Journal of Anesthesia, Analgesia and Critical Care (Online)最新文献

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Chlorhexidine is not effective at any concentration in preventing ventilator-associated pneumonia: a systematic review and network meta-analysis. 任何浓度的洗必泰对预防呼吸机相关肺炎均无效:系统综述和网络荟萃分析。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-05-03 DOI: 10.1186/s44158-024-00166-2
Alessandro De Cassai, Tommaso Pettenuzzo, Veronica Busetto, Christian Legnaro, Chiara Pretto, Alessio Rotondi, Annalisa Boscolo, Nicolò Sella, Marina Munari, Paolo Navalesi
{"title":"Chlorhexidine is not effective at any concentration in preventing ventilator-associated pneumonia: a systematic review and network meta-analysis.","authors":"Alessandro De Cassai, Tommaso Pettenuzzo, Veronica Busetto, Christian Legnaro, Chiara Pretto, Alessio Rotondi, Annalisa Boscolo, Nicolò Sella, Marina Munari, Paolo Navalesi","doi":"10.1186/s44158-024-00166-2","DOIUrl":"https://doi.org/10.1186/s44158-024-00166-2","url":null,"abstract":"<p><strong>Introduction: </strong>Oral chlorhexidine has been widely used for ventilator-associated pneumonia prevention in the critical care setting; however, previous studies and evidence synthesis have generated inconsistent findings. Our study aims to investigate if different concentrations of oral chlorhexidine may be effective in preventing such complication in intensive care unit patients.</p><p><strong>Methods: </strong>After pre-registration (Open Science Framework: 8CUKF), we conducted a network meta-analysis with the following PICOS: adult patients (age > 18 years old) undergoing invasive mechanical ventilation admitted in ICU (P); any concentration of chlorhexidine used for oral hygiene (I); placebo, sham intervention, usual care, or no intervention (C); rate of VAP (primary outcome), mechanical ventilation length, ICU length of stay (LOS), hospital LOS, mortality (secondary outcomes) (O); randomized controlled trials (S). We used the following database: PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and EMBASE without any limitation in publication date or language.</p><p><strong>Results: </strong>Chlorhexidine did not demonstrate any significant advantage over the control group in preventing ventilator-associated pneumonia or reducing mortality, duration of mechanical ventilation, length of stay in the intensive care unit, or overall mortality.</p><p><strong>Conclusions: </strong>Chlorhexidine oral decontamination does not reduce the rate of ventilator-associated pneumonia in critically ill adult patients and its routine use could not be recommended.</p><p><strong>Trial registration: </strong>Registration number: Open Science Framework: 8CUKF.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11067293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain. 电神经调节治疗慢性疼痛的解剖生理学基础和应用技术。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-05-02 DOI: 10.1186/s44158-024-00167-1
Giusy Guzzi, Attilio Della Torre, Andrea Bruni, Angelo Lavano, Vincenzo Bosco, Eugenio Garofalo, Domenico La Torre, Federico Longhini
{"title":"Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain.","authors":"Giusy Guzzi, Attilio Della Torre, Andrea Bruni, Angelo Lavano, Vincenzo Bosco, Eugenio Garofalo, Domenico La Torre, Federico Longhini","doi":"10.1186/s44158-024-00167-1","DOIUrl":"https://doi.org/10.1186/s44158-024-00167-1","url":null,"abstract":"<p><p>Chronic pain, a complex and debilitating condition, poses a significant challenge to both patients and healthcare providers worldwide. Conventional pharmacological interventions often prove inadequate in delivering satisfactory relief while carrying the risks of addiction and adverse reactions. In recent years, electric neuromodulation emerged as a promising alternative in chronic pain management. This method entails the precise administration of electrical stimulation to specific nerves or regions within the central nervous system to regulate pain signals. Through mechanisms that include the alteration of neural activity and the release of endogenous pain-relieving substances, electric neuromodulation can effectively alleviate pain and improve patients' quality of life. Several modalities of electric neuromodulation, with a different grade of invasiveness, provide tailored strategies to tackle various forms and origins of chronic pain. Through an exploration of the anatomical and physiological pathways of chronic pain, encompassing neurotransmitter involvement, this narrative review offers insights into electrical therapies' mechanisms of action, clinical utility, and future perspectives in chronic pain management.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11064427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23. 脓毒症和脓毒性休克患者的辅助免疫治疗药物:多学科 23.
