JMIR perioperative medicine最新文献

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Description of the Content and Quality of Publicly Available Information on the Internet About Inhaled Volatile Anesthesia and Total Intravenous Anesthesia: Descriptive Study. 互联网上关于吸入性挥发性麻醉和全静脉麻醉的公开信息的内容和质量描述:描述性研究。
JMIR perioperative medicine Pub Date : 2023-11-02 DOI: 10.2196/47714
Xinwen Hu, Bethany R Tellor Pennington, Michael S Avidan, Sachin Kheterpal, Nastassjia G deBourbon, Mary C Politi
{"title":"Description of the Content and Quality of Publicly Available Information on the Internet About Inhaled Volatile Anesthesia and Total Intravenous Anesthesia: Descriptive Study.","authors":"Xinwen Hu, Bethany R Tellor Pennington, Michael S Avidan, Sachin Kheterpal, Nastassjia G deBourbon, Mary C Politi","doi":"10.2196/47714","DOIUrl":"10.2196/47714","url":null,"abstract":"<p><strong>Background: </strong>More than 300 million patients undergo surgical procedures requiring anesthesia worldwide annually. There are 2 standard-of-care general anesthesia administration options: inhaled volatile anesthesia (INVA) and total intravenous anesthesia (TIVA). There is limited evidence comparing these methods and their impact on patient experiences and outcomes. Patients often seek this information from sources such as the internet. However, the majority of websites on anesthesia-related topics are not comprehensive, updated, and fully accurate. The quality and availability of web-based patient information about INVA and TIVA have not been sufficiently examined.</p><p><strong>Objective: </strong>This study aimed to (1) assess information on the internet about INVA and TIVA for availability, readability, accuracy, and quality and (2) identify high-quality websites that can be recommended to patients to assist in their anesthesia information-seeking and decision-making.</p><p><strong>Methods: </strong>Web-based searches were conducted using Google from April 2022 to November 2022. Websites were coded using a coding instrument developed based on the International Patient Decision Aids Standards criteria and adapted to be appropriate for assessing websites describing INVA and TIVA. Readability was calculated with the Flesch-Kincaid (F-K) grade level and the simple measure of Gobbledygook (SMOG) readability formula.</p><p><strong>Results: </strong>A total of 67 websites containing 201 individual web pages were included for coding and analysis. Most of the websites provided a basic definition of general anesthesia (unconsciousness, n=57, 85%; analgesia, n=47, 70%). Around half of the websites described common side effects of general anesthesia, while fewer described the rare but serious adverse events, such as intraoperative awareness (n=31, 46%), allergic reactions or anaphylaxis (n=29, 43%), and malignant hyperthermia (n=18, 27%). Of the 67 websites, the median F-K grade level was 11.3 (IQR 9.5-12.8) and the median SMOG score was 13.5 (IQR 12.2-14.4), both far above the American Medical Association (AMA) recommended reading level of sixth grade. A total of 51 (76%) websites distinguished INVA versus TIVA as general anesthesia options. A total of 12 of the 51 (24%) websites explicitly stated that there is a decision to be considered about receiving INVA versus TIVA for general anesthesia. Only 10 (20%) websites made any direct comparisons between INVA and TIVA, discussing their positive and negative features. A total of 12 (24%) websites addressed the concept of shared decision-making in planning anesthesia care, but none specifically asked patients to think about which features of INVA and TIVA matter the most to them.</p><p><strong>Conclusions: </strong>While the majority of websites described INVA and TIVA, few provided comparisons. There is a need for high-quality patient education and decision support about the choice of INVA v","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e47714"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10654911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71429917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal Generalizability of Machine Learning Models for Predicting Postoperative Delirium Using Electronic Health Record Data: Model Development and Validation Study. 利用电子健康记录数据预测术后谵妄的机器学习模型的时间通用性:模型开发和验证研究。
JMIR perioperative medicine Pub Date : 2023-10-26 DOI: 10.2196/50895
Koutarou Matsumoto, Yasunobu Nohara, Mikako Sakaguchi, Yohei Takayama, Syota Fukushige, Hidehisa Soejima, Naoki Nakashima, Masahiro Kamouchi
