Journal of immunological sciences最新文献_第8页

Commentary: "Interference of Doxycycline Pretreatment in a Model of Abdominal Aortic Aneurysms" 评论:《强力霉素预处理对腹主动脉瘤模型的干扰》

Journal of immunological sciences Pub Date : 2018-11-01 DOI: 10.29245/2578-3009/2018/6.1155

K. Mata

引用次数: 1

A Review of a Diagnostic Tool: Galactomannan 半乳甘露聚糖是一种诊断工具

Journal of immunological sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3009/2018/5.1137

D. Karapınar

引用次数: 8

Demonstration of Mosquito Midgut Antigen for the Effective Control of Mosquito Population 蚊中肠抗原对蚊虫种群控制效果的论证

Journal of immunological sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3009/2018/5.1148

Sabahat Abdullah, S. Rahman, A. Naveed, Pakistan

{"title":"Demonstration of Mosquito Midgut Antigen for the Effective Control of Mosquito Population","authors":"Sabahat Abdullah, S. Rahman, A. Naveed, Pakistan","doi":"10.29245/2578-3009/2018/5.1148","DOIUrl":"https://doi.org/10.29245/2578-3009/2018/5.1148","url":null,"abstract":"Mosquito-borne diseases can be reduced drastically with the aid of vaccines which provoke mosquitocidal or mosquito-killing effect. The midgut of mosquito performs a fundamental role in the development and the transmission of ailment. Anti-midgut antibodies show the extensive variety of activity, blockading the development of pathogen in various species of mosquitoes. In addition to reducing the egg-laying ability of mosquitoes and survivorship also block the transmission activity of pathogen. Mitsuhashi and Maramorosch media was used to culture the mosquito midgut cells. The cells were formalin inactivated and injected into the rabbits in plain and adjuvanted form to raise hyperimmune serum. The serum was processed for IHA and serum showing high titre were selected for blood feeding assay. The blood from the rabbits was fed to the mosquitos to observe the mosquitocidal effect of the antigen. In blood feeding assay killing of mosquitoes was also observed after regular interval of time. The overall results proved that mosquito midgut contains antigenic peptides that may be able to induce the antibody response. These antigenic peptides somehow irritate digestive mucosa of the mosquitoes on blood feeding and have the potential to kill or reduce the mosquito population.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74782315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Identification of ω-sites of Glycosylphosphatidylinositol Anchored Proteins 糖基磷脂酰肌醇锚定蛋白ω-位点的鉴定

Journal of immunological sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3009/2018/5.1151

Yusuke Masuishi, Shota Endo, H. Kasuga, Tomoo Hidaka, T. Kakamu, Hikariga-oka, Fukushima City

{"title":"Identification of ω-sites of Glycosylphosphatidylinositol Anchored Proteins","authors":"Yusuke Masuishi, Shota Endo, H. Kasuga, Tomoo Hidaka, T. Kakamu, Hikariga-oka, Fukushima City","doi":"10.29245/2578-3009/2018/5.1151","DOIUrl":"https://doi.org/10.29245/2578-3009/2018/5.1151","url":null,"abstract":"Unique and complex post-translational modifications are present in the outer leaflet of the plasma membrane. Glycosylphosphatidylinositol (GPI) anchoring is essential for the expression of several outer membrane proteins on the cell surface. A common GPI anchor structure is constituted by glycan moiety, lipid moiety, phosphate and ethanolamine. GPI-anchored proteins (GPI-APs) are observed among eukaryotic species. Abnormal GPI anchoring of proteins is thought to cause various diseases such as paroxysmal nocturnal hemoglobinuria. Recently, many inherited GPI deficiencies (IGDs) have been reported to cause epilepsy, mental retardation, coarse facial features, and multiple organ anomalies. Diseases caused by abnormal GPI anchoring will probably continue to increase, because it is still unknown how many causative genes of IGDs are present. Therefore, in order to study these diseases, the analytical methods of GPI-APs will become important in the future. To date, many methods have been developed for analysis of GPI- APs. In this review, we attempt to summarize the present knowledge about comprehensive analytical methods of GPI-APs and introduce briefly some GPI anchor-related diseases.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75270791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological Approach to A Special Benign Tumor with Regard to its Differential Diagnose Spectrum: Intranodal Palisaded Myofibroblastoma 一种特殊良性肿瘤的病理诊断:结内栅栏性肌成纤维细胞瘤

Journal of immunological sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3009/2018/5.1158

Y. Karabulut

引用次数: 0

Expression, Functions, and Treatment Target of PD-L1 (B7-H1) in Multiple Myeloma PD-L1 (B7-H1)在多发性骨髓瘤中的表达、功能及治疗靶点

Journal of immunological sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3009/2018/5.1162

