Journal of substance abuse最新文献

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Childhood emotional abuse and depression: The mediating roles of emotion regulation and resilience 儿童情绪虐待与抑郁:情绪调节和心理弹性的中介作用
Journal of substance abuse Pub Date : 2023-10-06 DOI: 10.37576/abuse.2023.050
Megan Houghton, Leah Greenwood
{"title":"Childhood emotional abuse and depression: The mediating roles of emotion regulation and resilience","authors":"Megan Houghton, Leah Greenwood","doi":"10.37576/abuse.2023.050","DOIUrl":"https://doi.org/10.37576/abuse.2023.050","url":null,"abstract":"Childhood adverse experiences are associated with an increased susceptibility to low psychopathology. Childhood emotional abuse (CEA) is a widespread adversity, known to be associated with depression. Yet, the underlying mechanisms contributing to the relationship remain unclear. The present study aimed to explore the association between CEA and depression and identify potential mediating factors, focusing specifically on emotion regulation and resilience. Participants (N = 110) completed an online survey assessing experiences of CEA, depression levels, emotional regulation strategies, and resilience levels. A mediation analysis found that CEA has a direct influence on the onset of depression. Interestingly, only the expressive suppression emotional regulation strategy and resilience were found to mediate the relationship between CEA and depression. Cognitive reappraisal was not a mediator. The results add to the growing literature emphasising the association between CEA and depression. The implications for clinicians would be to explore the emotional regulation strategies and resilience in clients with known CEA. In the future, when assessing the outcome of CEA, it is critical to consider all aspects of the effects of CEA. Rather than primarily focusing on the presence of depression, clinicians should consider the fact that CEA often hinders one’s social, cognitive, and emotional development.","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135303638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
‘You never cared about me’: An analysis of ethnic minority men’s coping mechanisms and risk factors after a relationship breakdown “你从来没有关心过我”:一项对少数民族男性在关系破裂后的应对机制和风险因素的分析
Journal of substance abuse Pub Date : 2023-10-06 DOI: 10.37576/abuse.2023.052
Jevon Blackman, Faisal Satti
{"title":"‘You never cared about me’: An analysis of ethnic minority men’s coping mechanisms and risk factors after a relationship breakdown","authors":"Jevon Blackman, Faisal Satti","doi":"10.37576/abuse.2023.052","DOIUrl":"https://doi.org/10.37576/abuse.2023.052","url":null,"abstract":"Relationship breakdown is one of the most traumatic and stressful life events that an individual can experience. This study aims to analyse the impact of relationship breakdown on ethnic minority men, focusing on their coping strategies and risk factors. Despite common misconceptions, ethnic minority men often experience significant emotional distress following relationship breakdown. However, there is limited research in this area. This study uses a correlation and regression analysis to identify the relationship between ethnic background and perceived social support, emotional distress, emotional approach and rebound relationships, and if ethnic background is a predictor for these variables. The study also assessed the effectiveness of rebound relationships, as coping mechanisms. A questionnaire was administered to 141 participants, revealing a significant negative correlation between ethnic background and perceived social support. The regression analysis showed that ethnic background had a minimal and statistically insignificant impact on the variables studied. Additionally, 66% of participants had never engaged in rebound relationships. Overall, this research highlights that ethnic minority men tend to receive less social support after a relationship breakdown, and rebound relationships are not effective coping mechanisms. Results are considered further in relation to their application to the quality of relationships, including those that may have ‘toxic’ components (e.g., abuse).","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135303949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From night owl to angry bird: Investigating the association between chronotype and aggression 从夜猫子到愤怒的小鸟:调查睡眠类型和攻击性之间的关系
Journal of substance abuse Pub Date : 2023-10-06 DOI: 10.37576/abuse.2023.051
Leah Greenwood, Niamh Tattersall
