Journal of multimorbidity and comorbidity最新文献

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Focusing on burden and capacity to support self-management of chronic health conditions: A pilot trial of care coordination in rural Australia. 注重负担和能力,以支持慢性健康状况的自我管理:澳大利亚农村护理协调的试点试验。
IF 2.7
Journal of multimorbidity and comorbidity Pub Date : 2026-02-27 eCollection Date: 2026-01-01 DOI: 10.1177/26335565261417400
Ruth Hardman, Stephen Begg, Evelien Spelten
{"title":"Focusing on burden and capacity to support self-management of chronic health conditions: A pilot trial of care coordination in rural Australia.","authors":"Ruth Hardman, Stephen Begg, Evelien Spelten","doi":"10.1177/26335565261417400","DOIUrl":"10.1177/26335565261417400","url":null,"abstract":"<p><strong>Introduction: </strong>Managing multiple health conditions can create a demanding workload, especially when capacity is limited. This can lead to disengagement and poor health outcomes. Our pilot trial explored the feasibility of care coordination using a minimally-disruptive medicine approach.</p><p><strong>Methods: </strong>The setting was a community health service in rural Victoria, Australia. People with multimorbidity and complex life demands were linked to care coordinators who evaluated and addressed burden and capacity imbalance, informed by client priorities. Clinicians underwent training in capacity-burden assessment and participated in ongoing case conferencing. A mixed-methods evaluation was undertaken guided by Bowen's feasibility framework with treatment burden and quality of life as quantitative outcomes.</p><p><strong>Results: </strong>26 clients (mean age 66.5 years) engaged with 3 care coordinators. Clients reported high treatment burden with a mean of 11 chronic conditions each, dominated by mental health and chronic pain conditions. The program was highly acceptable to clients, who reported increased control over their health and life demands. Six-month outcomes showed a significant reduction in treatment burden level (MMTBQ) p=0.019, Phi=0.524 and improvement in quality-of-life scores (EQ-VAS) p=0.019. Clinicians valued the program and highlighted the importance of putting aside one's discipline lens and focusing on the client priorities, aided by the assessment tools and training.</p><p><strong>Discussion: </strong>A burden-capacity model of care coordination is feasible in the community health setting and may lead to reduced treatment burden. Barriers identified were related to community health funding and structures favouring single diseases and disciplinary boundaries, which may not reflect the lived experience of clients.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565261417400"},"PeriodicalIF":2.7,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12953959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of the Short Treatment Burden Questionnaire (STBQ) including a Global Treatment Burden Question (GTBQ): Cognitive interviews with adults living with multimorbidity. 制定短期治疗负担问卷(STBQ),包括全球治疗负担问题(GTBQ):对患有多种疾病的成年人进行认知访谈。
IF 2.7
Journal of multimorbidity and comorbidity Pub Date : 2026-02-26 eCollection Date: 2026-01-01 DOI: 10.1177/26335565261417393
Rebecca Goulding, Polly Duncan, Anastasiia G Kovalenko, Chloe Gamlin, Simon Chilcott, Simon D S Fraser, Jose M Valderas, Rachel Johnson
{"title":"Development of the Short Treatment Burden Questionnaire (STBQ) including a Global Treatment Burden Question (GTBQ): Cognitive interviews with adults living with multimorbidity.","authors":"Rebecca Goulding, Polly Duncan, Anastasiia G Kovalenko, Chloe Gamlin, Simon Chilcott, Simon D S Fraser, Jose M Valderas, Rachel Johnson","doi":"10.1177/26335565261417393","DOIUrl":"10.1177/26335565261417393","url":null,"abstract":"<p><strong>Background: </strong>A short patient reported outcome measure (PROM) could help identify people experiencing high treatment burden.</p><p><strong>Objectives: </strong>To develop the Short Treatment Burden Questionnaire (STBQ), a novel PROM comprising a Global Treatment Burden Question (GTBQ) and items to identify areas of difficulty; improve its understandability and face validity; and explore patient views on using it in clinical practice.