Advances in Orthopedics最新文献

{"title":"Optimal Correction of Adult Spinal Deformities Requires Restoration of Distal Lumbar Lordosis.","authors":"S Pesenti,&nbsp;S Prost,&nbsp;A Muñoz McCausland,&nbsp;K Farah,&nbsp;P Tropiano,&nbsp;S Fuentes,&nbsp;B Blondel","doi":"10.1155/2021/5572181","DOIUrl":"https://doi.org/10.1155/2021/5572181","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study is to analyze results according to postoperative pelvic incidence-lumbar lordosis (PI-LL) mismatch in the management of adult spine deformity (ASD) patients. Recently, it has been reported that in addition to lumbar lordosis amount, lordosis repartition between its proximal and distal parts was crucial.</p><p><strong>Methods: </strong>We enrolled 77 consecutive ASD patients who underwent posterior spinal fusion and deformity correction between 2015 and 2018. On preoperative and 1-year follow-up radiographs, we analyzed different parameters such as L1-S1 lumbar lordosis, L1-L4 proximal lordosis (PLL), L4-S1 distal lordosis (DLL), pelvic tilt (PT), sagittal vertical axis (SVA), and PI-LL mismatch. Comparisons were performed according to postoperative PI-LL mismatch (defined as \"aligned\" when PI-LL was <10°). The relationship between lordosis distribution and postoperative alignment status was investigated.</p><p><strong>Results: </strong>On the whole series, average lumbar lordosis, SVA, and PI-LL improved (28.2° vs.43.5°, 82 vs. 51 mm, and 26°vs. 14°, all <i>p</i> < 0.001, respectively). On the other hand, PT remained unchanged (30° vs. 28°, <i>p</i> > 0.05). 35 patients were classified as \"aligned\" and 42 as \"not aligned.\" Patients from the \"aligned\" group had a significantly lower PI than patients from the \"not aligned\" group (52° vs. 61°, <i>p</i>=0.009). Postoperative PLL was not different between groups (18° vs. 16° <i>p</i> > 0.05), whereas DLL was significantly higher in the \"aligned\" group (31° vs. 22°, <i>p</i>=0.003). PI-LL was significantly correlated to DLL (rho = 0.407, <i>p</i> < 0.001) but not with PLL (rho = 0.110, <i>p</i>=0.342).</p><p><strong>Conclusions: </strong>Our results revealed that in ASD patients, postoperative malalignment was associated with a lack of DLL restoration. \"Not aligned\" patients had also a significantly higher pelvic incidence. Specific attention must be paid to restore optimal distal lumbar lordosis in order to set the amount and the distribution of optimal postoperative lumbar lordosis.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"5572181"},"PeriodicalIF":1.3,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38940902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single Intramedullary K-Wire Is Sufficient for the Management of Nonthumb Metacarpal Shaft Fractures.","authors":"Mohamed I Abulsoud,&nbsp;Mohammed Elmarghany,&nbsp;Tharwat Abdelghany,&nbsp;Mohamed Abdelaal,&nbsp;Mohamed F Elhalawany,&nbsp;Ahmed R Zakaria","doi":"10.1155/2021/9963186","DOIUrl":"https://doi.org/10.1155/2021/9963186","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the outcome after the internal fixation of diaphyseal metacarpal fractures by a single intramedullary K-wire.</p><p><strong>Methods: </strong>In this prospective case series study, conducted from July 2017 to June 2019 in 23 adult patients with a single, unstable, diaphyseal metacarpal fracture, outcomes after internal surgical fixation using a single antegrade intramedullary K-wire were evaluated. The outcomes were evaluated by union rate, time to union, handgrip measurements at 6 and 12 months, and the modified Disabilities of the Arm, Shoulder, and Hand (DASH) score at 12 months.</p><p><strong>Results: </strong>The study population consisted of 17 males and 6 females, with a mean patient age of 28.4 ± 8.5 years (range, 16-45 years). The median time to final follow-up was 14 ± 1.8 months (range: 12-24 months). The mean duration of the union was 7.3 ± 1.6 weeks (range: 5-11 weeks), with a union rate of 95.7% (22 cases). The mean handgrip strength was 68% ± 12.8% of the strength of the uninjured hand after 6 months and 92.7% ± 6.9% after 12 months. The mean modified DASH score was 2.6 ± 0.26 after 12 months (range: 0-5.8). There were no cases of malrotation or infection. In conclusion, using a single 1.8-2.0 mm K-wire gives excellent functional outcomes and union rate without significant complications when used to treat an unstable metacarpal shaft fracture.