{"title":"From night owl to angry bird: Investigating the association between chronotype and aggression","authors":"Leah Greenwood, Niamh Tattersall","doi":"10.37576/abuse.2023.051","DOIUrl":"https://doi.org/10.37576/abuse.2023.051","url":null,"abstract":"Recent attempts to understand the sleep-aggression relationship highlight the importance of the role of cognition. A related but separate concept of sleep, chronotype (i.e., sleep timings) has also been suggested to contribute to levels of aggression. The current study explores the relationship between chronotype, sleep quality, hostility, aggression, and intimate partner violence (IPV). Two hundred and eight participants completed online questionnaires to explore the contribution of hostility and sleep quality as mediators of the chronotype-aggression relationship. Findings indicate that chronotype was associated with levels of aggression, with those with later chronotypes reporting higher levels of aggression. Two mediation models revealed that this relationship was mediated by hostile cognitions (i.e., hostile attribution biases), and partially mediated by sleep quality. The chronotype-IPV relationship was explored, but the association was not significant. Findings indicate that those with late chronotypes may be more susceptible to hostile cognitions which leads to aggressive outcomes. However, there may be additional factors contributing to this relationship when considering violence in relationships. Aggression-focused interventions may benefit from dissecting an individual’s sleep patterns to reduce hostile cognitions and future research would benefit from objective measures of both chronotype and aggression.","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135303741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rural–urban differences in the distribution of parent-reported risk factors for substance use among young adolescents 青少年中父母报告的物质使用危险因素分布的城乡差异
Journal of substance abuse Pub Date : 2001-12-01 DOI: 10.1016/S0899-3289(01)00091-8
Richard Spoth, Catherine Goldberg, Tricia Neppl, Linda Trudeau, Suhasini Ramisetty-Mikler
{"title":"Rural–urban differences in the distribution of parent-reported risk factors for substance use among young adolescents","authors":"Richard Spoth,&nbsp;Catherine Goldberg,&nbsp;Tricia Neppl,&nbsp;Linda Trudeau,&nbsp;Suhasini Ramisetty-Mikler","doi":"10.1016/S0899-3289(01)00091-8","DOIUrl":"10.1016/S0899-3289(01)00091-8","url":null,"abstract":"<div><p><strong>Purpose:</strong> We examined rural–urban differences in cumulative risk for youth substance use. A recent report [National Center on Addiction and Substance Abuse (CASA) 2000] found that the rural–urban distribution of substance use and known risk factors for substance use differed; in many cases rural youth showed higher levels of use, as well as higher levels of risk factors. The current investigation, while not directly examining substance use, further examined rural–urban differences in the distribution of risk factors for youth substance use, based on information from parent reports. <strong>Method:</strong> Study 1 data were collected from a random sample of Midwestern parents (<em>n</em>=339) with a young adolescent between the ages of 11 and 13 years. Study 2 data were collected from a second sample of Midwestern parents (<em>n</em>=593). <strong>Results:</strong> Analyses of rural–urban comparisons demonstrated higher levels of cumulative risk among rural youth. An evaluation of the sensitivity of the analysis to rural–urban classification schemes indicated that the findings were robust, but that there was some minor variation in rural–urban differences by classification scheme. <strong>Implications:</strong> Results contribute to an explanation of findings from earlier reports of rural–urban differences in substance use, and suggest directions for future research on rural–urban distributions of youth risk factors.</p></div>","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0899-3289(01)00091-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56360262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Tobacco smoking in marijuana-dependent outpatients 大麻依赖门诊病人的吸烟情况
Journal of substance abuse Pub Date : 2001-12-01 DOI: 10.1016/S0899-3289(01)00093-1
Brent A. Moore , Alan J. Budney
{"title":"Tobacco smoking in marijuana-dependent outpatients","authors":"Brent A. Moore ,&nbsp;Alan J. Budney","doi":"10.1016/S0899-3289(01)00093-1","DOIUrl":"10.1016/S0899-3289(01)00093-1","url":null,"abstract":"<div><p><strong>Purpose:</strong> Among marijuana-dependent individuals, approximately 50% smoke tobacco. These individuals are exposed to increased risks of respiratory and other health problems. The current study examined whether tobacco smoking among marijuana-dependent individuals is also associated with increased psychosocial and substance abuse problems. <strong>Methods:</strong> Marijuana-dependent individuals (<em>N</em><span>=174) seeking treatment for marijuana problems completed a 2–3 h assessment. Current tobacco smokers were compared to ex-smokers and never smokers on demographic, psychosocial, and substance use characteristics, and treatment outcome. In addition to univariate comparisons, multivariate analyses using multinomial logistic regression were conducted to control for the correlated nature of the predictor variables. </span><strong>Results:</strong> Current tobacco smokers earned less income and reported histories of more alcohol problems than never smokers and had fewer years of education, more legal problems, more psychiatric symptoms, and an earlier age of marijuana initiation than ex- and never smokers. Over the course of treatment, current tobacco smokers had significantly fewer marijuana-negative urine specimens and fewer weeks of continuous marijuana abstinence than ex-smokers. <strong>Implications:</strong><span> Current tobacco smokers appear to represent a subgroup of marijuana-dependent individuals who have increased psychosocial problems compared to ex- and never smokers and may not respond as well to treatment than ex-smokers.</span></p></div>","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0899-3289(01)00093-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56360349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 70
