Journal of translational science最新文献

{"title":"Bell’s palsy and lip HSV-1 infection: importance of subcutaneous access","authors":"M. Boukhvalova, Emma Mortensen, Diego Lopez, B. Herold, J. Blanco","doi":"10.15761/jts.1000473","DOIUrl":"https://doi.org/10.15761/jts.1000473","url":null,"abstract":"Although HSV-1 has been implicated in facial palsy for a long time, testing and treating for HSV is not routine. The lack of a meaningful demonstration of how HSV-1 would cause facial palsy has limited progress in this field. Herein we demonstrate that the depth of the lip HSV-1 infection defines the course of the disease, with deeper subcutaneous infection allowing virus access to the facial nerve and causing facial palsy. HSV-1 inoculated subcutaneously caused extensive facial paralysis in cotton rats Sigmodon hispidus, while virus inoculated in the same area of the lip by skin surface abrasion did not. Demyelination along the facial nerve (CN VII) accompanied subcutaneous HSV-1 infection and was identified as the possible underlying mechanism of the disease. This causality demonstration is particularly important in light of increased facial palsy outbreaks associated with SARS-CoV-2 infection and SARS-CoV-2 and influenza vaccinations.","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43499714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical research reactivation during the COVID-19 pandemic: An academic center process and lessons for the future.","authors":"Jennifer Armstrong,&nbsp;Alison Lakin,&nbsp;Laurie Blumberg-Romero,&nbsp;Thomas Campbell,&nbsp;John Heldens,&nbsp;Christopher Lieu,&nbsp;Jenae Neiman,&nbsp;Erin Sandene,&nbsp;Matthew Steinbeiss,&nbsp;Darcy Thompson,&nbsp;Jason Tregellas,&nbsp;Thomas Flaig,&nbsp;Janine Higgins","doi":"10.15761/jts.1000468","DOIUrl":"https://doi.org/10.15761/jts.1000468","url":null,"abstract":"<p><strong>Background: </strong>Clinical research is a central mission of the University of Colorado Anschutz Medical Campus (CU-Anschutz). On March 18, 2020, due to rising COVID-19 rates and personal protective equipment (PPE) shortages, an emergency approval process for critical research essential to the care and safety of patients, including COVID-19 trials, was enacted. All other clinical research studies requiring face-to-face visits were placed on hold to protect participant and staff safety.</p><p><strong>Methods: </strong>A clinical research TaskForce was rapidly assembled, consisting of a cross- section of campus clinical research operations leaders, including affiliate hospitals. This group developed a guidance document and process where the primary prioritization factor was positive therapeutic benefit/risk (Groups 2-5). A REDCap form demarcating items including research visit types and safety plans was designed. A separate Space Plan Committee approval was required to gauge environmental health and safety.</p><p><strong>Results: </strong>A total of 654 protocols were approved over 31 weeks using this process. Group 2 review and approvals occurred within 5 days of campus reactivation, and 65 days after original clinical research hold. Groups 3 through 5 were opened for submission and review in a phased approach. The majority proactively submitted IRB protocol amendments to minimize face-to-face participant/staff contact. There were no cases of COVID-19 outbreak in research participants.</p><p><strong>Conclusion: </strong>Clinical research reactivation was rapidly implemented in a transparent, collaborative, broadly supported, and efficient process of staged reactivation while prioritizing the health and safety of participants and staff at CU-Anschutz. This model is practical and easily generalizable to other medical research campuses.</p>","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9399666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"StemSpine™ : Autologous paraspinal administration of bone marrow aspirate for treatment of lower back pain caused by lumbar angina","authors":"Javier E Paino, Nicole Tuma, Thomas E Ichim, Courtney E Bartlett, Jorge Tuma","doi":"10.15761/jts.1000474","DOIUrl":"https://doi.org/10.15761/jts.1000474","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bell's palsy and lip HSV-1 infection: importance of subcutaneous access.","authors":"Marina S Boukhvalova,&nbsp;Emma Mortensen,&nbsp;Diego Lopez,&nbsp;Betsy C Herold,&nbsp;Jorge Cg Blanco","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Although HSV-1 has been implicated in facial palsy for a long time, testing and treating for HSV is not routine. The lack of a meaningful demonstration of how HSV-1 would cause facial palsy has limited progress in this field. Herein we demonstrate that the depth of the lip HSV-1 infection defines the course of the disease, with deeper subcutaneous infection allowing virus access to the facial nerve and causing facial palsy. HSV-1 inoculated subcutaneously caused extensive facial paralysis in cotton rats <i>Sigmodon hispidus</i>, while virus inoculated in the same area of the lip by skin surface abrasion did not. Demyelination along the facial nerve (CN VII) accompanied subcutaneous HSV-1 infection and was identified as the possible underlying mechanism of the disease. This causality demonstration is particularly important in light of increased facial palsy outbreaks associated with SARS-CoV-2 infection and SARS-CoV-2 and influenza vaccinations.