Acta Neurochirurgica最新文献

{"title":"Drilling technique of the internal auditory canal in vestibular schwannoma surgery assisted by neuronavigated autofocus microscope","authors":"Maddalena Dardo,&nbsp;Luca Campagnaro,&nbsp;Andrea Boschi,&nbsp;Serena Tola,&nbsp;Franco Trabalzini,&nbsp;Alessandro Della Puppa","doi":"10.1007/s00701-025-06679-1","DOIUrl":"10.1007/s00701-025-06679-1","url":null,"abstract":"<div><h3>Background</h3><p>The wide anatomical variability of temporal bone structures makes the application of neuronavigation particularly useful. This technical note outlines an IAC drilling technique performed with the assistance of a neuronavigated autofocus microscope to enhance intraoperative anatomical orientation, facilitate tailored bone removal and prevent injuries at the intraosseous petrous structures.</p><h3>Method</h3><p>From January 2023 to January 2024, twenty-one out of thirty-six patients with vestibular schwannoma underwent a retrosigmoid transmeatal approach with IAC drilling assisted by the neuronavigated autofocus microscope. The technique employed the autofocus function of the surgical microscope as an active navigation pointer, with real-time trajectory feedback display through the heads-up display. This setup enables continuous intraoperative adaptation of the drilling path to individual anatomical landmarks.</p><h3>Results</h3><p>Postoperative high-resolution CT imaging confirmed preservation of critical intraosseous structures in all but one case, which showed limited endolymphatic duct violation. No injuries to the posterior semicircular canal, common crus, or jugular bulb were observed. Complete tumour resection was achieved in all patients. The technique has enabled different drilling angles and trajectories tailored to individual patient anatomy.</p><h3>Conclusions</h3><p>The IAC drilling, performed under the assistance of a neuronavigation-integrated autofocus microscope, provides a tailored anatomy-guided approach. This technique facilitates individualized exposure of the intrameatal tumour component while supporting the preservation of critical intraosseous petrous structures. By continuously adapting the drilling trajectory to the patient’s specific anatomy, it enables a controlled removal of the IAC posterior wall and may contribute to reducing the risk of unintended structural injury.</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06679-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145145405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How I do it: simultaneous microvascular decompression for dolichoectatic vertebrobasilar artery-associated trigeminal neuralgia and hemifacial spasm","authors":"Chingiz Nurimanov,&nbsp;Karashash Menlibayeva,&nbsp;Iroda Mammadinova,&nbsp;Yerbol Makhambetov","doi":"10.1007/s00701-025-06688-0","DOIUrl":"10.1007/s00701-025-06688-0","url":null,"abstract":"<div><h3>Background</h3><p>Concurrent ipsilateral trigeminal neuralgia (TN) and hemifacial spasm (HFS) are rare and typically caused by dolichoectatic vertebrobasilar compression.</p><h3>Method</h3><p>A 59-year-old male with refractory TN and HFS underwent preoperative MRI revealing neurovascular conflict at the root entry zones. Simultaneous microvascular decompression (MVD) of the trigeminal and facial nerves was performed via a retrosigmoid craniotomy using Teflon padding.</p><h3>Conclusion</h3><p>The patient experienced immediate and sustained symptom resolution at the 18-month follow-up. Simultaneous MVD is effective for treating dual cranial nerve compression by dolichoectatic vessels.</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06688-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145145009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive pedicle screw placement with image-guided navigation in cervical spine injuries","authors":"Clemens Weber,&nbsp;Kjell Akre,&nbsp;Cecilia Avellan,&nbsp;Maziar Behbahani,&nbsp;David Werner","doi":"10.1007/s00701-025-06680-8","DOIUrl":"10.1007/s00701-025-06680-8","url":null,"abstract":"<div><h3>Introduction</h3><p>MIS pedicle screw placement is a novel technique for the management of unstable injuries of the cervical spine. This study aims to evaluate the feasibility of MIS pedicle screw placement and to compare perioperative, postoperative and radiological outcomes between MIS and conventional open approaches.