Journal of endocrinology and diabetes最新文献_第3页

Relationship Between Serum Cortisol and Dietary Behavior in Non Diabetes Obese Cameroonian People 喀麦隆非糖尿病肥胖人群血清皮质醇与饮食行为的关系

Journal of endocrinology and diabetes Pub Date : 2019-11-01 DOI: 10.15226/2374-6890/6/3/001134

Martine Claude Etoa Etoga, A. Boli, Noel Mbango Ekouta, W. T. B. Nga, Guy Mvogo, S. E. Bagnaka, Djahmeni Eric Noel, Sobngwi Eugène, M. Banya

{"title":"Relationship Between Serum Cortisol and Dietary Behavior in Non Diabetes Obese Cameroonian People","authors":"Martine Claude Etoa Etoga, A. Boli, Noel Mbango Ekouta, W. T. B. Nga, Guy Mvogo, S. E. Bagnaka, Djahmeni Eric Noel, Sobngwi Eugène, M. Banya","doi":"10.15226/2374-6890/6/3/001134","DOIUrl":"https://doi.org/10.15226/2374-6890/6/3/001134","url":null,"abstract":"Background: Dietary behavior refers to all the behaviors of an individual related to the consumption of food. In addition to environmental, socio-cultural and cognitive factors, the hormonal system plays an important role in the regulation of food intake. The aim of this study was to establish the relationship between the adrenocorticotropic axis and dietary behavior in obese subjects in Cameroon. Methods: This was a cross-sectional and analytical study over a period of 3 months at the National Obesity Center of Yaoundé. We included people who came to a dietetic consultation and had a BMI ≥ 30kg / m2. All patients with a known Cushing’s syndrome, or who taking corticosteroids, as well as any other drug that has an influence on the bioavailability of dexamethasone were excluded. We evaluated the corticotropic axis by quantitative determination of plasma cortisol before and after the overnight dexamethasone suppression test. After the clinical examination, the eating behavior was assessed using the Three-Factor Eating Questionnaire Test (TFEQ-R18). Results: We included 25 patients (15 women and 10 men) aged 54 ± 10 years and with an average BMI of 37.8 kg / m2. There was an association between BMI hyperphagia of disinhibition, cognitive restriction and hunger (P <0.0001). There was a significant association between disinhibition hyperphagia, susceptibility to hunger, cognitive restriction, and the level of cortisol after the overnight dexamethasone suppression test (P <0.0001). Conclusion: The strong association between eating disorders, body mass index, and cortisol levels suggests that the adrenocorticotropic axis would influence dietary behavior in obese subjects.","PeriodicalId":73731,"journal":{"name":"Journal of endocrinology and diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48876580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Term Effects of Metformin in a Non-Diabetic Population with Differentiated Thyroid Carcinoma 二甲双胍对非糖尿病分化型甲状腺癌患者的长期疗效

Journal of endocrinology and diabetes Pub Date : 2019-10-30 DOI: 10.15226/2374-6890/6/3/001133

