Accident Analysis & Prevention最新文献

Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes 百里香、芹菜和盐霉素对妊娠巴尔基母羊抗氧化能力和产奶量相关神经递质的影响

Accident Analysis & Prevention Pub Date : 2021-05-31 DOI: 10.11648/J.AAP.20210601.14

S. Eid, O. Ahmed-Farid, H. M. El-Zaher, M. Shabaan

{"title":"Thyme, Celery and Salinomycin Implication on Antioxidant Capacity and Neurotransmitters Related to Milk Production in Pregnant Barki Ewes","authors":"S. Eid, O. Ahmed-Farid, H. M. El-Zaher, M. Shabaan","doi":"10.11648/J.AAP.20210601.14","DOIUrl":"https://doi.org/10.11648/J.AAP.20210601.14","url":null,"abstract":"The experiment goal was the investigation of thyme (T), celery (C) and salinomycin effects on immune response, neurotransmitters related to milk production in Barki ewes. Total 72 mature ewes (2-3 years & 40±1.5 Kg BW) randomly pined equally into five groups. Group-1 was control; groups 2 & 3 received 20g/head/day T and C, respectively. Group-4 received 10g T+ 10g C/head/day, group-5 treated with salinomycin 1g/head/day. Samples collected during 2nd, 3rd trimester of pregnancy and on delivery day (DD); milk yield assessed on 15, 30 and 45-day postpartum. T and/or C and salinomycin increased (P 0.05). During late pregnancy 5-HT, DA, NE & Trp increased (P<0.05) in the thyme and/or celery group. While on DD salinomycin increased neurotransmitters (P<0.05) with an insignificant increase in other groups. Milk yield increased (P<0.05) during 15, 30 and 45 days postpartum in T and/or C groups than control and salinomycin. In conclusion, the applied treatments had a significant effect on reproductive performance, immune response in ewes throughout pregnancy and DD periods, and milk production during the postpartum period.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"256 1","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77535459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studying Resistance of Some Dairy Cattle Breeds to Heat Stress in Relation to Milk Yield 一些奶牛品种耐热性与产奶量的关系研究

Accident Analysis & Prevention Pub Date : 2021-05-14 DOI: 10.11648/J.AAP.20210601.13

A. Gad, S. Emara, S. Eid, H. El-Zaher

{"title":"Studying Resistance of Some Dairy Cattle Breeds to Heat Stress in Relation to Milk Yield","authors":"A. Gad, S. Emara, S. Eid, H. El-Zaher","doi":"10.11648/J.AAP.20210601.13","DOIUrl":"https://doi.org/10.11648/J.AAP.20210601.13","url":null,"abstract":"The objective for our work was to estimate the milk yield and blood biochemical constituents of and weight daily gain of calves recently born from imported cows under hot summer conditions in Egypt. Thirty late- pregnant cows, aged 22-24 months, chosen randomly were used in this study. Experiment was carried out during the period from third stage of pregnancy and continued to 8 weeks postpartum. Imported late-pregnant cows divided into three groups, each group was 10 cows. 1st group was Brown Swiss (BS) cows, 2nd group was Simmental (S) cows and 3rd group was Holstein (H). Results showed that H cows have a lowest rectal temperature (RT) and respiration rate (RR) in compare with BS and S cows. Results showed that H cows have a highest daily milk yield while S cows have lowest values. BS and H cows have significantly higher total protein, albumin and urea concentrations than S cows. While, globulin and glucose concentrations were significantly higher in BS than its concentrations in S and H cows, respectively. Total cholesterol, phospholipids and creatinine concentrations showed the lowest values in BS cows as compare with S and H cows. Otherwise, BS cows have the highest triglycerides concentration as compare with H and S cows. About liver function showed the highest activity for AST in S cows and for ALT in H cows as compared of other groups. BS cows have significantly higher T4 and Estradiol17β levels than its levels in S and H cows, respectively. Birth weight of newborn both male and female calves as well as daily body weight gain of calves produced from the three imported cows were not differs Significantly. Two months weight of calves produced from S cows was significantly higher than BS and H cows, respectively. In conclusion, the three imported breed cows appears good resistance to heat stress effects under hot summer conditions in Egypt with extremely resistance for H cows.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"36 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2021-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74739327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Search for Quantitative Parameters of Scan Path of Image Viewing by Biologically Motivated Model 基于生物动机模型的图像浏览扫描路径定量参数搜索

