Journal of molecular and cellular cardiology plus最新文献

{"title":"Intermittent Fasting: A Powerful Strategy to Lower The Risk of Myocardial Infarction","authors":"Miloslava Chalupova , Kristyna Holzerova , Daniel Benak , Gabriela Pavlinkova , Marketa Hlavackova","doi":"10.1016/j.jmccpl.2025.100594","DOIUrl":"10.1016/j.jmccpl.2025.100594","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100594"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Protective Mechanism of Ufmylation Against Heart Failure","authors":"Varsha Tandra, Juan Ayala, Maryam R. Gazik, Honglin Li, Huabo Su, Jie Li","doi":"10.1016/j.jmccpl.2025.100570","DOIUrl":"10.1016/j.jmccpl.2025.100570","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100570"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147538614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deletion of Cd248 in Postn+ myofibroblast fails to attenuate pressure-overload induced cardiac remodeling and fibrosis in mice","authors":"Donghua Li ,&nbsp;Dongmei Zhong ,&nbsp;Tian Tan ,&nbsp;Zhilei Huang ,&nbsp;Mingyue Wu ,&nbsp;Yongshan Liu ,&nbsp;Yalin Zhang ,&nbsp;Chen Liu ,&nbsp;Jie Xu ,&nbsp;Fu-Li Xiang","doi":"10.1016/j.jmccpl.2026.100837","DOIUrl":"10.1016/j.jmccpl.2026.100837","url":null,"abstract":"<div><div>Cardiac fibrosis driven by activated myofibroblasts is a central feature of pressure-overload heart disease. CD248 (Endosialin/TEM1) has been implicated as a pro-fibrotic marker in ischemic cardiac injury, but its role in pressure overload remains unclear. Here, we tested whether selective deletion of Cd248 in Periostin-expressing (<em>Postn</em>^<em>+</em>) myofibroblasts mitigates pressure-overload cardiomyopathy induced by transverse aortic constriction (TAC). We generated inducible PostnMCM^+/−;Cd248^fl/fl mice and validated tamoxifen-driven recombination specifically in <em>Postn</em>^<em>+</em> interstitial cells. <em>In vitro</em>, Cd248 knockdown in primary adult mouse cardiac fibroblasts reduced TGF-β1–induced migration and the expression of actomyosin contractile markers; however, it notably failed to suppress the expression of key matrix genes (<em>Col1a1</em>, <em>Postn</em>), indicating a molecular uncoupling of cytoskeletal dynamics from collagen synthesis. Consistent with this, Postn-restricted Cd248 deletion in vivo produced no significant differences in survival, echocardiographic indices, histological fibrosis, or cardiomyocyte hypertrophy compared to controls at 8 weeks post-TAC. Furthermore, while <em>Cd248</em>^<em>+</em> fibroblasts in the TAC model were enriched for chemotactic signaling programs, immune cell infiltration remained negligible, rendering this immunomodulatory function redundant. These data indicate that while CD248 regulates fibroblast cytoskeletal dynamics <em>in vitro</em>, it is dispensable for matrix production and fibrosis in vivo during pressure overload. Our results highlight the profound context-dependence of CD248 as an anti-fibrotic target.</div></div><div><h3>eTOC blurb</h3><div>In pressure‑overloaded mouse hearts, deleting <em>Cd248</em> specifically in <em>Postn</em>⁺ myofibroblasts fails to improve cardiac remodeling or fibrosis, despite clear cell-autonomous effects on cultured primary cardiac fibroblast migration and activation <em>in vitro</em>. Single‑cell and transcriptomic analyses reveal that while CD248 regulates actomyosin-related cytoskeletal dynamics, it is dispensable for extracellular matrix production in this specific hemodynamic context. These findings highlight the profound context‑dependent efficacy of CD248‑targeted antifibrotic strategies across different etiologies of heart disease.