</p><h3>Methods</h3><p>This single-centre cohort study included patients with unstable injuries of the cervical spine treated with open approaches for pedicle or lateral mass screw fixation or MIS approaches for pedicle screw fixation. Perioperative and postoperative variables were compared. All screw positions were classified according to the Bredow classification.</p><h3>Results</h3><p>Twenty patients with unstable injuries of the cervical spine were included, 10 undergoing conventional open posterior fixation (87 screws) and 10 undergoing MIS cervical pedicle screw fixation (48 screws). In the MIS group, significantly fewer vertebrae were instrumented (2.4 vs. 4.5; <i>p</i> = 0.008) and significantly fewer screws placed (4.8 vs. 8.7; p = 0.009). Operative time was significantly shorter in patients operated with MIS approach (183 vs. 132 min; p = 0.020). Also, there was a significant reduction in blood loss per surgery in patients operated with a MIS approach compared to an open approach (145 vs. 891 ml; p = 0.002). Out of 87 pedicle and lateral mass screws placed with an open approach 99% were classified as Bredow grade 1 or 2. All 48 screws placed with a MIS approach were rated as Bredow grade 1 or 2.</p><h3>Conclusions</h3><p>This feasibility study provides preliminary evidence that surgery with MIS approach with navigated pedicle screws may be associated with reduced length of surgery and intraoperative blood loss compared to open surgery. Radiological evaluation of screw placement showed a good positioning with both open and minimally invasive approach. The results highlight the need for further investigation in larger, controlled trials to more rigorously evaluate the potential benefits and risks of this approach.</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06680-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volume of parasagittal dura is associated with blood markers of systemic inflammation","authors":"Paulina Eide,&nbsp;Erik Melin,&nbsp;Geir Ringstad,&nbsp;Per Kristian Eide,&nbsp;Angelika Sorteberg","doi":"10.1007/s00701-025-06682-6","DOIUrl":"10.1007/s00701-025-06682-6","url":null,"abstract":"<div><h3>Background</h3><p>The parasagittal dura (PSD) has been hypothesized to act as a neuro-immunological hub, though evidence in favor of the hypothesis is limited. The present study explored whether there is any association between volume and function of PSD and blood markers that may be indicative of systemic inflammation.</p><h3>Methods</h3><p>The patient material included 76 subjects examined with intrathecal contrast-enhanced magnetic resonance imaging (MRI) where the contrast served as a cerebrospinal fluid (CSF) tracer. They were dichotomized into a control- (Ctrl) and a CSF-group. We investigated the correlations between blood markers indicative of systemic inflammation and the volume of PSD, enrichment of tracer in the PSD, and blood-measures of CSF clearance. The blood markers included C-reactive protein (CRP), erythrocyte volume fraction (EVF), hemoglobin (Hb), platelet count, neutrophiles, lymphocytes, and the neutrophil-to-lymphocyte ratio as well as the platelet-to-lymphocyte ratio. Assessment of subjective sleep quality also was included in the analysis.</p><h3>Results</h3><p>The main finding was that higher CRP indicative of systemic inflammation was correlated with lower volume of PSD. There was an association between lower EVF and Hb levels and lower volume of PSD, but this finding could be explained by confounders such as age, sex and disease. Confounders also explained a correlation between EVF and CSF clearance variables. Impaired subjective sleep quality was associated with markers of systemic inflammation, but not with PSD volume.</p><h3>Conclusion</h3><p>Higher CRP was correlated with lower volume of PSD suggesting that the size of this anatomical structure associates with systemic inflammation. Further studies are needed to determine whether PSD volume could serve as an imaging marker of systemic inflammation.</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06682-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragmatic pacing after cervical spinal cord injury due to gunshot wound: a 14-year institutional experience","authors":"Collin M. Labak,&nbsp;Eric Z. Herring,&nbsp;Elliot Crooks,&nbsp;Stanley F. Bazarek,&nbsp;Gabriel A. Smith,&nbsp;Raymond Onders","doi":"10.1007/s00701-025-06678-2","DOIUrl":"10.1007/s00701-025-06678-2","url":null,"abstract":"<div><h3>Purpose</h3><p>High cervical spinal cord injury (SCI) due to gunshot wound (GSW) represents an extremely devastating injury class not only due to quadriplegia, but also the high incidence of chronic mechanical ventilation (MV) due to injury to the spinal nerves that innervate the diaphragm. Diaphragmatic pacemaker (DP) implantation is a potential option to liberate individuals from chronic MV by assisting with diaphragm contraction and therefore improving respiratory function.