Journal of cancer immunology最新文献_第2页

Enhancing the Efficacy of CAR-T Cell Therapy: A Comprehensive Exploration of Cellular Strategies and Molecular Dynamics. 增强 CAR-T 细胞疗法的疗效：细胞策略与分子动力学的全面探索。

Journal of cancer immunology Pub Date : 2024-01-01 DOI: 10.33696/cancerimmunol.6.080

Mehmet A Baysal, Abhijit Chakraborty, Apostolia M Tsimberidou

{"title":"Enhancing the Efficacy of CAR-T Cell Therapy: A Comprehensive Exploration of Cellular Strategies and Molecular Dynamics.","authors":"Mehmet A Baysal, Abhijit Chakraborty, Apostolia M Tsimberidou","doi":"10.33696/cancerimmunol.6.080","DOIUrl":"10.33696/cancerimmunol.6.080","url":null,"abstract":"The emergence of chimeric antigen receptor T cell (CAR-T cell) therapy has revolutionized cancer treatment, particularly for hematologic malignancies. This commentary discusses developments in CAR-T cell therapy, focusing on the molecular mechanisms governing T cell fate and differentiation. Transcriptional and epigenetic factors play a pivotal role in determining the specificity, effectiveness, and durability of CAR-T cell therapy. Understanding these mechanisms is crucial to improve the efficacy and decrease the adverse events associated with CAR-T cell therapies, unlocking the full potential of these approaches. T cell differentiation in CAR-T cell product manufacturing plays an important role in clinical outcomes. A positive correlation exists between the clinical efficacy of CAR-T cell therapy and signatures of memory, whereas a negative correlation has been observed with signatures of effector function or exhaustion. The effectiveness of CAR-T cell products is likely influenced by T-cell frequency and by their ability to proliferate, which is closely linked to early T cell differentiation. The differentiation process involving distinct T memory cell subsets is initiated upon antigen elimination, indicating infection resolution. In chronic infections or cancer, T cells may undergo exhaustion, marked by continuous inhibitory receptor expression, decreased cytokine production, and diminished proliferative capacity. Other cell subsets, such as CD4+ T cells, innate-like T lymphocytes, NKT cells, and cord blood-derived hematopoietic stem cells, offer unique advantages in developing the next-generation CAR-T cell-based therapies. Future research should focus on optimizing T-cell-enhancing approaches and developing strategies to potentially cure patients with hematological diseases and solid tumors.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":"6 1","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11308461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary: On the Emerging Role of Innate Lymphoid Cells in Bladder Cancer. 评论：先天性淋巴细胞在膀胱癌中的新作用。

Journal of cancer immunology Pub Date : 2024-01-01 DOI: 10.33696/cancerimmunol.6.093

Zaineb Hassouneh, Gang Huang, Nu Zhang, Manjeet Rao, Neelam Mukherjee

引用次数: 0

Emulating the Role of Neutrophils in Head and Neck Cancer Microenvironment: Prognostic Role and Therapeutic Strategies 模拟中性粒细胞在癌症头颈部微环境中的作用：预后作用和治疗策略

Journal of cancer immunology Pub Date : 2023-08-28 DOI: 10.33696/cancerimmunol.5.076

Khushwant Singh, P. K. Gautam

{"title":"Emulating the Role of Neutrophils in Head and Neck Cancer Microenvironment: Prognostic Role and Therapeutic Strategies","authors":"Khushwant Singh, P. K. Gautam","doi":"10.33696/cancerimmunol.5.076","DOIUrl":"https://doi.org/10.33696/cancerimmunol.5.076","url":null,"abstract":"Head and neck squamous cell carcinoma (HNSCC) are a group of cancers that affect various parts of the head and neck, such as the lip, oral cavity, oropharynx, hypopharynx, and nasopharynx. In India, it accounts for approximately 30–40% of all cancers, while in the United States, it represents around 4% of all cancer cases. HNSCC is a significant contributor to cancer-related deaths globally. While smoking is linked to HNSCC, recent research has confirmed the importance of the human papillomavirus (HPV) in its development. Additionally, HNSCC is characterized by immune deficiencies, where the tumor microenvironment alters immune cell activity to facilitate carcinogenesis. However, researchers have identified novel immunotherapeutic targets for HNSCC, mainly by studying the involvement of inflammatory cells such as neutrophils, eosinophils, and macrophages. Unfortunately, patients with recurring malignancy and distant metastases have limited treatment options, with a prognosis of less than one year. Platinum-based chemotherapy, cetuximab, and other conventional therapies are used to treat recurrent and metastatic HNSCC. The pro and anti-tumor roles of neutrophils in cancer and immunotherapy are explored in this study, with a focus on HNSCC. The primary objective is to increase our understanding of HNSCC biology and immunobiology to uncover viable therapeutic options that are both valid and less cytotoxic.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41455223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prognostic Factors of Nintedanib-docetaxel in Patients with Previously Treated Non-small-cell Lung Cancer Nintedanib-docetaxel治疗前非小细胞肺癌癌症患者的预后因素