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-04-30 DOI: 10.1186/s44158-024-00165-3
Massimo Girardis, Irene Coloretti, Massimo Antonelli, Giorgio Berlot, Stefano Busani, Andrea Cortegiani, Gennaro De Pascale, Francesco Giuseppe De Rosa, Silvia De Rosa, Katia Donadello, Abele Donati, Francesco Forfori, Maddalena Giannella, Giacomo Grasselli, Giorgia Montrucchio, Alessandra Oliva, Daniela Pasero, Ornella Piazza, Stefano Romagnoli, Carlo Tascini, Bruno Viaggi, Mario Tumbarello, Pierluigi Viale
{"title":"Adjunctive immunotherapeutic agents in patients with sepsis and septic shock: a multidisciplinary consensus of 23.","authors":"Massimo Girardis, Irene Coloretti, Massimo Antonelli, Giorgio Berlot, Stefano Busani, Andrea Cortegiani, Gennaro De Pascale, Francesco Giuseppe De Rosa, Silvia De Rosa, Katia Donadello, Abele Donati, Francesco Forfori, Maddalena Giannella, Giacomo Grasselli, Giorgia Montrucchio, Alessandra Oliva, Daniela Pasero, Ornella Piazza, Stefano Romagnoli, Carlo Tascini, Bruno Viaggi, Mario Tumbarello, Pierluigi Viale","doi":"10.1186/s44158-024-00165-3","DOIUrl":"https://doi.org/10.1186/s44158-024-00165-3","url":null,"abstract":"<p><strong>Background: </strong>In the last decades, several adjunctive treatments have been proposed to reduce mortality in septic shock patients. Unfortunately, mortality due to sepsis and septic shock remains elevated and NO trials evaluating adjunctive therapies were able to demonstrate any clear benefit. In light of the lack of evidence and conflicting results from previous studies, in this multidisciplinary consensus, the authors considered the rational, recent investigations and potential clinical benefits of targeted adjunctive therapies.</p><p><strong>Methods: </strong>A panel of multidisciplinary experts defined clinical phenotypes, treatments and outcomes of greater interest in the field of adjunctive therapies for sepsis and septic shock. After an extensive systematic literature review, the appropriateness of each treatment for each clinical phenotype was determined using the modified RAND/UCLA appropriateness method.</p><p><strong>Results: </strong>The consensus identified two distinct clinical phenotypes: patients with overwhelming shock and patients with immune paralysis. Six different adjunctive treatments were considered the most frequently used and promising: (i) corticosteroids, (ii) blood purification, (iii) immunoglobulins, (iv) granulocyte/monocyte colony-stimulating factor and (v) specific immune therapy (i.e. interferon-gamma, IL7 and AntiPD1). Agreement was achieved in 70% of the 25 clinical questions.</p><p><strong>Conclusions: </strong>Although clinical evidence is lacking, adjunctive therapies are often employed in the treatment of sepsis. To address this gap in knowledge, a panel of national experts has provided a structured consensus on the appropriate use of these treatments in clinical practice.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11059820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung (extracorporeal CO2 removal) and renal (continuous renal replacement therapy) support: the role of ultraprotective strategy in Covid 19 and non-Covid 19 ARDS. A case-control study. 肺(体外二氧化碳清除)和肾(持续肾替代疗法)支持:超保护策略在 Covid 19 和非 Covid 19 ARDS 中的作用。病例对照研究。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-04-27 DOI: 10.1186/s44158-024-00164-4
Daniela Pasero, Laura Pistidda, Davide Piredda, Corrado Liperi, Andrea Cossu, Raffaella Esposito, Angela Muroni, Cristiano Mereu, Carlino Rum, Gian Pietro Branca, Franco Mulas, Mariangela Puci, Giovanni Sotgiu, Pierpaolo Terragni
{"title":"Lung (extracorporeal CO<sub>2</sub> removal) and renal (continuous renal replacement therapy) support: the role of ultraprotective strategy in Covid 19 and non-Covid 19 ARDS. A case-control study.","authors":"Daniela Pasero, Laura Pistidda, Davide Piredda, Corrado Liperi, Andrea Cossu, Raffaella Esposito, Angela Muroni, Cristiano Mereu, Carlino Rum, Gian Pietro Branca, Franco Mulas, Mariangela Puci, Giovanni Sotgiu, Pierpaolo Terragni","doi":"10.1186/s44158-024-00164-4","DOIUrl":"https://doi.org/10.1186/s44158-024-00164-4","url":null,"abstract":"<p><strong>Background: </strong>Preliminary studies suggest that moderate ARDS and acute renal failure might benefit from extracorporeal CO<sub>2</sub> removal (ECCO<sub>2</sub>R) coupled with CRRT. However, evidence is limited and potential for this coupled treatment may need to be explored. The aim of the present study was to evaluate whether a protective driving pressure was obtained applying low-flow ECCO<sub>2-</sub>R plus CRRT in patients affected by moderate ARDS with COVID-19 compared to an historical group without COVID-19.