</p><h3>Methods</h3><p>We conducted a retrospective chart review at our institution to identify patients with high cervical SCI due to GSW who underwent DP implantation and had 6 months or more of clinical follow-up.</p><h3>Results</h3><p>Fourteen patients were included for chart review. Twelve patients were male; 9 were African American. Twelve had complete (ASIA A) SCI, of whom 7 had an injury at or above C3. Six of 12 (50%) patients whose MV status was documented achieved 4 h and 24 h per day of MV independence. All patients in whom detailed respiratory function data could be attained showed percentage tidal volumes over baseline requirement (PTVOB) greater than 100% (median:151.9%).</p><h3>Conclusion</h3><p>Consistent with previously published data, DP implantation for SCI due to GSW seems to have benefit with regard to MV independence and other respiratory metrics. This held true regardless of injury level or whether the DP was implanted during index hospitalization or in a delayed fashion. DP implantation is a viable option to consider in patients with high cervical SCI after GSW in both the acute and chronic setting to grant patients a potential for MV liberation.</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06678-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145110653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding: “Recurrence patterns and clinical outcomes in adult cerebellar glioblastoma”","authors":"Thiebaud Picart,&nbsp;Delphine Poncet,&nbsp;Marc Barritault,&nbsp;David Meyronet,&nbsp;Francois Ducray","doi":"10.1007/s00701-025-06671-9","DOIUrl":"10.1007/s00701-025-06671-9","url":null,"abstract":"","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06671-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative speech impairment and cranial nerve deficits in children undergoing posterior fossa tumor surgery with intraoperative MRI – a prospective multinational study","authors":"Aske Foldbjerg Laustsen,&nbsp;Jonathan Kjær Grønbæk,&nbsp;Radek Frič,&nbsp;Shivaram Avula,&nbsp;Conor Mallucci,&nbsp;Pelle Nilsson,&nbsp;Per Nyman,&nbsp;Péter Hauser,&nbsp;Katalin Mudra,&nbsp;Rosita Kiudeliene,&nbsp;Saulius Ročka,&nbsp;Magnus Aasved Hjort,&nbsp;Rick Brandsma,&nbsp;Eelco Hoving,&nbsp;Andrea Carai,&nbsp;Vladimír Beneš,&nbsp;Jana Táborská,&nbsp;Christian Dorfer,&nbsp;Sandra Jacobs,&nbsp;Miriam Pavon-Mengual,&nbsp;Jane Skjøth-Rasmussen,&nbsp;Kjeld Schmiegelow,&nbsp;Astrid Sehested,&nbsp;René Mathiasen,&nbsp;Marianne Juhler","doi":"10.1007/s00701-025-06669-3","DOIUrl":"10.1007/s00701-025-06669-3","url":null,"abstract":"<div><h3>Background</h3><p>Postoperative speech impairment (POSI) and cranial nerve deficits (CND) are common complications of pediatric posterior fossa (PF) tumor surgery. Intraoperative MRI (ioMRI) has proven a useful tool in achieving gross total resection. The risk of POSI and CND with ioMRI remains unclear, making it the primary scope of this study. Additionally, we assessed whether POSI was associated with CND.</p><h3>Methods</h3><p>We prospectively included pediatric patients undergoing PF tumor surgery in 36 centers across 15 European countries. Neurological status and speech were assessed preoperatively and 1–4 weeks postoperatively. Surgical details, including tumor location and use of ioMRI, were recorded within 72 h of surgery. Postoperative CND were categorized as 0, 1, 2, or ≥ 3 nerves affected; POSI as habitual, reduced speech, or mutism. Proportional odds models estimated odds ratios (OR) for 1) POSI with stepwise adjustment for tumor location and age, and 2) CND with adjustment for preoperative CND and tumor location. Subgroup analyses assessed systematic differences, missing data, center-level effects, and histology adjustment.</p><h3>Results</h3><p>Of 790 primary PF tumor surgeries, 141 (18%) involved ioMRI. POSI occurred in 183/790 (23%) and postoperative CND in 213/790 (27%). POSI-risk with ioMRI showed non-significant unadjusted OR (95% CI) 0.83 (0.53;1.30); adjusted OR 0.76 (0.43;1.35). Fewer CNDs were observed with ioMRI (unadjusted OR 0.63 (0.40;1.00), adjusted OR 0.58 (0.33;0.94), p = 0.03). POSI-risk was associated with more CNDs (adjusted OR for 1 CND: 2.06 (1.15;3.68); 2 CND: 2.13 (1.02;4.42); ≥ 3 CND: 4.15 (1.98;8.70), p &lt; 0.05).