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"9963186"},"PeriodicalIF":1.3,"publicationDate":"2021-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39032807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Musculoskeletal Corticosteroid Injection during COVID-19 Pandemic in Sabah: Is It Safe?","authors":"Mohamad Azwan Aziz, Redzal Abu Hanifah, Azmi Mohamed Mohd Nahar","doi":"10.1155/2021/8863210","DOIUrl":"10.1155/2021/8863210","url":null,"abstract":"<p><p>Musculoskeletal corticosteroid injection is commonly used as an adjunct to help patients in pain management. In this current COVID-19 pandemic, many clinicians would differ from this treatment as steroid is considered an immunosuppressive drug and could risk the patient of developing severe adverse effects if contracting COVID-19. This is a retrospective study based in Sabah, Malaysia, examining the prevalence of COVID-19 infection following musculoskeletal corticosteroid injection from 1 December 2019 until 30 June 2020 in the sports medicine clinic and the orthopedic clinic. Patients who received musculoskeletal corticosteroid injection were called by telephone and asked about visits to the emergency department or government health clinic for influenza-like illness symptoms or severe acute respiratory infection that would require screening of COVID-19. Thirty-five patients who responded to the call were included, with mean ages of 47.9 years ± 15.1. 52% were male respondents, while 48% were female. 25% of them were diabetics, and 2.9% of them had a history of lymphoproliferative disorders. The mean pain score before injection was 6.74 ± 1.03 and after injection pain was 2.27 ± 1.63. In this study, there were 11.4% (<i>n</i> = 4) with minor complications of steroid injection, that is, skin discoloration. Nonetheless, there were no severe complications due to corticosteroids reported. There were no reported cases of COVID-19 among the respondents following corticosteroid injection. Musculoskeletal pain would affect a person's well-being and activities; thus, its management requires that careful consideration with risk-benefit analysis be made before administering musculoskeletal corticosteroid injection during COVID-19 pandemic.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"8863210"},"PeriodicalIF":1.2,"publicationDate":"2021-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25566201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal Humerus Reconstruction after Tumor Resection: An Overview of Surgical Management.","authors":"Antonio D'Arienzo, Edoardo Ipponi, Alfio Damiano Ruinato, Silvia De Franco, Simone Colangeli, Lorenzo Andreani, Rodolfo Capanna","doi":"10.1155/2021/5559377","DOIUrl":"10.1155/2021/5559377","url":null,"abstract":"<p><p>Proximal humerus is one of the anatomical sites that are most frequently involved by bone and soft tissue malignant tumors. Alone or in association with adjuvant treatments, surgery represents the main therapeutic option to treat and eradicate these diseases. Once the first-line option, in the last decades, amputation lost its role as treatment of choice for the large majority of cases in favor of the modern limb sparing surgery that promises to preserve anatomy and-as much as possible-upper limb functionality. Currently, the main approaches used to replace proximal humerus after a wide resection in oncologic surgery can be summarized in biological reconstructions (allografts and autografts), prosthetic reconstructions (anatomic endoprostheses, total reverse shoulder prostheses), and graft-prosthetic composite reconstructions. The purpose of this overview is to present nowadays surgical options for proximal humerus reconstruction in oncological patients, with their respective advantages and disadvantages.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"5559377"},"PeriodicalIF":1.3,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25585600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided Peripheral Nerve Blocks Performed by Orthopedic Surgeons: A Retrospective, Multicenter Study in Akita Prefecture, Japan.","authors":"Tatsuru Tomioka,&nbsp;Seietsu Senma,&nbsp;Yuichiro Narita,&nbsp;Masakazu Urayama,&nbsp;Satoshi Yumoto,&nbsp;Hiroki Ito,&nbsp;Toshiaki Aizawa,&nbsp;Tsuyoshi Shirahata,&nbsp;Hiroshi Aonuma,&nbsp;Nozomi Kaga,&nbsp;Norimitsu Masutani,&nbsp;Yusuke Yuasa,&nbsp;Hikaru Saito,&nbsp;Kunio Ebata,&nbsp;Kentaro Ouchi,&nbsp;Naohisa Miyakoshi,&nbsp;Yoichi Shimada","doi":"10.1155/2021/5580591","DOIUrl":"https://doi.org/10.1155/2021/5580591","url":null,"abstract":"<p><p>The