Journal of neuroparasitology最新文献

Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult. 脊髓损伤先天性弓形虫病证实与神经影像学，包括他们的成功治疗在成人。

Journal of neuroparasitology Pub Date : 2012-03-01 DOI: 10.4303/jnp/235533

Delilah Burrowes, Kenneth Boyer, Charles N Swisher, A Gwendolyn Noble, Mari Sautter, Peter Heydemann, Peter Rabiah, Daniel Lee, Rima McLeod

{"title":"Spinal Cord Lesions in Congenital Toxoplasmosis Demonstrated with Neuroimaging, Including Their Successful Treatment in an Adult.","authors":"Delilah Burrowes, Kenneth Boyer, Charles N Swisher, A Gwendolyn Noble, Mari Sautter, Peter Heydemann, Peter Rabiah, Daniel Lee, Rima McLeod","doi":"10.4303/jnp/235533","DOIUrl":"https://doi.org/10.4303/jnp/235533","url":null,"abstract":"Neuroimaging studies for persons in the National Collaborative Chicago-Based Congenital Toxoplasmosis Study (NCCCTS) with symptoms and signs referable to the spinal cord were reviewed. Three infants had symptomatic spinal cord lesions, another infant a Chiari malformation, and another infant a symptomatic peri-spinal cord lipoma. One patient had an unusual history of prolonged spinal cord symptoms presenting in middle age. Neuroimaging was used to establish her diagnosis and response to treatment. This 43 year-old woman with congenital toxoplasmosis developed progressive leg spasticity, weakness, numbness, difficulty walking, and decreased visual acuity and color vision without documented re-activation of her chorioretinal disease. At 52 years of age, spinal cord lesions in locations correlating with her symptoms and optic atrophy were diagnosed with 3 Tesla MRI scan. Treatment with pyrimethamine and sulfadiazine decreased her neurologic symptoms, improved her neurologic examination, and resolved her enhancing spinal cord lesions seen on MRI.","PeriodicalId":73863,"journal":{"name":"Journal of neuroparasitology","volume":"3 2012","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593714/pdf/nihms-367017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31303093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

The Impact of HIV Coinfection on Cerebral Malaria Pathogenesis. 艾滋病毒合并感染对脑疟疾发病机制的影响。

Journal of neuroparasitology Pub Date : 2012-01-01 Epub Date: 2012-03-02 DOI: 10.4303/jnp/235547

Sarah Hochman, Kami Kim

引用次数: 0

Cutaneous Acanthamoebiasis with CNS Involvement Post- Transplantation: Implication for Differential Diagnosis of Skin Lesions in Immunocompromised Patients 移植后累及中枢神经系统的皮肤棘阿米巴病:免疫功能低下患者皮肤病变鉴别诊断的意义

Journal of neuroparasitology Pub Date : 2012-01-01 DOI: 10.4303/JNP/N120801

Andrea A. D’Auria, J. Lin, P. Geiseler, Y. Qvarnstrom, Rebecca Bandea, S. Roy, R. Sriram, C. Paddock, S. Zaki, Gene H. Kim, G. Visvesvara

{"title":"Cutaneous Acanthamoebiasis with CNS Involvement Post- Transplantation: Implication for Differential Diagnosis of Skin Lesions in Immunocompromised Patients","authors":"Andrea A. D’Auria, J. Lin, P. Geiseler, Y. Qvarnstrom, Rebecca Bandea, S. Roy, R. Sriram, C. Paddock, S. Zaki, Gene H. Kim, G. Visvesvara","doi":"10.4303/JNP/N120801","DOIUrl":"https://doi.org/10.4303/JNP/N120801","url":null,"abstract":"We report a 62-year-old male who presented status post lung transplantation with subcutaneous nodules. One week later, he showed signs of altered mental status; brain imaging demonstrated mass effect in the cerebellum and meningoencephalitis. In spite of treatment with a broad range of antimicrobials, he died. A punch biopsy of the skin lesions showed a superficial and deep mixed inflammatory infiltrate admixed with large mononuclear cells. A diagnosis of cutaneous amoebiasis was made and the amoebae were identified as Acanthamoeba spp. based on immunofluorescent stains and PCR assays. Cutaneous Acanthamoebiasis is a rare infection in immunocompro- mised patients, particularly organ recipients. It is important that this entity is included in the differential diagnosis of immunocompromised patients who have cutaneous infections that are not responding to antibiotics. An early diagnosis is crucial since cutaneous Acanthamoebiasis can disseminate to the central nervous system and cause granulomatous amoebic encephalitis (GAE), which is usually fatal.","PeriodicalId":73863,"journal":{"name":"Journal of neuroparasitology","volume":"3 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71099539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Neurologic Manifestations of Leishmania spp. Infection. 利什曼原虫感染的神经学表现。