</p><p><strong>Methods: </strong>Prototype development drew on the validated Multimorbidity Treatment Burden Questionnaire (MTBQ) and a single-item global measure. Adults, aged 18-65, living with multimorbidity were recruited from English general practices. Three rounds of cognitive interviews, with think-aloud and prompts, were conducted (July-October 2023). After each round, data were analysed, suggested changes and uncertainties discussed and modifications made. Public contributors were involved throughout.</p><p><strong>Results: </strong>Participants (n = 15) were predominantly female (67%) and White British (87%). Issues were identified with the layout, instructions, and order and wording of response options, with some aspects interpreted in unintended ways. The number of issues and consequent changes reduced with each round of interviews. Participants highlighted potential benefits of using the STBQ in clinical practice, including encouraging patients to mention things they may not otherwise bring up. They suggested the STBQ could inform both individual patient care and practice-level service improvement.</p><p><strong>Conclusions: </strong>Robust qualitative methods were used to develop a novel PROM for use in clinical practice and research. The STBQ demonstrated face validity and was relatively easy to use. Further work has been undertaken to validate the GTBQ. Guidance will outline how the STBQ could support patient care.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565261417393"},"PeriodicalIF":2.7,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges for the design of randomised trials for interventions for people with multiple long-term conditions: Recruitment and outcome selection. 针对多种长期疾病患者的干预措施的随机试验设计的挑战:招募和结果选择。
IF 2.7
Journal of multimorbidity and comorbidity Pub Date : 2026-02-19 eCollection Date: 2026-01-01 DOI: 10.1177/26335565251376613
Sally J Singh, Rod S Taylor
{"title":"Challenges for the design of randomised trials for interventions for people with multiple long-term conditions: Recruitment and outcome selection.","authors":"Sally J Singh, Rod S Taylor","doi":"10.1177/26335565251376613","DOIUrl":"10.1177/26335565251376613","url":null,"abstract":"<p><p>The burden of multiple long-term conditions is significant for the individual and society. Exploring interventions to alleviate disease progression, accumulation of long-term conditions and symptom burden is crucial. This commentary debates two important considerations for intervention design and subsequent recruitment approaches.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565251376613"},"PeriodicalIF":2.7,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimorbidity combinations among older adults in Singapore: A cross-sectional study using polyclinic data. 新加坡老年人的多病组合:一项使用多诊所数据的横断面研究。
IF 2.7
Journal of multimorbidity and comorbidity Pub Date : 2026-02-17 eCollection Date: 2026-01-01 DOI: 10.1177/26335565261417399
Victoria Koh, Shilpa Tyagi, Gerald Choon-Huat Koh, Sai Zhen Sim, Meena Sundram, Lawrence Lam, Ngiap Chuan Tan, Eng Sing Lee
{"title":"Multimorbidity combinations among older adults in Singapore: A cross-sectional study using polyclinic data.","authors":"Victoria Koh, Shilpa Tyagi, Gerald Choon-Huat Koh, Sai Zhen Sim, Meena Sundram, Lawrence Lam, Ngiap Chuan Tan, Eng Sing Lee","doi":"10.1177/26335565261417399","DOIUrl":"10.1177/26335565261417399","url":null,"abstract":"<p><strong>Background: </strong>Multimorbidity, the co-occurrence of multiple chronic conditions, is commonly managed in primary care and increasingly prevalent. Researchers are increasingly studying the unique combinations of chronic conditions and their associations with health service utilisation. However, published studies largely focus on common dyads and triads of chronic conditions. This study aims to determine the prevalence and combinations of multimorbidity among older adults managed in Singapore's primary care.</p><p><strong>Methods: </strong>A cross-sectional analysis of all Singapore citizens and permanent residents aged ≥50 years who visited any polyclinic between July 2017 to June 2018 was conducted. Patient diagnoses up to year 2012 were reviewed using 23 chronic condition categories to define multimorbidity. All multimorbidity combinations and their prevalence were analysed.