Journal of cellular signaling最新文献_第3页

The Human Gut Phageome: Identification and Roles in the Diseases 人类肠道噬菌体:鉴定及其在疾病中的作用

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.100

M. Nabi-Afjadi, Samaneh Teymouri, Fatemeh Monfared, Seyed Mostafa Noorbakhsh Varnosfaderani, Hossein Halimi

引用次数: 0

Activation of the 5-hydroxytryptamine Degradation System in Cells and Organ Injury 5-羟色胺降解系统在细胞和器官损伤中的激活

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.099

J. Fu

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The Finer Points of Podocyte Sphingolipid Metabolism in Diabetic Kidney Disease 糖尿病肾病足细胞鞘脂代谢的精细点

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.097

A. Mitrofanova, Rachel Njeim, A. Fornoni

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Structural Insights into Protein-Ligand Interactions of Small Leucine Rich Repeat Proteoglycans with a Large Number of Binding Partners: An Overview 具有大量结合伙伴的小亮氨酸重复蛋白聚糖的蛋白质-配体相互作用的结构见解:综述

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.098

N. Matsushima, Hiroki Miyashita, D. Batkhishig, R. Kretsinger

{"title":"Structural Insights into Protein-Ligand Interactions of Small Leucine Rich Repeat Proteoglycans with a Large Number of Binding Partners: An Overview","authors":"N. Matsushima, Hiroki Miyashita, D. Batkhishig, R. Kretsinger","doi":"10.33696/signaling.4.098","DOIUrl":"https://doi.org/10.33696/signaling.4.098","url":null,"abstract":"Small leucine rich repeat proteoglycans (SLRPs) exist in the extracellular matrix. SLRPs contain tandem arrays of LRRs flanked by cysteine clusters at the both N- and C-termini. The extreme N- and/or C-termini contain low complexity sequences, glycosaminoglycan (GAG) chain and/or sulfated tyrosine residues in some members of SLRPs. The LRR solenoid structure may be divided into four parts consisting of a concave surface, an ascending surface, a convex surface, and a descending surface. SLRPs share many biological functions including collagen fibrillogenesis, signaling, innate immunity, and inflammation through the binding of various ligands. We undertake a comprehensive literature search of publications in order to make a list of ligands of SLRPs. We describe and discuss the interacting sites of SLRPs to binding partners. The protein-ligand interactions occur on not only the concave surface but also the ascending surface and the N- or C-terminal capping regions. In addition, the extreme N- and/or C-terminal regions with the GAG chains or sulfated tyrosine residues participate in ligand-interactions.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88284951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

F-ATP Synthase Inhibitory Factor 1 in Regulation of Mitochondria Permeability Transition Pore and Metabolic Reprogramming F-ATP合成酶抑制因子1在线粒体通透性、过渡孔和代谢重编程中的调控作用

Journal of cellular signaling Pub Date : 2023-06-13 DOI: 10.33696/signaling.4.096

Lishu Guo

引用次数: 0

Improving Cancer Epigenetic Therapy; A Glimpse of NRF2 改进癌症表观遗传治疗;NRF2的一瞥

Journal of cellular signaling Pub Date : 2023-05-31 DOI: 10.33696/signaling.4.095

Tahereh Kashkoulinejad-Kouhi

{"title":"Improving Cancer Epigenetic Therapy; A Glimpse of NRF2","authors":"Tahereh Kashkoulinejad-Kouhi","doi":"10.33696/signaling.4.095","DOIUrl":"https://doi.org/10.33696/signaling.4.095","url":null,"abstract":"One of the mechanisms used by epigenetic therapy is the elevation of host cell-derived double stranded RNA (dsRNA) baseline levels through overexpression of genomic repetitive elements especially Alu retroelements. The dsRNAs trigger immunogenic responses since immune system cannot distinguish between endogenous and exogenous dsRNAs derived from viral infections; hence called “Viral mimicry response”. These dsRNAs are recognized by pattern recognition receptors (PRRs) such as MDA-5 which further induce inflammatory responses through interferon secretion. However, the response is limited through the function of some editing enzymes such as ADAR1 which destabilizes the formation of dsRNAs and renders the therapy less efficient through attenuating interferon secretion by immune cells. Since, some cancer cells can survive even after ADAR1 inhibition, it is speculated that there might be other mechanism which contribute to dsRNA destabilization. Since dsRNA formation derived from retroelement transcripts mimics viral infections, we tried to review the mechanistic approaches applied during host-pathogen interaction to highlight a possible candidate which might be cogitable for further investigations in epigenetic therapy. dsRNAs produced by RNA viruses are sensed by PRRs and activate nuclear factor erythroid 2 p45-related factor 2 (NRF2) which further downregulates STING protein and attenuates IFN release. RNA viruses such as SARS-CoV-2 have the potential to impair NRF2 signaling and eliminate its inhibitory effect from STING, leading to excessive release of IFNs and destroy pulmonary cells through cytokine release storm (CRS). Here, we briefly explain that NRF2, in a very downstream side of anti-viral response, might be a potential candidate target in combination with epigenetic therapy to circumvent the limitations in cancer epigenetic therapy.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88570470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Chromosome Replication and Segregation Unit of Mycobacterium and Its Comparative Analysis with Model Organisms: From Drug Targets to Drug Identification 了解分枝杆菌的染色体复制分离单元及其与模式生物的比较分析:从药物靶点到药物鉴定

Journal of cellular signaling Pub Date : 2023-05-18 DOI: 10.33696/signaling.4.094