Journal of neuroparasitology Pub Date : 2011-04-09 DOI: 10.4172/2314-7326.1000123

C. Petersen, M. Greenlee

引用次数: 23

Neurologic Manifestations ofLeishmania spp.Infection 利什曼原虫感染的神经学表现

Journal of neuroparasitology Pub Date : 2011-01-01 DOI: 10.4303/JNP/N110401

C. Petersen, M. Greenlee

引用次数: 17

Neurologic Manifestations of Leishmania spp. Infection. 利什曼原虫感染的神经学表现。

Journal of neuroparasitology Pub Date : 2011-01-01

Christine Anne Petersen, M Heather West Greenlee

引用次数: 0

Implication of Uncoupling Protein 2 in Immunity to Herpes Simplex Virus Type I in Resistant and Susceptible Mouse Strains 解偶联蛋白2在耐药和易感小鼠株对ⅰ型单纯疱疹病毒免疫中的意义

Journal of neuroparasitology Pub Date : 2011-01-01 DOI: 10.4303/JNP/N110101

Laurie Rouger, Yan Sergerie, D. Arsenijevic, É. Paradis, G. Boivin, D. Richard

引用次数: 1

Prevalence and Morphological Characteristics of Taenia multiceps Cysts (Coenurus Cerebralis) from Abattoir-Slaughtered and Experimentally Infected Goats 屠宰场屠宰和实验感染山羊多头带绦虫囊肿的流行及形态学特征

Journal of neuroparasitology Pub Date : 2011-01-01 DOI: 10.4303/JNP/235532

S. Afonso, S. Mukaratirwa, K. Hajovska, B. Capece, C. Crist, E. Mondlane

{"title":"Prevalence and Morphological Characteristics of Taenia multiceps Cysts (Coenurus Cerebralis) from Abattoir-Slaughtered and Experimentally Infected Goats","authors":"S. Afonso, S. Mukaratirwa, K. Hajovska, B. Capece, C. Crist, E. Mondlane","doi":"10.4303/JNP/235532","DOIUrl":"https://doi.org/10.4303/JNP/235532","url":null,"abstract":"One hundred and forty nine indigenous goats slaughtered at the Tete municipal abattoir, Mozambique, and fifty seven goats experimentally infected with Taenia multiceps eggs were inspected to determine the prevalence, predilection sites and morphological characteristic of cysts and scoleces of T. multiceps. The experimentally infected goats of mixed sexes were divided into Group one (28 animals slaughtered at 10 weeks post-infection) and Group two (29 animals slaughtered at 22 weeks post-infection). Each animal was experimentally infected with 3000 eggs of T. multiceps recuperated from experimentally infected dogs. The prevalence of infection was 14.8% in the naturally infected goats, 78.6% for Group 1 and 82.8% for Group 2 of the experimentally infected goats. The muscle and subcutaneous tissues were the most common anatomic location of cysts in both the naturally and experimentally infected (Group 1 and 2) goats with a prevalence of 9.1%, 82% and 75% respectively and this was followed by the brain in the naturally infected (8.5%), and Group 2 (11.4%) and the heart and mesentery (4.5%) in Group 2. In the abattoir-slaughtered goats, animals with one cyst were more frequent in both muscular and subcutaneous tissues (73.3%) and brain (75%) and fewer animals were found to harbor two or more cysts.","PeriodicalId":73863,"journal":{"name":"Journal of neuroparasitology","volume":"2 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71099113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Detection of Toxoplasma DNA in the Peripheral Blood of HIV-Positive Patients with Neuro-opportunistic Infections by a Real-Time PCR Assay 实时荧光定量PCR检测hiv阳性神经机会性感染患者外周血弓形虫DNA

