Journal of cellular signaling最新文献_第3页

Novel Drug Development for Treatment of COVID-19 by In Silico Analysis: Identification of SARS-Cov-2 Inhibiting Streptomyces Compounds 利用计算机分析开发治疗COVID-19的新药物:鉴定抑制SARS-Cov-2链霉菌的化合物

Journal of cellular signaling Pub Date : 2023-05-18 DOI: 10.33696/signaling.4.092

J. Kumar, Prachi Gholap, T. Pillai

{"title":"Novel Drug Development for Treatment of COVID-19 by In Silico Analysis: Identification of SARS-Cov-2 Inhibiting Streptomyces Compounds","authors":"J. Kumar, Prachi Gholap, T. Pillai","doi":"10.33696/signaling.4.092","DOIUrl":"https://doi.org/10.33696/signaling.4.092","url":null,"abstract":"In accordance with the present epidemiological paradigm, viral mutations of the virus are on the rise, and their natural effects are being selected for at a higher rate than normal. According to the World Health Organization (WHO), the global COVID-19 pandemic induced by the Delta and Omicron strain of the SARS-CoV-2 virus could propagate and disseminate more rapidly than other viruses thanks to its many mutations, and these also caused some very significant health problems. The established medications would eventually start to lose their efficacy since the variation mutated more quickly than the original stain. As protein spikes are the point of origin or epitome for the mutations to take place, it would be most effective to target the remaining vital enzymes by binding the proteins with the largest pocket sizes. The objective of the current work is to employ in-silico analysis to discover the streptomyces chemicals that suppress the SARS-CoV-2 virus as well as its mutated strains thus promoting a healthy body. Based on the drug likeness property of compounds when subjected to molecular docking, a total of 14 compounds were identified and selected from the PUBCHEM database that showed highest binding energy with the targeted Receptor Binding Domain. The compounds namely - Streptomyces tanashiensis; Thaxtomin A; Bafilomycin A1 from Streptomyces griseus and few others as mentioned further on more research would support and confirm the utilizing of these to create new medications to treat the novel SARS-CoV-2 infectious strains.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90754645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Mechanism of CDC42 Promoting HCC Metastasis CDC42促进肝癌转移的潜在机制

Journal of cellular signaling Pub Date : 2023-05-01 DOI: 10.33696/signaling.4.091

Miaoling Tang, Rongni Feng, Jun Yu Li

引用次数: 0

A Computational Investigation on Rho-related GTP-binding Protein RhoB through Molecular Modeling and Molecular Dynamics Simulation Study rho相关gtp结合蛋白RhoB的分子建模和分子动力学模拟研究

Journal of cellular signaling Pub Date : 2023-04-24 DOI: 10.33696/signaling.4.089

Shamrat Kumar Paul, Chowdhury Lutfun Nahar Metu, Sunita Kumari Sutihar, Md. Saddam, Bristi Paul, Md. Lutful Kabir, Md. Mostofa Uddin Helal

{"title":"A Computational Investigation on Rho-related GTP-binding Protein RhoB through Molecular Modeling and Molecular Dynamics Simulation Study","authors":"Shamrat Kumar Paul, Chowdhury Lutfun Nahar Metu, Sunita Kumari Sutihar, Md. Saddam, Bristi Paul, Md. Lutful Kabir, Md. Mostofa Uddin Helal","doi":"10.33696/signaling.4.089","DOIUrl":"https://doi.org/10.33696/signaling.4.089","url":null,"abstract":"Background: An indispensable member of the Rho family, RhoB is an isoprenylated small GTPases that modulate the cellular cytoskeletal organization. While DNA gets damaged, it takes part in the neoplastic apoptotic mechanism. In this study, we evaluated the structure of Rho-related GTP-binding protein RhoB due to the unavailability of 3D structure in the protein data bank database. Results: The expected pI value of RhoB was 5.10 (acidic). The target–template alignment was computed using the GMQE value meanwhile 6hxu.1.A from Homo sapiens was selected as the template structure. The Swiss model was exploited to complete the model construction task. The structural compatibility and stability were revealed after a 100ns molecular dynamics simulation using GROMACA employing the OPLS-AA force field. Based on their fluctuating activity and their location between 100 and 110 and 140 and 150, PCA analysis discovered relevant residues. Conclusion: By providing an insight into the biophysical phenomenon of Rho-related GTP-binding protein RhoB inhibitors, this study will assist future investigations addressing the relationship between gene mutation and abnormalities produced by protein Rho-related GTP-binding protein RhoB in apoptotic events.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135278556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purinergic P2X7 Receptor as a Potential Targeted Therapy for COVID-19-associated Lung Cancer Progression 嘌呤能P2X7受体作为covid -19相关肺癌进展的潜在靶向治疗

Journal of cellular signaling Pub Date : 2023-03-07 DOI: 10.33696/signaling.4.087

