Journal of cellular signaling最新文献_第2页

DIS3L2: Unveiling a New Player in Tumorigenesis, with a Key Role in Colorectal Cancer DIS3L2:揭示肿瘤发生的新参与者，在结直肠癌中起关键作用

Journal of cellular signaling Pub Date : 2023-10-24 DOI: 10.33696/signaling.4.104

Juan F. García-Moreno, Paulo Matos, Luísa Romão

{"title":"DIS3L2: Unveiling a New Player in Tumorigenesis, with a Key Role in Colorectal Cancer","authors":"Juan F. García-Moreno, Paulo Matos, Luísa Romão","doi":"10.33696/signaling.4.104","DOIUrl":"https://doi.org/10.33696/signaling.4.104","url":null,"abstract":"DIS3L2 is a 3’-5’ exoribonuclease that recognizes and degrades uridylated transcripts in an exosome-independent manner and participates in several RNA degradation pathways, such as the nonsense-mediated mRNA decay, or the surveillance of aberrant structured non-coding RNAs. Although some studies have linked DIS3L2 to tumorigenesis and cancer-related processes, its exact role in the development and progression of cancer has remained unclear since the discovery of DIS3L2's ribonuclease activity a decade ago. While some authors have reported evidence of a tumor suppressor role for this exoribonuclease, other studies have shown DIS3L2 as a driver of tumorigenesis. Although differences in tissue type and methodologic approaches may somewhat account for the opposing findings, a recent study from our group further supports a pro-tumorigenic role for DIS3L2, this time in promoting colorectal cancer (CRC) progression. Indeed, proper DIS3L2 expression was proven essential to maintain key tumorigenic properties in CRC cells, including cell proliferation and invasion. Here, we summarize the current state of knowledge regarding the impact of DIS3L2 in cancer, namely in colorectal cancer. The collected data unveils DIS3L2 as a novel putative therapeutic target in cancer that warrants further investigation.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135273263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depleting Cellular Retinoic Acid Binding Protein 1 Impairs UPRmt 消耗细胞维甲酸结合蛋白1损害UPRmt

Journal of cellular signaling Pub Date : 2023-10-24 DOI: 10.33696/signaling.4.102

Chin-Wen Wei, Thomas Lerdall, Fatimah Najjar, Li-Na Wei

{"title":"Depleting Cellular Retinoic Acid Binding Protein 1 Impairs UPRmt","authors":"Chin-Wen Wei, Thomas Lerdall, Fatimah Najjar, Li-Na Wei","doi":"10.33696/signaling.4.102","DOIUrl":"https://doi.org/10.33696/signaling.4.102","url":null,"abstract":"Mitochondrial dysfunction underlines neurodegenerative diseases which are mostly characterized by progressive degeneration of neurons. We previously reported that Cellular retinoic acid Binding protein 1 (Crabp1) knockout (CKO) mice spontaneously developed age-dependent motor degeneration, with defects accumulated in spinal motor neurons (MNs), the only cell type in spinal cord that expresses CRABP1. Here we uncovered that mitochondrial DNA (mtDNA) content and the expression of genes involved in respiration were significantly reduced in CKO mouse spinal cord, accompanied by significantly elevated reactive oxygen species (ROS) and unfolded protein load, indicating that CRABP1 deficiency caused mitochondrial dysfunction. Further analyses of spinal cord tissues revealed significant reduction in the expression and activity of superoxide dismutase 2 (SOD2), as well as defected mitochondrial unfolded protein response (UPRmt) pathway, specifically an increase in ATF5 mRNA but not its protein level, which suggested failure in the translational response of ATF5 in CKO. Consistently, eukaryotic initiation factor-2α, (eIF2α) phosphorylation was reduced in CKO spinal cord. In a CRABP1 knockdown MN1 model, siCrabp1-MN1, we validated the cell-autonomous function of CRABP1 in modulating the execution of UPRmt. This study reveals a new functional role for CRABP1 in the execution of mitochondrial stress response, that CRABP1 modulates eIF2α phosphorylation thereby contributing to ATF5 translational response that is needed to mitigate mitochondria stress.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"21 11-12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135267061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presence of Elevated Interleukin – 6 (IL-6) in the Blood of COVID-19 Convalescent Patients (40 – 93 Days) Post Onset of Symptoms Could be an Indicator of Ongoing Activation of the Immune System COVID-19恢复期患者(症状出现后40 - 93天)血液中白细胞介素-6 (IL-6)升高可能是免疫系统持续激活的一个指标

