Treatment of Insulin Autoimmune Syndrome - A Tri Prong Approach

Abstract

Insulin Autoimmune Syndrome (IAS) manifests as transient self-limiting endogenous hyperinsulinemic hypoglycemia. It is characterized by the presence of insulin autoantibodies which bind insulin and the unpredictable release of insulin from insulinautoantibody complexes resulting in spontaneous hypoglycemia. . It needs to be considered in patients of hypoglycemia (in non-diabetic individuals) to avoid unnecessary investigations and surgical interventions. Treatment of Insulin autoimmune syndrome has always been an enigma. We suggest a tri prong approach, with the pharmacological cocktail of alpha glucose inhibitor, steroids, and diazoxide along with dietary modifications after the elimination of the culprit agent. The targeting of the three major pathogenetic mechanisms when initiated early holds the potential of earlier relief of symptoms and accelerated recovery. Journal of Diabetes and Treatment Tadakamalla, et al. J Diabetes Treat 6: 1094. www.doi.org/10.29011/2574-7568.001094 www.gavinpublishers.com