Sexual assault and alcohol abuse: A comparison of lesbians and heterosexual women 性侵犯和酗酒:女同性恋和异性恋女性的比较
Journal of substance abuse Pub Date : 2001-12-01 DOI: 10.1016/S0899-3289(01)00095-5
Tonda L Hughes , Timothy Johnson , Sharon C Wilsnack
{"title":"Sexual assault and alcohol abuse: A comparison of lesbians and heterosexual women","authors":"Tonda L Hughes ,&nbsp;Timothy Johnson ,&nbsp;Sharon C Wilsnack","doi":"10.1016/S0899-3289(01)00095-5","DOIUrl":"10.1016/S0899-3289(01)00095-5","url":null,"abstract":"<div><p><strong>Purpose:</strong> To compare and contrast lesbians' and heterosexual women's experiences of sexual assault and to investigate relationships between sexual assault and alcohol abuse. <strong>Methods:</strong> In-depth interviews were conducted with 63 lesbians and a demographically matched comparison group of 57 heterosexual women. Lesbians' and heterosexual women's experiences of sexual assault, drinking levels, and alcohol-abuse indicators were compared using descriptive statistics. LISREL analysis was used to test the effects of sexual assault on a latent measure of alcohol abuse. <strong>Results:</strong> Lesbians reported more childhood sexual experiences, were more likely to meet the study definition for childhood sexual abuse (CSA), and were more likely to perceive themselves as having been sexually abused as children. CSA was associated with lifetime alcohol abuse in both lesbian and heterosexual women. However, adult sexual assault (ASA) was associated with alcohol abuse only in heterosexual women. <strong>Implications:</strong><span> Sexual assault is a common experience among both lesbians and heterosexual women. Findings emphasize the importance of asking about sexual assault in health histories, and assessing clients for substance abuse and other sequelae of sexual assault.</span></p></div>","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0899-3289(01)00095-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56360452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 136
Cigar risk perceptions in focus groups of urban African American youth 城市非裔美国青年焦点群体的雪茄风险认知
Journal of substance abuse Pub Date : 2001-12-01 DOI: 10.1016/S0899-3289(01)00092-X
Ruth E. Malone , Valerie Yerger , Charles Pearson
{"title":"Cigar risk perceptions in focus groups of urban African American youth","authors":"Ruth E. Malone ,&nbsp;Valerie Yerger ,&nbsp;Charles Pearson","doi":"10.1016/S0899-3289(01)00092-X","DOIUrl":"10.1016/S0899-3289(01)00092-X","url":null,"abstract":"<div><p><strong>Purpose:</strong> To explore cigar use perceptions among urban African American youth. <strong>Methods:</strong> A convenience sample (<em>n</em>=50) of African American volunteer participants, ages 14–18, participated in six audiotaped focus groups conducted in two California cities. Transcriptions were analyzed using iterative strategies. <strong>Results:</strong> Most youth believed cigars were harmful to health, yet a disjuncture existed between this abstract belief and the socially embedded understandings revealed in discussions. Some youth felt that cigars were more “natural” and therefore less harmful than cigarettes. For some, that understanding rested on a mistaken assumption that nicotine was an artificial additive not present in cigars. Youth had received little cigar-specific health education. They reported that cigars were easily obtained, noted cigars' social cachet, and drew attention to new brands targeting youth. <strong>Implications:</strong> Perceptions of risk are not merely interesting “subjective” findings but are important determinants of actual use patterns and may not correlate with abstract beliefs. Recent cigarette brand repositionings, such as Winston's “no additives” campaign, have widely publicized the many substances added to cigarettes. Some youth may take lack of cigar-specific preventive education as an indication that cigars do not contain such substances, including nicotine. Misperceptions about risks of cigar and cigar/marijuana smoking must be addressed through consistent, coordinated, and comprehensive tobacco control efforts for all tobacco products.</p></div>","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0899-3289(01)00092-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56360282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 77
What is the role of impression management in adolescent cigarette smoking? 印象管理在青少年吸烟中的作用是什么?