Journal of cellular signaling Pub Date : 2023-10-24 DOI: 10.33696/signaling.4.103

J Bolodeoku, C Anyaeche, M Bass, TK Kim

{"title":"Presence of Elevated Interleukin – 6 (IL-6) in the Blood of COVID-19 Convalescent Patients (40 – 93 Days) Post Onset of Symptoms Could be an Indicator of Ongoing Activation of the Immune System","authors":"J Bolodeoku, C Anyaeche, M Bass, TK Kim","doi":"10.33696/signaling.4.103","DOIUrl":"https://doi.org/10.33696/signaling.4.103","url":null,"abstract":"IL-6 concentrations rise with the onset of COVID-19 infection and is detected in 68% of patients on admission but is expected to reduce after the acute phase. IL-6 concentrations at time points: (2-7 days), (6-11 days), (11-15 days) and (13-20 days) after intensive care unit (ICU) admission showed the highest level of IL-6 concentrations at time point 2-7 days, we decided to characterize IL-6 concentrations in serum samples collected in the sera of COVID-19 convalescent patients (40 – 93 days) post onset of symptoms. The estimated IL- 6 concentrations detected ranged between 2.65 pg/ml and 29.01 pg/ml, with a median of 9.18 pg/ml. Nine out of the 28 (32.14%) patients had normal IL-6 levels (<7 pg/ml) and 19 of the 28 patients (68%) had IL-6 elevated concentrations (>7 pg/ml). The IL-6 concentrations were grouped normal (<7 pg.ml, n= 9), mildly elevated (7 – 10 pg/ml, n = 10) and elevated (>10 pg/ml n = 9). There was no relationship between IL-6 concentrations with gender, days from onset of symptoms, days from subsiding symptoms and COVID-19 IgG antibodies. There was some relationship with age, as the younger patient cohort produced much higher IL-6 concentrations than the older patient cohort. This study describes an increase in blood IL-6 concentrations in the sera of COVID-19 convalescent patients (40 – 93 days) post onset of symptoms like that seen in COVID patients on admission and higher levels seen in the younger patient cohort indicating that “cytokine storms” still occur in the recovery phase.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135267046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding Elongasome Unit of Mycobacterium and its Comparative Analysis with Other Model Organisms 分枝杆菌长体单元的认识及其与其他模式生物的比较分析

Journal of cellular signaling Pub Date : 2023-09-22 DOI: 10.33696/signaling.4.101

Preeti Jain

引用次数: 0

The Human Gut Phageome: Identification and Roles in the Diseases 人类肠道噬菌体:鉴定及其在疾病中的作用

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.100

M. Nabi-Afjadi, Samaneh Teymouri, Fatemeh Monfared, Seyed Mostafa Noorbakhsh Varnosfaderani, Hossein Halimi

引用次数: 0

Activation of the 5-hydroxytryptamine Degradation System in Cells and Organ Injury 5-羟色胺降解系统在细胞和器官损伤中的激活

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.099

J. Fu

引用次数: 0

The Finer Points of Podocyte Sphingolipid Metabolism in Diabetic Kidney Disease 糖尿病肾病足细胞鞘脂代谢的精细点

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.097

A. Mitrofanova, Rachel Njeim, A. Fornoni

引用次数: 0

Structural Insights into Protein-Ligand Interactions of Small Leucine Rich Repeat Proteoglycans with a Large Number of Binding Partners: An Overview 具有大量结合伙伴的小亮氨酸重复蛋白聚糖的蛋白质-配体相互作用的结构见解:综述

Journal of cellular signaling Pub Date : 2023-08-11 DOI: 10.33696/signaling.4.098

