Journal of cellular signaling最新文献_第2页

Presence of Elevated Interleukin – 6 (IL-6) in the Blood of COVID-19 Convalescent Patients (40 – 93 Days) Post Onset of Symptoms Could be an Indicator of Ongoing Activation of the Immune System COVID-19恢复期患者(症状出现后40 - 93天)血液中白细胞介素-6 (IL-6)升高可能是免疫系统持续激活的一个指标

Journal of cellular signaling Pub Date : 2023-10-24 DOI: 10.33696/signaling.4.103

J Bolodeoku, C Anyaeche, M Bass, TK Kim

{"title":"Presence of Elevated Interleukin – 6 (IL-6) in the Blood of COVID-19 Convalescent Patients (40 – 93 Days) Post Onset of Symptoms Could be an Indicator of Ongoing Activation of the Immune System","authors":"J Bolodeoku, C Anyaeche, M Bass, TK Kim","doi":"10.33696/signaling.4.103","DOIUrl":"https://doi.org/10.33696/signaling.4.103","url":null,"abstract":"IL-6 concentrations rise with the onset of COVID-19 infection and is detected in 68% of patients on admission but is expected to reduce after the acute phase. IL-6 concentrations at time points: (2-7 days), (6-11 days), (11-15 days) and (13-20 days) after intensive care unit (ICU) admission showed the highest level of IL-6 concentrations at time point 2-7 days, we decided to characterize IL-6 concentrations in serum samples collected in the sera of COVID-19 convalescent patients (40 – 93 days) post onset of symptoms. The estimated IL- 6 concentrations detected ranged between 2.65 pg/ml and 29.01 pg/ml, with a median of 9.18 pg/ml. Nine out of the 28 (32.14%) patients had normal IL-6 levels (<7 pg/ml) and 19 of the 28 patients (68%) had IL-6 elevated concentrations (>7 pg/ml). The IL-6 concentrations were grouped normal (<7 pg.ml, n= 9), mildly elevated (7 – 10 pg/ml, n = 10) and elevated (>10 pg/ml n = 9). There was no relationship between IL-6 concentrations with gender, days from onset of symptoms, days from subsiding symptoms and COVID-19 IgG antibodies. There was some relationship with age, as the younger patient cohort produced much higher IL-6 concentrations than the older patient cohort. This study describes an increase in blood IL-6 concentrations in the sera of COVID-19 convalescent patients (40 – 93 days) post onset of symptoms like that seen in COVID patients on admission and higher levels seen in the younger patient cohort indicating that “cytokine storms” still occur in the recovery phase.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135267046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Elongasome Unit of Mycobacterium and its Comparative Analysis with Other Model Organisms 分枝杆菌长体单元的认识及其与其他模式生物的比较分析

Journal of cellular signaling Pub Date : 2023-09-22 DOI: 10.33696/signaling.4.101

Preeti Jain

引用次数: 0

The Human Gut Phageome: Identification and Roles in the Diseases 人类肠道噬菌体:鉴定及其在疾病中的作用

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.100

M. Nabi-Afjadi, Samaneh Teymouri, Fatemeh Monfared, Seyed Mostafa Noorbakhsh Varnosfaderani, Hossein Halimi

引用次数: 0

Activation of the 5-hydroxytryptamine Degradation System in Cells and Organ Injury 5-羟色胺降解系统在细胞和器官损伤中的激活

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.099

J. Fu

引用次数: 0

The Finer Points of Podocyte Sphingolipid Metabolism in Diabetic Kidney Disease 糖尿病肾病足细胞鞘脂代谢的精细点

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.097

A. Mitrofanova, Rachel Njeim, A. Fornoni

引用次数: 0

Structural Insights into Protein-Ligand Interactions of Small Leucine Rich Repeat Proteoglycans with a Large Number of Binding Partners: An Overview 具有大量结合伙伴的小亮氨酸重复蛋白聚糖的蛋白质-配体相互作用的结构见解:综述