</p><p><strong>Methods: </strong>A case-control study has been conducted comparing a group of consecutive moderate ARDS patients presenting AKI and affected by COVID-19, who needed low-flow ECCO<sub>2-</sub>R plus CRRT to achieve an ultra-protective ventilatory strategy, with historical group without COVID-19 that matched for clinical presentation and underwent the same ultra-protective treatment. V<sub>T</sub> was set at 6 mL/kg predicted body weight then ECCO<sub>2</sub>R was assessed to facilitate ultra-protective low V<sub>T</sub> ventilation to preserve safe Pplat and low driving pressure.</p><p><strong>Results: </strong>ECCO<sub>2</sub>R+CRRT reduced the driving pressure from 17 (14-18) to 11.5 (10-15) cmH<sub>2</sub>O (p<0.0004) in the fourteen ARDS patients by decreasing V<sub>T</sub> from 6.7 ml/kg PBW (6.1-6.9) to 5.1 (4.2-5.6) after 1 hour (p <0.0001). In the ARDS patients with COVID-19, the driving pressure reduction was more effective from baseline 18 (14-24) cmH<sub>2</sub>O to 11 (10-15) cmH<sub>2</sub>O (p<0.004), compared to the control group from 15 (13-17) to 12(10-16) cmH<sub>2</sub>O (p< 0.03), after one hour. ECCO<sub>2</sub>R+CRRT did not affected 28 days mortality in the two groups, while we observed a shorter duration of mechanical ventilation (19 {7-29} vs 24 {22-38} days; p=0.24) and ICU length of stay (19 {7-29} vs 24 {22-78} days; p=0.25) in moderate ARDS patients with COVID-19 compared to control group.</p><p><strong>Conclusions: </strong>In moderate ARDS patients with or without COVID-19 disease, ECCO<sub>2</sub>R+CRRT may be and effective supportive treatment to reach protective values of driving pressure unless severe oxygenation defects arise requiring ECMO therapy initiation.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11055375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis. 更正:用于诱导和维持全身麻醉的异丙酚与丙泊酚的疗效和安全性:系统综述和荟萃分析。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-04-24 DOI: 10.1186/s44158-024-00162-6
Muhammad Hudaib, Hurais Malik, Syeda Javeria Zakir, Samra Rabbani, Dhanushan Gnanendran, Abdul Rehman Shah Syed, Noor Fatima Suri, Javeria Khan, Arham Iqbal, Nowal Hussain, Muhammad Abdullah, Satesh Kumar, Mahima Khatri, Giustino Varrassi
{"title":"Correction: Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis.","authors":"Muhammad Hudaib, Hurais Malik, Syeda Javeria Zakir, Samra Rabbani, Dhanushan Gnanendran, Abdul Rehman Shah Syed, Noor Fatima Suri, Javeria Khan, Arham Iqbal, Nowal Hussain, Muhammad Abdullah, Satesh Kumar, Mahima Khatri, Giustino Varrassi","doi":"10.1186/s44158-024-00162-6","DOIUrl":"https://doi.org/10.1186/s44158-024-00162-6","url":null,"abstract":"","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11040967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis. 用于全身麻醉诱导和维持的环丙酚与异丙酚的疗效和安全性:系统综述和荟萃分析。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-04-11 DOI: 10.1186/s44158-024-00160-8
Muhammad Hudaib, Hurais Malik, Syeda Javeria Zakir, Samra Rabbani, Dhanushan Gnanendran, Abdul Rehman Shah Syed, Noor Fatima Suri, Javeria Khan, Arham Iqbal, Nowal Hussain, Muhammad Abdullah, Satesh Kumar, Mahima Khatri, Giustino Varrassi