</p><p><strong>Results: </strong>Among 502,036 polyclinic patients aged ≥50 years, 59.9% had multimorbidity. Of 4,194,050 possible multimorbidity combinations, 13,959 were observed. Combinations comprised between three to 13 chronic conditions. The most prevalent and costly combinations consisted three to four chronic conditions: (1) hyperlidaemia/hypertension/diabetes; (2) hyperlidaemia/hypertension/diabetes/functional limitation; (3) hyperlidaemia/hypertension/functional limitation; (4) hyperlipidaemia/hypertension/diabetes/cardiovascular disease; (5) hyperlipidaemia/hypertension/diabetes/arthritis; (6) hyperlipidaemia/hypertension/arthritis; (7) hyperlipidaemia/hypertension/cardiovascular disease; (8) hyperlipidaemia/hypertension/diabetes/obesity; (9) hyperlipidaemia/hypertension/diabetes/stroke; (10) hyperlipidaemia/hypertension/arthritis/functional limitation; (11) hyperlipidaemia/hypertension/diabetes/kidney.</p><p><strong>Conclusion: </strong>Although a wide variety of combinations were observed, hyperlipidaemia and hypertension were common in the most prevalent and costly combinations. As current management of chronic conditions focusses on disease-specific clinical outcomes, findings from this study suggest a need to optimise clinical outcomes for common multimorbidity combinations rather than simply aggregating outcomes for all conditions within the combination.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565261417399"},"PeriodicalIF":2.7,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12914068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post-COVID-19 conditions identified by ICD-10-CM code in a cohort of U.S. primary care patients, 2021 - 2023. 2021 - 2023年美国初级保健患者队列中ICD-10-CM代码确定的covid -19后疾病
IF 2.7
Journal of multimorbidity and comorbidity Pub Date : 2026-02-12 eCollection Date: 2026-01-01 DOI: 10.1177/26335565261422426
Xiaoyu Wang, Esther Velásquez, Sharon Saydah, Emilia H Koumans, Ilia Rochlin, Sebastian Romano, David H Rehkopf, Nicole D Ford
{"title":"Post-COVID-19 conditions identified by ICD-10-CM code in a cohort of U.S. primary care patients, 2021 - 2023.","authors":"Xiaoyu Wang, Esther Velásquez, Sharon Saydah, Emilia H Koumans, Ilia Rochlin, Sebastian Romano, David H Rehkopf, Nicole D Ford","doi":"10.1177/26335565261422426","DOIUrl":"10.1177/26335565261422426","url":null,"abstract":"<p><strong>Objectives: </strong>Describe patient characteristics, healthcare utilization, and Post-COVID-associated conditions among primary care patients with an ICD-10-CM diagnosis code for Post COVID-19 Condition (U09.9).</p><p><strong>Methods: </strong>Using electronic health record (EHR) data from the American Family Cohort, a U.S. national primary care dataset, we identified patients with a U09.9 diagnosis documented October 1, 2021-June 1, 2023. Patient data were categorized into three periods: pre-pandemic (2016-2019), pandemic pre-index (2020 to the first U09.9 diagnosis, or 'index' date), and post-index (index date to the last observation). Post-COVID-associated conditions were aggregated <i>a priori</i> into 12 body systems.</p><p><strong>Results: </strong>We identified 10,265 patients with a U09.9 diagnosis code; 81.9% were ≥40 years, 63.3% female, 74.4% White, and 70.5% resided in metropolitan counties. Patients averaged 12.7 primary care encounters in the year before the index U09.9 diagnosis, compared to 9.2 encounters annually in the post-index period. Over 68% of patients who had ≥1 pre-pandemic encounters had ≥1 underlying medical conditions. The prevalence of conditions across 9 out of 12 body systems increased from the pre-pandemic to the pandemic pre-index period for patients who had ≥1 conditions. Prevalence of respiratory and musculoskeletal conditions had the largest decrease from the pandemic pre-index to the post-index period.</p><p><strong>Conclusions: </strong>Compared to adults who self-report Long COVID in nationally representative population-based surveys, patient characteristics in this cohort highlight a potential diagnosis gap - particularly for patients with rural residence or high county-level socioeconomic deprivation. Given frequent healthcare utilization and clinical complexity, primary care may require additional resources to meet patient needs.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565261422426"},"PeriodicalIF":2.7,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12901935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of the Tilburg Frailty Indicator with mortality, readmission, and healthcare contacts in adult patients with multimorbidity. 蒂尔堡衰弱指标与多病成人患者死亡率、再入院率和医疗接触者的关系
