Journal of diabetes and treatment最新文献

{"title":"Treatment of Insulin Autoimmune Syndrome - A Tri Prong Approach","authors":"Yashaswini Tadakamalla, P. Kumar, B. Sethi, Chethan Dev Krishne Gowde","doi":"10.29011/2574-7568.001094","DOIUrl":"https://doi.org/10.29011/2574-7568.001094","url":null,"abstract":"Insulin Autoimmune Syndrome (IAS) manifests as transient self-limiting endogenous hyperinsulinemic hypoglycemia. It is characterized by the presence of insulin autoantibodies which bind insulin and the unpredictable release of insulin from insulinautoantibody complexes resulting in spontaneous hypoglycemia. . It needs to be considered in patients of hypoglycemia (in non-diabetic individuals) to avoid unnecessary investigations and surgical interventions. Treatment of Insulin autoimmune syndrome has always been an enigma. We suggest a tri prong approach, with the pharmacological cocktail of alpha glucose inhibitor, steroids, and diazoxide along with dietary modifications after the elimination of the culprit agent. The targeting of the three major pathogenetic mechanisms when initiated early holds the potential of earlier relief of symptoms and accelerated recovery. Journal of Diabetes and Treatment Tadakamalla, et al. J Diabetes Treat 6: 1094. www.doi.org/10.29011/2574-7568.001094 www.gavinpublishers.com","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42194293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Low Vitamin D Levels and Metabolic Syndrome in Patients Attending Consultation at a Tertiary Level Hospital","authors":"D. Ly-Liu, A. Becerra-Fernández, M. Aguilar-Vilas, Gilberto Pérez-López, D. Ly-Pen","doi":"10.29011/2574-7568.001093","DOIUrl":"https://doi.org/10.29011/2574-7568.001093","url":null,"abstract":"Background and Aim: Vitamin D is involved in multiple metabolic alterations that affect adiposity, glycemic control and cardiovascular risk factors. Cardiovascular Diseases (CVD) are the leading cause of global mortality. The aim of the study is to investigate the prevalence of low levels of vitamin D and Metabolic Syndrome (MS) in our population, and which cardiovascular markers and diseases are related to vitamin D deficiency. Methods and Results: Descriptive cross-sectional study of patients attending endocrinology consultations at Ramón y Cajal Hospital, from March 2015 to May 2017. A total of 234 patients were included, 49.1% had vitamin D deficiency and 53.8% had MS. Increased waist circumference was the factor with the highest prevalence (61.74%) in individuals with vitamin D levels <20 ng/ml compared to the rest of the groups (p<0.05). The decrease in HDL cholesterol, glycated hemoglobin and insulin resistance were the cardiovascular markers related to vitamin D deficiency (p <0.05). The CVD associated with low levels of vitamin D were type 2 diabetes mellitus (T2DM) (p<0.02), acute myocardial failure (p<0.01) and coronary revascularization (p<0.005). All these conditions were associated with men (p<0.05). Conclusions: Patients with MS had significantly lower vitamin D values than those without MS. Vitamin D deficiency is related to the development of major cardiovascular events in relation to T2DM pathogenesis, from microvascular alterations to the latter macro vascular processes. The therapeutic and nutritional approach to central obesity, HDL-cholesterol levels and diabetes metabolism markers, with an elevation of vitamin D, would decrease the prevalence of MS and CVD. Journal of Diabetes and Treatment Ly-Liu D, et al. J Diabetes Treat 6: 1093. www.doi.org/10.29011/2574-7568.001093 www.gavinpublishers.com","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42802042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Glycemic Index Foods: A Resolution to Ameliorate Type 2 Diabetes","authors":"","doi":"10.29011/2574-7568.001087","DOIUrl":"https://doi.org/10.29011/2574-7568.001087","url":null,"abstract":"","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69454812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Metabolic Syndrome among Bangladeshi Male Patients with Type 2 Diabetes Mellitus in a Newly Developing Country","authors":"","doi":"10.29011/2574-7568.001085","DOIUrl":"https://doi.org/10.29011/2574-7568.001085","url":null,"abstract":"","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69454695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the Chlorite-Based Drug WF10 on Hemoglobin A1c, Hematological Biomarkers in Uncontrolled Diabetic Patients with Foot Ulcer","authors":"Narongchai Yingsakmongkol, C. Tanunyutthawongse, Joerg Flemmig, Friedrich-Wilhelm Kuehne","doi":"10.29011/2574-7568.001086","DOIUrl":"https://doi.org/10.29011/2574-7568.001086","url":null,"abstract":"Aims: To evaluate degree and kinetics of WF10 effects on HbA1c, associated hematological biomarkers, and wound healing in uncontrolled T2DM patients with DFU. Methods: In this prospective, interventional, pretest-posttest study, 40 DFU patients with HbA1c > 8.5 % were treated with standard therapy plus five weekly infusions of the chlorite-based drug WF10 within outpatient department. Besides HbA1c kinetics, we studied red blood cell distribution width (RDW-CV) value, neutrophil-lymphocyte ratio (NLR) and wound healing at week (W) 0, 4, 8 and 12. Results: In 38 PP-treated patients WF10 decreased HbA1c value from 10.48 % at baseline (BL) to 8.06 % at W8 and Wound Severity Score (WSS) from 8.0 to 1.4 (both p < 0.0001) at W12. RDW-CV was diminished from 13.5 % to 12.8 % (p = 0.0021), NLR decreased from 2.8 to 2.2 (NS) but significantly decreased in patients with NLR > 3.5 at BL, from 6.3 to 3.2. No serious side effect of WF10 was observed. Conclusion: Standard therapy of DFU plus adjunct WF10 application consistently and long-lastingly decreased high HbA1c values and showed good outcome of wound healing in patients with uncontrolled diabetes. The used treatment protocol is applicable for outpatient treatment.","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69454748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of COVID-19 in Hospital in-patients with Type-2 Diabetes","authors":"","doi":"10.29011/2574-7568.001089","DOIUrl":"https://doi.org/10.29011/2574-7568.001089","url":null,"abstract":"","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69454926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab as a Novel and Effective Treatment for Refractory Necrobiosis Lipoidica","authors":"","doi":"10.29011/2574-7568.001091","DOIUrl":"https://doi.org/10.29011/2574-7568.001091","url":null,"abstract":"","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69455236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing patients with Diabetes Mellitus after a cholera attack: A retrospective analysis in a tertiary center and specialty clinic in Sana’a Yemen","authors":"B. Al-Sharafi, Shafiq A. Alemad, Nuha A. Al-Yousfi","doi":"10.29011/2574-7568.001083","DOIUrl":"https://doi.org/10.29011/2574-7568.001083","url":null,"abstract":"Objective: We aimed to investigate patients with diabetes mellitus who presented for management of their diabetes after developing cholera during the cholera epidemic in Yemen. Patients and methods: This is a retrospective chart review of all patients with the diagnosis of Diabetes Mellitus (DM) who presented after an attack of cholera from June 2018-June 2019 in 2 clinics (endocrinology and nephrology) in the University of Science and Technology hospital in Sana’a Yemen and a private endocrinology clinic. Also, 120 charts were reviewed as a control group on patients with diabetes mellitus with no history of cholera. Result: A total of148 charts were reviewed, 28 patients with diabetes mellitus who presented within 2 months of developing cholera and 120 patients with diabetes mellitus but no history of cholera who served as the control group. The mean age of the patients with a history of cholera was 54.8 (SD 14.7) and in the control group was 52.4 (SD 17.4). In the 21 patients with cholera that were on oral hypoglycemic agents (OHA) or no medications before the attack, 66.7% (N=14) required insulin after developing cholera. In comparison to the control group, 54.2% (N=65) patients were on OHA or no medications at presentation and none of these patients were started on insulin at the initial visit (p-value <0.001). In those patients who had been switched to insulin in the cholera group 78.5% (N=11) of them still required insulin months after developing cholera and only 21.5% (N=3) were able to switch back to OHA. Among the 7 patients on insulin before the attack, 85% (N=6) of them required an increase in the dose of insulin. Conclusion: The majority of patients who presented to us after developing cholera required insulin and those already on insulin required an increase in their dose. Physicians caring for cholera patients should be aware of this and if not able to manage while the patient is being rehydrated should advise the patient to seek medical attention for management of their diabetes after rehydration if having hyperglycemia.","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69454584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Hemoglobin A1c and Glycemia in African Americans with and without Sickle Cell trait and Whites, Results from CARDIA and the Jackson Heart Study.","authors":"Wen-Chih Wu, Mary E Lacy, Adolfo Correa, Mercedes Carnethon, Alexander P Reiner, Charles B Eaton, Gregory A Wellenius","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>1.1.It was reported that Hemoglobin A1c (HbA1c) values of African-Americans (AAs) were on average higher than whites whereas AAs with Sickle-Cell-Trait (SCT) had lower HbA1c values compared to AAs without SCT despite controlling for average glycaemia. We evaluated the HbA1c-glucose relationship between AAs with and without SCT, and whites using data from two cohort studies.