Advances in pharmacology最新文献_第4页

TL1A: A model for a precision medicine approach in the treatment of Crohn's disease and ulcerative colitis. TL1A：治疗克罗恩病和溃疡性结肠炎的精准医疗方法模型。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.apha.2024.10.014

Janine M Bilsborough, Stephan R Targan

{"title":"TL1A: A model for a precision medicine approach in the treatment of Crohn's disease and ulcerative colitis.","authors":"Janine M Bilsborough, Stephan R Targan","doi":"10.1016/bs.apha.2024.10.014","DOIUrl":"https://doi.org/10.1016/bs.apha.2024.10.014","url":null,"abstract":"Inflammatory bowel disease (IBD) is a collective term for chronic inflammatory diseases of the intestinal tract. The term IBD encompasses two main forms, Crohn's disease (CD) and Ulcerative colitis (UC). CD is characterized by inflammation throughout the length of the gut, especially the ileum and colon, and is often complicated with fistulae and/or intestinal strictures. Ulcerative colitis (UC) is inflammatory disease restricted to the colon and rectum. In practice however, IBD is a heterogenous disease with CD and UC representing the extremes of a continuum of diseases with varied clinical presentation, including disease location, severity, and manifestation of extraintestinal diseases. This disease heterogeneity poses a challenge to successful and efficacious therapeutic treatment as the etiology driving disease in individual patients is unknown and likely to be multifactorial, including genetic predisposition, environmental factors such as the microbiota, as well as social behaviors such as smoking and diet. Precision medicine provides a strategy to account for disease heterogeneity and diverse etiology to select for patients most likely to respond to a given therapeutic. In this chapter we present an example of the development of a novel antibody therapeutic, Tulisokibart, as a model for a Precision Medicine approach to the successful treatment of patients with IBD.","PeriodicalId":7366,"journal":{"name":"Advances in pharmacology","volume":"101 ","pages":"287-299"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulators of nicotine reward and reinforcement. 尼古丁奖赏和强化的调节剂。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2024-02-10 DOI: 10.1016/bs.apha.2023.10.005

Brandon J Henderson, Samuel Tetteh-Quarshie, Nathan A Olszewski

引用次数: 0

Immunity on ice: The impact of methamphetamine on peripheral immunity. 冰上免疫：甲基苯丙胺对外周免疫的影响。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2023-10-24 DOI: 10.1016/bs.apha.2023.09.003

Emily J Miller, Habibeh Khoshbouei

{"title":"Immunity on ice: The impact of methamphetamine on peripheral immunity.","authors":"Emily J Miller, Habibeh Khoshbouei","doi":"10.1016/bs.apha.2023.09.003","DOIUrl":"10.1016/bs.apha.2023.09.003","url":null,"abstract":"Methamphetamine (METH) regulation of the dopamine transporter (DAT) and central nervous system (CNS) dopamine transmission have been extensively studied. However, our understanding of how METH influences neuroimmune communication and innate and adaptive immunity is still developing. Recent studies have shed light on the bidirectional communication between the CNS and the peripheral immune system. They have established a link between CNS dopamine levels, dopamine neuronal activity, and peripheral immunity. Akin to dopamine neurons in the CNS, a majority of peripheral immune cells also express DAT, implying that in addition to their effect in the CNS, DAT ligands such as methamphetamine may have a role in modulating peripheral immunity. For example, by directly influencing DAT-expressing peripheral immune cells and thus peripheral immunity, METH can trigger a feed-forward cascade that impacts the bidirectional communication between the CNS and peripheral immune system. In this review, we aim to discuss the current understanding of how METH modulates both innate and adaptive immunity and identify areas where knowledge gaps exist. These gaps will then be considered in guiding future research directions.","PeriodicalId":7366,"journal":{"name":"Advances in pharmacology","volume":"99 ","pages":"217-250"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current and emerging therapeutic strategies for perianal fistula in Crohn's disease patients. 克罗恩病患者肛周瘘的现有和新兴治疗策略。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2024-10-24 DOI: 10.1016/bs.apha.2024.10.013

Kailei Ding, Jiayuan Kong, Ling Li, Florin M Selaru, Alyssa Parian, Hai-Quan Mao

引用次数: 0

The pharmacology and neurotoxicology of synthetic cathinones. 合成卡西酮的药理学和神经毒理学。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2023-12-26 DOI: 10.1016/bs.apha.2023.12.001

Mariana Angoa-Perez, Donald M Kuhn

{"title":"The pharmacology and neurotoxicology of synthetic cathinones.","authors":"Mariana Angoa-Perez, Donald M Kuhn","doi":"10.1016/bs.apha.2023.12.001","DOIUrl":"10.1016/bs.apha.2023.12.001","url":null,"abstract":"The synthetic cathinones are man-made compounds derived from the naturally occurring drug cathinone, which is found in the khat plant. The drugs in this pharmacological class that will be the focus of this chapter include mephedrone, MDPV, methcathinone and methylone. These drugs are colloquially known as \"bath salts\". This misnomer suggests that these drugs are used for health improvement or that they have legitimate medical uses. The synthetic cathinones are dangerous drugs with powerful pharmacological effects that include high abuse potential, hyperthermia and hyperlocomotion. These drugs also share many of the pharmacological effects of the amphetamine class of drugs including methamphetamine, amphetamine and MDMA and therefore have high potential to cause damage to the central nervous system. The synthetic cathinones are frequently taken in combination with other psychoactive drugs such as alcohol, marijuana and the amphetamine-like stimulants, creating a situation where heightened pharmacological and neurotoxicological effects are likely to occur. Despite the structural features shared by the synthetic cathinones and amphetamine-like stimulants, including their actions at monoamine transporters and receptors, the effects of the synthetic cathinones do not always match those of the amphetamines. In particular, the synthetic cathinones are far less neurotoxic than their amphetamine counterparts, they produce a weaker hyperthermia, and they cause less glial activation. This chapter will briefly review the pharmacology and neurotoxicology of selected synthetic cathinones with the aim of delineating key areas of agreement and disagreement in the literature particularly as it relates to neurotoxicological outcomes.","PeriodicalId":7366,"journal":{"name":"Advances in pharmacology","volume":"99 ","pages":"61-82"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting proliferating cell nuclear antigen (PCNA) for cancer therapy. 靶向增殖细胞核抗原（PCNA）治疗癌症。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2024-05-14 DOI: 10.1016/bs.apha.2024.04.002