Accident Analysis & Prevention Pub Date : 2021-05-08 DOI: 10.11648/J.AAP.20210601.12

Shaposhnikov Dmitry, Podladchikova Lubov, Lazurenko Dmitry, Kiroy Valery

{"title":"Search for Quantitative Parameters of Scan Path of Image Viewing by Biologically Motivated Model","authors":"Shaposhnikov Dmitry, Podladchikova Lubov, Lazurenko Dmitry, Kiroy Valery","doi":"10.11648/J.AAP.20210601.12","DOIUrl":"https://doi.org/10.11648/J.AAP.20210601.12","url":null,"abstract":"The model of viewing scan path formation to search for quantitative parameters of scan path type is presented. In computer simulations, it was revealed that the structure of artificial scan path (focal or spatial ones) significantly (p<0,05) correlates with the number of return fixations of input window on recently viewed image areas. It was revealed that with the decrease of the coefficient of IOR, the model in most cases forms trajectories of focal type. On the contrary, as the coefficient of the IOR increases, model spatial type trajectories dominated. In addition to differences in the number of return fixations of the input window of the model between focal and spatial trajectories, a trend of differences between the two types of model trajectories in the amplitude of window jumps was found. The model assumption about the possibility of a quantitative characteristic of the trajectory structure based on return fixations is confirmed at processing the results of psychophysical tests of free viewing and search for modified fragments of complex images. It was shown that the number of gaze return fixations is significantly (p<0,05) higher in tests of free image viewing compared to search tests. The results obtained allow us to consider the probability of return fixations as a quantitative criterion to determine of scan path type.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"146 1","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2021-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80542835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Possible Way to Improve the Quality of Speech Perception by Increasing the Number of Electrodes in a Cochlear Implant from 8 to 22 通过将人工耳蜗的电极数量从8个增加到22个来提高语音感知质量的可能方法

Accident Analysis & Prevention Pub Date : 2020-12-31 DOI: 10.11648/J.AAP.20200502.18

Margarita Stefanovich

{"title":"A Possible Way to Improve the Quality of Speech Perception by Increasing the Number of Electrodes in a Cochlear Implant from 8 to 22","authors":"Margarita Stefanovich","doi":"10.11648/J.AAP.20200502.18","DOIUrl":"https://doi.org/10.11648/J.AAP.20200502.18","url":null,"abstract":"A cochlear implant (CI) helps a person with auditory receptor pathology restore the ability to hear and understand speech. The partial loss of the information about the frequency and loudness of the audio signal is the main difference from the natural sound perception. CIs of various types differ in the number of stimulated electrodes: 12, 16, 20, or 22. The quality of speech perception is significantly improved by increasing the number of stimulated electrodes from 4 to 7 and almost does not change with a further increase in the number of electrodes from 8 to 22. When speech is perceived in all types of CI, 3 to 6 adjacent electrodes are usually stimulated simultaneously. When a single electrode is stimulated, the CI user hears a sound with a single pitch. When two adjacent electrodes E(n) and E(n+1) are simultaneously stimulated, a virtual frequency channel (VFC) is formed, and the CI user hears a sound with an intermediate pitch {Z(n)+Z(n+1)}/2, provided that the adjacent electrodes on the right and left are not stimulated. When three or more adjacent electrodes are simultaneously stimulated, the CI user hears a sound with the same pitch, which depends on the distance from the electrode with the largest amplitude of stimulating pulses to the apex of the cochlea. There was no suggestion as to why the quality of speech perception does not improve when the number of electrodes increases from 8 to 22 in the scientific literature for the period from 1997 to 2019. This article proposes a method for adjusting the mode electrodes stimulation, which creates conditions for the formation of virtual frequency channels. The CI user will be able to hear a greater number of sounds of various pitch. A method for correcting the algorithm for controlling the stimulation of electrodes, which can be used in any type of CI, is proposed.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"15 1","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72908504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Royal Jelly Supplement on Ewe's Milk Fat Content and Fatty Acid Profile During the Early Stage of Lactation 添加蜂王浆对哺乳期早期母羊乳脂含量和脂肪酸分布的影响