{"title":"Efficacy and safety of ciprofol versus propofol for induction and maintenance of general anesthesia: a systematic review and meta-analysis.","authors":"Muhammad Hudaib, Hurais Malik, Syeda Javeria Zakir, Samra Rabbani, Dhanushan Gnanendran, Abdul Rehman Shah Syed, Noor Fatima Suri, Javeria Khan, Arham Iqbal, Nowal Hussain, Muhammad Abdullah, Satesh Kumar, Mahima Khatri, Giustino Varrassi","doi":"10.1186/s44158-024-00160-8","DOIUrl":"https://doi.org/10.1186/s44158-024-00160-8","url":null,"abstract":"<p><strong>Background: </strong>Propofol has been the gold standard for anesthesia induction and maintenance due to its rapid onset and favorable pharmacokinetic properties. However, the search for alternative agents with improved safety and efficacy has led to the emergence of ciprofol (HSK3486), a structural analog of propofol. This systematic review and meta-analysis aim to comprehensively assess the safety and efficacy of ciprofol compared to propofol for anesthesia induction and maintenance in adult patients undergoing surgical procedures.</p><p><strong>Methods: </strong>This study included only double-arm RCTs in which participants were aged eighteen or older undergoing surgery. For the statistical analysis of the extracted data, we employed RevMan 5.4.1.</p><p><strong>Results: </strong>Ciprofol demonstrated a promising trend of higher anesthesiologists' satisfaction during the induction phase (MD 0.14, 95%, CI - 0.28 to 0.56, p = 0.51), whereas Propofol was favored during maintenance. Propofol also exhibited advantages with a shorter time to successful anesthesia induction (MD 0.08 min, 95% CI 0.00 to 0.15, p = 0.04), and quicker attainment of full alertness (MD 0.11 min, 95% CI - 1.29 to 1.52, p = 0.87), suggesting its efficiency in clinical practice. Importantly, there were no significant disparities in the success rate of anesthesia.</p><p><strong>Conclusion: </strong>Both ciprofol and propofol demonstrate comparable efficacy and safety for anesthesia induction and maintenance in adult patients undergoing surgery. While propofol provides a faster onset of induction, ciprofol exhibits advantages in terms of pain management. Clinicians should consider these findings when selecting anesthetic agents, and tailoring choices to individual patient needs and clinical scenarios.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11008023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ciprofol as compared to propofol for sedation and general anesthesia: a systematic review of randomized controlled trials. 用于镇静和全身麻醉的异丙酚与丙泊酚的比较:随机对照试验的系统回顾。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-04-08 DOI: 10.1186/s44158-024-00159-1
Jessica M Currò, Cristina Santonocito, Federica Merola, Simone Messina, Marco Sanfilippo, Serena Brancati, Filippo Drago, Filippo Sanfilippo
{"title":"Ciprofol as compared to propofol for sedation and general anesthesia: a systematic review of randomized controlled trials.","authors":"Jessica M Currò, Cristina Santonocito, Federica Merola, Simone Messina, Marco Sanfilippo, Serena Brancati, Filippo Drago, Filippo Sanfilippo","doi":"10.1186/s44158-024-00159-1","DOIUrl":"https://doi.org/10.1186/s44158-024-00159-1","url":null,"abstract":"<p><strong>Background: </strong>Propofol is the most commonly used hypnotic agent used during sedation and general anesthesia (GA) practice, offering faster recovery compared to benzodiazepines. However, cardiovascular impact of propofol and pain at injection are commonly encountered side effects. Ciprofol is a novel disubstituted phenol derivative, and there is growing evidence regarding its clinical use.</p><p><strong>Methods: </strong>We conducted a systematic literature search (updated on 23 July 2023) to evaluate safety and efficacy of ciprofol in comparison to propofol in patients undergoing procedures under sedation or GA. We focused on randomized controlled trials (RCTs) only, extrapolating data on onset and offset, and on the side effects and the pain at injection.</p><p><strong>Results: </strong>The search revealed 14 RCTs, all conducted in China. Eight RCTs studied patients undergoing sedation, and six focused on GA. Bolus of ciprofol for sedation or induction of GA varied from 0.2 to 0.5 mg/kg. In four studies using ciprofol for maintenance of GA, it was 0.8-2.4 mg/kg/h. Ciprofol pharmacokinetics seemed characterized by slower onset and offset as compared to propofol. Pain during injection was less frequent in the ciprofol group in all the 13 studies reporting it. Eight studies reported \"adverse events\" as a pooled outcome, and in five cases, the incidence was higher in the propofol group, not different in the remaining ones. Occurrence of hypotension was the most commonly investigated side effects, and it seemed less frequent with ciprofol.</p><p><strong>Conclusion: </strong>Ciprofol for sedation or GA may be safer than propofol, though its pharmacokinetics may be less advantageous.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11000282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between hypomagnesemia and serum lactate levels in patients with sepsis: a retrospective observational study. 脓毒症患者低镁血症与血清乳酸水平之间的关系:一项回顾性观察研究。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-04-03 DOI: 10.1186/s44158-024-00158-2