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.098

N. Matsushima, Hiroki Miyashita, D. Batkhishig, R. Kretsinger

{"title":"Structural Insights into Protein-Ligand Interactions of Small Leucine Rich Repeat Proteoglycans with a Large Number of Binding Partners: An Overview","authors":"N. Matsushima, Hiroki Miyashita, D. Batkhishig, R. Kretsinger","doi":"10.33696/signaling.4.098","DOIUrl":"https://doi.org/10.33696/signaling.4.098","url":null,"abstract":"Small leucine rich repeat proteoglycans (SLRPs) exist in the extracellular matrix. SLRPs contain tandem arrays of LRRs flanked by cysteine clusters at the both N- and C-termini. The extreme N- and/or C-termini contain low complexity sequences, glycosaminoglycan (GAG) chain and/or sulfated tyrosine residues in some members of SLRPs. The LRR solenoid structure may be divided into four parts consisting of a concave surface, an ascending surface, a convex surface, and a descending surface. SLRPs share many biological functions including collagen fibrillogenesis, signaling, innate immunity, and inflammation through the binding of various ligands. We undertake a comprehensive literature search of publications in order to make a list of ligands of SLRPs. We describe and discuss the interacting sites of SLRPs to binding partners. The protein-ligand interactions occur on not only the concave surface but also the ascending surface and the N- or C-terminal capping regions. In addition, the extreme N- and/or C-terminal regions with the GAG chains or sulfated tyrosine residues participate in ligand-interactions.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88284951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

F-ATP Synthase Inhibitory Factor 1 in Regulation of Mitochondria Permeability Transition Pore and Metabolic Reprogramming F-ATP合成酶抑制因子1在线粒体通透性、过渡孔和代谢重编程中的调控作用

Journal of cellular signaling Pub Date : 2023-06-13 DOI: 10.33696/signaling.4.096

Lishu Guo

引用次数: 0

Improving Cancer Epigenetic Therapy; A Glimpse of NRF2 改进癌症表观遗传治疗;NRF2的一瞥

Journal of cellular signaling Pub Date : 2023-05-31 DOI: 10.33696/signaling.4.095

Tahereh Kashkoulinejad-Kouhi

{"title":"Improving Cancer Epigenetic Therapy; A Glimpse of NRF2","authors":"Tahereh Kashkoulinejad-Kouhi","doi":"10.33696/signaling.4.095","DOIUrl":"https://doi.org/10.33696/signaling.4.095","url":null,"abstract":"One of the mechanisms used by epigenetic therapy is the elevation of host cell-derived double stranded RNA (dsRNA) baseline levels through overexpression of genomic repetitive elements especially Alu retroelements. The dsRNAs trigger immunogenic responses since immune system cannot distinguish between endogenous and exogenous dsRNAs derived from viral infections; hence called “Viral mimicry response”. These dsRNAs are recognized by pattern recognition receptors (PRRs) such as MDA-5 which further induce inflammatory responses through interferon secretion. However, the response is limited through the function of some editing enzymes such as ADAR1 which destabilizes the formation of dsRNAs and renders the therapy less efficient through attenuating interferon secretion by immune cells. Since, some cancer cells can survive even after ADAR1 inhibition, it is speculated that there might be other mechanism which contribute to dsRNA destabilization. Since dsRNA formation derived from retroelement transcripts mimics viral infections, we tried to review the mechanistic approaches applied during host-pathogen interaction to highlight a possible candidate which might be cogitable for further investigations in epigenetic therapy. dsRNAs produced by RNA viruses are sensed by PRRs and activate nuclear factor erythroid 2 p45-related factor 2 (NRF2) which further downregulates STING protein and attenuates IFN release. RNA viruses such as SARS-CoV-2 have the potential to impair NRF2 signaling and eliminate its inhibitory effect from STING, leading to excessive release of IFNs and destroy pulmonary cells through cytokine release storm (CRS). Here, we briefly explain that NRF2, in a very downstream side of anti-viral response, might be a potential candidate target in combination with epigenetic therapy to circumvent the limitations in cancer epigenetic therapy.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88570470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Chromosome Replication and Segregation Unit of Mycobacterium and Its Comparative Analysis with Model Organisms: From Drug Targets to Drug Identification 了解分枝杆菌的染色体复制分离单元及其与模式生物的比较分析:从药物靶点到药物鉴定