</div></div>","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100837"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147395613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of a new spontaneous atrial fibrillation mouse model and a novel pathological mechanism","authors":"Chun-Han Chang ,&nbsp;Yung-Ting Hsiao ,&nbsp;Agian Jeffilano Barinda ,&nbsp;Ippei Shimizu","doi":"10.1016/j.jmccpl.2025.100528","DOIUrl":"10.1016/j.jmccpl.2025.100528","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100528"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Head to Head Comparison of Semaglutide and Colchicine for Treating Atrial Remodeling in Post MI Rats with Reduced Ejection Fraction","authors":"Or Levi ,&nbsp;Aviv Komissar ,&nbsp;Noam Dalal ,&nbsp;Sigal Elyagon ,&nbsp;Shira Burg ,&nbsp;Bernard Attali ,&nbsp;Gideon Gradwol ,&nbsp;Gal Tsaban ,&nbsp;Yana Kakzanov ,&nbsp;Avishag Laish-Farkash ,&nbsp;Sharon Etzion ,&nbsp;Yoram Etzion","doi":"10.1016/j.jmccpl.2025.100531","DOIUrl":"10.1016/j.jmccpl.2025.100531","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100531"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147536737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAMK2D underlies cardiac dysfunction in RBM20 cardiomyopathy","authors":"Maarten van den Hoogenhof ,&nbsp;Matthias Dewenter ,&nbsp;Thiago Britto-Borges ,&nbsp;Javier Duran ,&nbsp;Elena Kemmling ,&nbsp;Laura Konrad ,&nbsp;David Lennermann ,&nbsp;Joshua Hartmann ,&nbsp;Julia Kornienko ,&nbsp;Laura Schraft ,&nbsp;Theresa Bock ,&nbsp;Marcus Kruger ,&nbsp;Christoph Dieterich ,&nbsp;Lars Steinmetz ,&nbsp;Johannes Backs","doi":"10.1016/j.jmccpl.2025.100583","DOIUrl":"10.1016/j.jmccpl.2025.100583","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100583"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRP channel has an outsized impact on Ca2+ overload in dystrophic cardiomyopathy by adapting a novel structure","authors":"Annabelle Brusacoram ,&nbsp;Raymundo Nunez ,&nbsp;Brian Smith ,&nbsp;Brian Lin","doi":"10.1016/j.jmccpl.2025.100526","DOIUrl":"10.1016/j.jmccpl.2025.100526","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100526"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The SGLT2 inhibitor, dapagliflozin, improves glucose homeostasis and pathological cardiac remodelling in female T2D mice, without impact on obesity or cardiac function","authors":"Abhipree Sharma ,&nbsp;Minh Deo ,&nbsp;Tayla Bishop ,&nbsp;Abdullah Mamun ,&nbsp;Timothy Roberts ,&nbsp;Alex Parker ,&nbsp;Anida Velagic ,&nbsp;Karly Sourris ,&nbsp;Karin Jandeleit-Dahm ,&nbsp;Miles De Blasio ,&nbsp;Rebecca Ritchie","doi":"10.1016/j.jmccpl.2025.100579","DOIUrl":"10.1016/j.jmccpl.2025.100579","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100579"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The activation of the integrated stress response alters cardiac metabolism in Barth syndrome cardiomyopathy","authors":"Jan Dudek ,&nbsp;Ilona Kutschka ,&nbsp;Edoardo Bertero ,&nbsp;Christina Wasmus ,&nbsp;Ke Xiao ,&nbsp;Lifeng Yang ,&nbsp;Xinyu Chen ,&nbsp;Yasuhiro Oshima ,&nbsp;Marcus Fischer ,&nbsp;Werner Schmitz ,&nbsp;Peter Rehling ,&nbsp;Thomas Thum ,&nbsp;Takahiro Higuchi ,&nbsp;Joshua Rabinowitz ,&nbsp;Christoph Maack","doi":"10.1016/j.jmccpl.2025.100518","DOIUrl":"10.1016/j.jmccpl.2025.100518","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100518"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy","authors":"Laura Sen-Martín ,&nbsp;Angel Fernández-Trasancos ,&nbsp;Miguel A. López-Unzu ,&nbsp;Dyvia Pathak ,&nbsp;Alessia Ferrarini ,&nbsp;Verónica Labrador-Cantarero ,&nbsp;David Sánchez-Ortiz ,&nbsp;María Rosaria Pricolo ,&nbsp;Natalia Vicente ,&nbsp;Diana Velázquez-Carreras ,&nbsp;Lucía Sánchez-García ,&nbsp;Jose Angel Nicolás-Avila ,&nbsp;María Sánchez-Díaz ,&nbsp;Saskia Schlossarek ,&nbsp;Lorena Cussó ,&nbsp;Manuel Desco ,&nbsp;María Villalba-Orero ,&nbsp;Gabriela Guzmán-Martínez ,&nbsp;Enrique Calvo ,&nbsp;Roberto Barriales-Villa ,&nbsp;Jorge Alegre-Cebollada","doi":"10.1016/j.jmccpl.2025.100517","DOIUrl":"10.1016/j.jmccpl.2025.100517","url":null,"abstract":"","PeriodicalId":73835,"journal":{"name":"Journal of molecular and cellular cardiology plus","volume":"15 ","pages":"Article 100517"},"PeriodicalIF":2.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147537939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}