Journal of food allergy最新文献_第5页

Use of emergency backup resources during open food challenges at a pediatric tertiary care center 在儿科三级保健中心的开放式食品挑战期间使用紧急备用资源

Journal of food allergy Pub Date : 2020-12-01 DOI: 10.2500/jfa.2020.1.200015

Samantha M. Knox, J. Bjelac, Wei Liu, B. Schroer

{"title":"Use of emergency backup resources during open food challenges at a pediatric tertiary care center","authors":"Samantha M. Knox, J. Bjelac, Wei Liu, B. Schroer","doi":"10.2500/jfa.2020.1.200015","DOIUrl":"https://doi.org/10.2500/jfa.2020.1.200015","url":null,"abstract":"Background: Oral food challenge (OFC) remains the criterion standard diagnostic procedure for food allergy. Although the need for OFCs has increased, some allergists may not perform them due to the risk for adverse events and lack of backup resources. Objective:\u0000 The study aimed to elucidate the frequency of reactions in which emergency backup resources were used and reported on various challenge outcomes at a tertiary pediatric hospital. Methods: We retrospectively reviewed children and young adults (ages, 0‐21 years)\u0000 who completed OFCs in 2013‐2018 at Cleveland Clinic Children’s Hospital. Demographics, atopic history, culprit food, reaction history, and diagnostic testing as well as challenge details and outcomes were collected and analyzed. Results: A total of 1269 challenges\u0000 of 812 unique patients ages 5 months to 21 years were reviewed. More than half of challenges were performed in patients with a history of a reaction and positive testing result before challenge. The foods with the highest proportion of allergic outcomes were egg, sesame, and baked egg. More\u0000 than one-third of challenge reactions were grade 3 or 4 anaphylaxis when using a food-induced anaphylaxis grading scale. Epinephrine was used for reactions in 7.2% of all challenges. Reactions in five challenges (0.4%) prompted utilization of backup emergency resources. Conclusion:\u0000 On review of nearly 1300 OFCs, emergency backup resources were rarely used, despite a large proportion of moderate-to-severe reactions. The need for backup resources during food challenges is rare, which suggests that most typical allergy offices are able to treat OFC reactions.","PeriodicalId":73751,"journal":{"name":"Journal of food allergy","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90251850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Legume and Sesame Oral Food Challenge Outcomes 豆类和芝麻口腔食品挑战结果

Journal of food allergy Pub Date : 2020-11-25 DOI: 10.21203/rs.3.rs-113278/v1

Jacob J. Pozin, A. Devonshire, Kevin Tom, M. Makhija, A. M. Singh

{"title":"Legume and Sesame Oral Food Challenge Outcomes","authors":"Jacob J. Pozin, A. Devonshire, Kevin Tom, M. Makhija, A. M. Singh","doi":"10.21203/rs.3.rs-113278/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-113278/v1","url":null,"abstract":"\u0000 Background: Legume and sesame are emerging food allergens. The utility of specific IgE testing (sIgE) to predict clinical reactivity to these allergens is not well described.Objective: To describe clinical outcomes and sIgE in sesame and legume OFCs. Methods: We performed a retrospective review of 74 legume and sesame oral food challenges (OFC) performed between 2007-2017 at the Ann & Robert H. Lurie Children’s Hospital of Chicago. Clinical data, OFC outcome, and sIgE to legume and sesame were collected. Receiver operating characteristic curves (ROC) and logistic regression models predicting OFC outcome were generated. Results: Twenty-eight patients (median age 6.15 years) passed legume OFC (84.85%), and twenty-five patients (median age 5.91 years) passed sesame OFC (60.98%). The median sIgE to legume was 1.41 kUa/L, and 2.34 kUa/L, to sesame. For patients who failed legume OFC, 67% had cutaneous, 16.5% had gastrointestinal, and 16.5% had anaphylaxis. Of these reactions, 80% were controlled with Benadryl alone and 20% required epinephrine. For patients who failed sesame OFC, 53% had cutaneous, 12% had gastrointestinal, and 35% had anaphylaxis. Of these reactions, 6% required epinephrine, 31% were controlled with Benadryl alone, and 63% required additional epinephrine or steroids. Conclusion: Most OFC to legumes were passed and reactions to failed legume OFCs were more likely to be non-severe. Failing an OFC to sesame was almost twice as likely compared to failing a legume OFC, and reactions to failed sesame OFC were often more severe. Sesame sIgE did not correlate with OFC outcome.","PeriodicalId":73751,"journal":{"name":"Journal of food allergy","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88265143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new journal with a specific purpose: Food allergy. 一本有特定目的的新期刊：食物过敏。

Journal of food allergy Pub Date : 2019-11-04 eCollection Date: 2019-11-01 DOI: 10.2500/jfa.2019.1.100000

Russell A Settipane