shortage of doctors is a societal problem, especially in rural areas such as Akita Prefecture, Japan. Therefore, it is not unusual in Akita for orthopedic surgeons to perform upper and lower limb surgeries under ultrasound-guided peripheral nerve blocks managed by the operators themselves. Multicenter studies of ultrasound-guided peripheral nerve blocks performed by orthopedic surgeons have not been reported. The purpose of this study was to clarify the safety and reliability of ultrasound-guided peripheral nerve blocks performed by orthopedic surgeons in Akita. A total of 1,674 upper extremity surgery cases operated under ultrasound-guided peripheral nerve blocks at 8 hospitals in Akita prefecture from April 2016 to April 2018 were investigated retrospectively. These blocks were performed by a total of 37 orthopedic surgeons, including senior surgeons and residents. In 321 of the 1,674 cases (19%), local anesthetics were added to the surgical field. Two cases with special factors were converted to general anesthesia. There were 2 cases of complications associated with the nerve block, but they were all transient and recovered promptly. The block site and the hospital where the block was performed showed a significant relationship with the addition of local anesthetics to the surgical site (<i>P</i> < 0.001). Surgery time, age at surgery, and surgical site showed no significant relationships with the addition of local anesthetics. The volume of the anesthetic used for the nerve block showed a significant inverse relationship with the addition of local anesthetics (<i>P</i>=0.040). Many orthopedic surgeons in Akita prefecture began to perform ultrasound-guided peripheral nerve blocks, which had a reliable anesthesia effect with no noticeable complications, whether performed by residents or senior orthopedic surgeons, and this is a useful anesthetic technique for orthopedic surgeons.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"5580591"},"PeriodicalIF":1.3,"publicationDate":"2021-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7969096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25525085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injury Related to Fall and Its Predictors among Medically Diagnosed Adults with Visual Impairment in Ethiopia: An Observational Cross-Sectional Study.","authors":"Moges Gashaw,&nbsp;Biruk Adie Admass","doi":"10.1155/2021/6686068","DOIUrl":"https://doi.org/10.1155/2021/6686068","url":null,"abstract":"<p><strong>Background: </strong>Fall-related injury is the common cause of unintentional injury and premature death among people with visual impairment. So far, the knowledge about fall-related injuries among medically diagnosed visual impairment people living in low- and middle-income countries is scarce. Hence, this study is a preliminary attempt to assess the fall-related injury and its determinants among adult people with medically diagnosed visual impairment individuals.</p><p><strong>Methods: </strong>An institutional-based cross-sectional study was conducted from March to July 2018 with a total sample size of 337 study participants. The study participants were recruited by using a systematic random sampling method. Univariable and multivariable binary logistic regression model analysis was used to identify predictors of fall-related injuries with IBM Statistical Package for Social Sciences version 23.</p><p><strong>Results: </strong>A total of 320 adults with visual impairments participants have participated in this study. The finding of this study was reported as follows: 24.7% of (95% CI: 20.0-29.4%) adults with visual impairments experienced one or more fall-related injuries. The main predictors of fall-related injuries identified by multivariate analysis were severity of visual impairment: moderate (AOR, 2.91; 95% CI: 1.23 - 6.87), severe (AOR, 3.58; 95% CI: 1.26-10.17), cause of visual impairment: cataract (AOR, 10.63; 95% CI: 2.49 - 45.26), diabetic retinopathy (AOR, 15.35; 95% CI: 2.51-93.96), taking medication (AOR, 6.35; 95% CI: 2.93-13.75), having family support (AOR, 2.13; 95% CI: 1.08 - 4.19), and depression (AOR 3.82, 95% CI: 1.27-11.45).</p><p><strong>Conclusion: </strong>Soft tissue injuries were the most common fall-related injuries reported by the study participants. The severity of visual impairment, the cause of visual impairment, taking one or more medication, having family support, and having depression were significant predictors of fall-related injuries.