Advances in Pharmacological Sciences最新文献_第6页

Neuroprotection in Glaucoma: Old and New Promising Treatments. 青光眼的神经保护:新旧有希望的治疗方法。

Advances in Pharmacological Sciences Pub Date : 2017-01-01 Epub Date: 2017-10-17 DOI: 10.1155/2017/4320408

Dario Rusciano, Salvatore Pezzino, Maria Giulia Mutolo, Rossella Giannotti, Aloisa Librando, Nicola Pescosolido

{"title":"Neuroprotection in Glaucoma: Old and New Promising Treatments.","authors":"Dario Rusciano, Salvatore Pezzino, Maria Giulia Mutolo, Rossella Giannotti, Aloisa Librando, Nicola Pescosolido","doi":"10.1155/2017/4320408","DOIUrl":"https://doi.org/10.1155/2017/4320408","url":null,"abstract":"Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible for the neurodegenerative damage are not clear. Undoubtedly, the high intraocular pressure (IOP) and the secondary ischemic and mechanical damage of the optic nerve have a crucial role in retinal ganglion cell (RGC) death. Several studies specifically analyzed the events that lead to nerve fiber layer thinning, showing the importance of both intra- and extracellular factors. In parallel, many neuroprotective substances have been tested for their efficacy and safety in hindering the negative effects that lead to RGC death. New formulations of these compounds, also suitable for chronic oral administration, are likely to be used in clinical practice in the future along with conventional therapies, in order to control the progression of the visual impairment due to primary open-angle glaucoma (POAG). This review illustrates some of these old and new promising agents for the adjuvant treatment of POAG, with particular emphasis on forskolin and melatonin.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2017 ","pages":"4320408"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4320408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36921683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Downregulation of Thromboxane A₂ Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery. 大鼠肾动脉血栓素A2受体下调主要通过核因子- κ b信号通路发生。

Advances in Pharmacological Sciences Pub Date : 2017-01-01 Epub Date: 2017-07-09 DOI: 10.1155/2017/6507048

Yaping Zhang, Man Mi, Yan-Hua Xie, Si-Wang Wang, Lars Edvinsson, Cang-Bao Xu

{"title":"Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery.","authors":"Yaping Zhang, Man Mi, Yan-Hua Xie, Si-Wang Wang, Lars Edvinsson, Cang-Bao Xu","doi":"10.1155/2017/6507048","DOIUrl":"https://doi.org/10.1155/2017/6507048","url":null,"abstract":"Thromboxane A2 (TXA2) acts on TXA2 receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-κB) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. Rat renal artery segments were organ cultured for 6 or 24 h. Downregulation of TP receptors was monitored using myograph (contractile function), real-time PCR (receptor mRNA), and immunohistochemistry (receptor protein). Specific inhibitors (MG-132 and BMS345541) for NF-κB signaling pathway were used to dissect the underlying molecular mechanisms involved. Compared to fresh (noncultured) segments, organ culture of the renal artery segments for 24 h induced a significant rightward shift of U46619 (TP receptor agonist) contractile response curves (pEC50: 6.89 ± 0.06 versus 6.48 ± 0.04, P < 0.001). This decreased contractile response to U46619 was paralleled with decreased TP receptor mRNA and protein expressions in the renal artery smooth muscle cells. Specific inhibitors (MG-132 and BMS345541) for NF-κB signaling pathway significantly abolished the decreased TP protein expression and receptor-mediated contractions. In conclusion, downregulation of TP receptors in the renal artery smooth muscle cells occurs mainly via the NF-κB signaling pathway.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2017 ","pages":"6507048"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6507048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35292644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phytochemical and Pharmacological Review of Cryptolepis sanguinolenta (Lindl.) Schlechter. Cryptolepis sanguinolenta (Lindl.) Schlechter 的植物化学和药理综述。

Advances in Pharmacological Sciences Pub Date : 2017-01-01 Epub Date: 2017-10-15 DOI: 10.1155/2017/3026370