Accident Analysis & Prevention Pub Date : 2020-10-21 DOI: 10.11648/J.AAP.20200502.15

A. A. El-Tarabany, O. Ahmed-Farid, S. Emara, M. S. El-Tarabany

{"title":"Impact of Royal Jelly Supplement on Ewe's Milk Fat Content and Fatty Acid Profile During the Early Stage of Lactation","authors":"A. A. El-Tarabany, O. Ahmed-Farid, S. Emara, M. S. El-Tarabany","doi":"10.11648/J.AAP.20200502.15","DOIUrl":"https://doi.org/10.11648/J.AAP.20200502.15","url":null,"abstract":"The aim was to study the possible effects of royal jelly (RJ) supplementation on milk fat content and fatty acids (FA) profile of ewes during the early stage of lactation. Randomly, thirty-six Ossimi ewes were divided into two groups (18 animals each). The first group was offered the basal diet which was considered as a control group, whereas the second group was fed the basal diet, in addition to a supplement of a single bolus of RJ (1000 mg/head) every two days as a treated group. Regardless the effect of time, the RJ-supplemented group recorded a non-significant increase in daily milk yield (1.22 kg) when compared with the control (1.08 kg) group (P<0.063). While, the RJ-supplemented ewes showed significantly increase in milk fat percentage (P<0.008) as compared to control group. Lactating ewes in the control group produced significantly higher contents of milk C14:0 (P<0.036) and C18:0 (P<0.027) saturated FA than that in the RJ group. However, the contents of milk C6:0 and C17:0 in the RJ group were significantly greater than that estimated in the control (P<0.050 and 0.041, respectively). Furthermore, Lactating ewes supplemented with RJ produced significantly higher contents of milk C16:1 (P<0.001), C18:1 (P<0.001) and C18:2 (P<0.046) unsaturated FA than the control group. It can be concluded that supplementation of ewes during the early stage of lactation with RJ can improve the nutritive value of milk fat, and appears to be an opportunity to modify the concentrations of certain milk fatty acids.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"28 1","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90717967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subjective vs. Objective Urine Color: Effect of Hydration Status 主观与客观尿色:水合状态的影响

Accident Analysis & Prevention Pub Date : 2020-09-04 DOI: 10.11648/J.AAP.20200502.12

Tory A. Edwards, R. Belasco, Alfonso Joaquin Munoz, V. Rayo, M. Buono

{"title":"Subjective vs. Objective Urine Color: Effect of Hydration Status","authors":"Tory A. Edwards, R. Belasco, Alfonso Joaquin Munoz, V. Rayo, M. Buono","doi":"10.11648/J.AAP.20200502.12","DOIUrl":"https://doi.org/10.11648/J.AAP.20200502.12","url":null,"abstract":"Purpose: To investigate the validity of urine color as a metric of hydration status using CIE L*a*b* color space, as compared to the commonly used subjective 8-point scale. Methods: A total of 151 urine samples were collected from subjects (N=28) in various states of hydration. Urine osmolality and urine specific gravity (USG) were measured in each sample. Urine color was assessed by the subjective 8-point urine color scale and quantified using CIE L*a*b* color space. RESULTS: The correlation between the CIE b*-value and urine osmolality (rs=0.89) was determined to be significantly (p=0.004) greater than the correlation between the subjective 8-point urine color scale and urine osmolality (rs=0.85). The correlation between the CIE b*-value and USG (rs=0.90) was also determined to be significantly (p < 0.001) greater than the correlation between the urine color chart and USG (rs=0.84). Lastly, the correlation between urine color as determined by the 8-point subjective urine color chart and the CIE b*-value had a strong relationship (rs=0.92). Conclusions: The correlations of the quantitative CIE b*-value with urine osmolality and USG were significantly greater than the correlations with the 8-point subjective urine color scale. This suggests that a quantitative measurement of urine color via spectrophotometry is a better measure for assessing hydration status vs. subjective determination of urine color. The results of the current study raise the possibility of spectrophotometry as an additional non-invasive method of determining hydration status.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"78 1","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2020-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84656496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Beneficial Effects of Yoga on Memory and Cognition Associated to Stress 瑜伽对与压力相关的记忆和认知的有益影响

