Journal of vascular diseases最新文献

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Introduction to a New Open Access Journal by MDPI: Journal of Vascular Diseases MDPI新开放获取期刊简介:血管疾病杂志

Journal of vascular diseases Pub Date : 2022-05-07 DOI: 10.3390/jvd1010001

H. Henkes

引用次数: 0

Effect of Mirogabalin on Chemotherapy-Induced Peripheral Neuropathy Caused by Gemcitabine Plus Nab-Paclitaxel Therapy in Pancreatic Cancer Patients: A Pilot Study 米罗巴林对吉西他滨联合nab -紫杉醇治疗胰腺癌患者化疗诱导的周围神经病变的影响:一项初步研究

Journal of vascular diseases Pub Date : 2021-10-11 DOI: 10.21203/rs.3.rs-948459/v1

Yusuke Takasaki, T. Fujisawa, Mako Ushio, Sho Takahashi, Wataru Yamagata, Akinori Suzuki, Koichi Ito, K. Ochiai, Ko Tomishima, Shigeto Ishi, H. Isayama

{"title":"Effect of Mirogabalin on Chemotherapy-Induced Peripheral Neuropathy Caused by Gemcitabine Plus Nab-Paclitaxel Therapy in Pancreatic Cancer Patients: A Pilot Study","authors":"Yusuke Takasaki, T. Fujisawa, Mako Ushio, Sho Takahashi, Wataru Yamagata, Akinori Suzuki, Koichi Ito, K. Ochiai, Ko Tomishima, Shigeto Ishi, H. Isayama","doi":"10.21203/rs.3.rs-948459/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-948459/v1","url":null,"abstract":"\u0000 Purpose: Gemcitabine/nab-paclitaxel (GnP) therapy is widely used to treat pancreatic cancer (PC), but chemotherapy-induced peripheral neuropathy (CIPN) is common. Mirogabalin is a novel drug for treating peripheral neuropathy. We investigated the effects of mirogabalin on CIPN due to GnP therapy in PC patients.Methods: This was a single-center retrospective pilot study. Patients who had previously received or were currently receiving GnP for PC and had taken mirogabalin for at least 2 weeks for CIPN, were included. Patients completed a questionnaire about their symptoms before and after taking mirogabalin. The primary outcome was the change in numbness and tingling scores on the patient-reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). Secondary outcomes were the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire–Chemotherapy-Induced Peripheral Neuropathy (QLQ-CIPN20) (Japanese version) score, numerical rating scale (NRS) pain score, and adverse events (AEs).Results: Increased numbness and tingling severity (1.84 vs. 1.76; P=0.63) and interference with daily life (1.42 vs. 1.44; P=0.80) were not seen in any of the 25 enrolled patients. The scores on the sensory subscale of the QLQ-CIPN improved significantly after treatment (17.5 vs. 15.7; P=0.02). AEs occurred in 22 patients (88%), but there were no serious AEs (≥ grade 3).Conclusions: Mirogabalin may control the progression of CIPN caused by GnP therapy in PC patients, and improved sensory neuropathy significantly in our patients. However, since the incidence of AEs is high, mirogabalin should be used with caution.","PeriodicalId":74009,"journal":{"name":"Journal of vascular diseases","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73273176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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