M. Eleonora, B. Margherita, Minuto N Michele, C. Lucia, G. Massimo

{"title":"Long Term Effects of Metformin in a Non-Diabetic Population with Differentiated Thyroid Carcinoma","authors":"M. Eleonora, B. Margherita, Minuto N Michele, C. Lucia, G. Massimo","doi":"10.15226/2374-6890/6/3/001133","DOIUrl":"https://doi.org/10.15226/2374-6890/6/3/001133","url":null,"abstract":"Introduction: Differentiated thyroid carcinoma (DTC) is the most frequent endocrine neoplasm. Type 2 diabetes mellitus (DMT2) and cancer share several risk factors. Metformin is used as an anti-hyperglycemic agent to reduce insulin resistance. Its anti-proliferative role is widely discussed in the literature. Materials and Methods: 95 DTC patients without a diagnosis of DMT2 (group 1), in whom metformin was started, 79 non-diabetics DTC patients who did not start metformin (group 2) served as a control group. All subjects were evaluated at the baseline and after 12 and 24 months. Group 1 was also evaluated at 3 months and 36 month to assess the tolerability of metformin and then the therapy compliance. Results: Prospective evaluation of group 1 versus group 2: no differences in the values of TSH at 24 months (P = 0.23); no differences in L-T4 dosages. No significant difference in Tg values emerged between group 1 and group 2 (P = 0.06), nor between baseline Tg and the values at 3 (P = 0.06), 12 (P = 0.1), 24 months (P = 0.25) after the start of metformin. No differences in group 1 in the values of Tg (P = 0,79) or TSH (P=0.26) between baseline and 36 months. In group 1, a significant difference was found in total cholesterol levels between the baseline and the 3-month (P = 0.01), 12-month (P = 0.0001), 24-month (P = 0.005) and 36 months-examinations (P = 0.0001); total cholesterol levels progressively declined in group 1, and a significant difference emerged between group 1 and group 2 at 12 (P = 0.036) and 24 months (P = 0.01). Conclusions: The present study has the most numerous DTC population without DM in whom metformin has been started as off-label therapy. Metformin did not seem to have an effect on TSH. Metformin reduced total and LDL cholesterol levels, yielding a possible cardiovascular advantage. Tg data were inconclusive, perhaps because this population has a very good prognosis after primary treatments.","PeriodicalId":73731,"journal":{"name":"Journal of endocrinology and diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44493032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Experience with the Hybrid Closed-Loop Insulin Delivery System (MinimedTM 670G) compared to Sensor Augmented Therapy (MiniMedTM 640G) and standard care 混合闭环胰岛素输送系统(MinimedTM 670G)与传感器增强治疗(MinimedTM 640G)和标准治疗的临床经验比较

Journal of endocrinology and diabetes Pub Date : 2019-10-10 DOI: 10.15226/2374-6890/6/2/001132

L. Distiller, S. Landau, D. Segal, S. Govender, W. May, G. Hough, J. V. Dyk

{"title":"Clinical Experience with the Hybrid Closed-Loop Insulin Delivery System (MinimedTM 670G) compared to Sensor Augmented Therapy (MiniMedTM 640G) and standard care","authors":"L. Distiller, S. Landau, D. Segal, S. Govender, W. May, G. Hough, J. V. Dyk","doi":"10.15226/2374-6890/6/2/001132","DOIUrl":"https://doi.org/10.15226/2374-6890/6/2/001132","url":null,"abstract":"Background: This real-world clinical study compared the efficacy of a hybrid closed-loop system (HCL) to a sensor integrated pump (SIP) system and usual care. Methods: Twenty-four subjects aged 8 to 65 years were randomly selected from 6 clinical centers to take part in this prospective study. Subjects were on a variety of standard care programs at base-line (Phase 1) and then used SIP for two months (Phase 2) followed by two months on HCL (Phase 3). Results: Compared with baseline, the mean HbA1c for the cohort reduced by 0.37% after 2 months of SIP therapy and by 0.7% after 2 months of HCL therapy. At study end, the mean HbA1c for the cohort was 7.2%. Time in severe hypoglycemia reduced to 0.4% (0.7% at baseline) for both SIP and HCL therapies. Time below 70 mg/dl reduced progressively between Phase 1 (baseline therapy), Phase 2 (SIP) and Phase 3 (HCL) (6%, 2.5% and 1.5% respectively) of the study. In the study intervention arms, less time was spent above 180 mg/dl (32.1% with SIP and 25.5% with HCL) versus 37% at baseline. The mean time-in-range (TIR) achieved was 72.5% with HCL, versus 65.2% with SIP (58.3% at baseline). Similarly, 50% of the subjects achieved a TIR of over 70% on HCL versus 33% on SIP (8% at baseline). Conclusions: This small, prospective, real-world study demonstrated that irrespective of the starting parameters, SIP therapy reduced mean HbA1c levels, TIR and hypoglycemic events. Implementation of an HCL system enhanced these outcomes further.","PeriodicalId":73731,"journal":{"name":"Journal of endocrinology and diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47348376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness Combination of Foot Care with Active Range of Motion (ROM) and Plantar Exercise for Reducing Diabetic Foot Ulcer Risk in Diabetes Mellitus Type II 足部护理与活动度(ROM)和足底运动相结合对降低II型糖尿病足溃疡风险的有效性

Journal of endocrinology and diabetes Pub Date : 2019-09-03 DOI: 10.15226/2374-6890/6/2/001131

Normawati Ajeng Titah, Mardiyono Mns, Anwar M Choiroel Skm, S. Ari, Siregar Irma Hy