Journal of cancer immunology Pub Date : 2023-08-28 DOI: 10.33696/cancerimmunol.5.077

L. Cabezón-Gutiérrez, S. Custodio-Cabello, V. Pacheco-Barcia, Magda Palka-Kotlowska, Catalina Saez-Bertrand, Marta Blasco-Guerrero

{"title":"Prognostic Factors of Nintedanib-docetaxel in Patients with Previously Treated Non-small-cell Lung Cancer","authors":"L. Cabezón-Gutiérrez, S. Custodio-Cabello, V. Pacheco-Barcia, Magda Palka-Kotlowska, Catalina Saez-Bertrand, Marta Blasco-Guerrero","doi":"10.33696/cancerimmunol.5.077","DOIUrl":"https://doi.org/10.33696/cancerimmunol.5.077","url":null,"abstract":"Background: In advanced non-small-cell lung cancer (NSCLC), second-line treatment with nintedanib plus docetaxel improves survival compared with docetaxel, especially in patients with adenocarcinoma histology who progressed within 9 months after the start of firstline treatment. It is therefore necessary to identify new biomarkers/prognostic factors that select the patients who benefit from this type of treatment.\u0000\u0000Patients and Methods: In this single-center retrospective study, we included patients treated NSCLC with nintedanib plus docetaxel in the second/third line and analyzed potential prognostic factors, many of them related to the inflammatory environment; PD-L1 expression levels, Lung Immune Prognostic Index (LIPI), derived neutrophil/lymphocytes ratio (dNLR), etc.\u0000\u0000Results: Among 16 patients included in this analysis, the overall response rate was 12.5%, median progression-free survival was 2 months (95% CI, 1.22-2.78) and median overall survival was 6 months (95% CI, 2.11-9.89). LDH level is the only variable related to the disease control rate (70% in normal versus 0% in elevated LDH). The variables analyzed with prognostic significance were; no brain metastases (HR 0.33, 95% CI 0.14-0.78; p=0.011), less than 3 metastatic sites (HR 0.33, 95% CI 0.14-0.78; p=0.011), the non-use of antiangiogenic drugs in the first line (HR 0.53, 95% CI: 0.29-0.98; p=0.043), the absence of elevated LDH at the start of treatment (HR 0.55, 95% CI: 0.3-1; p=0.051) and the absence of liver metastases (HR 0.55, 95% CI: 0.29-1; p=0.05).\u0000\u0000Conclusions: In NSCLC patients with less than three metastatic sites, no brain or liver metastases, normal LDH values and not previously treated with antiangiogenic drugs in the first line showed a better prognosis when treated with second/third line with nintedanib plus docetaxel.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48719982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epithelial Mesenchymal Transition: The Ultimate Driver of Cancer on Difficult Paths 上皮间充质转移：癌症在艰难道路上的终极驱动力

Journal of cancer immunology Pub Date : 2023-07-07 DOI: 10.33696/cancerimmunol.5.075

Devavrat Tripathi, P. Gupta, S. Kulkarni

{"title":"Epithelial Mesenchymal Transition: The Ultimate Driver of Cancer on Difficult Paths","authors":"Devavrat Tripathi, P. Gupta, S. Kulkarni","doi":"10.33696/cancerimmunol.5.075","DOIUrl":"https://doi.org/10.33696/cancerimmunol.5.075","url":null,"abstract":"Metastasis is the perilous aspect of cancer and is responsible for 90% of deaths due to cancer. It represents an enigmatic and complex biological cascade that is poorly understood. The constant development in cancer research and the advent of new principles in metastasis have discovered some of the molecular keystones like epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) of this cascade. Acknowledgment of the communications between cancer cells and their micro-environment enlightens the biology of metastasis and allows us to understand the mechanism of EMT induction and its role in governing invasion, migration, plasticity, colonization, and therapeutic resistance. EMT is the principal reason behind the cancer cells’ complex behavior, tremendous plasticity, survival, and adoption in a constantly changing environment. Thus, EMT is a perfect driver mechanism to execute metastasis and develop resistance against conventional and targeted therapies. Studies have also discovered the role of EMT in CSCs generation and offered us prospects for evolving more effective treatments to target metastasis and improved patient prognosis.\u0000\u0000Our primary aim in the present review is to summarize the induction and role of EMT in cancer. This review not only discusses the role of EMT in metastasis but also uncovers the role of EMT in survival, metabolism, and CSCs generation. Further, in this review, we also discuss the strategy to target the EMT for the development of new and effective therapeutics for cancer management.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42190982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative Feedback Expansion of Tregs Caused by Endogenous IL-2 Limits the Activity of IL-2-based Therapies 内源性IL-2引起的Tregs负反馈扩张限制了基于IL-2的治疗的活性