Newman Osafo, Kwesi Boadu Mensah, Oduro Kofi Yeboah

{"title":"Phytochemical and Pharmacological Review of Cryptolepis sanguinolenta (Lindl.) Schlechter.","authors":"Newman Osafo, Kwesi Boadu Mensah, Oduro Kofi Yeboah","doi":"10.1155/2017/3026370","DOIUrl":"10.1155/2017/3026370","url":null,"abstract":"Ethnopharmacological relevance: Cryptolepis sanguinolenta is a scrambling thin-stemmed shrub found in Africa. Traditionally in West Africa, it is employed in the treatment of malaria, diarrhea, and respiratory conditions. This review discusses the traditional importance as well as the phytochemical, ethnomedical, pharmacological, and toxicological importance of this plant.Materials and methods: Excerpta Medica Database, Google Scholar, Springer, and PubMed Central were the electronic databases used to search for and filter primary studies on Cryptolepis sanguinolenta.Results: The detailed review of various studies conducted on C. sanguinolenta and some of its constituents gives an important body of proof of its potential therapeutic benefits and also of its use as a source of lead compounds with therapeutic potentials.Conclusion: The review on C. sanguinolenta is important in identifying grey areas in the research on this medicinal plant and also provides comprehensive data thus far to continue research on this plant.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2017 ","pages":"3026370"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36090015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats 大鼠长期服用异烟肼、奈韦拉平和扑热息痛时IL-2和IL-10的变化

Advances in Pharmacological Sciences Pub Date : 2016-11-20 DOI: 10.1155/2016/3094783

Zanelle Bekker, A. Walubo, J. D. du Plessis

{"title":"Changes in IL-2 and IL-10 during Chronic Administration of Isoniazid, Nevirapine, and Paracetamol in Rats","authors":"Zanelle Bekker, A. Walubo, J. D. du Plessis","doi":"10.1155/2016/3094783","DOIUrl":"https://doi.org/10.1155/2016/3094783","url":null,"abstract":"The aim of this study was to illustrate the initial subclinical drug-induced liver injury and the associated adaptive immune response by monitoring for the changes in plasma IL-2, IL-10, and some cytochrome P450 activity during chronic administration of nevirapine (NVP), isoniazid (INH), and paracetamol (PAR) in rats without clinical hepatotoxicity. Male Sprague-Dawley (SD) rats were divided into four groups (saline (S), NVP, INH, and PAR) of 25 animals each. The drugs were administered daily for 42 days at therapeutic doses (NVP 200 mg/kg, PAR 500 mg/kg, and INH 20 mg/kg) to the respective groups by oral gavage and five rats per group were sacrificed weekly. All the three drugs induced a subclinical liver injury in the first 2-3 weeks followed by healing, indicating adaption. The liver injury was pathologically similar and was associated with immune stimulation and increased cytochrome P450 activity. NVP- and PAR-induced liver injury lasted up to 14 days while that for INH lasted for 28 days. NVP-induced liver injury was associated with increased IL-2, CD4 count, and CYP3A2 activity, followed by increased IL-10 during the healing phase. In conclusion, the initial drug-induced subclinical liver injury, its spontaneous healing, and the associated adaptive immune response have been demonstrated.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3094783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64318222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism 木参醇提物抑制谷氨酸诱导的疼痛及参与atp敏感的K+通道的抗痛觉机制

Advances in Pharmacological Sciences Pub Date : 2016-10-12 DOI: 10.1155/2016/3790860

