Journal of proteins and proteomics最新文献_第10页

Proteomic and metabolomic analysis of Nothapodytes nimmoniana (J. Graham) extracts’ treatment on HeLa cells Nothapodytes nimmonana (J. Graham)提取物对HeLa细胞的蛋白质组学和代谢组学分析

Journal of proteins and proteomics Pub Date : 2020-03-01 DOI: 10.1007/s42485-020-00031-0

S. Gayakwad, Amey Shirolkar, S. Warkad, Shraddha Bharsakale, S. Gaidhani, S. Pawar

引用次数: 1

Computational analysis of regulatory genes network pathways among devastating cancer diseases 毁灭性癌症疾病中调控基因网络通路的计算分析

Journal of proteins and proteomics Pub Date : 2020-03-01 DOI: 10.1007/s42485-020-00032-z

Tasnimul Alam Taz, Md. Kawsar, B. K. Paul, K. Ahmed

引用次数: 1

Natural vs. random protein sequences: the novel neural network approach based on time series analysis 自然与随机蛋白质序列:基于时间序列分析的新型神经网络方法

Journal of proteins and proteomics Pub Date : 2020-03-01 DOI: 10.1007/s42485-020-00029-8

A. Tsygvintsev

引用次数: 0

Mass spectrometry-based identification and characterization of human hypothetical proteins highlighting the inconsistency across the protein databases 基于质谱的人类假设蛋白质的鉴定和表征突出了蛋白质数据库的不一致性

Journal of proteins and proteomics Pub Date : 2020-03-01 DOI: 10.1007/s42485-020-00030-1

Johny Ijaq, N. Bethi, M. Jagannadham

引用次数: 4

A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies. COVID - 19蛋白质组学方法综述:靶向治疗策略的新视角

Journal of proteins and proteomics Pub Date : 2020-01-01 Epub Date: 2020-11-02 DOI: 10.1007/s42485-020-00052-9

Rashmi Rana, Vaishnavi Rathi, Nirmal Kumar Ganguly

{"title":"A comprehensive overview of proteomics approach for COVID 19: new perspectives in target therapy strategies.","authors":"Rashmi Rana, Vaishnavi Rathi, Nirmal Kumar Ganguly","doi":"10.1007/s42485-020-00052-9","DOIUrl":"https://doi.org/10.1007/s42485-020-00052-9","url":null,"abstract":"World Health Organisation declared COVID-19 a pandemic on March 11, 2020. It was temporarily named as 2019-nCoV then subsequently named as COVID-19 virus. A coronavirus is a group of viruses, known to be zoonotic, causing illness ranging from acute to mild respiratory infections. These are spherical or pleomorphic enveloped particles containing positive sense RNA. The virus enters host cells, its uncoated genetic material transcribes, and translates. Since it has started spreading rapidly, protective measures have been taken all over the world. However, its transmission has been proved to be unstoppable and the absence of an effective drug makes the situation worse. The scientific community has gone all-out to discover and develop a possible vaccine or a competent antiviral drug. Other domains of biological sciences that promise effective results and target somewhat stable entities that are proteins, could be very useful in this time of crisis. Proteomics and metabolomics are the vast fields that are equipped with sufficient technologies to face this challenge. Various protein separation and identification techniques are available which facilitates the analysis of various types of interactions among proteins and their evolutionary lineages. The presented review aims at confronting the question: 'how proteomics can help in tackling SARS-CoV-2?' It deals with the role of upcoming proteome technology in these pandemic situations and discusses the proteomics approach towards the COVID-19 dilemma.","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"11 4","pages":"223-232"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42485-020-00052-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38579430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Virtualization of science education: a lesson from the COVID-19 pandemic. 科学教育虚拟化:2019冠状病毒病大流行的教训。

Journal of proteins and proteomics Pub Date : 2020-01-01 Epub Date: 2020-05-31 DOI: 10.1007/s42485-020-00038-7

Sandipan Ray, Sanjeeva Srivastava

引用次数: 67

A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry. 靶向质谱法快速灵敏检测SARS-CoV-2病毒

