15, 2019.</p><p><strong>Interventions: </strong>None MEASUREMENTS AND MAIN RESULTS: Anonymous, online survey. Demographic variables, familiarity with CPR, previous experience with FWR or OWR, and open-ended questions and 4-point Likert items assessing level of agreement with statements on OWR were included. Scores equal or greater than 2 represented positive agreement. An overall OWR mean score was calculated from Likert items. Seventy-nine (19.4%; 95% confidence interval [CI], 15.7%-23.7%) participants reported having been involved with FWR, and 13 (3.2%; 95% CI, 1.8%-5.5%) reported having witnessed CPR on their pet. Owners were significantly more likely to participate in OWR if they had been present for FWR (P = 0.0004). Ninety-two percent of respondents who had been present for OWR would elect to be present again (95% CI, 62.1%-99.6%). Whether present for OWR or not, owners believed there may be benefits from witnessing CPR and had overall positive feelings toward the practice (OWR mean score, 2.87, SD 0.45 and 2.68, SD 0.54, respectively). Most respondents (78.6%; 95% CI, 74.2%-82.4%) felt that owners should be offered the opportunity to witness CPR on their pets.</p><p><strong>Conclusions: </strong>Owners expressed overall positive experiences with and attitudes toward OWR and believe the option for presence should be provided. As pet owners become more aware of FWR in human medicine, veterinarians may need to be prepared to entertain the possibility of OWR and owners' wishes to remain with their pet during CPR.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":"32 3","pages":"322-333"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39692789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Armelle deLaforcade, Lenore Bacek, Marie-Claude Blais, Corrin Boyd, Benjamin M Brainard, Daniel L Chan, Stefano Cortellini, Robert Goggs, Guillaume L Hoareau, Amy Koenigshof, Ron Li, Alex Lynch, Alan Ralph, Elizabeth Rozanski, Claire R Sharp
{"title":"2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1- Defining populations at risk.","authors":"Armelle deLaforcade, Lenore Bacek, Marie-Claude Blais, Corrin Boyd, Benjamin M Brainard, Daniel L Chan, Stefano Cortellini, Robert Goggs, Guillaume L Hoareau, Amy Koenigshof, Ron Li, Alex Lynch, Alan Ralph, Elizabeth Rozanski, Claire R Sharp","doi":"10.1111/vec.13204","DOIUrl":"10.1111/vec.13204","url":null,"abstract":"<p><strong>Objectives: </strong>To expand the number of conditions and interventions explored for their associations with thrombosis in the veterinary literature and to provide the basis for prescribing recommendations.</p><p><strong>Design: </strong>A population exposure comparison outcome format was used to represent patient, exposure, comparison, and outcome. Population Exposure Comparison Outcome questions were distributed to worksheet authors who performed comprehensive searches, summarized the evidence, and created guideline recommendations that were reviewed by domain chairs. The revised guidelines then underwent the Delphi survey process to reach consensus on the final guidelines. Diseases evaluated in this iteration included heartworm disease (dogs and cats), immune-mediated hemolytic anemia (cats), protein-losing nephropathy (cats), protein-losing enteropathy (dogs and cats), sepsis (cats), hyperadrenocorticism (cats), liver disease (dogs), congenital portosystemic shunts (dogs and cats) and the following interventions: IV catheters (dogs and cats), arterial catheters (dogs and cats), vascular access ports (dogs and cats), extracorporeal circuits (dogs and cats) and transvenous pacemakers (dogs and cats).</p><p><strong>Results: </strong>Of the diseases evaluated in this iteration, a high risk for thrombosis was defined as heartworm disease or protein-losing enteropathy. Low risk for thrombosis was defined as dogs with liver disease, cats with immune-mediated hemolytic anemia, protein-losing nephropathy, sepsis, or hyperadrenocorticism.</p><p><strong>Conclusions: </strong>Associations with thrombosis are outlined for various conditions and interventions and provide the basis for management recommendations. Numerous knowledge gaps were identified that represent opportunities for future studies.