Caroline K Søgaard, Marit Otterlei

引用次数: 0

Modafinil, an atypical CNS stimulant? 莫达非尼，一种非典型中枢神经兴奋剂？

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2023-11-22 DOI: 10.1016/bs.apha.2023.10.006

Melinda Hersey, Gianluigi Tanda

{"title":"Modafinil, an atypical CNS stimulant?","authors":"Melinda Hersey, Gianluigi Tanda","doi":"10.1016/bs.apha.2023.10.006","DOIUrl":"10.1016/bs.apha.2023.10.006","url":null,"abstract":"Modafinil is a central nervous system stimulant approved for the treatment of narcolepsy and sleep disorders. Due to its wide range of biochemical actions, modafinil has been explored for other potential therapeutic uses. Indeed, it has shown promise as a therapy for cognitive disfunction resulting from neurologic disorders like ADHD, and as a smart drug in non-medical settings. The mechanism(s) of actions underlying the therapeutic efficacy of this agent remains largely elusive. Modafinil is known to inhibit the dopamine transporter, thus decreasing dopamine reuptake following neuronal release, an effect shared by addictive psychostimulants. However, modafinil is unique in that only a few cases of dependence on this drug have been reported, as compared to other psychostimulants. Moreover, modafinil has been tested, with some success, as a potential therapeutic agent to combat psychostimulant and other substance use disorders. Modafinil has additional, but less understood, actions on other neurotransmitter systems (GABA, glutamate, serotonin, norepinephrine, etc.). These interactions, together with its ability to activate selected brain regions, are likely one of the keys to understand its unique pharmacology and therapeutic activity as a CNS stimulant. In this chapter, we outline the pharmacokinetics and pharmacodynamics of modafinil that suggest it has an \"atypical\" CNS stimulant profile. We also highlight the current approved and off label uses of modafinil, including its beneficial effects as a treatment for sleep disorders, cognitive functions, and substance use disorders.","PeriodicalId":7366,"journal":{"name":"Advances in pharmacology","volume":"99 ","pages":"287-326"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting glutamate carboxypeptidase II in IBD. 在 IBD 中靶向谷氨酸羧肽酶 II。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2024-10-15 DOI: 10.1016/bs.apha.2024.10.001

Diane E Peters

引用次数: 0

Emerging therapeutics for the management of intestinal fibrosis and strictures. 治疗肠纤维化和狭窄的新兴疗法。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2024-10-02 DOI: 10.1016/bs.apha.2024.09.001

Yub Raj Neupane, Thanuja Marasarakottige Yogananda, Sri Vishnu Kiran Rompicharla, Florin M Selaru, Laura M Ensign

引用次数: 0

Epigenetic inheritance of phenotypes associated with parental exposure to cocaine. 与父母接触可卡因有关的表型的表观遗传。

Advances in pharmacology Pub Date : 2024-01-01 Epub Date: 2023-11-07 DOI: 10.1016/bs.apha.2023.10.004

Matthew T Rich, Sarah E Swinford-Jackson, R Christopher Pierce

{"title":"Epigenetic inheritance of phenotypes associated with parental exposure to cocaine.","authors":"Matthew T Rich, Sarah E Swinford-Jackson, R Christopher Pierce","doi":"10.1016/bs.apha.2023.10.004","DOIUrl":"10.1016/bs.apha.2023.10.004","url":null,"abstract":"Parental exposure to drugs of abuse induces changes in the germline that can be transmitted across subsequent generations, resulting in enduring effects on gene expression and behavior. This transgenerational inheritance involves a dynamic interplay of environmental, genetic, and epigenetic factors that impact an individual's vulnerability to neuropsychiatric disorders. This chapter aims to summarize recent research into the mechanisms underlying the inheritance of gene expression and phenotypic patterns associated with exposure to drugs of abuse, with an emphasis on cocaine. We will first define the epigenetic modifications such as DNA methylation, histone post-translational modifications, and expression of non-coding RNAs that are impacted by parental cocaine use. We will then explore how parental cocaine use induces heritable epigenetic changes that are linked to alterations in neural circuitry and synaptic plasticity within reward-related circuits, ultimately giving rise to potential behavioral vulnerabilities. This discussion will consider phenotypic differences associated with gestational as well as both maternal and paternal preconception drug exposure and will emphasize differences based on offspring sex. In this context, we explore the complex interactions between genetics, epigenetics, environment, and biological sex. Overall, this chapter consolidates the latest developments in the multigenerational effects and long-term consequences of parental substance abuse.","PeriodicalId":7366,"journal":{"name":"Advances in pharmacology","volume":"99 ","pages":"169-216"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140100820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0