Journal of molecular and cellular cardiology plus最新文献

{"title":"Pulmonary Vein Isolation with Pulsed Field Ablation in a Patient with Persistent Left Superior Vena: Potential for Transmural Ablation","authors":"Neshi Weerasooriya , Jonathan Ariyaratnam , Mohan Jayakumar , Shaun Evans , Monika Gawalko , Alessandra Pina , Sanjai Pattu Valappil , Mohamed Abbas , Samuel J. Tu , Dennis H. Lau , Glenn Young , Kurt C. Roberts-Thomson , Mehrdad Emami , Prashanthan Sanders , Christopher X. Wong","doi":"10.1016/j.jmccpl.2025.100533","DOIUrl":"10.1016/j.jmccpl.2025.100533","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100533"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peroxisomal adaptations in Barth syndrome: compensatory roles of catalase and plasmalogen biosynthesis in oxidative stress regulation","authors":"Elsie Vidah Kajese , Malte Hachmann , Christoph Maack , Srikanth Karnati , Jan Dudek","doi":"10.1016/j.jmccpl.2025.100548","DOIUrl":"10.1016/j.jmccpl.2025.100548","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100548"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGK1: A novel target in fibrosis-induced atrial fibrillation","authors":"Alina S. Bilal , Scott A. Hahn , Matthew B. Murphy , Victoria B. Murray , Katherine T. Murray , Christopher C. Glembotski , Erik A. Blackwood","doi":"10.1016/j.jmccpl.2025.100525","DOIUrl":"10.1016/j.jmccpl.2025.100525","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100525"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing a novel ASO therapy for Friedreich ataxia cardiomyopathy using a pre-clinical human vascularised cardiac organoid model","authors":"Jarmon G. Lees , Li Li , Haoxiang Zhang , Anne M. Kong , Andrew Treller , Geraldine M. Mitchell , Mirella Dottori , Alice Pebay , Stephen Wilcox , Mark Chong , Roger Peverill , Martin Delatyki , Jeffrey M. Pullin , Davis McCarthy , Jill S. Napierala , Marek Napierala , Shiang Y. Lim","doi":"10.1016/j.jmccpl.2025.100527","DOIUrl":"10.1016/j.jmccpl.2025.100527","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100527"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Loss Attenuates Left Atrial Electrical Remodelling Associated With Obesity In Mice Fed High-Fat Diet","authors":"Olivia Baines , Rina Sha , Sophie Broadway-Stringer , Abbie Hayes , Katja Gehmlich , Manish Kalla , Andrew P. Holmes , Christopher O'Shea , Davor Pavlovic","doi":"10.1016/j.jmccpl.2025.100562","DOIUrl":"10.1016/j.jmccpl.2025.100562","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100562"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procollagen C-proteinase Enhancer-1 (PCPE-1) Drives Cardiac Remodeling in Chronic Kidney Disease","authors":"Tin May Aung , Yung Ting Hsiao , Ippei Shimizu","doi":"10.1016/j.jmccpl.2025.100547","DOIUrl":"10.1016/j.jmccpl.2025.100547","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100547"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Long Non-coding RNA Regulators of Cardiomyocyte Specification using CRISPRi Screening","authors":"Ryan Fan Ruiming , Mick Lee Chang Jie , Roger Foo Sik Yin","doi":"10.1016/j.jmccpl.2025.100500","DOIUrl":"10.1016/j.jmccpl.2025.100500","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100500"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated heart–blood RNA editome profiling reveals circulating A-to-I editing candidates linked to dilated cardiomyopathy myocardial signatures and heart failure","authors":"Korina Karagianni ,&nbsp;Mantiana Topouzi ,&nbsp;Ilektra Mitsi ,&nbsp;Theodoros Sklaviadis ,&nbsp;Antigone Lazou ,&nbsp;Dimitra Dafou","doi":"10.1016/j.jmccpl.2026.100838","DOIUrl":"10.1016/j.jmccpl.2026.100838","url":null,"abstract":"<div><h3>Background</h3><div>Dilated cardiomyopathy (DCM) is a leading cause of heart failure (HF), yet molecular signatures that are detectable in blood and mechanistically anchored in myocardial pathology remain limited. Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional regulator in the heart, but its biomarker potential in human DCM and its reflection in the circulation are not well defined.</div></div><div><h3>Methods</h3><div>We performed comprehensive RNA editome profiling of human myocardium from DCM patients and non-failing donors, and integrated these results with peripheral blood RNA editing profiles from HF patients and controls, using a SPRINT-based pipeline with stringent in-house post-postprocessing and quality filtering. Global editing distributions and site-level differential editing were assessed, and shared heart–blood candidates were evaluated for directionality and functional enrichment.</div></div><div><h3>Results</h3><div>Cardiac RNA editing was dominated by ADAR-mediated A-to-I events and was significantly increased in DCM, with prominent enrichment in Alu elements and a higher number of unique editing sites compared with controls. Site-level analysis identified a predominantly hyper-edited DCM signature, mapping to genes and pathways linked to cardiomyopathy and cellular stress, including hypoxia and apoptosis. Cross-tissue comparison revealed 107 shared differentially edited sites between DCM heart and HF blood, with subsets showing concordant directionality. Shared targets were enriched for innate immune and type I interferon signaling, RIG-I pathway regulation, hypoxia-related responses, and apoptosis.</div></div><div><h3>Conclusions</h3><div>DCM is associated with global myocardial A-to-I hyper-editing and a robust, multi-locus editing program. Importantly, a subset of these disease-associated editing events is detectable in peripheral blood from heart failure patients, supporting the feasibility of HF-associated circulating RNA editing signatures that reflect myocardial pathology.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100838"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered 3D Cardiac Organoids to Model Diabetic Cardiomyopathy for Mechanistic Insights and Drug Discovery","authors":"Ren Jie Phang ,&nbsp;Nan Su ,&nbsp;Anne Kong ,&nbsp;Shiang Yong Lim ,&nbsp;Jarmon Gerald Lees","doi":"10.1016/j.jmccpl.2025.100536","DOIUrl":"10.1016/j.jmccpl.2025.100536","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100536"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The adipocyte βeta3-adrenergic receptor remotely modulates myocardial remodeling","authors":"Lorena Cascarano,&nbsp;Hrag Esfahani,&nbsp;Delphine De Mulder,&nbsp;Nathalie Fabian,&nbsp;Roxane Verdoy,&nbsp;Vania-Orline Keza,&nbsp;Alberto Melecchi,&nbsp;Chantal Dessy,&nbsp;Jean-Luc Balligand,&nbsp;Lauriane Michel","doi":"10.1016/j.jmccpl.2025.100507","DOIUrl":"10.1016/j.jmccpl.2025.100507","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100507"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}