Journal of translational science最新文献

{"title":"Serum levels of gamma-glutamyl transpeptidase in relation to HCC human biology and prognosis.","authors":"B I Carr,&nbsp;H Akkiz,&nbsp;H G Bag,&nbsp;U Karaoğullarından,&nbsp;K Yalçın,&nbsp;N Ekin,&nbsp;A Özakyol,&nbsp;E Altıntaş,&nbsp;H Y Balaban,&nbsp;H Şimşek,&nbsp;A Uyanıkoğlu,&nbsp;A Balkan,&nbsp;S Kuran,&nbsp;O Üsküdar,&nbsp;Y Ülger,&nbsp;B Güney,&nbsp;A Delik","doi":"10.15761/jts.1000446","DOIUrl":"https://doi.org/10.15761/jts.1000446","url":null,"abstract":"<p><strong>Background and aim: </strong>Hepatocellular carcinoma (HCC) biomarkers are limited, as even the best studied, alpha-fetoprotein (AFP), is elevated in no more than 50% of HCC patients. The aim was to evaluate several serum liver function tests in relation to survival and tumor characteristics in a large cohort of Turkish HCC patients.</p><p><strong>Methods: </strong>We retrospectively examined the serum levels of gamma glutamyl transpeptidase (GGT) in relation to patient survival.</p><p><strong>Results: </strong>Kaplan-Meier analysis showed that only GGT and albumin amongst liver function tests, were significantly associated with survival. Survival worsened with increase in GGT levels semi-quantitatively. Increase in GGT levels was also found to significantly correlate with an increase in maximum tumor diameter from 4.5 to 7 cm, a 20-fold increase in serum alpha-fetoprotein level, an increase in tumor multifocality from 20 to 54% of patients, and a doubling in percent of patients with portal vein thrombosis (PVT) from 20 to 40%. Serum GGT levels also showed significant survival differences for patients with low AFP levels. A doublet combination of serum GGT with albumin levels was associated with higher hazard ratios in a Cox regression analysis, as compared with single parameter GGT. The combination parameter pair was also prognostically useful in the low-AFP patient subcohort and was associated with significant differences in patient tumor characteristics.</p><p><strong>Conclusions: </strong>Serum GGT levels and especially combination serum GGT plus albumin levels, were significantly associated both with HCC patient survival and tumor aggressiveness characteristics, regardless of AFP levels in a large Turkish cohort. This might be especially useful since the majority of HCC patients do not have elevated levels of AFP.</p>","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"7 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39430651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The geropathology of organ-specific aging.","authors":"Jenna Klug, Sara Christensen, Denise M Imai, Timothy A Snider, Warren Ladiges","doi":"10.15761/jts.1000458","DOIUrl":"10.15761/jts.1000458","url":null,"abstract":"<p><p>Aging is a complex multidimensional process of progressive decline affecting multiple organ systems by a number of processes that are still not well understood. While many studies have focused on the approach of studying aging across multiple organs, assessment of the contribution of individual organs to overall aging processes is under appreciated. The ability to study and compare organs in the context of organismal aging has been documented recently using a geropathology grading platform in laboratory mice. This concept consists of identifying and grading age-related histologic lesions within organs to generate a quantitative lesion score for each organ, which is representative of the presence and degree of organ-related pathology, and can be compared to scores from other organs examined. This geropathology approach provides a powerful tool to elucidate the basic mechanisms of aging in multiple organs, as well as the response of organs to therapeutic interventions. Furthermore, ongoing work with the concept has expanded and adapted the geropathology grading system to other preclinical animal model species that are commonly used to understand disease associated phenotypes in aging humans, ultimately adding to the utility of the concept.</p>","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10755956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of minocycline on microvascular complications in murine models of type 1 and type 2 diabetes.","authors":"Stephanie A Eid,&nbsp;Phillipe D O'Brien,&nbsp;Lucy M Hinder,&nbsp;John M Hayes,&nbsp;Faye E Mendelson,&nbsp;Hongyu Zhang,&nbsp;Samanthi Narayanan,&nbsp;Steven F Abcouwer,&nbsp;Frank C Brosius,&nbsp;Subramaniam Pennathur,&nbsp;Masha G Savelieff,&nbsp;Eva L Feldman","doi":"10.15761/jts.1000431","DOIUrl":"https://doi.org/10.15761/jts.1000431","url":null,"abstract":"<p><p>Diabetes is a global healthcare problem associated with enormous healthcare and personal costs. Despite glucose lowering agents that control glycaemia, both type 1 (T1D) and type (T2D) diabetes patients often develop microvascular complications that increase morbidity and mortality. Current interventions rely on careful glycemic control and healthy lifestyle choices, but these are ineffective at reversing or completely preventing the major microvascular complications, diabetic peripheral neuropathy (DPN), diabetic retinopathy (DR), and diabetic kidney disease (DKD). Minocycline, a tetracycline antibiotic with anti-inflammatory and anti-apoptotic properties, has been proposed as a protective agent in diabetes. However, there are no reported studies evaluating the therapeutic efficacy of minocycline in T1D and T2D models for all microvascular complications (DPN, DR, and DKD). Therefore, we performed metabolic profiling in streptozotocin-induced T1D and db/db T2D models and compared the efficacy of minocycline in preventing complications to that of insulin and pioglitazone in both models. Minocycline partially ameliorated DR and DKD in T1D and T2D animals, but was less effective than insulin or pioglitazone, and failed to improve DPN in either model. These results suggest that minocycline is unlikely to improve outcomes beyond that achieved with current available therapies in patients with T1D or T2D associated microvascular complications.