IF 3
Journal of multimorbidity and comorbidity Pub Date : 2026-01-30 eCollection Date: 2026-01-01 DOI: 10.1177/26335565251415477
Thomas J Hjelholt, Thomas Veedfald, Anne Frølich, Charlotte Appel, Henrik Holm Thomsen, Anders Prior, Anne Dorthe Bjerrum, Marianne Balsby, Anne Marie Schak Jensen, Lene Kongsgaard Nielsen
{"title":"Association of the Tilburg Frailty Indicator with mortality, readmission, and healthcare contacts in adult patients with multimorbidity.","authors":"Thomas J Hjelholt, Thomas Veedfald, Anne Frølich, Charlotte Appel, Henrik Holm Thomsen, Anders Prior, Anne Dorthe Bjerrum, Marianne Balsby, Anne Marie Schak Jensen, Lene Kongsgaard Nielsen","doi":"10.1177/26335565251415477","DOIUrl":"10.1177/26335565251415477","url":null,"abstract":"<p><strong>Purpose: </strong>Frailty is closely related to multimorbidity and unfavorable outcomes. The Tilburg Frailty Indicator (TFI) is a self-reported assessment comprising 15 questions across three domains. We assessed whether the TFI predicts 180-day mortality, 30-day readmission and healthcare contacts among adults with multimorbidity across a broad age range.</p><p><strong>Methods: </strong>Single-center prospective cohort study including adults with multimorbidity. Follow-up was 180 days. Cox regression analyses estimated hazard ratios (HRs) with 95% confidence intervals (CIs) for death and readmission. Poisson regression estimated incidence rate ratios (IRR) of any health care contact. Exposure was TFI as both a dichotomous and a 0-15 points integer variable. Analyses were adjusted for age and sex.</p><p><strong>Results: </strong>We included 471 participants, median age 70 years (IQR 60-76 years) with an average of 6.0 chronic diseases. In adjusted analyses, frailty (TFI score > 5) was associated with HR 4.6 (CI 2.2, 9.7) for death and HR 2.6 (CI 1.7, 4.1) for readmission. Frailty was associated with an IRR of 1.5 (CI 1.3, 1.7) of any health care contact. A one-point increase in TFI score conferred increments in relative estimates across all outcomes.</p><p><strong>Conclusions: </strong>Our findings extend prior TFI research from older community-dwelling cohorts to multimorbid adults across clinical settings; TFI was both dichotomously and point-by point associated with adverse outcomes. TFI is a self-reported tool that offers a practical and efficient alternative to traditional frailty scoring systems, requiring neither clinical metrics nor expert evaluation, reducing time and resource demands. TFI may be a relevant multidomain risk assessment tool for care pathways in multimorbidity.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565251415477"},"PeriodicalIF":3.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in quality of life in people with multimorbidity: A cross-sectional survey comparing MMQ1 and EQ-5D-5L. 多重疾病患者生活质量的变化:MMQ1和EQ-5D-5L的横断面调查比较
IF 3
Journal of multimorbidity and comorbidity Pub Date : 2026-01-16 eCollection Date: 2026-01-01 DOI: 10.1177/26335565251410275
Kieran D Sweeney, Dilek Coskun, Volkert Siersma, Lucy E Stirland, Bruce Guthrie, Stewart W Mercer, John B Brodersen
