Journal of surgery and research最新文献_第2页

Modulation of Inflammatory Response by Electromagnetic Field Stimulation in Traumatic Brain Injury in Yucatan Swine. 电磁场刺激对尤卡坦猪脑外伤炎症反应的调节作用

Journal of surgery and research Pub Date : 2024-01-01 Epub Date: 2024-01-31 DOI: 10.26502/jsr.10020338

Yssel Mendoza-Mari, Vikrant Rai, Mohamed M Radwan, James Brazdzionis, David A Connett, Dan E Miulli, Devendra K Agrawal

{"title":"Modulation of Inflammatory Response by Electromagnetic Field Stimulation in Traumatic Brain Injury in Yucatan Swine.","authors":"Yssel Mendoza-Mari, Vikrant Rai, Mohamed M Radwan, James Brazdzionis, David A Connett, Dan E Miulli, Devendra K Agrawal","doi":"10.26502/jsr.10020338","DOIUrl":"10.26502/jsr.10020338","url":null,"abstract":"Traumatic brain injury is a leading cause of disability and death worldwide and represents a high economic burden for families and national health systems. After mechanical impact to the head, the first stage of the damage comprising edema, physical damage, and cell loss gives rise to a second phase characterized by glial activation, increased oxidative stress and excitotoxicity, mitochondrial damage, and exacerbated neuroinflammatory state, among other molecular calamities. Inflammation strongly influences the molecular events involved in the pathogenesis of TBI. Therefore, several components of the inflammatory cascade have been targeted in experimental therapies. Application of Electromagnetic Field (EMF) stimulation has been found to be effective in some inflammatory conditions. However, its effect in the neuronal recovery after TBI is not known. In this pilot study, Yucatan miniswine were subjected to TBI using controlled cortical impact approach. EMF stimulation via a helmet was applied immediately or two days after mechanical impact. Three weeks later, inflammatory markers were assessed in the brain tissues of injured and contralateral non-injured areas of control and EMF-treated animals by histomorphometry, immunohistochemistry, RT-qPCR, Western blot, and ELISA. Our results revealed that EMF stimulation induced beneficial effect with the preservation of neuronal tissue morphology as well as the reduction of inflammatory markers at the transcriptional and translational levels. Immediate EMF application showed better resolution of inflammation. Although further studies are warranted, our findings contribute to the notion that EMF stimulation could be an effective therapeutic approach in TBI patients.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"7 1","pages":"20-40"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10883333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical Assessment of the Neurological Complications during High-Risk Anesthesia Procedures. 高风险麻醉过程中神经并发症的关键评估。

Journal of surgery and research Pub Date : 2024-01-01 Epub Date: 2024-06-06

Fihr Chaudhary, Zubair Ahmed, Devendra K Agrawal

{"title":"Critical Assessment of the Neurological Complications during High-Risk Anesthesia Procedures.","authors":"Fihr Chaudhary, Zubair Ahmed, Devendra K Agrawal","doi":"","DOIUrl":"","url":null,"abstract":"Damage to the peripheral and central nervous systems is frequently irreversible. Surgically induced neurological damage and anesthesia may result in catastrophic situations for patients and their families. The incidence of significant neurological complications during the perioperative period is examined in this article. In contrast to other organs like the kidney, heart, liver, lungs, and skeletal system, native neurological function cannot be replaced with artificial parts or devices soon. Ignoring brain function during the perioperative period has been a systemic problem in anesthesiology, even though the central and peripheral nervous systems are crucial. This bold claim is intended to draw attention to the fact that, unlike the circulatory and respiratory systems, which have been routinely monitored for decades, the brain and other neural structures do not have a standard monitoring during surgery and anesthesia. Given that the brain and spinal cord are the principal therapeutic targets of analgesics and anesthetics, this deficiency in clinical care is even more alarming. Organs that are notoriously hard to repair or replace after damage have, up until now, received comparatively little attention. In this article, a succinct overview of five neurological complications associated with surgery and anesthesia is presented. After critically reviewing the literature on the subject, the article is focused to common (delirium), controversial (postoperative cognitive decline), and potentially catastrophic (stroke, spinal cord ischemia, or postoperative visual loss) adverse events in the neurological surgery setting. The findings will increase awareness of major neurological complications to the involved surgical and anesthesia team and enhance preventive and treatment strategies during the perioperative period.","PeriodicalId":73961,"journal":{"name":"Journal of surgery and research","volume":"7 2","pages":"250-266"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141473276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncoplastic Breast Conservation made Possible with Precision Marker for Expansive Disease - A Case Study 扩张性疾病的精确标记使肿瘤乳房保护成为可能-一个案例研究

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020280

Sonia Y Khan, K. Daniele, Casey Cook, Rakhshanda Layeequr Rahman

引用次数: 0

Cardiothoracic Surgery Training: An Honest and Anonymous Assessment of the Trainee Experience 心胸外科训练:学员经验的诚实和匿名评估

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020275

Fatima G Wilder, Jason J. Han, William G Cohen, C. Louis, J. Mehaffey, A. Brescia, D. Blitzer, Jessica GY Luc, G. Coyan, Jordan P. Bloom, M. Cevasco, Ahmet Kilic

引用次数: 0

The Efficacy and Patient Satisfaction with a Mini-Scleral Lens after penetrating Keratoplasty 穿透性角膜移植术后微型巩膜晶状体的疗效及患者满意度

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020291

C. Peris-Martínez, Magdalena Catalán-Gómez, Esteban Porcar-Izquierdo, J. C. Montalt-Rodrigo, M. J. Roig-Revert

引用次数: 0

Designing a Resident Led Otolaryngology Clinic at a Community Health Center: An Initial Experience 在社区卫生中心设计一个居民主导的耳鼻喉科诊所:初步经验

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020309

E. Frank, Christopher D Vuong, Nathan H Lee, Shannon O Calaguas, K. Nguyen, P. Krishna, Daniel I Kwon

引用次数: 0

Left Atrial Dissection During Percutaneous Coronary Intervention: Case Report and Review of Literature 经皮冠状动脉介入治疗中左房夹层的病例报告及文献复习

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020273

Sanjeev Vaderah, Rishi Parmar, Nainika Vaderah, Alex Parrish, S. Gafoor

引用次数: 0

Overall Survival of Hepatocellular Carcinoma Patients with Associated Diabetes Mellitus - A New Possible Prognostic Score 肝细胞癌合并糖尿病患者的总生存率——一种新的可能的预后评分方法

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020277

M. A., De Giorgio M, Piccin A, Ferro F, Vittadello F, Marzi L, Pelizzaro F, Spizzo G, F. A., Di Vasto M, Seeber A.

引用次数: 0

A Rare Case of ACEi-associated Angioedema of the Small Bowel 一例罕见的乙酰胆碱相关性小肠血管性水肿

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020282

B. Ladna, V. Rodriguez, Naueen A Chaudhry, A. Pham

引用次数: 1

A study on significant prognostic factors in patients with stage IB Gastric Cancer IB期胃癌患者预后影响因素的研究

Journal of surgery and research Pub Date : 2023-01-01 DOI: 10.26502/jsr.10020319

Keishiro Aoyagi, Yu Tanaka, Hideaki Kaku, Yuya Tanaka, Taro Isobe, Naotaka Murakami, Seiya Ishibashi, Fumihiko Fujita

引用次数: 0