N. Matsushima, Hiroki Miyashita, D. Batkhishig, R. Kretsinger

{"title":"Structural Insights into Protein-Ligand Interactions of Small Leucine Rich Repeat Proteoglycans with a Large Number of Binding Partners: An Overview","authors":"N. Matsushima, Hiroki Miyashita, D. Batkhishig, R. Kretsinger","doi":"10.33696/signaling.4.098","DOIUrl":"https://doi.org/10.33696/signaling.4.098","url":null,"abstract":"Small leucine rich repeat proteoglycans (SLRPs) exist in the extracellular matrix. SLRPs contain tandem arrays of LRRs flanked by cysteine clusters at the both N- and C-termini. The extreme N- and/or C-termini contain low complexity sequences, glycosaminoglycan (GAG) chain and/or sulfated tyrosine residues in some members of SLRPs. The LRR solenoid structure may be divided into four parts consisting of a concave surface, an ascending surface, a convex surface, and a descending surface. SLRPs share many biological functions including collagen fibrillogenesis, signaling, innate immunity, and inflammation through the binding of various ligands. We undertake a comprehensive literature search of publications in order to make a list of ligands of SLRPs. We describe and discuss the interacting sites of SLRPs to binding partners. The protein-ligand interactions occur on not only the concave surface but also the ascending surface and the N- or C-terminal capping regions. In addition, the extreme N- and/or C-terminal regions with the GAG chains or sulfated tyrosine residues participate in ligand-interactions.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88284951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

F-ATP Synthase Inhibitory Factor 1 in Regulation of Mitochondria Permeability Transition Pore and Metabolic Reprogramming F-ATP合成酶抑制因子1在线粒体通透性、过渡孔和代谢重编程中的调控作用

Journal of cellular signaling Pub Date : 2023-06-13 DOI: 10.33696/signaling.4.096

Lishu Guo

引用次数: 0

Improving Cancer Epigenetic Therapy; A Glimpse of NRF2 改进癌症表观遗传治疗;NRF2的一瞥

Journal of cellular signaling Pub Date : 2023-05-31 DOI: 10.33696/signaling.4.095

Tahereh Kashkoulinejad-Kouhi

{"title":"Improving Cancer Epigenetic Therapy; A Glimpse of NRF2","authors":"Tahereh Kashkoulinejad-Kouhi","doi":"10.33696/signaling.4.095","DOIUrl":"https://doi.org/10.33696/signaling.4.095","url":null,"abstract":"One of the mechanisms used by epigenetic therapy is the elevation of host cell-derived double stranded RNA (dsRNA) baseline levels through overexpression of genomic repetitive elements especially Alu retroelements. The dsRNAs trigger immunogenic responses since immune system cannot distinguish between endogenous and exogenous dsRNAs derived from viral infections; hence called “Viral mimicry response”. These dsRNAs are recognized by pattern recognition receptors (PRRs) such as MDA-5 which further induce inflammatory responses through interferon secretion. However, the response is limited through the function of some editing enzymes such as ADAR1 which destabilizes the formation of dsRNAs and renders the therapy less efficient through attenuating interferon secretion by immune cells. Since, some cancer cells can survive even after ADAR1 inhibition, it is speculated that there might be other mechanism which contribute to dsRNA destabilization. Since dsRNA formation derived from retroelement transcripts mimics viral infections, we tried to review the mechanistic approaches applied during host-pathogen interaction to highlight a possible candidate which might be cogitable for further investigations in epigenetic therapy. dsRNAs produced by RNA viruses are sensed by PRRs and activate nuclear factor erythroid 2 p45-related factor 2 (NRF2) which further downregulates STING protein and attenuates IFN release. RNA viruses such as SARS-CoV-2 have the potential to impair NRF2 signaling and eliminate its inhibitory effect from STING, leading to excessive release of IFNs and destroy pulmonary cells through cytokine release storm (CRS). Here, we briefly explain that NRF2, in a very downstream side of anti-viral response, might be a potential candidate target in combination with epigenetic therapy to circumvent the limitations in cancer epigenetic therapy.","PeriodicalId":73645,"journal":{"name":"Journal of cellular signaling","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88570470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0