Journal of pharmacy and pharmacology research最新文献

{"title":"A Framework on Developing an Integrative Medicine Clinical Practice Guideline (CPG) for Systemic Lupus erythematosus (SLE) with Comorbidities Management in Hong Kong","authors":"Yuanyuan Chen, Philip Hei Li, Cheng Zhang, Ning Wang, Yibin Feng, Che-Shing Lau","doi":"10.26502/fjppr.085","DOIUrl":"https://doi.org/10.26502/fjppr.085","url":null,"abstract":"","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134883193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Media Exposure on Anxiety in Kuwait during COVID-19 Outbreak","authors":"Lulua Alasousi Sara al Hammouri, Sara al Al-abdulhadi, Ahmad T. Al-Sultan","doi":"10.26502/fjppr.072","DOIUrl":"https://doi.org/10.26502/fjppr.072","url":null,"abstract":",","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends of Per-Patient Healthcare Cost and Resource Utilization of Opioid Use Disorder Among Privately Insured Individuals in The United States from 2005-2014","authors":"Bibo Jiang, Li Wang, Douglas Leslie","doi":"10.26502/fjppr.084","DOIUrl":"https://doi.org/10.26502/fjppr.084","url":null,"abstract":"","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"190 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134883147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Problem of Home Therapy during COVID-19 Pandemic in Italy: Government Guidelines versus Freedom of Cure?","authors":"Serafino Fazio,&nbsp;Marco Cosentino,&nbsp;Franca Marino,&nbsp;Sergio Pandolfi,&nbsp;Elisabetta Zanolin,&nbsp;Paolo Bellavite","doi":"10.26502/fjppr.055","DOIUrl":"https://doi.org/10.26502/fjppr.055","url":null,"abstract":"<p><p>After starting in late 2019, COVID-19 spread worldwide, and Italy was one of the first Western nations to be seriously affected. At that time, both the virus and the disease were little known and there were no Evidence-Based Medicine indications for treatment. The Italian Health Ministry guidelines claimed that, unless oxygen saturation fell to <92%, no pharmacological treatment was necessary during the first 72 hours, other than on a purely symptomatic basis, preferably with paracetamol. As later confirmed, that delay in therapeutic intervention may have been responsible for numerous hospital admissions and a very high lethality (3.5 %). To try to remedy this situation, several volunteer groups were formed, managing to promptlycure thousands of patients at home with non-steroidal anti-inflammatory drugs and a variety of re-purposed drugs (principally hydroxychloroquine, ivermectin) and supplements (such as antioxidants, polyphenols and vitamin D). Although not documented by any randomized controlled studies, these approaches were nonetheless based on the best available evidence, were aimed at addressing otherwise unmet major needs and produced a significant reduction of hospitalizations, of symptom duration, and a complete recovery from the disease compared with late treatment, according to some retrospective observational studies and the clinical experience of many physicians. A prompt discussion, with a clear and open exchange between healthcare Institutions and the said groups of voluntary physicians, could clarify the most effective approaches to reduce the number of hospitalizations and the lethality of this disease.</p>","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"6 3","pages":"100-114"},"PeriodicalIF":0.0,"publicationDate":"2022-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9471922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluate Effectiveness of Hubbard Purification Rundown Process for Victims of Dioxin/Agent Orange and Related Strengths, Challenges","authors":"Hoang Duc Hau, Tran Ngoc Tam","doi":"10.26502/fjppr.056","DOIUrl":"https://doi.org/10.26502/fjppr.056","url":null,"abstract":"studies shown that dioxin, once pervades the can cause complicated damages at multiple sites, leading to several Current dioxin detoxification methods mainly address symptoms through integrated measures such as improving health with a diet rich in protein, vitamins, stimulating immunity, taking liver supplements to