{"title":"Effectiveness Combination of Foot Care with Active Range of Motion (ROM) and Plantar Exercise for Reducing Diabetic Foot Ulcer Risk in Diabetes Mellitus Type II","authors":"Normawati Ajeng Titah, Mardiyono Mns, Anwar M Choiroel Skm, S. Ari, Siregar Irma Hy","doi":"10.15226/2374-6890/6/2/001131","DOIUrl":"https://doi.org/10.15226/2374-6890/6/2/001131","url":null,"abstract":"Diabetic Foot Ulcer (DFU) is a devastating complication of diabetes mellitus and affects 15% of people with diabetes mellitus. Approximately 50-70% all of lower limb amputations are due to DFU. Moreover, DFU causes losses in financial and physical distress. The American Diabetes Association stated that preventive care could decrease DFU risk. This study aimed to assess the effectiveness of a combination of foot care with active ROM and plantar exercise for preventing DFU and reducing its risks. Thirty-four people with diabetes mellitus type 2 who fulfilled the inclusion criteria were selected randomly and divided to control and intervention groups. They were assessed by questionnaires and observation checklist. The pre-test was assessed using Inlow’s 60-second diabetic foot screening tool. All the subjects got daily foot care for two weeks. But subjects in the intervention group got the combination of daily foot care every day and active Range of Motion (ROM), and plantar exercise every two days. The data were analyzed statistically (dependent and independent-test) The result showed that there was a significant difference before and after intervention in both groups. But the contribution of risk decrease in the intervention group (40.1%) was higher than the control one (14.3%). There was a significant influence of the combination of daily foot car with ROM and plantar exercise (p-value 0.000). This combination of daily foot care with ROM and Plantar Exercise is recommended to prevent the complication of Diabetes Mellitus.","PeriodicalId":73731,"journal":{"name":"Journal of endocrinology and diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48067866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Interaction of Normal Blood Glucose Level with Mouth Shape 正常血糖水平与口腔形状的相互作用

Journal of endocrinology and diabetes Pub Date : 2019-05-23 DOI: 10.15226/2374-6890/6/2/001130

M. K. Javed, M. Qadir

引用次数: 0

Usefulness of the evaluation of the titres of glutamic acid decarboxylase autoantibody (GADAs) in patients with diabetes 评估糖尿病患者谷氨酸脱羧酶自身抗体（GADAs）滴度的有用性

Journal of endocrinology and diabetes Pub Date : 2019-04-04 DOI: 10.15226/2374-6890/6/2/001129

E. Otto-Buczkowska, N Jainta, J. Stańczyk

{"title":"Usefulness of the evaluation of the titres of glutamic acid decarboxylase autoantibody (GADAs) in patients with diabetes","authors":"E. Otto-Buczkowska, N Jainta, J. Stańczyk","doi":"10.15226/2374-6890/6/2/001129","DOIUrl":"https://doi.org/10.15226/2374-6890/6/2/001129","url":null,"abstract":"Diabetes mellitus is a group of diseases characterized by chronic increase of glucose level. Recent years brought much progress in understanding its complex pathogenesis. The classification that has been valid since 1999 which divided diabetes mellitus to type 1, type 2, gestational, and a group of “other specific syndromes.” has become inadequate to current knowledge. The differential diagnostics of types of the diseases is playing an increasing role in diabetology, as it enables selection of optimal treatment methods, as well as, the assessment of prognosis referring to the diabetes course and complications occurrence. One of the indicators enabling such an assessment is the determination of the titres of autoantibodies, among them anti-GAD. Increasing the titre of these autoantibodies indicates an autoimmune basis for the development of diabetes and the need for insulin therapy in its treatment. Materials and methods: This paper presents a retrospective analysis of 7 patients with diabetes diagnosed initially as type 2 diabetes. The determination of the level of C-peptide and the titres of autoantibodies carried out in subsequent years allowed us to verify the diagnosis of type diabetes. Conclusion: This analysis indicates the importance of determining the level of C-peptide and the titres of autoantibodies for the early diagnosis of autoimmune diabetes mellitus.","PeriodicalId":73731,"journal":{"name":"Journal of endocrinology and diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47580553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Frequency of Insulin Resistance in Children with Chronic Hepatic Disease 慢性肝病患儿胰岛素抵抗频率的研究