Ken Tonai, Shinshu Katayama, Kansuke Koyama, Hisashi Imahase, Shin Nunomiya
{"title":"Association between hypomagnesemia and serum lactate levels in patients with sepsis: a retrospective observational study.","authors":"Ken Tonai, Shinshu Katayama, Kansuke Koyama, Hisashi Imahase, Shin Nunomiya","doi":"10.1186/s44158-024-00158-2","DOIUrl":"https://doi.org/10.1186/s44158-024-00158-2","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-3 emphasizes the recognition of sepsis-induced cellular metabolic abnormalities, and utilizes serum lactate level as a biomarker of cellular metabolic abnormalities. Magnesium plays an important role as a cofactor in glucose metabolism, although it is not well known that magnesium deficiency causes elevated serum lactate levels. Additionally, it remains unclear how magnesium status affects the role of serum lactate levels as a marker of metabolic abnormalities in sepsis. Thus, this study aimed to investigate the association between serum magnesium and lactate levels in patients with sepsis and explore this relationship from the perspectives of time course and circulatory abnormalities.</p><p><strong>Methods: </strong>This retrospective observational study of adult patients with sepsis was performed at the 16-bed intensive care unit of Jichi Medical University Hospital between June 2011 and December 2017. The relationship between serum magnesium and lactate levels for 5 days from intensive care unit admission was investigated along the time course. Multivariate logistic regression analysis was performed to evaluate the association between serum magnesium and lactate levels during intensive care unit admission.</p><p><strong>Results: </strong>Among 759 patients included, 105 had hypomagnesemia (magnesium level < 1.6 mg/dL), 558 had normal serum magnesium levels (1.6-2.4 mg/dL), and 96 had hypermagnesemia (magnesium level > 2.4 mg/dL) at intensive care unit admission. From intensive care unit admission to day 5, the hypomagnesemia group had higher serum lactate levels and a higher frequency of lactic acidosis than the normal magnesium level and hypermagnesemia groups (70% vs. 51.6% vs. 50%; P < 0.001). Hypomagnesemia at intensive care unit admission was independently associated with lactic acidosis, i.e., lactic acid level > 2 mmol/L (odds ratio, 2.76; 95% confidence interval, 1.60-4.76; P < 0.001).</p><p><strong>Conclusions: </strong>Hypomagnesemia was associated with serum lactate levels in the early and post-resuscitation phases of sepsis. Further studies are needed to elucidate whether the magnesium status is associated with sepsis-induced cellular and metabolic abnormalities.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10988873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulsed radiofrequency on peripheral nerve as a rehabilitation aid. 将脉冲射频治疗周围神经作为康复辅助手段。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-03-19 DOI: 10.1186/s44158-024-00156-4
Giulia Bongiorno, Helena Biancuzzi, Francesca Dal Mas, Rym Bednarova, Alessandro Vittori, Luca Miceli
{"title":"Pulsed radiofrequency on peripheral nerve as a rehabilitation aid.","authors":"Giulia Bongiorno, Helena Biancuzzi, Francesca Dal Mas, Rym Bednarova, Alessandro Vittori, Luca Miceli","doi":"10.1186/s44158-024-00156-4","DOIUrl":"https://doi.org/10.1186/s44158-024-00156-4","url":null,"abstract":"<p><p>The work described below explores the field of the effects of pulsed radiofrequency for pain relief purposes. While the effects of this technique on pain modulation (A-delta and C fibers) are relatively well-known, little has been written yet about the potential of pulsed radiofrequency interactions with other fibers. The proposed algorithm, specifically elaborated, investigates the effect of this technique on neuromuscular fatigue, through a surface electromyographic study of the femoral nerve of a patient with residual pain after knee arthroplasty surgery, before and after the treatment. This work yields a preliminary result that is encouraging for subsequent large-scale studies.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dissemination of clinical and scientific practice through social media: a SIAARTI consensus-based document. 通过社交媒体传播临床和科学实践:基于 SIAARTI 共识的文件。