Journal of proteins and proteomics Pub Date : 2020-01-01 Epub Date: 2020-08-31 DOI: 10.1007/s42485-020-00044-9

Praveen Singh, Rahul Chakraborty, Robin Marwal, V S Radhakrishan, Akash Kumar Bhaskar, Himanshu Vashisht, Mahesh S Dhar, Shalini Pradhan, Gyan Ranjan, Mohamed Imran, Anurag Raj, Uma Sharma, Priyanka Singh, Hemlata Lall, Meena Dutta, Parth Garg, Arjun Ray, Debasis Dash, Sridhar Sivasubbu, Hema Gogia, Preeti Madan, Sandhya Kabra, Sujeet K Singh, Anurag Agrawal, Partha Rakshit, Pramod Kumar, Shantanu Sengupta

{"title":"A rapid and sensitive method to detect SARS-CoV-2 virus using targeted-mass spectrometry.","authors":"Praveen Singh, Rahul Chakraborty, Robin Marwal, V S Radhakrishan, Akash Kumar Bhaskar, Himanshu Vashisht, Mahesh S Dhar, Shalini Pradhan, Gyan Ranjan, Mohamed Imran, Anurag Raj, Uma Sharma, Priyanka Singh, Hemlata Lall, Meena Dutta, Parth Garg, Arjun Ray, Debasis Dash, Sridhar Sivasubbu, Hema Gogia, Preeti Madan, Sandhya Kabra, Sujeet K Singh, Anurag Agrawal, Partha Rakshit, Pramod Kumar, Shantanu Sengupta","doi":"10.1007/s42485-020-00044-9","DOIUrl":"https://doi.org/10.1007/s42485-020-00044-9","url":null,"abstract":"In the last few months, there has been a global catastrophic outbreak of severe acute respiratory syndrome disease caused by the novel coronavirus SARS-CoV-2 affecting millions of people worldwide. Early diagnosis and isolation are key to contain the rapid spread of the virus. Towards this goal, we report a simple, sensitive and rapid method to detect the virus using a targeted mass spectrometric approach, which can directly detect the presence of virus from naso-oropharyngeal swabs. Using a multiple reaction monitoring we can detect the presence of two peptides specific to SARS-CoV-2 in a 2.3 min gradient run with 100% specificity and 90.5% sensitivity when compared to RT-PCR. Importantly, we further show that these peptides could be detected even in the patients who have recovered from the symptoms and have tested negative for the virus by RT-PCR highlighting the sensitivity of the technique. This method has the translational potential of in terms of the rapid diagnostics of symptomatic and asymptomatic COVID-19 and can augment current methods available for diagnosis of SARS-CoV-2.","PeriodicalId":73910,"journal":{"name":"Journal of proteins and proteomics","volume":"11 3","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42485-020-00044-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38553317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Structural insights into the molecular mechanisms of pectinolytic enzymes 果胶分解酶分子机制的结构见解

Journal of proteins and proteomics Pub Date : 2019-11-16 DOI: 10.1007/s42485-019-00027-5

Anuradha Kanungo, B. Bag

引用次数: 6

In-silico molecular characterization and mutational analysis of inter-alpha-trypsin inhibitor heavy chain 4 in rheumatoid arthritis 类风湿关节炎中α -胰蛋白酶抑制剂重链4的硅基分子特征和突变分析

Journal of proteins and proteomics Pub Date : 2019-11-05 DOI: 10.1007/s42485-019-00026-6

S. Khakha, SoundharaRajan G, Ankita Sharma, P. Kumari, S. Sahi, S. Biswas

引用次数: 0

Acetogenins as potential checkpoint-2 kinase inhibitors: an in silico analysis 醋酸原蛋白作为潜在的检查点-2激酶抑制剂:计算机分析

Journal of proteins and proteomics Pub Date : 2019-11-05 DOI: 10.1007/s42485-019-00025-7

P. Meghana, Jain R. Sandeep Kumar, T. Sandeep, N. Prashanth, H. Kumaraswamy

引用次数: 2