Advances in pharmacology最新文献_第9页

Examining the effects of psychoactive drugs on complex behavioral processes in laboratory animals. 检验精神活性药物对实验动物复杂行为过程的影响。

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/bs.apha.2021.09.001

Brian D. Kangas

引用次数: 0

Pharmacological developments in antihypertensive treatment through nitric oxide-cGMP modulation. 通过一氧化氮- cgmp调节抗高血压治疗的药理学进展。

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/bs.apha.2022.01.001

Annika A. Jüttner, A. Danser, A. Roks

引用次数: 4

Cytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain. 细胞色素P450酶与哺乳动物大脑内药物和神经毒素的代谢。

Advances in pharmacology Pub Date : 2022-01-01 Epub Date: 2022-06-10 DOI: 10.1016/bs.apha.2022.04.003

Marlaina R Stocco, Rachel F Tyndale

{"title":"Cytochrome P450 enzymes and metabolism of drugs and neurotoxins within the mammalian brain.","authors":"Marlaina R Stocco, Rachel F Tyndale","doi":"10.1016/bs.apha.2022.04.003","DOIUrl":"https://doi.org/10.1016/bs.apha.2022.04.003","url":null,"abstract":"Cytochrome P450 enzymes (CYPs) that metabolize xenobiotics are expressed and active in the brain. These CYPs contribute to the metabolism of many centrally acting compounds, including clinically used drugs, drugs of abuse, and neurotoxins. Although CYP levels are lower in the brain than in the liver, they may influence central substrate and metabolite concentrations, which could alter resulting centrally-mediated responses to these compounds. Additionally, xenobiotic metabolizing CYPs are highly variable due to genetic polymorphisms and regulation by endogenous and xenobiotic molecules. In the brain, these CYPs are sensitive to xenobiotic induction. As a result, CYPs in the brain vary widely, including among humans, and this CYP variation may influence central metabolism and resulting response to centrally acting compounds. It has been demonstrated, using experimental manipulation of CYP activity in vivo selectively within the brain, that CYP metabolism in the brain alters central substrate and metabolite concentrations, as well as drug response and neurotoxic effects. This suggests that variability in xenobiotic metabolizing CYPs in the human brain may meaningfully contribute to individual differences in response to, and effects of, centrally acting drugs and neurotoxins. This chapter will provide an overview of CYP expression in the brain, endogenous- and xenobiotic-mediated CYP regulation, and the functional impact of CYP-mediated metabolism of drugs and neurotoxins in the brain, with a focus on experimental approaches in mice, rats, and non-human primates, and a discussion regarding the potential role of xenobiotic metabolizing CYPs in the human brain.","PeriodicalId":7366,"journal":{"name":"Advances in pharmacology","volume":" ","pages":"73-106"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Behavioral Pharmacology of Drug Abuse: Current Status 药物滥用行为药理学:现状

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/s1054-3589(22)x0002-1

引用次数: 0

Human behavioral pharmacology of psychedelics. 迷幻药的人类行为药理学。

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/bs.apha.2021.10.003

J. Strickland, Matthew W. Johnson

引用次数: 3

Sphingosine-1-phosphate and Sphingosine-1-phosphate receptors in the cardiovascular system: pharmacology and clinical implications. 鞘氨醇-1-磷酸和鞘氨醇-1-磷酸受体在心血管系统中的作用:药理学和临床意义

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/bs.apha.2022.02.001

S. Spampinato, M. Sortino, Salvatore Salomone

引用次数: 3

Relaxin/serelaxin for cardiac dysfunction and heart failure in hypertension. 舒张素/舒张素治疗高血压心功能障碍和心力衰竭。

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/bs.apha.2022.04.002

Prasad Chunduri, Shrey A Patel, S. Levick

引用次数: 0

Cytochrome P450 polymorphism: From evolution to clinical use. 细胞色素P450多态性:从进化到临床应用。

Advances in pharmacology Pub Date : 2022-01-01 Epub Date: 2022-07-18 DOI: 10.1016/bs.apha.2022.04.004

Magnus Ingelman-Sundberg

{"title":"Cytochrome P450 polymorphism: From evolution to clinical use.","authors":"Magnus Ingelman-Sundberg","doi":"10.1016/bs.apha.2022.04.004","DOIUrl":"https://doi.org/10.1016/bs.apha.2022.04.004","url":null,"abstract":"The cytochromes P450s can be divided in two groups, those of high importance for endogenous functions being evolutionary quite stable and those participating in detoxification of drugs and other xenobiotics having less important endogenous functions. In the latter group extensive genetic diversity has been allowed and in addition this is of high importance for survival in different environments. The genetic polymorphisms in these genes have evolved to some extent based on dietary restrictions and environmental factors and have not been subject of conservation due to less importance for survival. In cases of high dietary selection events, gene multiplication and amplification events have been seen. The different variants in genes encoding drug metabolizing enzymes can be used as genetic biomarkers (pharmacogenomic labels) for adjustment of drug treatment leading to less adverse drug reactions and better response. Indeed, this has improved the use of personalized medicine, although the missing heredity seen based on twin studies indicates that there are indeed many more genetic variants to be discovered before one can achieve a satisfactory relationship between genotype and phenotype with respect to drug metabolism and toxicity.","PeriodicalId":7366,"journal":{"name":"Advances in pharmacology","volume":" ","pages":"393-416"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40711066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human behavioral pharmacology of stimulant drugs: An update and narrative review. 人类行为药理学的兴奋剂药物:更新和叙述回顾。

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/bs.apha.2021.07.001

Ashley Strzelecki, J. Weafer, W. Stoops

引用次数: 5

Interactions between opioids and stimulants: Behavioral pharmacology of abuse-related effects. 阿片类药物和兴奋剂之间的相互作用:滥用相关影响的行为药理学。

Advances in pharmacology Pub Date : 2022-01-01 DOI: 10.1016/bs.apha.2021.10.002

David R. Maguire, Vanessa Minervini

引用次数: 2