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":"32 1","pages":"289-314"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9322658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41670204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abstracts from the International Veterinary Emergency and Critical Care Symposium, and the European Veterinary Emergency and Critical Care Annual Congress 2021.","authors":"","doi":"10.1111/vec.13104","DOIUrl":"https://doi.org/10.1111/vec.13104","url":null,"abstract":"","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":"31 S1","pages":"S2-S41"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.13104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39379026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Abstracts from the International Veterinary Emergency and Critical Care Symposium, and the European Veterinary Emergency and Critical Care Annual Congress 2020.","authors":"","doi":"10.1111/vec.12988","DOIUrl":"https://doi.org/10.1111/vec.12988","url":null,"abstract":"","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":"30 S1","pages":"S1-S34"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12988","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38335769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natashia A Evans, R. Hardie, Julie M Walker, J. Bach
{"title":"Temporary abdominal packing for management of persistent hemorrhage after liver lobectomy in three dogs with hepatic neoplasia.","authors":"Natashia A Evans, R. Hardie, Julie M Walker, J. Bach","doi":"10.1111/vec.12873","DOIUrl":"https://doi.org/10.1111/vec.12873","url":null,"abstract":"OBJECTIVE\u0000To describe the technique and outcome of temporary abdominal packing for control of persistent hemorrhage from liver lobectomy sites in 3 dogs with hepatic neoplasia.\u0000\u0000\u0000SERIES SUMMARY\u0000Three dogs were treated with massive transfusion for hemoperitoneum secondary to bleeding hepatic tumors. Surgical resection of the affected liver lobe(s) was performed but hemostasis could not be achieved through conventional methods. All 3 dogs demonstrated acidosis, hypothermia, and coagulopathy. Temporary abdominal packing of liver lobectomy sites was performed and hemostasis was achieved in all dogs. One dog died prior to removal of the packing. The other 2 dogs had the packing removed with no evidence of rebleeding. One dog was euthanized after removal of the packing due to acute kidney injury and the remaining dog survived to discharge.\u0000\u0000\u0000NEW OR UNIQUE INFORMATION PROVIDED\u0000Temporary abdominal packing combined with medical management was successful in achieving hemostasis in all 3 dogs, however, 2 dogs died of complications related to multiple organ dysfunction syndrome. Temporary abdominal packing may be considered when definitive surgical hemostasis cannot be achieved or in unstable patients not able to tolerate prolonged surgical times. Further research is needed to better define efficacy, optimal patient selection, packing technique, timing of removal, and complications associated with temporary abdominal packing.","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12873","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48194189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Hansen, Mia G Stephansen, J. Fjeldborg, G. van Galen
{"title":"Effect of standard clinical procedures on blood glucose concentration in clinically healthy horses.","authors":"S. Hansen, Mia G Stephansen, J. Fjeldborg, G. van Galen","doi":"10.1111/vec.12879","DOIUrl":"https://doi.org/10.1111/vec.12879","url":null,"abstract":"BACKGROUND\u0000Blood glucose concentrations fluctuate with stress, but little is known on how it is influenced by clinical procedures. The objective was to investigate the effect of clinical procedures on blood glucose concentration in healthy horses.\u0000\u0000\u0000MATERIALS AND METHODS\u0000Prospective, experimental study. Seven hospital-owned research horses were included in the study. A total of 4 horses were sampled either during a control sedation trial or during 3 different student workshops (prepurchase, oral, and rectal examination-the latter 2 with sedation). Blood samples were taken every 15 minutes and glucose concentration in whole blood was measured immediately with a previously validated handheld glucometer until normalization after the end of the workshops. No food was provided during sampling periods.\u0000\u0000\u0000KEY FINDINGS\u0000All measured blood glucose concentrations remained within reference interval. A significant increase in blood glucose concentration between baseline and peak was found during sedation (P = 0.005) and the oral workshop (P = 0.031). A decrease was found during prepurchase examination (P = 0.006; before exercising). Peak glucose concentration values between the sedation trial and both the oral (P = 0.065) and rectal workshop (P = 0.709) were not statistically different. Glucose measurements returned to baseline 1 hour after completion of the workshops.\u0000\u0000\u0000SIGNIFICANCE\u0000No impact of different clinical procedures on the blood glucose concentration over the effects of sedation was found. It is advisable to wait 1 hour after a procedure to measure blood for glucose concentration in horses.","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41647584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katelyn C Hlusko, Sonya C Hansen, Brad M Matz, L. Bacek, H. Boothe, J. Bellah, D. Tillson