Accident Analysis & Prevention Pub Date : 2020-07-14 DOI: 10.11648/J.AAP.20200502.11

S. Mitra, Mousumi Mitra, M. Saha, D. Nandi

{"title":"Beneficial Effects of Yoga on Memory and Cognition Associated to Stress","authors":"S. Mitra, Mousumi Mitra, M. Saha, D. Nandi","doi":"10.11648/J.AAP.20200502.11","DOIUrl":"https://doi.org/10.11648/J.AAP.20200502.11","url":null,"abstract":"Stress generally occurs due to the organism’s non-specific response against some kind of demand imposed on them. The compensatory responses to these stresses are known as stress response. The stressful stimuli can advance the physiological and psychological effects on the body which includes executive functions of the brain. The prefrontal cortex shows an important connection between the circuits that are linked with emotions, memory and planning. Due to this activation of stressful condition or situation damage occurs in the prefrontal cortex because of the catecholaminergic nature of its innervating afferents in the other parts of the brain. Along with hippocampus, the amygdala and prefrontal cortex define the aspects of memory and visual processing within brain. The decrease in PNS and GABAergic activity that causes stress related disorders can be corrected by yoga practice resulting in amelioration of disease system in the brain such as reduction in anxiety and improvement in cognitive function. Depression, Post Traumatic Stress Disorder (PTSD) that are elevated by stress shows low heart rate variability (HRV) and GABAergic activity which can be improved in response to yoga based interventions. Yoga practices show increase in the proportion of gray matter and escalation in activation of amygdala and frontal cortex of the brain. It was concluded that breathing, meditation and posture based yoga increased overall brain function and activity.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"51 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84009622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Blue and Red Light on Wheat Leaves 蓝光和红光对小麦叶片的影响

Accident Analysis & Prevention Pub Date : 2020-05-19 DOI: 10.11648/J.AAP.20200501.12

Azizov Ibrahim Vahab, Gasymova Fazile Imtu, Ibrahimova Ulker Faik, Tagiyeva Kenul Rafik, Abdullayeva Asmar Bahruz

{"title":"Impact of Blue and Red Light on Wheat Leaves","authors":"Azizov Ibrahim Vahab, Gasymova Fazile Imtu, Ibrahimova Ulker Faik, Tagiyeva Kenul Rafik, Abdullayeva Asmar Bahruz","doi":"10.11648/J.AAP.20200501.12","DOIUrl":"https://doi.org/10.11648/J.AAP.20200501.12","url":null,"abstract":"The effect of blue and red light on the activity of catalase and ascorbate peroxidase, the content of proteins and soluble carbohydrates in the leaves of wheat varieties under the action of sodium chloride was investigated. The objects of the research were bread wheat Saratovskaya-29 (Triticum aestivum L.) and durum wheat Barakatli-95 (Triticum durum Desf.). Plants were grown in laboratory conditions in an aqueous medium using a Knoop nutrient medium. Experimental plants were coated with transparent films transmitting light at wavelengths of 420-480 nm (blue light) and 640-680 nm (red light). During the growing season, samples of fully formed leaves were taken for physiological and biochemical studies every week at 11 a. m. Under the action of sodium chloride, the accumulation of hydrogen peroxide in white light was higher than in blue and red light. Low catalase activity also observed in blue and red light under the action of sodium chloride in both varieties. In the bread wheat variety Saratovskaya -29 the level of hydrogen peroxide, the activity of catalase and ascorbate peroxidase enzymes were lower than those of the Barakatli-95 durum wheat variety. Blue light stimulated the synthesis of proteins, while red light stimulated the synthesis of carbohydrates. Blue and red light prevented the formation of H2O2 under the action of NaCl.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"11 1","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2020-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73636631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malaria Parasitaemia and Changes in Follicle Stimulating Hormone and Luteinizing Hormone Levels of Adult Mice 疟疾寄生虫病与成年小鼠促卵泡激素和黄体生成素水平的变化

Accident Analysis & Prevention Pub Date : 2020-04-14 DOI: 10.11648/J.AAP.20200501.11