Journal of endocrinology and diabetes Pub Date : 2019-03-25 DOI: 10.15226/2374-6890/6/2/001128

F. Mirrashidi, H. Ilkhanipoor, S. Dehghani, H. Moravej

{"title":"Examining the Frequency of Insulin Resistance in Children with Chronic Hepatic Disease","authors":"F. Mirrashidi, H. Ilkhanipoor, S. Dehghani, H. Moravej","doi":"10.15226/2374-6890/6/2/001128","DOIUrl":"https://doi.org/10.15226/2374-6890/6/2/001128","url":null,"abstract":"Background: Liver is one of the most important insulin target organs and insulin resistance (IR) accompanies chronic hepatic disease. IR is one of the main pathophysiological features characteristic of chronic hepatic diseases. As a result, early diagnosis of IR is very important in patients with chronic hepatic disease. Methods: After recording demographic properties of the patients and calculating the rate of IR (HOMA-IR) and severity of hepatic disease (PELD/MELD Scores), statistical analysis of the obtained data was performed to compute the frequency and relationship of IR based on age, sex, body mass index (BMI), the type of background disease, and severity of hepatic disease. Statistical analyses were performed using SPSS Software. Results: The results obtained showed that the frequency of males, under 12 years old, with BMI values under 18.5 kg/m2were higher. However, IR rate was higher in female gender, age group of above 12 years old, and normal BMI. The effect of age and BMI parameters on IR was also statistically significant (p<0.001), while sex and disease severity had no significant effect on IR. Conclusion: The diagnosis and treatment of the affected children at lower ages and administration of proper dietary regimens could assist in preventing disease progression and also in more effective treatment.","PeriodicalId":73731,"journal":{"name":"Journal of endocrinology and diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48101364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotional Intelligence is Associated with Blood Level Glucose: A Brief Report 情绪智力与血糖水平有关:一个简短的报告

Journal of endocrinology and diabetes Pub Date : 2019-03-01 DOI: 10.15226/2374-6890/6/1/001127

Leehu Zysberg

引用次数: 1

Evaluating Osteoporotic Fracture Risk in Latin American Countries 拉丁美洲国家骨质疏松性骨折风险评估

Journal of endocrinology and diabetes Pub Date : 2019-02-26 DOI: 10.15226/2374-6890/6/1/001125

Enrique López Gavilánez, Angel Segale Bajana

引用次数: 0

Social Determinants Related to Type 2 Diabetes Self-Care and Control Measures 与2型糖尿病自我护理和控制措施相关的社会决定因素

Journal of endocrinology and diabetes Pub Date : 2019-02-26 DOI: 10.15226/2374-6890/6/1/001126

M. Sayadi, S. Ayatollahi, L. Malekmakan, Sadegh Karami Daranjani, A. Zare

{"title":"Social Determinants Related to Type 2 Diabetes Self-Care and Control Measures","authors":"M. Sayadi, S. Ayatollahi, L. Malekmakan, Sadegh Karami Daranjani, A. Zare","doi":"10.15226/2374-6890/6/1/001126","DOIUrl":"https://doi.org/10.15226/2374-6890/6/1/001126","url":null,"abstract":"Introduction: Diabetes Mellitus (DM) as a common metabolic disorder, is a controllable disease by the self-care and maintaining the blood sugar. This study is designed to investigate the social determinants of diabetes self-care and control measures. Methods: It is an analytical cross-sectional study conducted on 310 type-2 DM patients of Shiraz University of Medical Science by convenient sampling method. Self-care behaviors data were collected by self-care scale of Toobert and Glasgow from January to April 2017. Demographic data and serum level of HbA1c were collected. Data were analyzed by SPSS 16 and the significance level was considered as 5%. Results: In this study, 310 patients with Mean±SD age of 52.11±8.20 were investigated. Significant relationships were observed between self-care and education level (p=0.02) and job (p=0.005). Also a significant reverse relationship was observed between diabetes control and physical activity, weight management and self-care (p<0.05). Conclusion: Results showed that education level and job can increase self-care especially in weight management and physical activity; therefore, increase of these factors will result in better control of diabetes. In terms of job, it was observed that retired people had more self-care which could be due to their education level and having enough time for these actions.","PeriodicalId":73731,"journal":{"name":"Journal of endocrinology and diabetes","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0