Hamidreza Zalpoor, A. Akbari, M. Nabi-Afjadi, Ali Norouzi, F. Seif, M. Pornour

{"title":"Purinergic P2X7 Receptor as a Potential Targeted Therapy for COVID-19-associated Lung Cancer Progression","authors":"Hamidreza Zalpoor, A. Akbari, M. Nabi-Afjadi, Ali Norouzi, F. Seif, M. Pornour","doi":"10.33696/signaling.4.087","DOIUrl":"https://doi.org/10.33696/signaling.4.087","url":null,"abstract":"Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection is a serious threat to lung cancer patients. Hereby, we hypothesize that Coronavirus disease 2019 (COVID-19) may contribute to lung cancer progression by increasing extracellular adenosine triphosphate (ATP) levels and hyperactivating the purinergic P2X purinoceptor 7 receptor (P2X7R). Hyperactivation of P2X7R by increased extracellular ATP may stimulate multiple signaling pathways and factors such as NLRP3 inflammasome; as a result, interleukin (IL)-1β, and IL-18 pro-inflammatory cytokines are released, JNK, Rho kinase, HMGB1-RAGE, PI3K/AKT, hypoxia-inducible factor-1 alpha (HIF-1α), and ERK. NLRP3 activation may play a pivotal role in fatal cytokine storm in critically ill patients with COVID-19 and tumor progression in patients with lung cancer. Consequently, inhibiting these signaling pathways may deviate immune responses toward anti-tumoral responses, and suppress lung cancer progression and cytokine storms. Therefore, targeting P2X7R by means of oxidized ATP and anti-P2X7 monoclonal antibodies may provide promising therapeutic approaches to prevent lung cancer progression in COVID-19 patients; however, no clinical trials have yet been conducted, and their clinical efficacy remains to be elucidated.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90714182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Targeting SCUBE3 in Hepatocellular Carcinoma 靶向SCUBE3治疗肝细胞癌

Journal of cellular signaling Pub Date : 2023-03-07 DOI: 10.33696/signaling.4.088

Teng Liu, Xia Yang, Ke Wang, Q. Luo

引用次数: 0

Radiation-induced Bystander Effect and Its Possible Countermeasures 辐射诱发的旁观者效应及其可能的对策

Journal of cellular signaling Pub Date : 2023-03-07 DOI: 10.33696/signaling.4.086

G. Ghosh

引用次数: 0

Augmenting Venetoclax Activity Through Signal Transduction in AML. 在AML中通过信号转导增强Venetoclax活性。

Journal of cellular signaling Pub Date : 2023-01-01 DOI: 10.33696/signaling.4.085

Ian Michael Bouligny, Keri Renee Maher, Steven Grant

引用次数: 2

Optogenetics Sheds Light on Brown and Beige Adipocytes. 光遗传学揭示棕色和米色脂肪细胞。

Journal of cellular signaling Pub Date : 2023-01-01 DOI: 10.33696/signaling.4.105

Aaron Clifford Brown

引用次数: 0

Targeting the Complex Protein Network of MYCN-amplified Anaplastic Ependymoma: A Case Report 靶向mycn扩增间变性室管膜瘤复杂蛋白网络1例

Journal of cellular signaling Pub Date : 2022-12-22 DOI: 10.33696/signaling.3.082

MD Michael P. Castro

{"title":"Targeting the Complex Protein Network of MYCN-amplified Anaplastic Ependymoma: A Case Report","authors":"MD Michael P. Castro","doi":"10.33696/signaling.3.082","DOIUrl":"https://doi.org/10.33696/signaling.3.082","url":null,"abstract":"The MYCN oncoprotein has been notoriously undruggable and is infamous for causing aggressive cancer with poor outcomes in children and adults. Following surgery, radiation, and chemotherapy, patients who develop progressive disease have few treatment options. An analysis of the dysregulated protein network caused by MYCN amplification suggested co-targeting PLK1, AURKA, CKS1, AKT, MTOR, and USP7 would be useful to take advantage of synthetic lethal vulnerabilities while overcoming redundancies and resistance mechanisms that stabilize N-Myc by preventing its proteasome degradation. Naturopathic compounds, (genistein, tanshinone, resveratrol, betulinic acid) and fluoxetine were re-purposed to target the complex protein network in a patient with MYCN -amplified and PTEN -deficient multifocal, relapsed anaplastic ependymoma following standard therapy. The patient achieved a clinically meaningful and durable response for 6 months prior to developing disease progression characterized by chromosome 11q ( YAP1, BIRC2/3 ) amplification. The experience suggests molecularly-informed integration of naturopathic compounds can have utility for disease control and survival. The success, although anecdotal, suggests that the previous failure of single agent strategies could be overcome with a network targeting approach that simultaneously precipitates cell cycle arrest, rescues FBXW7 ubiquitination, and enhances oxidative stress. As such, MYCN may no longer be strictly unactionable but appears amenable to co-targeting key nodes in its self-sustaining disease network.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"201 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74888730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Insights into the Proteolytic Regulation of the Structural Protein Junctophilin-2 by Calpain Calpain对结构蛋白Junctophilin-2蛋白水解调控的新认识

Journal of cellular signaling Pub Date : 2022-12-22 DOI: 10.33696/signaling.3.081

G. Weninger, S. Lehnart

引用次数: 0