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"6686068"},"PeriodicalIF":1.3,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7936889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25486899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Fibular Fixation in Distal Tibia-Fibula Fractures: A Meta-Analysis.","authors":"Chengxin Li,&nbsp;Zhizhuo Li,&nbsp;Qiwei Wang,&nbsp;Lijun Shi,&nbsp;Fuqiang Gao,&nbsp;Wei Sun","doi":"10.1155/2021/6668467","DOIUrl":"https://doi.org/10.1155/2021/6668467","url":null,"abstract":"<p><strong>Objectives: </strong>The necessity of fibular fixation in distal tibia-fibula fractures remains controversial. This study aimed to assess its impact on radiographic outcomes as well as rates of nonunion and infection.</p><p><strong>Methods: </strong>A systematic search of the electronic databases of PubMed, Embase, and Cochrane library was performed to identify studies comparing the outcomes of reduction and internal fixation of the tibia with or without fibular fixation. Radiographic outcomes included malalignment and malrotation of the tibial shaft. Data regarding varus/valgus angulation, anterior/posterior angulation, internal/external rotation deformity, and the rates of nonunion and infection were extracted and then polled. A meta-analysis was performed using the random-effects model for heterogeneity.</p><p><strong>Results: </strong>Additional fibular fixation was statistically associated with a decreased rate of rotation deformity (OR = 0.13; 95% CI 0.02-0.82, <i>p</i>=0.03). However, there was no difference in the rate of malreduction between the trial group and the control group (OR = 0.86; 95% CI 0.27-2.74, <i>p</i>=0.80). There was also no difference in radiographic outcomes of varus-valgus deformity rate (OR = 0.17; 95% CI 0.03-1.00, <i>p</i>=0.05) or anterior-posterior deformity rate (OR = 0.76; 95% CI 0.02-36.91, <i>p</i>=0.89) between the two groups. Meanwhile, statistical analysis showed no significant difference in the nonunion rate (OR = 0.62; 95% CI 0.37-1.02, <i>p</i>=0.06) or the infection rate (OR = 0.81; 95% CI 0.18-3.67, <i>p</i>=0.78) between the two groups.</p><p><strong>Conclusions: </strong>Additional fibular fixation does not appear to reduce the rate of varus-valgus deformity, anterior-posterior deformity, or malreduction. Meanwhile, it does not appear to impair the union process or increase the odds of infection. However, additional fibular fixation was associated with decreased odds of rotation deformity compared to controls.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"6668467"},"PeriodicalIF":1.3,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25479789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterolateral Bone Window for Revision Broken Cemented Stem of Unipolar Hemiarthroplasty.","authors":"Mohamed Mosa Mohamed Mahmoud,&nbsp;Bahaaeldin Ibrahim,&nbsp;Amr Abdelhalem Amr,&nbsp;Maysara Abdelhalem Bayoumy","doi":"10.1155/2021/6620395","DOIUrl":"https://doi.org/10.1155/2021/6620395","url":null,"abstract":"<p><strong>Background: </strong>Fractured stem of the hip prosthesis is well documented in the literature. Although it is rare, it is considered as a challenging problem. Many techniques have been described to solve this problem. <i>Purpose of the Study</i>. Evaluation of the effect of anterolateral bone window for extraction of the cemented femoral stem of hemiarthroplasty in revision total hip replacement.</p><p><strong>Methods: </strong>The study included eight revision hip arthroplasties in eight patients, with a broken stem of cemented (Thompson) hemiarthroplasty, which has been revised by the anterolateral proximal femoral window. All cases received cemented cups and cement-in-cement stems, except one case who received cementless long stem. Clinical follow-up of cases by Harries hip score (HHS) and X-ray.</p><p><strong>Results: </strong>Functional improvement of HHS of all cases, with no signs of loosening, after a mean follow-up period of 1.5 years.</p><p><strong>Conclusion: </strong>Extraction of broken stem is a challenging procedure. Many techniques have been described for revision of cases with a fractured stem of hip prosthesis, but we think that the anterolateral femoral bone window is a reproducible technique due to the characteristics of simplicity, short-time procedure, less invasive, not requiring extra instruments, and can be successful for most patients.