</p>","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38886433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conducting a pre-consent process for clinical trials: Promoting a more-true informed consent","authors":"Wong Lx, Wong Jc, B. Chee, Bloom Gm, Sharma Mj, G. Liang, Park Jm","doi":"10.15761/jts.1000415","DOIUrl":"https://doi.org/10.15761/jts.1000415","url":null,"abstract":"1Department of Clinical Research and Leadership, The George Washington University, School of Medicine and Health Sciences, USA 2Department of Hematology and Oncology, Gastrointestinal Oncology, University of California, San Francisco, USA 3Department of Nursing, University of San Francisco School of Nursing and Health Professions, USA 4Department of Primary Care, Touro University College of Osteopathic Medicine – California, USA 5Department of Pulmonary, Critical Care, Allergy and Sleep Medicine, Interstitial Lung Disease, University of California, San Francisco, USA 6Department of Law, Santa Clara University School of Law, USA 7Department of Medical Education, Rush University Medical College, USA","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67492485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of stercoral perforation of colon compared with perforated colon diverticulum: A single center experience","authors":"Takahiro Murakami, Morihiro Katsura, Masafumi Ie, Takashi Kato","doi":"10.15761/jts.1000441","DOIUrl":"https://doi.org/10.15761/jts.1000441","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"165 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67493133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the global animal biodiversity in the search for new drugs - Reptiles","authors":"Dennis R.A. Mans, M. Djotaroeno, J. Pawirodihardjo, P. Friperson","doi":"10.15761/jts.1000457","DOIUrl":"https://doi.org/10.15761/jts.1000457","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The occurrence of antibody dependent enhancement (ADE) in SARS-CoV-2 infection: implications for treatment","authors":"M. Guastalegname, Laura D’argenio, A. Vallone","doi":"10.15761/jts.1000449","DOIUrl":"https://doi.org/10.15761/jts.1000449","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress in healthcare personnel involved in neonatal resuscitation – A systematic review","authors":"Styliani Paliatsiou, T. Boutsikou, T. Xanthos, Paraskevi Volak, R. Sokou, Z. Iliodromiti, N. Iacovidou","doi":"10.15761/jts.1000447","DOIUrl":"https://doi.org/10.15761/jts.1000447","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67498239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docetaxel causes lymphatic endothelial cell apoptosis and impairs lymphatic function and gene expression in vitro","authors":"Wong Am, Baik Je, H. Park, C. Li, Shi Jy, Kataru Rp, Mehrara Bj","doi":"10.15761/jts.1000402","DOIUrl":"https://doi.org/10.15761/jts.1000402","url":null,"abstract":"Introduction: Recent studies have shown that taxanes — chemotherapeutic agents commonly used for breast cancer treatment—may increase the risk of lymphedema development in breast cancer survivors. The purpose of this study was to analyze the effects of docetaxel on lymphatic endothelial cells (LEC) and define the cellular mechanisms that may account for this clinical relationship. Methods: Human dermal LECs were cultured in vitro with varying concentrations of docetaxel and LEC viability, proliferation, migration, tubule formation and lymphatic gene expression were analyzed. Results: Docetaxel, at a concentration of 100 µM, was cytotoxic to LECs resulting in impaired proliferation. At the lower concentrations (1 and 10 µM), docetaxel impaired LEC function by decreasing LEC migration and tubule formation. The expression of lymphatic markers podoplanin, LYVE1 and FLT4, but not PROX-1 were down-regulated in LECs following high concentration of docetaxel treatment (100 µM). Conclusion: High concentration of docetaxel induces LEC death and impair LEC proliferation and lymphatic gene expression. In contrast, low concentration of docetaxel significantly impairs LEC migration and tubule formation. These adverse effects of docetaxel may therefore provide a cellular mechanism underlying the clinical observation that taxane therapy increases the risk of lymphedema development in cancer patients.","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67491806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of individual placement and support (IPS) studies and results on health status of people with long-term mental disorder and competitive employment","authors":"F. R. Pulido, Nayra Caballero Estebaranz, Dácil Oramas Pérez, C. Palacín","doi":"10.15761/JTS.1000398","DOIUrl":"https://doi.org/10.15761/JTS.1000398","url":null,"abstract":"Ordinary employment, from the vulnerability-stress model, is believed to trigger relapses in people with long-term mental disorders when subjected to demanding work environments. To test the accuracy of this hypothesis, different databases between 1998 and 2019 (May) were consulted, using various key words. Randomized Clinical Trials (RCTs) that analyzed non-vocational outcomes related to symptomatology and hospitalizations in the Individual Placement and Support (IPS) strategy with severe mental disorders were specifically reviewed. A total of 383 references were reviewed, 26 were selected and 18 were included. Of the selected studies the follow-up period is between 12 months and 24 months for the most part. Samples usually range from 100-200 participants but there are studies with larger samples, one study with over 2059 participants. The most commonly used outcome is admissions and relapses, the most commonly used being days of hospitalization. The most widely used scales were on overall functioning, GAF and to measure relapse, PANNS and BPRS. Competitive employment was found not to cause relapses or hospitalisations, and long-term employment seemed to contribute to a favourable clinical evolution, although the degree of impact on the health status has yet to be proven.","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67492046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}