Journal of neuroparasitology Pub Date : 2011-01-01 DOI: 10.4303/JNP/N110402

Néstor Cardona, Natalia Basto, B. Parra, A. Zea, C. Pardo, A. Bonelo, Jorge Enrique

{"title":"Detection of Toxoplasma DNA in the Peripheral Blood of HIV-Positive Patients with Neuro-opportunistic Infections by a Real-Time PCR Assay","authors":"Néstor Cardona, Natalia Basto, B. Parra, A. Zea, C. Pardo, A. Bonelo, Jorge Enrique","doi":"10.4303/JNP/N110402","DOIUrl":"https://doi.org/10.4303/JNP/N110402","url":null,"abstract":"We determine if peripheral blood sample could be used for diagnosis of cerebral toxoplasmosis by a real-time PCR assay and we analyzed the clinical and laboratory findings in 22 patients with confirmed cerebral toxoplasmosis compared to 27 patients with other neuro- opportunistic infections. We compared two gene targets (B1 and RE) in the Taqman-PCR real-time assay. Efficiency values were also calculated. We found that 18.8% (4/22) of cases with cerebral toxoplasmosis and 7.4% (2/27) of patients with other neuroinfections had positive results with the Taqman PCR assay. The mean number of parasites was 67.7 (SD 69.0) tachyzoites/mL in patients with cerebral toxoplasmosis and of 31.8 (SD 6.3) tachyzoites/mL in other neuroinfections. Clinical symptoms as headache were significantly less frequent and focal neurological symptoms were significantly more frequent in cerebral toxoplasmosis than in other neuroinfections. In our conditions, real- time PCR on peripheral blood samples was not useful for diagnosis of cerebral toxoplasmosis.","PeriodicalId":73863,"journal":{"name":"Journal of neuroparasitology","volume":"2 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4303/JNP/N110402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71099529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

A Purification Method for Enrichment of the Toxoplasma gondii Cyst Wall. 刚地弓形虫囊壁富集纯化方法研究。

Journal of neuroparasitology Pub Date : 2010-12-01 DOI: 10.4303/jnp/N101001

Yi Wei Zhang, Sandra K Halonen, Yan Fen Ma, Herbert B Tanowtiz, Louis M Weiss

{"title":"A Purification Method for Enrichment of the Toxoplasma gondii Cyst Wall.","authors":"Yi Wei Zhang, Sandra K Halonen, Yan Fen Ma, Herbert B Tanowtiz, Louis M Weiss","doi":"10.4303/jnp/N101001","DOIUrl":"https://doi.org/10.4303/jnp/N101001","url":null,"abstract":"The tissue cyst wall of Toxoplasma gondii is a stage-specific structure that is produced by modification of the bradyzoite-containing parasitophorous vacuole. It is a limiting membrane structure and is critically important for cyst survival and transmission of infection. Studies on the structure and function of the cyst wall should provide new therapeutic strategies for the elimination or prevention of latency during T. gondii infection. The membrane proteins of the T. gondii cyst are an important target for studies of the biochemical and immunological function(s) of the cyst. However, the components of the cyst membrane have been poorly characterized due to the difficulty of purification of these membrane proteins. We developed a lectin DBA (Dolichos biflorus) coated magnetic bead isolation method to isolate T. gondii cyst wall proteins. Our data suggests that this method can isolate cyst wall proteins from both in vitro cell culture or in vivo mouse brain derived tissue cysts. Antibodies to these isolated protein preparations were shown to localize to the cyst wall.","PeriodicalId":73863,"journal":{"name":"Journal of neuroparasitology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2010-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115730/pdf/nihms287853.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30250049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13