Journal of substance abuse Pub Date : 2001-12-01 DOI: 10.1016/S0899-3289(01)00089-X
Frances O'Callaghan, Justin Doyle
{"title":"What is the role of impression management in adolescent cigarette smoking?","authors":"Frances O'Callaghan,&nbsp;Justin Doyle","doi":"10.1016/S0899-3289(01)00089-X","DOIUrl":"10.1016/S0899-3289(01)00089-X","url":null,"abstract":"<div><p><strong>Purpose:</strong> This study examined the role of impression management in cigarette smoking by linking the constructs of self-monitoring, perceived success in impression management, self-esteem and social anxiety among nonsmokers (NS), occasional smokers (OS), and frequent smokers (FS). <strong>Methods:</strong> High school students (<em>N</em><span>=243) in years 8–12 completed a questionnaire assessing the abovementioned variables. Multivariate discriminant function analysis and a priori contrasts were used to analyze the data. </span><strong>Results:</strong> In comparison to OS, FS and NS had the lowest levels of self-monitoring, perceived success in impression management and self-esteem, while having the highest levels of social anxiety. <strong>Implications:</strong> Cigarette use may serve an impression management function during adolescence and subsequently influences OS' level of smoking. Intervention programs need to give greater consideration to providing adolescents with alternative strategies for both social acceptance and the acquisition and maintenance of self-esteem.</p></div>","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0899-3289(01)00089-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56360209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Change in psychosocial functioning and social relations among women in residential substance abuse treatment 住院药物滥用治疗妇女的心理社会功能和社会关系的变化
Journal of substance abuse Pub Date : 2001-12-01 DOI: 10.1016/S0899-3289(01)00087-6
Danica Kalling Knight , Gail L Wallace , George W Joe , Sarah M Logan
{"title":"Change in psychosocial functioning and social relations among women in residential substance abuse treatment","authors":"Danica Kalling Knight ,&nbsp;Gail L Wallace ,&nbsp;George W Joe ,&nbsp;Sarah M Logan","doi":"10.1016/S0899-3289(01)00087-6","DOIUrl":"10.1016/S0899-3289(01)00087-6","url":null,"abstract":"<div><p><strong>Purpose:</strong> The purpose of this study was to examine the degree to which psychosocial functioning and social relationships changed during the first 3 months of treatment among women in a residential substance abuse program that emphasizes the importance of developing healthy relationships. <strong>Methods:</strong> Participants included 77 female clients admitted to the Salvation Army First Choice (FC) Program in Fort Worth, TX. Assessments of psychological functioning, family relations, and peer relations were administered at treatment entry and again after 3 months. Relationships with clients in treatment and friends outside treatment were measured separately. <strong>Results:</strong> Repeated-measures analyses of variance (ANOVA) indicated that interpersonal relationships improved. Family networks increased, family cohesion increased, and family conflict decreased. Peer networks changed as well, due in part to new relationships with other clients in treatment. The number of drug-using friends decreased, peer deviance and negative influence decreased, and social conformity among friends increased. There was a corresponding improvement in psychosocial functioning. <strong>Implications:</strong> Results suggested that relationship-centered treatment for women was effective. Clients reestablished connections with family members, disassociated from drug-using peers, and improved the quality of relationships with family members and friends. Further research is needed in order to examine the influence of specific treatment components and the potential long-term effects of changes in women's relationships.</p></div>","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0899-3289(01)00087-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56360140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Experimentally induced aggressive behavior in subjects with 3,4-methylenedioxy-methamphetamine (“Ecstasy”) use history 3,4-亚甲基二氧基甲基苯丙胺(“摇头丸”)使用史受试者的实验诱导攻击行为