{"title":"Variations in quality of life in people with multimorbidity: A cross-sectional survey comparing MMQ1 and EQ-5D-5L.","authors":"Kieran D Sweeney, Dilek Coskun, Volkert Siersma, Lucy E Stirland, Bruce Guthrie, Stewart W Mercer, John B Brodersen","doi":"10.1177/26335565251410275","DOIUrl":"10.1177/26335565251410275","url":null,"abstract":"<p><strong>Background: </strong>The Multimorbidity Questionnaire (MMQ1) is a patient-reported outcome measure assessing quality of life (QoL) in people with multimorbidity. An English-language version was recently validated for use in the United Kingdom. This study examines: (1) Whether MMQ1 detects expected variations in QoL according to individual characteristics; (2) How MMQ1 compares with EQ-5D-5L in detecting such variations, and in discriminating between different levels of QoL.</p><p><strong>Methods: </strong>A postal survey was distributed to 2753 patients with multimorbidity. Relationships between MMQ1 and EQ-5D-5L with six independent variables (long-term condition count, mental-physical multimorbidity, deprivation, self-rated QoL, age and sex) were examined using linear regression analyses. Discriminative ability was assessed using Receiver Operating Characteristic curves and sample size calculations with respect to consecutive classes of self-rated QoL.</p><p><strong>Results: </strong>597 responses were received (22%). Respondents had a mean age of 69.5 years and 48% were men. Higher long-term condition count, the presence of mental-physical multimorbidity and increasing deprivation were associated with poorer QoL on both measures. In addition, three MMQ1 domains demonstrated age-related variations in QoL that were not detected using EQ-5D-5L. MMQ1 exhibited superior discriminative ability to EQ-5D-5L, especially in distinguishing between individuals with 'Poor' vs 'Very Poor' self-rated QoL, where EQ-5D-5L was particularly weak.</p><p><strong>Conclusion: </strong>MMQ1 detected expected variations in QoL according to individual characteristics, supporting known-groups validity. It was superior to EQ-5D-5L in its ability to detect age-related variations in QoL and to discriminate between different levels of self-rated QoL. MMQ1 has the potential to improve the measurement of QoL in people with multimorbidity.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565251410275"},"PeriodicalIF":3.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12811566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal multimorbidity and chronic conditions as predictors of preterm birth: A matched case-control study in Cyprus. 产妇多病和慢性病作为早产的预测因素:塞浦路斯的匹配病例对照研究。
IF 3
Journal of multimorbidity and comorbidity Pub Date : 2026-01-13 eCollection Date: 2026-01-01 DOI: 10.1177/26335565251407931
Lenos Mastrou, Maria Kyprianidou, Demetris Lamnisos, Konstantinos Giannakou
{"title":"Maternal multimorbidity and chronic conditions as predictors of preterm birth: A matched case-control study in Cyprus.","authors":"Lenos Mastrou, Maria Kyprianidou, Demetris Lamnisos, Konstantinos Giannakou","doi":"10.1177/26335565251407931","DOIUrl":"10.1177/26335565251407931","url":null,"abstract":"<p><strong>Introduction: </strong>Preterm birth (PTB) is a leading global cause of neonatal morbidity and mortality. While individual maternal chronic conditions are established risk factors, the role of maternal multimorbidity remains underexplored. This study aimed to examine the association between maternal multimorbidity and PTB, and to identify chronic conditions associated with the occurrence and severity of PTB.</p><p><strong>Methods: </strong>A retrospective matched case-control study was conducted at Archbishop Makarios III Hospital in Nicosia, Cyprus. The sample included 978 singleton live births, consisting of 489 preterm cases (<37 weeks) matched 1:1 with 489 term controls (≥37 weeks) by maternal age and country of origin. Data were extracted from patient's medical records. Multimorbidity was defined as the presence of two or more chronic conditions. Conditional logistic regression assessed associations with PTB, and binary logistic regression examined predictors of extreme/very PTB (<32 weeks) versus moderate/late PTB (32 to <37 weeks).</p><p><strong>Results: </strong>Maternal multimorbidity was associated with increased odds of PTB (aOR = 1.80; 95% CI: 1.16-2.79; p=0.009). Hypertension (aOR=4.26; 95% CI: 1.84-9.86), kidney disease (aOR=3.67; 95% CI: 1.01-13.30), thrombophilia (aOR=3.53; 95% CI: 1.14-10.88), thyroid disorders (aOR = 1.77; 95% CI: 1.05-2.98), and allergies (aOR=1.82; 95% CI: 1.12-2.99) were independently associated with PTB. Diabetes was inversely associated with extreme PTB (aOR=0.19; 95% CI: 0.10-0.92).