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Journal of proteins and proteomics最新文献

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Comments on potential re-purposing of medicines against high-altitude illnesses towards SARS-CoV2: possibilities and pitfalls. 针对 SARS-CoV2 对高海拔地区疾病药物的潜在再利用：可能性与隐患。
Journal of proteins and proteomics Pub Date : 2021-01-01 Epub Date: 2021-01-20 DOI: 10.1007/s42485-020-00055-6
Yasmin Ahmad, Subhojit Paul, Rajeev Varshney, Bhuvnesh Kumar
{"title":"Comments on potential re-purposing of medicines against high-altitude illnesses towards SARS-CoV2: possibilities and pitfalls.","authors":"Yasmin Ahmad, Subhojit Paul, Rajeev Varshney, Bhuvnesh Kumar","doi":"10.1007/s42485-020-00055-6","DOIUrl":"10.1007/s42485-020-00055-6","url":null,"abstract":"<p><p>In the ongoing COVID-19 pandemic, the global fraternity of researchers has been assiduously investigating pharmacological interventions against the SARS-CoV2. This novel virus is known to gain entry through the ACE 2 receptor of pulmonary epithelial cells lining the respiratory tract. Many of its initial symptoms (e.g. difficulty breathing) resemble acute high altitude illnesses, particularly HAPE. Based on these overt symptoms, a number of high altitude researchers have speculated on repurposing of drugs used to treat acute altitude illnesses (especially HAPE). However, eminent high altitude researchers with medical expertise as well as some studies on the deeper causes underlying the overt symptoms have found that such repurposing maybe counter-productive. Other factors, (e.g. contra-indications of these drugs), make their use in COVID-19 patients hazardous. The fit-for-repurposing options maybe experimental prophylactic interventions (e.g. silymarin, curcumin) which have proven anti-oxidant and anti-inflammatory effects. Another line of thought focuses on proteomics-based investigations of such patients. However, apart from the logistical and safety issues, a targeted proteomics approach based on prior sound molecular investigations is a more logical approach instead of mere shotgun proteomics. In this commentary, we shed light on such issues associated with COVID-19.</p>","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"12 1","pages":"15-17"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7815497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38780942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico docking of natural compounds from plants against Rhizoctonia solani pectate lyase 植物天然化合物抗茄枯丝核菌果胶裂解酶的硅对接
Journal of proteins and proteomics Pub Date : 2020-11-27 DOI: 10.1007/s42485-020-00053-8
A. Mahanty, S. Lenka, P. Rath, S. Raghu, S. R. Prabhukarthikeyan
{"title":"In silico docking of natural compounds from plants against Rhizoctonia solani pectate lyase","authors":"A. Mahanty, S. Lenka, P. Rath, S. Raghu, S. R. Prabhukarthikeyan","doi":"10.1007/s42485-020-00053-8","DOIUrl":"https://doi.org/10.1007/s42485-020-00053-8","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"77 1","pages":"63 - 69"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74011383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantitative proteomics leads to identify dog brain proteins involved in rabies virus infection: implication in understanding viral pathophysiology 定量蛋白质组学鉴定犬脑蛋白参与狂犬病病毒感染:对理解病毒病理生理的意义
Journal of proteins and proteomics Pub Date : 2020-11-02 DOI: 10.1007/s42485-020-00051-w
S. Behera, R. Pharande, R. R. Reddy, S. Majee, S. Mukherjee, A. Suryawanshi
{"title":"Quantitative proteomics leads to identify dog brain proteins involved in rabies virus infection: implication in understanding viral pathophysiology","authors":"S. Behera, R. Pharande, R. R. Reddy, S. Majee, S. Mukherjee, A. Suryawanshi","doi":"10.1007/s42485-020-00051-w","DOIUrl":"https://doi.org/10.1007/s42485-020-00051-w","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"40 4 1","pages":"241 - 257"},"PeriodicalIF":0.0,"publicationDate":"2020-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85773574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene set enrichment analysis, network pharmacology and in silico docking approach to understand the molecular mechanism of traditional medicines for the treatment of diabetes mellitus 利用基因集富集分析、网络药理学和计算机对接等方法了解传统药物治疗糖尿病的分子机制
Journal of proteins and proteomics Pub Date : 2020-10-07 DOI: 10.1007/s42485-020-00049-4
Vishal S. Patil, Sanjay H. Deshpande, Darasaguppe R. Harish, Anuradha S. Patil, Rajashri Virge, Sinjini Nandy, Subarna Roy
{"title":"Gene set enrichment analysis, network pharmacology and in silico docking approach to understand the molecular mechanism of traditional medicines for the treatment of diabetes mellitus","authors":"Vishal S. Patil, Sanjay H. Deshpande, Darasaguppe R. Harish, Anuradha S. Patil, Rajashri Virge, Sinjini Nandy, Subarna Roy","doi":"10.1007/s42485-020-00049-4","DOIUrl":"https://doi.org/10.1007/s42485-020-00049-4","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"8 1","pages":"297 - 310"},"PeriodicalIF":0.0,"publicationDate":"2020-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73679903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Identification of natural lead compounds for leaf rust of Wheat: a molecular docking and simulation study 小麦叶锈病天然先导化合物鉴定:分子对接与模拟研究