Journal of cellular signaling Pub Date : 2023-05-18 DOI: 10.33696/signaling.4.094

P. Jain

{"title":"Understanding Chromosome Replication and Segregation Unit of Mycobacterium and Its Comparative Analysis with Model Organisms: From Drug Targets to Drug Identification","authors":"P. Jain","doi":"10.33696/signaling.4.094","DOIUrl":"https://doi.org/10.33696/signaling.4.094","url":null,"abstract":"Bacterium maintains its pathogenicity in the host by continuing replication and adopting temporal and spatial coordination of cell division steps such as cell wall synthesis, DNA replication, chromosome segregation, Z ring assembly, septum formation and finally cytokinesis. This multistep process requires spatiotemporal assembly of macromolecular complexes and is probably regulated by redundant and multifunctional activities of cell replication and division proteins. Two macromolecular assemblies of peptidoglycan biosynthesis, known as elongasome and divisome are known to drive the division of mother cell into two daughter cells and are characterized by the presence of signature protein complexes. Though the exact composition of macromolecular complexes is yet to be defined in Mycobacterium, the presence of some conserved proteins demonstrates the preservation of elementary units. Along with elongasome and divisome complexes, chromosome replication and segregation proteins are very important to understand as these proteins are very essential for bacilli survival, sustenance, and pathogenesis. In this review, along with presenting the differential features of Mycobacterium cell division process, we are comparing chromosome replication and segregation proteins of Mycobacterium with other bacterial species as we aim to identify structural and functional differences between these proteins in different species. In this review, we have also listed the potential drugs that can be tested to target Mycobacterium chromosome replication and segregation proteins. We expect that based on these differences identified, researchers would be able to direct their research in the characterization of Mycobacterium specific drug.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72916634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study on the Usage of Probiotics as a Safer Antipyretic 益生菌作为一种更安全的退烧药的应用研究

Journal of cellular signaling Pub Date : 2023-05-18 DOI: 10.33696/signaling.4.093

Shantanu Shrivastava, Nimisha Bhatu

{"title":"A Study on the Usage of Probiotics as a Safer Antipyretic","authors":"Shantanu Shrivastava, Nimisha Bhatu","doi":"10.33696/signaling.4.093","DOIUrl":"https://doi.org/10.33696/signaling.4.093","url":null,"abstract":"Most medicines and supplements which include probiotics have both expected clinical outcomes and unwanted side effects, which plays a major role when considering them as a mode of treatment. This review is an update about the advantages and disadvantages associated with the use of probiotics as part of a safe therapeutic armamentarium in health and other diseases. The advantages of probiotics run across multiple tissue systems in the body and a has a wide age spectrum. Probiotics also promote cardiovascular health, accelerate recovery from the condition of antibiotic-associated diarrhoea, decrease the effect of necrotizing enterocolitis with reduced inflammation, and accelerate the healing of the wound. Probiotics also contribute in treating chronic diseases for patients with type 2 diabetes as well as patients with HIV/AIDS. Moreover, probiotics play an important role in the treatment and/or prevention of cancers, especially those of the colon and bladder. On the other hand, probiotics also mimic serious threats to immunocompromised, genetically predisposed bodies, children, and newborns. Using probiotics may lead to bacteremia, fungemia, or septicemia when consumed more. Also, probiotics are found as a causative agent for pneumonia and abdominal abscesses, increase platelet aggregation, and promote antibiotic resistance among others. A huge number of microorganisms inhabit the human gut and consequently cause a compound network of the interactions of those organisms with each other and within the host cells, which stresses the requirement of extra caution in the use of probiotics as treatment therapy.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79095326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0