Journal of Anesthesia, Analgesia and Critical Care (Online) Pub Date : 2024-03-19 DOI: 10.1186/s44158-024-00157-3
Andrea Cortegiani, Denise Battaglini, Giovanna Amato, Astrid Ursula Behr, Katia Donadello, Sharon Einav, Maria Grazia Frigo, Giorgio Fullin, Alberto Giannini, Mariachiara Ippolito, Franco Marozzi, Roberta Monzani, Gianpaola Monti, Marcus J Schultz, Vito Torrano, Gianluca Villa, Antonino Giarratano
{"title":"Dissemination of clinical and scientific practice through social media: a SIAARTI consensus-based document.","authors":"Andrea Cortegiani, Denise Battaglini, Giovanna Amato, Astrid Ursula Behr, Katia Donadello, Sharon Einav, Maria Grazia Frigo, Giorgio Fullin, Alberto Giannini, Mariachiara Ippolito, Franco Marozzi, Roberta Monzani, Gianpaola Monti, Marcus J Schultz, Vito Torrano, Gianluca Villa, Antonino Giarratano","doi":"10.1186/s44158-024-00157-3","DOIUrl":"https://doi.org/10.1186/s44158-024-00157-3","url":null,"abstract":"<p><strong>Background: </strong>Dissemination of medical practice and scientific information through social media (SoMe) by clinicians and researchers is increasing. Broad exposure of information can promote connectivity within the scientific community, overcome barriers to access to sources, increase debate, and reveal layperson perspectives and preferences. On the other hand, practices lacking scientific evidence may also be promoted, laypeople may misunderstand the professional message, and clinician may suffer erosion of professional status. The aim of this project was to enhance awareness and advise the anesthesia community and clinicians at large about the potential risks advocate for responsible use of SoMe to disseminate information related to medical practices and knowledge.</p><p><strong>Methods: </strong>A modified Delphi process with prespecified consensus criteria was conducted among a multidisciplinary panel of experts, including anesthesiologists-intensivists, clinical psychologists, and forensic medicine specialists. Six items were identified: Ethics and deontological principles, the practice of sharing information via social media, legal aspects, psychological aspects, self-promotion, and criteria for appropriate dissemination. Statements and rationales were produced and subjected to blinded panelists' votes. After reaching consensus, a document was written which then underwent external review by experts uninvolved in the consensus process. The project was promoted by the Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care (SIAARTI).</p><p><strong>Results: </strong>Twelve statements were produced, and consensus was achieved for all. The panel concluded that the general principles guiding dissemination of professional information via SoMe must remain in line with the general principles of ethics, deontology, and scientific validity that guide the medical profession and science in general. Professional equity must be maintained while communicating via SoMe. Medical practices lacking support by scientific evidence should not be disseminated. Patients' informed consent must be obtained before dissemination of information, images, or data. Self-promotion must not be prioritized over any of these principles.</p><p><strong>Conclusions: </strong>When sharing medical practices and scientific information on SoMe, healthcare professionals are advised to act conscientiously and ethically. Local regulations should be adhered to. Institutional training on the potential risks and proper of SoMe for such purpose may contribute to preservation of professional integrity.</p>","PeriodicalId":73597,"journal":{"name":"Journal of Anesthesia, Analgesia and Critical Care (Online)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10949554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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