Journal of substance abuse Pub Date : 2001-12-01 DOI: 10.1016/S0899-3289(01)00094-3
Gilberto Gerra , Amir Zaimovic , Roberta Ampollini , Francesca Giusti , Roberto Delsignore , Maria Augusta Raggi , Gianni Laviola , Teodora Macchia , Francesca Brambilla
{"title":"Experimentally induced aggressive behavior in subjects with 3,4-methylenedioxy-methamphetamine (“Ecstasy”) use history","authors":"Gilberto Gerra ,&nbsp;Amir Zaimovic ,&nbsp;Roberta Ampollini ,&nbsp;Francesca Giusti ,&nbsp;Roberto Delsignore ,&nbsp;Maria Augusta Raggi ,&nbsp;Gianni Laviola ,&nbsp;Teodora Macchia ,&nbsp;Francesca Brambilla","doi":"10.1016/S0899-3289(01)00094-3","DOIUrl":"10.1016/S0899-3289(01)00094-3","url":null,"abstract":"<div><p><strong>Purpose:</strong> Objective measures of experimentally induced aggressiveness were evaluated in 12 male 3,4-methylenedioxy-methamphetamine (MDMA, “Ecstasy”) users, in comparison with 20 healthy male subjects. <strong>Methods:</strong> All the subjects were preliminarily submitted to DSM-IV interviews and Buss–Durkee Hostility Inventory (BDHI). During a laboratory task, the Point Subtraction Aggression Paradigm (PSAP), subjects earned monetary reinforcers with repeated button presses, and were provoked by the subtraction of money that was attributed to a fictitious other participant. Subjects could respond by ostensibly subtracting money from the fictitious subject (the aggressive response). Escape responses were also possible protecting the counter from monetary subtractions. <strong>Results:</strong> Money-earning responses were not different in Ecstasy users and controls; aggressive responses were significantly higher in Ecstasy users in comparison with control subjects (<em>F</em>=20.74, <em>P</em><span>&lt;.001). Baseline adrenocorticotropic hormone<span><span><span> (ACTH) and cortisol (CORT) levels were higher in Ecstasy users than in controls. No difference was found in </span>norepinephrine (NE) and epinephrine (EPI) basal levels of the two groups. During the experimentally induced aggressiveness, plasma ACTH concentrations increased significantly less and NE and EPI levels, together with heart rate (HR), increased significantly more in Ecstasy users than in healthy subjects. Despite ACTH-blunted responses, CORT did not increase differently from controls in Ecstasy users. PSAP aggressive responses positively correlated with </span>catecholamines and CORT changes, BDHI Direct Aggression and Irritability scores, both in Ecstasy users and controls. A significant correlation was found between Ecstasy exposure extent and aggressive responses (</span></span><em>r</em>=.78, <em>P</em>&lt;.001). <strong>Implications:</strong><span><span> Our findings suggest that Ecstasy users have higher outward-directed aggressiveness than healthy subjects. Aggressiveness in MDMA subjects seems to be associated more with MDMA pharmacological effects than with personality traits: Nevertheless, a premorbid psychobiological proneness to aggressive behavior cannot be excluded. Increased catecholamines reactivity, basal hypothalamus–pituitary–adrenal (HPA) axis hyperactivity, and blunted ACTH responses could be due to MDMA action on monoaminergic pathways and </span>adrenal function.</span></p></div>","PeriodicalId":73959,"journal":{"name":"Journal of substance abuse","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2001-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0899-3289(01)00094-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56360416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
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