protect liver cells, or taking antioxidants in combination with steaming. Abstract Objective : The aim of this study was to assess the effectiveness of Hubbard purification rundown (PR) process for victims of agent orange in the centers of detoxification. Methods : The study was designed as a cross-sectional study combining quantitative and qualitative methods and carried out on 30 dioxin patients, 21 health workers, and 299 medical records in Hanoi and Da Nang centers for dioxin detoxification (CDD) of Vietnam. Results: A small number of patients were clinically examined before enrolling in and after finishing the treatment, 35%, and 0% respectively. In addition, 15% of patients did not finish their daily PR session in the second step, while 20% of them were not evaluated daily for treatment effectiveness in the fourth step by health workers. Furthermore, 20% of patients did not follow all 6 steps of","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatoprotective Effects of Dawa-Ul-Kurkum, a Unani Polyherbal Preparation and the Possible Mechanisms in Experimental Model of Ethanol Induced Liver Damage in Rats","authors":"Mohd Rafi Reshi, K. Gulati, M. Naqvi, Nafaa Hassan, A. Ray","doi":"10.26502/fjppr.057","DOIUrl":"https://doi.org/10.26502/fjppr.057","url":null,"abstract":"The liver is an important organ that is involved in metabolism, storage, secretion, and detoxification. Chronic alcohol misuse can cause hepatotoxicity, putting the liver's normal function in jeopardy. Hepatotoxicity caused by ethanol is primarily caused by toxic byproducts of its metabolism, which cause oxidative stress [1]. Alcohol is a psychoactive chemical that has been linked to a variety of health concerns around the world [2]. Oxidative stress is one of the key mechanisms of ethanol-induced hepatotoxicity. Alcohol dehydrogenase converts ethanol to acetaldehyde, which is then oxidized to acetate by acetaldehyde dehydrogenase [3-6]. When ethanol is taken in excess, it is converted mostly to acetaldehyde by the enzyme cytochrome P450 (CYP2E1), which is implicated in the production of reactive oxygen species (ROS) [7-9]. As a result, oxidative stress is caused by an increase in ROS combined with a reduction in antioxidant capability. Recent research suggests that ethanol-induced oxidative stress plays a key role in the development and progression of alcoholic liver disease [10-12]. Abstract","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between High Absolute Lymphocyte Counts and Favorable Prognosis in Eribulin Therapy is seen in First-Line Chemotherapy for Metastatic Breast Cancer: Combined Analysis of Two Phase 2 Studies","authors":"K. Kimura, T. Takashima, Hiroyo Oku, Ayana Ikari, Tomo Tominaga, Saki Takai, Junna Sakane, Michiaki Tanaka, H. Kawajiri, S. Kashiwagi, S. Tokunaga, S. Nishimura, S. Noda, M. Iwamoto","doi":"10.26502/fjppr.059","DOIUrl":"https://doi.org/10.26502/fjppr.059","url":null,"abstract":"Iwamoto. The Relationship between High Absolute Lymphocyte Counts and Favorable Prognosis in Eribulin Therapy is seen in First-Line Chemotherapy for Metastatic Breast Cancer: Combined Analysis of Two Phase 2 Studies. Journal of Pharmacy and Pharmacology Research 6 (2022): 139-146. Abstract Background: While absolute lymphocyte count (ALC) and neutrophil-to-lymphocyte ratio (NLR) are associated with prolonged progression-free survival (PFS) and overall survival (OS), the influence of previous chemotherapy on blood cell counts may necessitate an evaluation of baseline ALC and NLR in first-line chemotherapy patients. Methods: Patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) who received first-line eribulin chemotherapy in two phase 2 trials (BIRICHEN and OMC-BC 03) were retrospectively analyzed. HER2-negative MBC patients who received first-line chemotherapy other than eribulin (treatment of physician’s choice; TPC) at Osaka Medical and Pharmaceutical University Hospital between March 2013 and March 2017 were also analyzed for comparison. Results: In the eribulin group, the median OS (mOS) was 30.9 and 17.8 months in the high-(H-)ALC (≥1500/μL; n = 33) and low-(L-)ALC (<1500/ μL; n = 26) groups, respectively (hazard ratio [HR], 0.52; 95% confidence interval [CI]: 0.27–1.01), whereas it was 30.9 and 15.4 months in the L-NLR (<2.5; n = 23) and H-NLR (≥2.5; n = 36) groups, respectively (HR, 0.49; 95% CI: 0.25–0.95). In the TPC group, neither ALC nor NLR was associated with OS or PFS extension. The Relationship between High Absolute Lymphocyte Counts and Favorable Prognosis in Eribulin Therapy is seen in First-Line Chemotherapy for Metastatic Breast Cancer: Combined Analysis of Two Phase 2 Studies. Journal of Pharmacy and Pharmacology Research 6 (2022):","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tragic Choices, Government Actions and the ‘domino effect’ the Case of the COVID - 19 Syndemic and the Italian scenario","authors":"Matteo Maria Cati","doi":"10.26502/jppr.0048","DOIUrl":"https://doi.org/10.26502/jppr.0048","url":null,"abstract":"","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69351365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edible Green Solvent for Optimized Catechins Extraction from Green Tea Leaves: Anti-Hypercholesterolemia.","authors":"Kazutoshi Fujioka,&nbsp;Taher A Salaheldin,&nbsp;Kavitha Godugu,&nbsp;Harold V Meyers,&nbsp;Shaker A Mousa","doi":"10.26502/fjppr.053","DOIUrl":"https://doi.org/10.26502/fjppr.053","url":null,"abstract":"<p><p>Catechin polyphenols are the major bioactive ingredients in green tea with various human health benefits. Extraction of catechins from green tea (GTE) leaves at optimized standard conditions is still a challenging approach. An optimized, rapid, and economic extraction method is industrially needed. We hypothesized that certain extraction techniques in the presence of natural polymers and antioxidants might improve GTE catechin extraction yield and its biological activity. The effect of microwave (30-60 seconds irradiation in a typical kitchen microwave) assisted extraction (MAE) and ultrasonic assisted extraction (UAE) techniques were evaluated separately and in combination. To study the effect of the extraction solvent, nine edible green solvent combinations were investigated namely water, ascorbic acid, chitosan/ascorbic acid, carboxymethylcellulose /ascorbic acid, methylcellulose /ascorbic acid, chitosan/methylcellulose/ascorbic acid, methylcellulose, chitosan/acetic acid, and ethanol. The amounts of extracted catechins from green tea leaves were quantified with HPLC-UV. Data showed that the use of MAE & UAE technique was the optimal in producing a higher extraction yield of catechins. Chitosan/ascorbic acid was the optimized solvent with high extraction efficiencies of catechins. Studies in high fat diet fed animals demonstrated significant reduction of total cholesterol and LDL-C by GTE after 3 weeks of oral daily administration. In conclusion, efficient extraction, and stabilization of catechins from green tea leaves demonstrated a significant lowering of high fat diet-mediated elevation in blood cholesterol and LDL-C levels.</p>","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"6 2","pages":"80-92"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9328406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40557708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Meropenem, Ceftazidime and Piperacillin Levels in Serum and Meropenem in Cerebrospinal Fluid by Liquid Chromatography for Routine Quantification","authors":"Stefan Günther, A. Reimer, H. Vogl, Stephan Spenke, Hanns-Christian Dinges, A. Schubert, Leopold Hj Eberhart, G. Geldner","doi":"10.26502/fjppr.062","DOIUrl":"https://doi.org/10.26502/fjppr.062","url":null,"abstract":"((4R,5S,6S)-3-[[(3S,5S)-5-[(Dimethylamino)carbonyl]-3-Abstract Objective: Therapeutic drug monitoring (TDM) of β-lactam antibiotics is a commonly used to prevent treatment failures in critically ill patients. A quick and simple high-performance liquid chromatography (HPLC) assay for the determination of meropenem, ceftazidime and piperacillin in human serum and meopenem in","PeriodicalId":73897,"journal":{"name":"Journal of pharmacy and pharmacology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}