Nushrat Sharmin Ani, Sudip Chakraborty, M. Moniruzzaman

{"title":"The Methanolic Extract from Murraya koenigii L. Inhibits Glutamate-Induced Pain and Involves ATP-Sensitive K+ Channel as Antinociceptive Mechanism","authors":"Nushrat Sharmin Ani, Sudip Chakraborty, M. Moniruzzaman","doi":"10.1155/2016/3790860","DOIUrl":"https://doi.org/10.1155/2016/3790860","url":null,"abstract":"Murraya koenigii L. is a perennial shrub, belonging to the family Rutaceae. Traditionally, the leaves of this plant are extensively used in treatment of a wide range of diseases and disorders including pain and inflammation. Although researchers have revealed the antinociceptive effects of this plant's leaves during past few years, the mechanisms underlying these effects are still unknown. Therefore, the present study evaluated some antinociceptive mechanisms of the methanolic extract of M. koenigii (MEMK) leaves along with its antinociceptive potential using several animal models. The antinociceptive effects of MEMK were evaluated using formalin-induced licking and acetic acid-induced writhing tests at the doses of 50, 100, and 200 mg/kg. In addition, we also justified the possible participations of glutamatergic system and ATP-sensitive potassium channels in the observed activities. Our results demonstrated that MEMK significantly (p < 0.01) inhibited the pain thresholds induced by formalin and acetic acid in a dose-dependent manner. MEMK also significantly (p < 0.01) suppressed glutamate-induced pain. Moreover, pretreatment with glibenclamide (an ATP-sensitive potassium channel blocker) at 10 mg/kg significantly (p < 0.05) reversed the MEMK-mediated antinociception. These revealed that MEMK might have the potential to interact with glutamatergic system and the ATP-sensitive potassium channels to exhibit its antinociceptive activities. Therefore, our results strongly support the antinociceptive effects of M. koenigii leaves and provide scientific basis of their analgesic uses in the traditional medicine.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3790860","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64348064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Thrombus Degradation by Fibrinolytic Enzyme of Stenotrophomonas sp. Originated from Indonesian Soybean-Based Fermented Food on Wistar Rats 印尼大豆发酵食品窄养单胞菌纤维蛋白溶酶对Wistar大鼠血栓的降解作用

Advances in Pharmacological Sciences Pub Date : 2016-08-21 DOI: 10.1155/2016/4206908

F. Nailufar, R. Tjandrawinata, M. Suhartono

{"title":"Thrombus Degradation by Fibrinolytic Enzyme of Stenotrophomonas sp. Originated from Indonesian Soybean-Based Fermented Food on Wistar Rats","authors":"F. Nailufar, R. Tjandrawinata, M. Suhartono","doi":"10.1155/2016/4206908","DOIUrl":"https://doi.org/10.1155/2016/4206908","url":null,"abstract":"Objective. To evaluate thrombus degrading effect of a fibrinolytic enzyme from food origin Stenotrophomonas sp. of Indonesia. Methods. Prior to animal study, the enzyme safety was tested using cell culture. The effect on expression of tissue plasminogen activator was also analysed in the cell culture. For in vivo studies, 25 Wistar rats were used: normal control, negative control, treatment groups with crude and semipurified enzyme given orally at 25 mg/kg, and positive control group which received Lumbrokinase at 25 mg/kg. Blood clot in the tail was induced by kappa carrageenan injection at 1 mg/kg BW. Results. Experiment with cell culture confirmed the enzyme safety at the concentration used and increased expression of tPA. Decreasing of thrombus was observed in the positive group down to 70.35 ± 23.11% of the negative control animals (100%). The thrombus observed in the crude enzyme treatment was down to 56.99 ± 15.95% and 71.5 ± 15.7% for semipurified enzyme. Scanning electron microscopy showed clearly that bood clots were found in the animals injected with kappa carrageenan; however, in the treatment and positive groups, the clot was much reduced. Conclusions. Oral treatment of enzyme from Stenotrophomonas sp. of Indonesian fermented food was capable of degrading thrombus induced in Wistar rats.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4206908","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64371269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Pharmacokinetics of Immediate and Sustained Release Cephalexin Administered by Different Routes to Llamas (Lama glama) 不同给药途径头孢氨苄速释和缓释对骆驼的药动学研究

Advances in Pharmacological Sciences Pub Date : 2016-03-09 DOI: 10.1155/2016/4621039