</p>","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9631455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40670023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of the anti-ageing efficacy and tolerance of nuceutical skinergy collagen shot® in Asian female adults: A preliminary study","authors":"Soh Karen, Khaiat Alain","doi":"10.15761/jts.1000471","DOIUrl":"https://doi.org/10.15761/jts.1000471","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dabrafenib plus trametinib in elderly patients (>75 years) with BRAF V600E mutated metastatic non-small-cell lung cancer: A multicenter retrospective experience from real-life","authors":"M. P, Marinis F, Romano G, Spitaleri G, G. D., Morabito A, Rocco D, T. M, Vitiello F, P. G, M. M, Gridelli C","doi":"10.15761/jts.1000472","DOIUrl":"https://doi.org/10.15761/jts.1000472","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes towards clinical trial participation among people living with chronic hepatitis B","authors":"Y. Ibrahim, C. Cohen, R. Araojo, Christine Merenda, Sarah Dykstra, Christine Lee","doi":"10.15761/jts.1000467","DOIUrl":"https://doi.org/10.15761/jts.1000467","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How smell regulates metabolism: The role of ectopically expressed olfactory receptors in lipid and glucose homeostasis","authors":"Ginevra Urbani, E. Distrutti, Michele Biagioli, S. Marchianò, S. Fiorucci","doi":"10.15761/jts.1000470","DOIUrl":"https://doi.org/10.15761/jts.1000470","url":null,"abstract":"","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67499276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain nutrients: Cerebral metabolism and micronutrients","authors":"U. Gröber, M. Holick, K. Kisters","doi":"10.15761/jts.1000399","DOIUrl":"https://doi.org/10.15761/jts.1000399","url":null,"abstract":"Optimal cognitive capacity is vital throughout all stages of life. Most notably a healthy nutrition in childhood and adolescence is crucial for brain development and cognitive performance. Micronutrients are an essential component of several general cellular functions as well as of functions to neurologic activity such as the synthesis of dopamine, serotonin, and myelin formation. An adequate dietary supply with brain active micronutrients, such as vitamins, minerals and omega-3 long-chain polyunsaturated fatty acids is therefore in school children of essential significance. The possibilities and limitations to boost the cognitive capacity of children for the purpose of a “brain doping” will be discussed. ISSN: 2639-4391","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45938898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma lipids, tumor parameters and survival in HCC patients with HBV and HCV.","authors":"H Akkiz, B I Carr, V Guerra, R Donghia, K Yalçın, U Karaoğullarından, E Altıntaş, A Özakyol, H Şimşek, H Y Balaban, A Balkan, A Uyanıkoğlu, N Ekin, A Delik","doi":"10.15761/jts.1000421","DOIUrl":"10.15761/jts.1000421","url":null,"abstract":"<p><strong>Introduction and aims: </strong>Hepatocellular carcinoma (HCC) is a consequence of chronic liver disease, particularly from hepatitis B or C and increasingly from obesity and metabolic syndrome. Since lipids are an important component of cell membranes and are involved in cell signaling and tumor cell growth, we wished to evaluate the relationship between HCC patient plasma lipids and maximum tumor diameter and other indices of HCC human biology.</p><p><strong>Methods: </strong>We examined prospectively-collected data from a multi-institutional collaborative Turkish HCC working group, from predominantly HBV-based patients, for plasma lipid profiles, consisting of triglycerides, total cholesterol, LDL-cholesterol (LDL) and HDL-cholesterol (HDL) and compared these with the associated patient maximum tumor diameter (MTD), portal vein thrombosis, alpha-fetoprotein (AFP) and also with patient survival.</p><p><strong>Results: </strong>We found that both low HDL (p=0.0002) and high LDL (p=0.003) levels were significantly associated with increased MTD, as well as in a final multiple linear regression model on MTD. The combination of low HDL combined with high HDL levels were significant in a regression model on MTD, PVT and an HCC Aggressiveness Index (Odds Ratio 12.91 compared to an Odds Ratio of 1 for the reference). Furthermore, in a Cox regression model on death, the HDL plus LDL combination had a significantly higher Hazard Ratio than the reference category.</p><p><strong>Conclusions: </strong>Low plasma HDL, high plasma LDL and especially the combination, were significantly related to more aggressive HCC phenotype and the combination was significantly related to a higher Hazard Ratio for death.</p>","PeriodicalId":74000,"journal":{"name":"Journal of translational science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39364769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}