</p><p><strong>Conclusions: </strong>Maternal multimorbidity and several chronic conditions are significant and independent predictors of PTB. These findings underscore the importance of comprehensive antenatal screening and integrated care for women with multiple health conditions. Tailored risk assessment strategies may help reduce the burden of PTB, particularly in populations with rising rates of chronic disease.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565251407931"},"PeriodicalIF":3.0,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12800006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differences in clinical profiles and cancer incidence among patients with type 2 diabetes in primary care: Comparison between multidisciplinary and usual management. 初级保健中2型糖尿病患者的临床概况和癌症发病率的差异:多学科和常规治疗的比较
IF 3
Journal of multimorbidity and comorbidity Pub Date : 2026-01-11 eCollection Date: 2026-01-01 DOI: 10.1177/26335565251410270
Sarah Tsz Yui Yau, Chi Tim Hung, Eman Yee Man Leung, Albert Lee, Eng Kiong Yeoh
{"title":"Differences in clinical profiles and cancer incidence among patients with type 2 diabetes in primary care: Comparison between multidisciplinary and usual management.","authors":"Sarah Tsz Yui Yau, Chi Tim Hung, Eman Yee Man Leung, Albert Lee, Eng Kiong Yeoh","doi":"10.1177/26335565251410270","DOIUrl":"10.1177/26335565251410270","url":null,"abstract":"<p><strong>Background: </strong>Multidisciplinary diabetes management has been designed to reduce the risk of diabetes-associated complications. Nevertheless, it remains underexplored whether multidisciplinary management may provide the added benefits of lowering cancer risk. This study aims to compare differences in clinical profiles and cancer incidence between patients receiving multidisciplinary and standard management in primary care.</p><p><strong>Methods: </strong>This retrospective cohort study identified patients who attended general outpatient clinics between year 1997 and 2021 without cancer history using territory-wide electronic health records of Hong Kong. Patients were followed up until December 31st, 2021. Cox regression weighted with inverse probability of treatment was applied to compare the risk of site-specific cancers (colon and rectum, liver, pancreas, stomach, bladder, kidney, and lung) between patients with usual diabetes care (n=25,301), multidisciplinary diabetes management (n=66,382), and those without diabetes (n=54,376).</p><p><strong>Results: </strong>The risk of developing liver and pancreatic cancers appeared to be attenuated in patients who received multidisciplinary diabetes care, when compared to those with usual care alone (aHRs for liver: 1.90, 95%CI 1.26-2.86 vs 2.26, 95%CI 1.47-3.46; pancreas: 3.47, 95%CI 1.41-8.53 vs 5.57, 95%CI 2.15-14.45), with reference to non-diabetes. Patients with usual diabetes care showed a higher risk of gastric cancer in unweighted model, but the association disappeared in weighted model. Overall, patients who received multidisciplinary diabetes management tended to be younger with less comorbidities.</p><p><strong>Conclusion: </strong>The risk of liver and pancreatic cancers appeared to be mitigated in patients receiving multidisciplinary diabetes care. Further studies are warranted to evaluate whether multidisciplinary management may provide additional benefits of cancer prevention.</p>","PeriodicalId":73843,"journal":{"name":"Journal of multimorbidity and comorbidity","volume":"16 ","pages":"26335565251410270"},"PeriodicalIF":3.0,"publicationDate":"2026-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12791211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145967860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The experience of older adults living with multimorbidity during the COVID-19 pandemic: A phenomenological study. 2019冠状病毒病大流行期间多病老年人的经历:现象学研究
IF 3
Journal of multimorbidity and comorbidity Pub Date : 2025-12-24 eCollection Date: 2025-01-01 DOI: 10.1177/26335565251408339
Bridget L Ryan, Judith Belle Brown, Saifora I Paktiss, Amanda L Terry
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