V. Kreil, L. Ambros, A. Prados, L. Tarragona, A. Monfrinotti, G. Bramuglia, M. Rebuelto

{"title":"Pharmacokinetics of Immediate and Sustained Release Cephalexin Administered by Different Routes to Llamas (Lama glama)","authors":"V. Kreil, L. Ambros, A. Prados, L. Tarragona, A. Monfrinotti, G. Bramuglia, M. Rebuelto","doi":"10.1155/2016/4621039","DOIUrl":"https://doi.org/10.1155/2016/4621039","url":null,"abstract":"We investigate the pharmacokinetics of two different cephalexin formulations administered to llamas by the intravenous (IV), intramuscular (IM), and subcutaneous (SC) routes, the minimum inhibitory concentration (MIC) of cephalexin against some Escherichia coli and staphylococci isolated from llamas, and we apply the PK/PD modelling approach, so that effective dosage recommendations for this species could be made. Six llamas received immediate (10 mg/kg, IV, IM, and SC) and sustained (8 mg/kg IM, SC) release cephalexin. Pharmacokinetic parameters were calculated by noncompartmental approach. Immediate release SC administration produced a significantly longer elimination half-life as compared with the IV and IM administration (1.3 ± 0.2 versus 0.6 ± 0.1 and 0.6 ± 0.1 h, resp.) and higher mean absorption time as compared with the IM administration (1.7 ± 0.5 versus 0.6 ± 0.4 h). Absolute bioavailability was in the range of 72–89% for both formulations and routes of administration. Cephalexin MIC90 values against staphylococci and E. coli were 1.0 and 8.0 μg/mL, respectively. Our results show that the immediate release formulation (10 mg/kg) would be effective for treating staphylococcal infections administered every 8 h (IM) or 12 h (SC), whereas the sustained release formulation (8 mg/kg) would require the IM or SC administration every 12 or 24 h, respectively.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4621039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64389398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study 雷米普利和坎地沙坦对心肌缺血再灌注损伤的保护作用:生化和透射电镜研究

Advances in Pharmacological Sciences Pub Date : 2016-03-06 DOI: 10.1155/2016/4608979

M. S. T. Sheik Uduman, Rajitha Reddy, Priyanka Punuru, G. Chakka, G. Karunakaran

{"title":"Protective Role of Ramipril and Candesartan against Myocardial Ischemic Reperfusion Injury: A Biochemical and Transmission Electron Microscopical Study","authors":"M. S. T. Sheik Uduman, Rajitha Reddy, Priyanka Punuru, G. Chakka, G. Karunakaran","doi":"10.1155/2016/4608979","DOIUrl":"https://doi.org/10.1155/2016/4608979","url":null,"abstract":"The present study was designed to investigate the role of combined administration of Ramipril and Candesartan against in vitro myocardial ischemic reperfusion injury in rat. Male Wistar albino rats were divided into five groups (n = 6) and treated with saline (10 mL/kg), Ramipril (2 mg/kg), Candesartan (1 mg/kg), and the combination of both drugs, respectively 24 h before induction of global ischemia (5 min of stabilization, 9 min of global ischemia, and 12 min of reflow). Combination of Ramipril and Candesartan when compared to the monotherapy significantly increased the levels of superoxide dismutase, reduced glutathione, catalase, and nitric oxide and decreased the levels of thiobarbituric acid reactive substances. In addition, the superior protective role of combination of Ramipril and Candesartan on ischemia induced myocardial damage was further confirmed by well preserved myocardial tissue architecture in light microscopy and transmission electron microscopy analysis studies. The combination was proved to be effective in salvaging the myocardial tissue against ischemic reperfusion injury when compared to the monotherapy of individual drugs and further investigations on protective mechanism of drugs by increasing the nitric oxide level at molecular levels are needed.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4608979","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64388349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Cytotoxic Activity of Holothuria leucospilota Extract against Leishmania infantum In Vitro 白蛉提取物对婴儿利什曼原虫体外细胞毒活性的研究

