miRNA 与砷诱发的癌变。

Q1 Pharmacology, Toxicology and Pharmaceutics

Advances in pharmacology Pub Date : 2023-01-01 Epub Date: 2023-02-06 DOI:10.1016/bs.apha.2022.10.002

Alexandra N Nail, Ana P Ferragut Cardoso, Lakyn K Montero, J Christopher States

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引用次数: 0

摘要

砷诱发癌症是一个世界性的健康问题。确定砷诱发癌症的分子机制对于制定治疗策略非常重要。众所周知，微RNA（miRNA）失调会影响人类癌症的发生和发展。一些研究发现，在长期暴露于砷的人的癌症中，以及在砷诱发癌变的细胞模型中，miRNA 表达的改变之间存在关联。本章全面综述了砷诱发癌症中的 miRNA 失调。

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miRNAs and arsenic-induced carcinogenesis.

Arsenic-induced carcinogenesis is a worldwide health problem. Identifying the molecular mechanisms responsible for the induction of arsenic-induced cancers is important for developing treatment strategies. MicroRNA (miRNA) dysregulation is known to affect development and progression of human cancer. Several studies have identified an association between altered miRNA expression in cancers from individuals chronically exposed to arsenic and in cell models for arsenic-induced carcinogenesis. This chapter provides a comprehensive review for miRNA dysregulation in arsenic-induced cancer.

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来源期刊

Advances in pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

9.10

自引率

0.00%

发文量