H. Tamura, M. Ishibashi, Mika Sunakawa, Hidemi Takahashi

{"title":"Expression, Functions, and Treatment Target of PD-L1 (B7-H1) in Multiple Myeloma","authors":"H. Tamura, M. Ishibashi, Mika Sunakawa, Hidemi Takahashi","doi":"10.29245/2578-3009/2018/5.1162","DOIUrl":"https://doi.org/10.29245/2578-3009/2018/5.1162","url":null,"abstract":"Programmed death ligand 1 (PD-L1) expression on myeloma cells is induced by JAK2, STAT3, and MEK1/2-mediated interleukin-6 signaling, a strong inducer of PD-L1 interferon-γ produced by T and natural killer cells, and APRIL produced by osteoclasts in the tumor microenvironment. The soluble form of PD-L1, derived from extracellular domains of PD-L1 molecules expressed in the tumor environment, may also contribute to tumor immune evasion. PD-L1-expressing myeloma cells not only have the ability to escape from the attack of tumor-specific T cells but also high proliferation potential. Furthermore, PD-L1 on myeloma cells delivers a reverse signal to tumor cells through PD-1 binding, resulting in the phosphorylation of Akt accompanied by the acquisition of resistance to anti-myeloma agents. Based on the function of PD-L1 in myeloma, the blockade of the PD-1–PD-L1 pathway is a reasonable treatment in refractory patients. Phase I/II clinical trials of anti-PD-1 antibody combined with immunomodulatory drugs demonstrated excellent effects in heavily pretreated multiple myeloma patients with acceptable tolerability. The timing and combination drug of anti-PD-1/PD-L1 antibodies should be considered to improve clinical effects with low mortality in refractory myeloma patients.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90654815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Evidence Supports the Hypothesis that Neutrophil Extracellular Traps are a Major Factor in Genesis and Progression of Chronic Obstructive Pulmonary Disease 新出现的证据支持中性粒细胞胞外陷阱是慢性阻塞性肺疾病发生和发展的主要因素的假设

Journal of immunological sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3009/2018/5.1161

A. Obermayer, W. Stoiber, Fikreta Grabcanovic-Musija, Salzburg, Austria

{"title":"Emerging Evidence Supports the Hypothesis that Neutrophil Extracellular Traps are a Major Factor in Genesis and Progression of Chronic Obstructive Pulmonary Disease","authors":"A. Obermayer, W. Stoiber, Fikreta Grabcanovic-Musija, Salzburg, Austria","doi":"10.29245/2578-3009/2018/5.1161","DOIUrl":"https://doi.org/10.29245/2578-3009/2018/5.1161","url":null,"abstract":"Since their discovery about fifteen years ago, neutrophil extracellular traps (NETs) have been recognized as an intrinsic part of vertebrate innate immunity and inflammatory response. Consisting of entangled strands of extracellular DNA decorated with histones, elastase, myeloperoxidase and other proteins, NETs entrap and kill pathogens, but are increasingly also found to contribute to acute and chronic inflammatory disease due to their toxicity to host cell and autoimmunity induction. Chronic obstructive pulmonary disease (COPD) turned out to be among the major disorders involving overshooting formation of NETs and associated adverse effect. In the present review, we summarize the progress in knowledge on the role of NETs in COPD pathology made since our first reports on this subject. We highlight recent substantial advances and discuss possible cause-and-effect relationships, connections with common comorbidities and interactions with drugs, also to illustrate the importance of NETs as a future diagnostic tool and target for new medication strategies.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77629385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Flow Cytometric Immunophenotyping Approach to the Detection of Regulated Cell Death Processes 流式细胞术免疫分型方法检测调节细胞死亡过程

Journal of immunological sciences Pub Date : 2018-09-01 DOI: 10.29245/2578-3009/2018/5.1159

G. Warnes

{"title":"A Flow Cytometric Immunophenotyping Approach to the Detection of Regulated Cell Death Processes","authors":"G. Warnes","doi":"10.29245/2578-3009/2018/5.1159","DOIUrl":"https://doi.org/10.29245/2578-3009/2018/5.1159","url":null,"abstract":"The use of the Western Blot technique has been the gold standard to determine protein expression and to semi-quantitate this expression in cell lysates. The recent publication of a flow cytometric immunophenotyping method employing fluorescently labelled antibodies to the intracellular labelling of antigens involved in Regulated Cell Death (RCD) processes has allowed the detection of three of these processes simultaneously which gave clarity to the interpretation of the relationship between apoptosis, RIP1 dependent apoptosis and necroptosis. Flow cytometry can now immunophenotype necroptosis by virtue of the up-regulation of RIP3 with simultaneous estimations of the degree of classic apoptosis (Caspase-3+ve/RIP3ve) and of RIP1-dependent apoptosis (Caspase-3+ve/RIP3+ve) in live and dead cell populations. This approach for detecting multiple forms of cell death has been confirmed by the use of apoptosis and necroptosis blocking agents, zVAD and necrostatin-1 after treatment with etoposide or shikonin which induced apoptosis and necroptosis. The addition of anti-PARP and H2AX antibodies for the detection of parthanatos and DNA damage showed that double negative Caspase-3-ve/RIP3-ve cells detected in a previous study have undergone parthanatos or still display a negative phenotype for any cell death process. A Flow Cytometric Immunophenotyping Approach to the Detection of Regulated Cell Death Processes A Vossenkamper1, G Warnes2* 1Centre for Immunobiology, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, 4 Newark Street, London E1 2AT, UK 2Flow Cytometry Core Facility, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, 4 Newark Street, London E1 2AT, UK","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84245645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Congenital Rubella Syndrome in The African Region - Data from Sentinel Surveillance. 非洲地区先天性风疹综合征-哨点监测数据。