P. Jain

{"title":"Understanding Chromosome Replication and Segregation Unit of Mycobacterium and Its Comparative Analysis with Model Organisms: From Drug Targets to Drug Identification","authors":"P. Jain","doi":"10.33696/signaling.4.094","DOIUrl":"https://doi.org/10.33696/signaling.4.094","url":null,"abstract":"Bacterium maintains its pathogenicity in the host by continuing replication and adopting temporal and spatial coordination of cell division steps such as cell wall synthesis, DNA replication, chromosome segregation, Z ring assembly, septum formation and finally cytokinesis. This multistep process requires spatiotemporal assembly of macromolecular complexes and is probably regulated by redundant and multifunctional activities of cell replication and division proteins. Two macromolecular assemblies of peptidoglycan biosynthesis, known as elongasome and divisome are known to drive the division of mother cell into two daughter cells and are characterized by the presence of signature protein complexes. Though the exact composition of macromolecular complexes is yet to be defined in Mycobacterium, the presence of some conserved proteins demonstrates the preservation of elementary units. Along with elongasome and divisome complexes, chromosome replication and segregation proteins are very important to understand as these proteins are very essential for bacilli survival, sustenance, and pathogenesis. In this review, along with presenting the differential features of Mycobacterium cell division process, we are comparing chromosome replication and segregation proteins of Mycobacterium with other bacterial species as we aim to identify structural and functional differences between these proteins in different species. In this review, we have also listed the potential drugs that can be tested to target Mycobacterium chromosome replication and segregation proteins. We expect that based on these differences identified, researchers would be able to direct their research in the characterization of Mycobacterium specific drug.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72916634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study on the Usage of Probiotics as a Safer Antipyretic 益生菌作为一种更安全的退烧药的应用研究

Journal of cellular signaling Pub Date : 2023-05-18 DOI: 10.33696/signaling.4.093

Shantanu Shrivastava, Nimisha Bhatu

{"title":"A Study on the Usage of Probiotics as a Safer Antipyretic","authors":"Shantanu Shrivastava, Nimisha Bhatu","doi":"10.33696/signaling.4.093","DOIUrl":"https://doi.org/10.33696/signaling.4.093","url":null,"abstract":"Most medicines and supplements which include probiotics have both expected clinical outcomes and unwanted side effects, which plays a major role when considering them as a mode of treatment. This review is an update about the advantages and disadvantages associated with the use of probiotics as part of a safe therapeutic armamentarium in health and other diseases. The advantages of probiotics run across multiple tissue systems in the body and a has a wide age spectrum. Probiotics also promote cardiovascular health, accelerate recovery from the condition of antibiotic-associated diarrhoea, decrease the effect of necrotizing enterocolitis with reduced inflammation, and accelerate the healing of the wound. Probiotics also contribute in treating chronic diseases for patients with type 2 diabetes as well as patients with HIV/AIDS. Moreover, probiotics play an important role in the treatment and/or prevention of cancers, especially those of the colon and bladder. On the other hand, probiotics also mimic serious threats to immunocompromised, genetically predisposed bodies, children, and newborns. Using probiotics may lead to bacteremia, fungemia, or septicemia when consumed more. Also, probiotics are found as a causative agent for pneumonia and abdominal abscesses, increase platelet aggregation, and promote antibiotic resistance among others. A huge number of microorganisms inhabit the human gut and consequently cause a compound network of the interactions of those organisms with each other and within the host cells, which stresses the requirement of extra caution in the use of probiotics as treatment therapy.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79095326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Drug Development for Treatment of COVID-19 by In Silico Analysis: Identification of SARS-Cov-2 Inhibiting Streptomyces Compounds 利用计算机分析开发治疗COVID-19的新药物:鉴定抑制SARS-Cov-2链霉菌的化合物

Journal of cellular signaling Pub Date : 2023-05-18 DOI: 10.33696/signaling.4.092

J. Kumar, Prachi Gholap, T. Pillai

{"title":"Novel Drug Development for Treatment of COVID-19 by In Silico Analysis: Identification of SARS-Cov-2 Inhibiting Streptomyces Compounds","authors":"J. Kumar, Prachi Gholap, T. Pillai","doi":"10.33696/signaling.4.092","DOIUrl":"https://doi.org/10.33696/signaling.4.092","url":null,"abstract":"In accordance with the present epidemiological paradigm, viral mutations of the virus are on the rise, and their natural effects are being selected for at a higher rate than normal. According to the World Health Organization (WHO), the global COVID-19 pandemic induced by the Delta and Omicron strain of the SARS-CoV-2 virus could propagate and disseminate more rapidly than other viruses thanks to its many mutations, and these also caused some very significant health problems. The established medications would eventually start to lose their efficacy since the variation mutated more quickly than the original stain. As protein spikes are the point of origin or epitome for the mutations to take place, it would be most effective to target the remaining vital enzymes by binding the proteins with the largest pocket sizes. The objective of the current work is to employ in-silico analysis to discover the streptomyces chemicals that suppress the SARS-CoV-2 virus as well as its mutated strains thus promoting a healthy body. Based on the drug likeness property of compounds when subjected to molecular docking, a total of 14 compounds were identified and selected from the PUBCHEM database that showed highest binding energy with the targeted Receptor Binding Domain. The compounds namely - Streptomyces tanashiensis; Thaxtomin A; Bafilomycin A1 from Streptomyces griseus and few others as mentioned further on more research would support and confirm the utilizing of these to create new medications to treat the novel SARS-CoV-2 infectious strains.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90754645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Mechanism of CDC42 Promoting HCC Metastasis CDC42促进肝癌转移的潜在机制

Journal of cellular signaling Pub Date : 2023-05-01 DOI: 10.33696/signaling.4.091

Miaoling Tang, Rongni Feng, Jun Yu Li

引用次数: 0