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"6620395"},"PeriodicalIF":1.3,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25453651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limb Lengthening after Primary Total Knee Arthroplasty: Customized Patient-Specific Instrumentation Does Not Affect Expected Limb Lengthening.","authors":"Christopher Fang,&nbsp;Kenneth McAlpine,&nbsp;Michael Gustin,&nbsp;Ruijia Niu,&nbsp;David Freccero,&nbsp;Matthew Gordon,&nbsp;Eric L Smith","doi":"10.1155/2021/5573319","DOIUrl":"https://doi.org/10.1155/2021/5573319","url":null,"abstract":"<p><strong>Introduction: </strong>Expectations for limb length differences after TKA are important for patient perception and outcomes. Limb length discrepancies may occur due to postoperative leg length increases, which can lead to decreased patient functionality and satisfaction and even possible litigation. The purpose of this study is to examine the frequency and extent of limb lengthening among various preoperative deformities and between two different implant systems.</p><p><strong>Methods: </strong>Preoperative and postoperative full-length standing radiographs were obtained between August 2018 and August 2019 to measure mechanical axis and limb length of operative limbs. Demographic information such as age, sex, and BMI was also collected. Patients were grouped into categories for pre- and postoperative subgroup analysis: valgus, varus, customized implant, and conventional implant. Regression analysis was performed to evaluate significant relationships.</p><p><strong>Results: </strong>Of the 121 primary TKAs analyzed, 62% of the knees showed an increase in limb length after TKA, with an average lengthening of 5.32 mm. Preoperative varus alignment was associated with a mean lengthening of 3.14 mm, while preoperative valgus alignment was associated with a mean lengthening of 16.2 mm. Overall, there were no statistically significant differences in limb lengths pre- and postoperatively (<i>p</i> = 0.23) and no significant changes in limb length for any subgroup. Further, no variables were associated with limb length changes (<i>p</i> = 0.49), including the use of customized implants (<i>p</i> = 0.2).</p><p><strong>Conclusions: </strong>Limb lengthening after TKA is common and, on average, occurs more significantly in valgus knees. No significant difference in limb lengthening could be demonstrated using customized over conventional implants. Preoperative counseling is important to manage patient expectations.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"5573319"},"PeriodicalIF":1.3,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25451455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thromboembolism in Malignant Musculoskeletal Tumour: A Literature Review.","authors":"Achmad Fauzi Kamal,&nbsp;Didi Saputra Ramang,&nbsp;Marcel Prasetyo","doi":"10.1155/2021/6678167","DOIUrl":"https://doi.org/10.1155/2021/6678167","url":null,"abstract":"<p><p>Malignant musculoskeletal tumour may cause considerable burden to general health. The fast growth combined with the tumour characteristics and its invasion capability resulted in the poor prognosis of malignant musculoskeletal tumour. Malignant musculoskeletal tumour may cause significant disability by destroying normal tissue that plays important role in body kinematics. Thromboembolism, including deep vein thrombosis, pulmonary embolism, and other kinds of venous thromboembolism, is one of the most underestimated complications of musculoskeletal tumour. Normally, thrombosis ensues when pathologic factors overcame the body hemostatic regulatory capabilities, which will predispose the body to the formation of thrombus. Venous thromboembolism in musculoskeletal tumour may develop as a result of interaction between the tumour pathologic capabilities and its interaction with normal bodily functions. In this study, we reviewed the burden of musculoskeletal tumour and its complication on global health. Then, the review will focus on the pathologic and clinical aspect of thromboembolism in malignant musculoskeletal tumour, including pathophysiology, diagnosis, and treatment based on recent findings and literature.</p>","PeriodicalId":7358,"journal":{"name":"Advances in Orthopedics","volume":"2021 ","pages":"6678167"},"PeriodicalIF":1.3,"publicationDate":"2021-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25452813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}