Journal of immunological sciences Pub Date : 2018-08-02

Balcha Masresha, Messeret Shibeshi, Reinhard Kaiser, Richard Luce, Regis Katsande, Richard Mihigo

{"title":"Congenital Rubella Syndrome in The African Region - Data from Sentinel Surveillance.","authors":"Balcha Masresha, Messeret Shibeshi, Reinhard Kaiser, Richard Luce, Regis Katsande, Richard Mihigo","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Rubella is a mild febrile rash illness caused by the rubella virus. The most serious consequence of rubella is congenital rubella syndrome (CRS), which occurs if the primary rubella infection occurs during early pregnancy, with subsequent infection of the placenta and the developing fetus.Methods: WHO supported countries to set up sentinel surveillance for CRS using standard case definitions, protocols, and case classification scheme. This descriptive analysis summarises the data from 5 countries which have been regularly reporting.Results: A total of 383 suspected cases of CRS were notified from the 5 countries as of December 2016, of which 52 cases were laboratory confirmed and 67 were confirmed on clinical grounds.The majority (43%) of confirmed CRS cases were in the age group 6 - 11 months. The most common major clinical manifestation (Group A) among the confirmed cases is congenital heart disease (72%) followed by cataracts (32%) and glaucoma (10%).Discussion and conclusions: The number of years of reporting from these sentinel sites is too short to describe trends in CRS occurrence across the years. However, the limited surveillance data has yielded comparable information with other developing countries prior to introduction of rubella vaccine. As more countries introduce rubella vaccine into their immunisation programs, there is a need to ensure that all rubella outbreaks are thoroughly investigated and documented, to expand sentinel surveillance for CRS in more countries in the Region, and to complement this with retrospective record reviews for CRS cases in selected countries.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37304192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five-year experience of African Vaccination Week implemented by the WHO Regional Office. 世界卫生组织区域办事处实施非洲疫苗接种周五年经验。

Journal of immunological sciences Pub Date : 2018-08-02

Joseph Okeibunor, Richard Mihigo, Blanche Anya, Felicitas Zawaira

{"title":"Five-year experience of African Vaccination Week implemented by the WHO Regional Office.","authors":"Joseph Okeibunor, Richard Mihigo, Blanche Anya, Felicitas Zawaira","doi":"","DOIUrl":"","url":null,"abstract":"The 5th edition of the African Vaccination Week (AVW) kicked off in Lusaka, Zambia, on 23 April 2016, the same day as did the 4th World Immunization Week (WIW), and vaccination week in other WHO regions. The theme was \"Save lives, prevent disabilities, vaccinate!\". The aim was to draw attention to the need to attain universal immunization coverage in the African Region by closing the immunization gap, while also celebrating the important polio eradication milestone reached in the African Region. Twenty-eight (59.6%) of the 47 countries in the African Region celebrated the AVW within the regionally set dates of 24th to 30th April 2015. However, given its flexibility, the celebration continued until September in 15 other countries in the Region. Three countries, namely Comoros, Gabon, and Cape Verde did not join the celebration for the 2015 edition of the AVW. Countries used the opportunity to introduce new vaccines into their routine immunization. Populations, hitherto unreached with basic health services were reached with needed services, such as vitamin A supplementation, deworming, and catch up immunization services. The programmes promoted awareness of the benefits of vaccines and the rights of communities to demand vaccines and immunization services to save lives and prevent disabilities. The number of participating countries rose steadily from 40 in 2011 to 43 and 46 countries in 2013 and 2014 respectively. The number ranged from one intervention integrated with AVW in 17 countries to 5 interventions integrated with the AVW in three countries. In 2015, 67.4% of the participating countries integrated other interventions with AVW activities.","PeriodicalId":73785,"journal":{"name":"Journal of immunological sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345372/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41160932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0