N. Obidike, Ebite Lilian Ozokor, O. Irikefe, Gbagbeke Kelvin Obakore, Kelechi Keneth Anachuna

{"title":"Malaria Parasitaemia and Changes in Follicle Stimulating Hormone and Luteinizing Hormone Levels of Adult Mice","authors":"N. Obidike, Ebite Lilian Ozokor, O. Irikefe, Gbagbeke Kelvin Obakore, Kelechi Keneth Anachuna","doi":"10.11648/J.AAP.20200501.11","DOIUrl":"https://doi.org/10.11648/J.AAP.20200501.11","url":null,"abstract":"To understand the treatment of malaria, it is important to understand the effect of the administration of specific anti-malarials on various physiological variables. Current study investigated the effect (s) of the anti-malarial, coartem and co-administration of the antioxidant, Vitamin E on the levels of Luteinising and Follicle Stimulating Hormones [LH and FSH] of malaria parasite infected mice. Twenty-eight (28) adult mice were obtained, acclimatized for two (2) weeks and randomly selected into four (4) groups of seven (7) rats per group. Group 1 (Control) received standard mice diet and water ad libitum, while group 2 mice were infected with malaria (Plasmodium berghei) and left untreated. Groups 3 and 4 were inoculated with malaria (Plasmodium berghei); then treated with coartem and coartem + vitamin E respectively. After three (3) weeks of administration of test substance, the mice blood samples were obtained from mice (for each group) and assayed for serum FSH and LH levels. Statistical comparison was then conducted (using the student t-test) against those of control group to ascertain the effects of the changes due to coartem and/or antioxidant vitamin E co-administration to plasmodium berghei infected mice. Study found a statistically significant increase in serum LH levels of male mice after inoculation with plasmodium berghei. This decrease was noticed more even with coartem and antioxidant vitamin E co-administration, implicative of a possible effect in fecundity levels of infected male mice. The level of FSH was significantly increased in infected mice, but however showed a reversal following treatment with coartem and/or antioxidant vitamin E. The effects on reproductive hormones seen here may mirror the effects in man. More studies are needed to elucidate that.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"95 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2020-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78162055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases Ras癌基因突变在急性髓系白血病患者中的作用:基于2502例病例的荟萃分析

Accident Analysis & Prevention Pub Date : 2019-02-18 DOI: 10.11648/J.AAP.20180302.11

Si Li, Peng-bo Zhang, Yong Zhang, Li Wang

{"title":"The Role of Ras Oncogene Mutations in Acute Myeloid Leukemia Patients: A Meta-analysis Based on 2502 Cases","authors":"Si Li, Peng-bo Zhang, Yong Zhang, Li Wang","doi":"10.11648/J.AAP.20180302.11","DOIUrl":"https://doi.org/10.11648/J.AAP.20180302.11","url":null,"abstract":"Background: the ras oncogene mutations frequently occurred in acute myeloid leukemia (AML), but as a prognostic factor remains inconclusive. Methods: The databases of PubMed, Web of Science, EMBASE, and the Cochrane. 22 eligible studies were included this study and analysis was conducted by Comprehensive Meta-Analysis Version 2 software program. All eligible study’s quality assessment refers to the European Lung Cancer Party quality scale. Results: Combined analysis showed that ras oncogene mutation was a poor impact on survival in AML patients (Hazard ratios (HRs): 1.50, 1.19-1.89, p <0.001). Nras gene mutation was a worse survival marker in AML (HR: 1.97, 95% CI: 1.35-2.89, p <0.001) and Kras gene mutations was no significance (HR: 1.32, 95% CI: 0.83-2.09, p =0.24) by stratified analysis. In the analysis of age bracket, adults with ras gene mutation had an unfavorable survival (HR: 1.55, 95% CI: 1.19-2.21, p =0.01) and children harbored ras gene mutation was not significantly with prognosis (HR: 1.22, 95% CI: 0.97-1.53, p =0.09) in AML. Conclusions: This study indicated that AML patients was poor prognosis especially in adult group with ras oncogene mutation, in which Nras mutation, but not Kras mutation involved in guiding survival.","PeriodicalId":7392,"journal":{"name":"Accident Analysis & Prevention","volume":"20 1","pages":"44"},"PeriodicalIF":0.0,"publicationDate":"2019-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84048538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1