Advances in Pharmacological Sciences Pub Date : 2016-02-28 DOI: 10.1155/2016/8195381

S. Khademvatan, Alborz Eskandari, J. Saki, M. Foroutan-Rad

{"title":"Cytotoxic Activity of Holothuria leucospilota Extract against Leishmania infantum In Vitro","authors":"S. Khademvatan, Alborz Eskandari, J. Saki, M. Foroutan-Rad","doi":"10.1155/2016/8195381","DOIUrl":"https://doi.org/10.1155/2016/8195381","url":null,"abstract":"Leishmaniasis is a tropical parasitic infection. The resistance and toxicity issues are the major complications and remain significant consequences related to the treatment of leishmaniasis with the recent and classical drugs. Thus there is an immediate requirement to develop new compounds for the treatment of this protozoan disease. Sea cucumbers or holothurians are potentially presented as the marine sources of antimicrobial and cytotoxic compounds. The aim of this study was investigation of in vitro antileishmanial activity of methanol extract of body wall, coelomic fluid, and cuvierian organs of Holothuria leucospilota obtained from coastal parts of Persian Gulf against Leishmania infantum promastigotes and axenic amastigotes. The colorimetric MTT assay was used to determine L. infantum promastigotes and axenic amastigotes viability at different concentrations of the extracts and drug control (Glucantime®) at time dependent manner and the results are represented as IC50 (50% of inhibitory concentration). Coelomic fluid was the most active extract among the three different extracts of H. leucospilota against L. infantum promastigotes and axenic amastigotes with IC50s of 62.33 μg/mL and 22.4 μg/mL and 73 μg/mL and 46 μg/mL at 48 and 72 hours after treatment, respectively. Cuvierian organs extract showed less toxicity with IC50s more than 1000 μg/mL for both Leishmania infantum axenic amastigotes and promastigotes forms after 48 and 72 hours of exposure. Results acquired from the present study propose that the sea cucumber H. leucospilota may be a provoking source of antileishmanial compounds and could be a lead source in the development of the potent antileishmanial and cytotoxic drugs.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/8195381","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64553968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015 水飞蓟素及其黄酮木脂素成分对重度β-地中海贫血的潜在作用综述

Advances in Pharmacological Sciences Pub Date : 2016-02-21 DOI: 10.1155/2016/3046373

Hadi Darvishi Khezri, E. Salehifar, M. Kosaryan, Aily Aliasgharian, H. Jalali, A. Hadian Amree

{"title":"Potential Effects of Silymarin and Its Flavonolignan Components in Patients with β-Thalassemia Major: A Comprehensive Review in 2015","authors":"Hadi Darvishi Khezri, E. Salehifar, M. Kosaryan, Aily Aliasgharian, H. Jalali, A. Hadian Amree","doi":"10.1155/2016/3046373","DOIUrl":"https://doi.org/10.1155/2016/3046373","url":null,"abstract":"Major β-thalassemia (β-TM) is one of the most common inherited hemolytic types of anemia which is caused as a result of absent or reduced synthesis of β-globin chains of hemoglobin. This defect results in red blood cells lysis and chronic anemia that can be treated by multiple blood transfusions and iron chelation therapy. Without iron chelation therapy, iron overload will cause lots of complications in patients. Antioxidant components play an important role in the treatment of the disease. Silymarin is an antioxidant flavonoid isolated from Silybum marianum plant. In the present study, we reviewed clinical and experimental studies investigating the use of silymarin prior to September 1, 2015, using PubMed, ISI Web of Knowledge, Science Direct, Scopus, Ovid, and Cochrane Library databases and we evaluated the potential effects of silymarin on controlling the complications induced by iron overload in patients with β-TM. Based on the results of the present study, we can conclude that silymarin may be useful as an adjuvant for improving multiple organ dysfunctions.","PeriodicalId":7389,"journal":{"name":"Advances in Pharmacological Sciences","volume":"2016 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/3046373","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64312459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 29