</p><h3>Conclusions</h3><p>ioMRI was not associated with increased risk of postoperative complications in this multicenter cohort. The reduction in CND among ioMRI cases may reflect derived effects on surgical decision-making, expertise, case-load and case-mix. Results should be interpreted with caution due to limited intraoperative data. The association between POSI-risk and cumulative CND may indicate extensive brainstem involvement. Our findings highlight the need to further explore how ioMRI-guided strategies affect functional outcomes in pediatric PF tumour surgery.</p><h3>Clinical Trials ID</h3><p>NCT02300766 (October 2014)</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06669-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Classification of intracranial aneurysm remnants after clipping in the era of three-dimensional digital subtraction angiography”","authors":"Jun Thorsteinsdottir,&nbsp;Christian Schichor","doi":"10.1007/s00701-025-06684-4","DOIUrl":"10.1007/s00701-025-06684-4","url":null,"abstract":"","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06684-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How I do it: purely intracondylar approach to the hypoglossal canal for the treatment of an intracanalicular hypoglossal lesion","authors":"Amedeo Piazza,&nbsp;Simone Olei,&nbsp;Maria Peris-Celda,&nbsp;Carlo Serra","doi":"10.1007/s00701-025-06629-x","DOIUrl":"10.1007/s00701-025-06629-x","url":null,"abstract":"<div><h3>Background and importance</h3><p>Lesions confined to the hypoglossal canal are rare, but may lead to invalidating symptoms. Moreover, extensive approaches to this region frequently require complex dissections and high surgical risks. We propose a minimally invasive approach specifically tailored to purely intracanalicular lesions of the hypoglossal canal.</p><h3>Clinical presentation</h3><p>With the aid of operative images and anatomic dissection, we present a clinical case of such a lesion and describe a targeted surgical approach for treatment.</p><h3>Conclusion</h3><p>For lesions purely confined to the hypoglossal canal, a tailored intracondylar approach is feasible and may, in selected cases, reduce surgical times and complications.</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06629-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145090508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes for spinal arachnoid cysts and webs: a case series","authors":"Lara Imwinkelried,&nbsp;Danial Nasiri,&nbsp;Ralph T. Schär,&nbsp;Johannes Goldberg,&nbsp;Levin Häni,&nbsp;Andreas Raabe,&nbsp;Christopher Marvin Jesse","doi":"10.1007/s00701-025-06665-7","DOIUrl":"10.1007/s00701-025-06665-7","url":null,"abstract":"<div><h3>Background</h3><p>Spinal arachnoid cysts (SAC) and spinal arachnoid webs (SAW) are intradural pathologies, often presenting with pain and/or myelopathic symptoms. Reports on postoperative outcomes for SAC and SAW are scarce. This study aims to assess the surgical outcomes of SAC and SAW.</p><h3>Methods</h3><p>Patients who underwent surgical treatment for SAC or SAW at our institution between 2011 and 2023 were retrospectively reviewed. Demographic data, radiological findings, surgical management, and clinical outcomes were evaluated using the modified McCormick (mMC) scale. Outcomes were categorized as \"favorable\" (mMC I-II) or \"unfavorable\" (mMC III-V).</p><h3>Results</h3><p>A total of 35 patients (29 SAC, 6 SAW) were analyzed. Mean age was 50.9 (SD ± 9.8) years. Males comprised 70.3% of cases (SAC: 64.5%, SAW: 100%). Most common symptoms were local or radiating pain (SAC 77.4%; SAW 100%), gait-disturbance (SAC 45.2%; SAW 16.7%), sensory-deficits (SAC 32.3%; SAW 66.7%) and impaired motor function (SAC 20%; SAW 16.7%). Median preoperative mMC was 2 in both groups (SAC IQR: 1; SAW IQR: 1). Median postoperative mMC was 1 in both groups (SAC CI 1.07–1.34; SAW CI 0.74–1.60). Favorable outcome (postoperative mMC I-II) was achieved in 26 SAC patients (90%) and 5 SAW patients (83%) respectively. Surgical complications occurred in 14.7%, all in the SAC group, without lasting deficits.</p><h3>Conclusion</h3><p>Surgical treatment for SAC and SAW appears to have an overall favorable outcome, though larger cohort analyses are needed. Surgery should be considered in symptomatic patients.\u0000</p></div>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":"167 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00701-025-06665-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}