</p><p><strong>Methods: </strong>1.2.We pooled data from Coronary-Artery-Risk-Development-Study-in-Young-Adults (CARDIA, n= 5,115, 2005-2011) and the Jackson-Heart-Study (JHS, n=5,301, 2000-2013). Whole exome sequencing in JHS and TaqMan-SNP-Genotyping Assays in CARDIA determined the SCT status in AAs. HbA1c was measured by two NGSP-certified assays without reportedly clinically significant interference from hemoglobin S. Participants without data on SCT or with hemoglobin SS, CC or AC were excluded, resulting in 6,623 participants (n=3,575 from CARDIA and n=3,048 from JHS). Generalized-estimating-equations estimated the cross-sectional association between fasting glucose and HbA1c(outcome) amongst whites, AAs with SCT, and AAs without SCT controlling for clinical-demographic factors.</p><p><strong>Results: </strong>1.3.Our analyses included 2,003 whites, 4,253 AAs without SCT and 367 AAs with SCT. AAs with and without SCT had similar clinical-demographic characteristics, whereas whites have lower fasting- and 2-hour-glucose values than AAs. Despite higher fasting-glucose values in AAs with SCT versus whites, their HbA1c values were similar (p=0.39). In the subset with 2-hour-glucose values, HbA1c values in AAs with SCT were lower than whites (p=0.007) despite higher 2-hour-glucose values.</p><p><strong>Conclusions: </strong>1.4.AAs with SCT have at least similar, if not lower, levels of mean HbA1c values than whites despite higher levels of glycaemia. Future research is warranted to assess whether these findings translate to clinical outcomes.</p>","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8939875/pdf/nihms-999280.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10293328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Transient Receptor Potential Channels Trpv1 and Trpm8 in Diabetic Peripheral Neuropathy.","authors":"Mallikarjuna R Pabbidi, Louis S Premkumar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>1.1.Transient Receptor Potential (Vanilloid 1) TRPV1 and (Melastatin 8) TRPM8 are heat and cold sensing non-selective cation channels, respectively. We sought to correlate the modulation of TRPV1- and TRPM8-mediated membrane currents and altered thermal sensitivity in Diabetic Peripheral Neuropathy (DPN).</p><p><strong>Method: </strong>1.2.Streptozotocin (STZ)-induced diabetic mice were used and thermal (heat and cold) pain sensitivities were determined using hot plate and acetone drop test, respectively. Membrane currents were recorded using patch-clamp techniques.</p><p><strong>Results: </strong>1.3.First, we tested thermal pain sensitivities to implicate a possible role of TRPV1 and TRPM8 in DPN. Paw withdrawal latency on a hot plate test was decreased, and acetone-induced cold sensitivity was enhanced in diabetic mice as compared to non-diabetic mice. Dorsal Root Ganglion (DRG) neurons dissociated from diabetic hyperalgesic mice exhibited an increase in TRPV1-mediated current and a decrease in TRPM8-mediated currents as compared to non-diabetic mice. Then, we determined the modulation of TRPV1- and TRPM8-mediated currents using HEK cells heterologously expressing TRPV1 by promoting PKC- and PKA-mediated phosphorylation. Both Phorbol 12,13-Dibutyrate (PDBu), a PKC activator and forskolin, a PKA activator upregulated TRPV1-mediated currents but downregulated TRPM8-mediated currents. In diabetic mice, intraplantar injection of capsaicin, a TRPV1 agonist-induced nocifensive behavior but the severity of this behavior was significantly lower when co-administered with menthol, a TRPM8 agonist.</p><p><strong>Conclusions: </strong>1.4.These findings suggest that diabetic thermal hyperalgesia mediated by up-regulation of TRPV1 function may be further aggravated by the downregulation of TRPM8 function. Targeting TRPV1 may be a useful approach to alleviate pain associated with DPN.</p>","PeriodicalId":73707,"journal":{"name":"Journal of diabetes and treatment","volume":"2017 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317870/pdf/nihms-1002094.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36838416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}