{"title":"Description of a novel technique for surgical placement of gastrostomy tubes in dogs.","authors":"Katelyn C Hlusko, Sonya C Hansen, Brad M Matz, L. Bacek, H. Boothe, J. Bellah, D. Tillson","doi":"10.1111/vec.12884","DOIUrl":"https://doi.org/10.1111/vec.12884","url":null,"abstract":"BACKGROUND\u0000Early enteral nutrition in dogs with critical illnesses, including septic peritonitis, has been shown to have a positive influence on patient outcome. Surgical placement of a gastrostomy tube (GT) is one option for providing early enteral nutrition. Complications, including premature tube removal or separation of the stomach from the body wall, can result in leakage of gastric contents into the abdominal cavity and subsequent peritonitis. A safe and reliable technique for the placement of a GT is desirable to minimize such complications.\u0000\u0000\u0000KEY CONCEPTS\u0000A modified method for surgical placement of a GT is described. A thoracic trocar catheter (TTC) with an attached Pezzer tube is inserted through a gastrotomy incision and exited through the left gastric body and body wall. A left-sided tube gastropexy is performed using an interlocking box (ILB) pattern.\u0000\u0000\u0000SIGNIFICANCE\u0000GT placement using a TTC is efficient, requiring minimal additional anesthesia time. The gastric defect created by the TTC conforms well with the Pezzer tube. As such, placement and utilization of the ILB suture pattern enables removal of the GT in the early postoperative period, if appropriate.","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12884","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48289008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ann Marie Zollo, Ashley L Ayoob, Jennifer E Prittie, Roger D Jepson, Kenneth E Lamb, Philip R Fox
{"title":"Utility of admission lactate concentration, lactate variables, and shock index in outcome assessment in dogs diagnosed with shock.","authors":"Ann Marie Zollo, Ashley L Ayoob, Jennifer E Prittie, Roger D Jepson, Kenneth E Lamb, Philip R Fox","doi":"10.1111/vec.12868","DOIUrl":"https://doi.org/10.1111/vec.12868","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether admission venous plasma lactate concentration, calculated lactate variables, or shock index (SI) could discriminate hospital survivors from nonsurvivors in dogs admitted with shock.</p><p><strong>Design: </strong>Prospective investigation performed over a 19-month period.</p><p><strong>Setting: </strong>Large urban private teaching hospital.</p><p><strong>Animals: </strong>Twenty-three dogs consecutively admitted to the ICU from January 2008 to July 2009 with initial peripheral venous plasma lactate concentration >2 mmol/L (18.0 mg/dL) and clinical and hemodynamic parameters consistent with shock.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>Heart rate, systolic blood pressure, and venous plasma lactate concentrations were serially recorded at predefined time points and used to calculate SI (SI = heart rate/systolic blood pressure) and lactate variables, including lactime (time lactate > 2.0 mmol/L), lactate clearance ([lactate<sub>initial</sub> - lactate<sub>delayed</sub> ]/lactate<sub>initial</sub> × 100), and LAC<sub>AREA</sub> (area under the lactate concentration versus time curve). Primary outcome was survival to discharge. Overall survival rate was 61%. Admission venous plasma lactate concentration did not differ between groups (P = 0.2). Lactime was shorter in survivors versus nonsurvivors (P = 0.02). Lactate clearance at 1, 10, 16, 24, and 36 hours, and final lactate clearance were greater in survivors versus nonsurvivors (P < 0.05). LAC<sub>AREA</sub> at time intervals 0-1, 1-4, 4-10, 10-16, 16-24, 24-30, and 30-36 hours was larger in nonsurvivors versus survivors (P < 0.05). Total LAC<sub>AREA</sub> did not differ between groups (P = 0.09). Admission SI and time to normalize SI (SI < 0.9) were not different between survivors and nonsurvivors (P > 0.05).</p><p><strong>Conclusions: </strong>While admission venous plasma lactate concentration could not discriminate between hospital survivors and nonsurvivors, lactate variables showed clinical utility to predict outcome in dogs with shock. Further studies are needed to determine SI reference ranges and optimal SI cut-off values to improve its prognostic ability in sick dogs.</p>","PeriodicalId":74015,"journal":{"name":"Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)","volume":"29 5","pages":"505-513"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/vec.12868","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37408663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}