Journal of proteins and proteomics Pub Date : 2020-10-06 DOI: 10.1007/s42485-020-00048-5
K. Sidhu, Sukhwinder Kaur Bhangu, R. Pathak, I. Yadav, P. Chhuneja
{"title":"Identification of natural lead compounds for leaf rust of Wheat: a molecular docking and simulation study","authors":"K. Sidhu, Sukhwinder Kaur Bhangu, R. Pathak, I. Yadav, P. Chhuneja","doi":"10.1007/s42485-020-00048-5","DOIUrl":"https://doi.org/10.1007/s42485-020-00048-5","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"103 1","pages":"283 - 295"},"PeriodicalIF":0.0,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80696028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Spectrin interactome under normal and HbE-disease conditions Spectrin在正常和乙型肝炎条件下相互作用
Journal of proteins and proteomics Pub Date : 2020-10-03 DOI: 10.1007/s42485-020-00050-x
Dipayan Bose, Sk Ramiz Islam, Sutapa Saha, A. Chakrabarti
{"title":"Spectrin interactome under normal and HbE-disease conditions","authors":"Dipayan Bose, Sk Ramiz Islam, Sutapa Saha, A. Chakrabarti","doi":"10.1007/s42485-020-00050-x","DOIUrl":"https://doi.org/10.1007/s42485-020-00050-x","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"1 1","pages":"233 - 240"},"PeriodicalIF":0.0,"publicationDate":"2020-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79089769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dysglycaemia and South Asian ethnicity: a proteomic discovery and confirmation analysis highlights differences in ZAG 低血糖和南亚种族:一项蛋白质组学发现和确认分析强调了ZAG的差异
Journal of proteins and proteomics Pub Date : 2020-10-01 DOI: 10.1007/s42485-020-00046-7
Harriet M. Pearsey, J. Henson, J. Sargeant, David Webb, J. Gill, C. Celis-Morales, Toru Suzuki, H. Waller, K. Khunti, L. Ng, Kelly A. Bowden-Davies, D. Cuthbertson, Andrew Jackson, M. Davies, T. Yates
{"title":"Dysglycaemia and South Asian ethnicity: a proteomic discovery and confirmation analysis highlights differences in ZAG","authors":"Harriet M. Pearsey, J. Henson, J. Sargeant, David Webb, J. Gill, C. Celis-Morales, Toru Suzuki, H. Waller, K. Khunti, L. Ng, Kelly A. Bowden-Davies, D. Cuthbertson, Andrew Jackson, M. Davies, T. Yates","doi":"10.1007/s42485-020-00046-7","DOIUrl":"https://doi.org/10.1007/s42485-020-00046-7","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"33 1","pages":"259 - 268"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80909311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative non-targeted metabolomics reveals differentiation of biochemical pathway network among fruits of natural populations and Cv. Alphonso of mango (Mangifera indica L.) 比较非靶向代谢组学揭示了自然群体和Cv果实间生化通路网络的差异。芒果(Mangifera indica L.)
Journal of proteins and proteomics Pub Date : 2020-10-01 DOI: 10.1007/s42485-020-00047-6
M. S. Dar, Yashwant Kumar, S. Punekar, V. Gupta, B. B. Dholakia, A. Giri
{"title":"Comparative non-targeted metabolomics reveals differentiation of biochemical pathway network among fruits of natural populations and Cv. Alphonso of mango (Mangifera indica L.)","authors":"M. S. Dar, Yashwant Kumar, S. Punekar, V. Gupta, B. B. Dholakia, A. Giri","doi":"10.1007/s42485-020-00047-6","DOIUrl":"https://doi.org/10.1007/s42485-020-00047-6","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"18 1","pages":"269 - 282"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75502978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Quantitative proteomics revealed the putative biomarker for detection of early-stage intra-mammary gland infection in cow 定量蛋白质组学揭示了奶牛早期乳腺内感染的推定生物标志物
Journal of proteins and proteomics Pub Date : 2020-09-01 DOI: 10.1007/s42485-020-00045-8
Shveta Bathla, A. Sindhu, Sudarshan Kumar, S. Dubey, S. Pattnaik, P. Rawat, A. Chopra, A. Mohanty
{"title":"Quantitative proteomics revealed the putative biomarker for detection of early-stage intra-mammary gland infection in cow","authors":"Shveta Bathla, A. Sindhu, Sudarshan Kumar, S. Dubey, S. Pattnaik, P. Rawat, A. Chopra, A. Mohanty","doi":"10.1007/s42485-020-00045-8","DOIUrl":"https://doi.org/10.1007/s42485-020-00045-8","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"47 1","pages":"173 - 181"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42485-020-00045-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72521024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Cloning, baculoviral expression, detergent optimization and purification of human serotonin 5-HT2A G-protein-coupled receptor 人5-羟色胺5-HT2A g蛋白偶联受体的克隆、杆状病毒表达、洗涤剂优化及纯化
Journal of proteins and proteomics Pub Date : 2020-07-27 DOI: 10.1007/s42485-020-00043-w
G. Mahesh
{"title":"Cloning, baculoviral expression, detergent optimization and purification of human serotonin 5-HT2A G-protein-coupled receptor","authors":"G. Mahesh","doi":"10.1007/s42485-020-00043-w","DOIUrl":"https://doi.org/10.1007/s42485-020-00043-w","url":null,"abstract":"","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"20 1","pages":"213 - 221"},"PeriodicalIF":0.0,"publicationDate":"2020-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73562169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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