Journal of cancer immunology Pub Date : 2023-05-23 DOI: 10.33696/cancerimmunol.5.074

I. Amit, Natalie Levitin, Meital Gadrich, May Ben-Mayor, T. Wyant, Reut Barak, Liron Danielpur, Morya Ifrach, Itzhak Meir, Olga Bluvshtein, Yehezkel Sasson, Sharon Fischman, Guy Nimrod, Michael Zhenin, Yair Fastman, J. Vasselli, Aron Knickerbocker, R. Herbst, Yanay Ofran

{"title":"Negative Feedback Expansion of Tregs Caused by Endogenous IL-2 Limits the Activity of IL-2-based Therapies","authors":"I. Amit, Natalie Levitin, Meital Gadrich, May Ben-Mayor, T. Wyant, Reut Barak, Liron Danielpur, Morya Ifrach, Itzhak Meir, Olga Bluvshtein, Yehezkel Sasson, Sharon Fischman, Guy Nimrod, Michael Zhenin, Yair Fastman, J. Vasselli, Aron Knickerbocker, R. Herbst, Yanay Ofran","doi":"10.33696/cancerimmunol.5.074","DOIUrl":"https://doi.org/10.33696/cancerimmunol.5.074","url":null,"abstract":"Stimulating effector T-cells (Teffs) without inducing regulatory T-cells (Tregs) has been the primary goal of IL-2-based therapies for cancer. Recently, modified IL-2 designed for differential T-cell expansion for the treatment of cancer has failed in the clinic. We propose that treatments based on exogenous administrations of modified IL-2 are inherently undermined by a negative feedback loop, caused by IL-2 secreted endogenously from activated effector T-cells. This endogenous IL-2 secretion subsequentially induces Treg expansion and inhibits the immune response that is essential for cancer clearance. Here, we demonstrate that treatments utilizing exogenous modified IL-2 indeed induce Treg expansion. To circumvent this negative feedback, we computationally designed a novel monoclonal humanized antibody (AU-007) that binds human IL-2 with pM affinity at a predefined epitope and completely blocks IL-2 binding to CD25 that is highly expressed on Tregs, without hindering IL-2 binding to CD122/CD132 dimer receptor expressed over effector cells. This epitope-specific, high-affinity antibody controls endogenous IL-2 and prevents it from expanding Tregs while allowing it to expand Teffs. We show that controlling endogenous IL-2 using AU-007 abrogates the negative feedback loop and replaces it with a positive feedback loop that enhances the expansion of NK cells and Teffs, an effect considered favorable for cancer immunotherapy.","PeriodicalId":73633,"journal":{"name":"Journal of cancer immunology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43784319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights from Long Noncoding RNAs into Cancer-immunity Cycle Regulation 长链非编码rna在癌症免疫周期调控中的应用

Journal of cancer immunology Pub Date : 2023-05-23 DOI: 10.33696/cancerimmunol.5.073

Yelin Liang, Yuan Zhang, Xirong Tan, Han Qiao, Jun Ma, Yingqin Li, Na Liu

引用次数: 0

Role of Liver Navigation in Surgery Planning and the Challenges 肝脏导航在手术计划中的作用和挑战

Journal of cancer immunology Pub Date : 2023-01-26 DOI: 10.33696/cancerimmunol.5.070

S. Dakua, Sagnika Dash, Sagarika Pati, J. Abinahed

引用次数: 0

Early Integration of Palliative Care for Patients Receiving Systemic Immunotherapy for Renal Cell Carcinoma. 为接受全身免疫疗法的肾细胞癌患者及早纳入姑息治疗。

Journal of cancer immunology Pub Date : 2023-01-01 DOI: 10.33696/cancerimmunol.5.072

Megan Stout, Akshay Thaper, Vivien Xu, Eric A Singer, Biren Saraiya

引用次数: 0

Molecular Iodine Misconceptions: A Novel Formulation Approach to Topical Iodine 分子碘的误解:局部碘的新配方方法

Journal of cancer immunology Pub Date : 2022-12-22 DOI: 10.33696/cancerimmunol.4.067

引用次数: 0