{"title":"Temporal Generalizability of Machine Learning Models for Predicting Postoperative Delirium Using Electronic Health Record Data: Model Development and Validation Study.","authors":"Koutarou Matsumoto, Yasunobu Nohara, Mikako Sakaguchi, Yohei Takayama, Syota Fukushige, Hidehisa Soejima, Naoki Nakashima, Masahiro Kamouchi","doi":"10.2196/50895","DOIUrl":"10.2196/50895","url":null,"abstract":"<p><strong>Background: </strong>Although machine learning models demonstrate significant potential in predicting postoperative delirium, the advantages of their implementation in real-world settings remain unclear and require a comparison with conventional models in practical applications.</p><p><strong>Objective: </strong>The objective of this study was to validate the temporal generalizability of decision tree ensemble and sparse linear regression models for predicting delirium after surgery compared with that of the traditional logistic regression model.</p><p><strong>Methods: </strong>The health record data of patients hospitalized at an advanced emergency and critical care medical center in Kumamoto, Japan, were collected electronically. We developed a decision tree ensemble model using extreme gradient boosting (XGBoost) and a sparse linear regression model using least absolute shrinkage and selection operator (LASSO) regression. To evaluate the predictive performance of the model, we used the area under the receiver operating characteristic curve (AUROC) and the Matthews correlation coefficient (MCC) to measure discrimination and the slope and intercept of the regression between predicted and observed probabilities to measure calibration. The Brier score was evaluated as an overall performance metric. We included 11,863 consecutive patients who underwent surgery with general anesthesia between December 2017 and February 2022. The patients were divided into a derivation cohort before the COVID-19 pandemic and a validation cohort during the COVID-19 pandemic. Postoperative delirium was diagnosed according to the confusion assessment method.</p><p><strong>Results: </strong>A total of 6497 patients (68.5, SD 14.4 years, women n=2627, 40.4%) were included in the derivation cohort, and 5366 patients (67.8, SD 14.6 years, women n=2105, 39.2%) were included in the validation cohort. Regarding discrimination, the XGBoost model (AUROC 0.87-0.90 and MCC 0.34-0.44) did not significantly outperform the LASSO model (AUROC 0.86-0.89 and MCC 0.34-0.41). The logistic regression model (AUROC 0.84-0.88, MCC 0.33-0.40, slope 1.01-1.19, intercept -0.16 to 0.06, and Brier score 0.06-0.07), with 8 predictors (age, intensive care unit, neurosurgery, emergency admission, anesthesia time, BMI, blood loss during surgery, and use of an ambulance) achieved good predictive performance.</p><p><strong>Conclusions: </strong>The XGBoost model did not significantly outperform the LASSO model in predicting postoperative delirium. Furthermore, a parsimonious logistic model with a few important predictors achieved comparable performance to machine learning models in predicting postoperative delirium.</p>","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e50895"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10636625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50164008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Mobile App for Postoperative Pain Management Among Older Veterans Undergoing Total Knee Arthroplasty: Mixed Methods Feasibility and Acceptability Pilot Study. 在接受全膝关节置换术的老年退伍军人中用于术后疼痛管理的移动应用程序:混合方法可行性和可接受性试点研究。
JMIR perioperative medicine Pub Date : 2023-10-18 DOI: 10.2196/50116
Jessica Kelley Morgan, Caitlin R Rawlins, Steven K Walther, Andrew Harvey, Annmarie O'Donnell, Marla Greene, Troy G Schmidt
{"title":"A Mobile App for Postoperative Pain Management Among Older Veterans Undergoing Total Knee Arthroplasty: Mixed Methods Feasibility and Acceptability Pilot Study.","authors":"Jessica Kelley Morgan,&nbsp;Caitlin R Rawlins,&nbsp;Steven K Walther,&nbsp;Andrew Harvey,&nbsp;Annmarie O'Donnell,&nbsp;Marla Greene,&nbsp;Troy G Schmidt","doi":"10.2196/50116","DOIUrl":"10.2196/50116","url":null,"abstract":"<p><strong>Background: </strong>Prescription opioid misuse risk is disproportionate among veterans; military veterans wounded in combat misuse prescription opioids at an even higher rate (46.2%). Opioid misuse is costly in terms of morbidity, mortality, and humanitarian and economic burden and costs the Civilian Health and Medical Program of the Department of Veterans Affairs more than US $1.13 billion annually. Preventing opioid misuse at the time of prescription is a critical component in the response to the opioid crisis. The CPMRx mobile app has been shown to decrease the odds of opioid misuse during the postoperative period.</p><p><strong>Objective: </strong>The overarching purpose of this feasibility pilot study was to explore whether deploying a mobile app (CPMRx) to track postoperative pain and medication use is feasible in a Department of Veterans Affairs medical center. In support of this goal, we had four complementary specific aims: (1) determine the technological and logistical feasibility of the mobile app, (2) assess the acceptability of the mobile app to participants, (3) measure demand for and engagement with the mobile app, and (4) explore the potential use of the mobile app to patients and providers.</p><p><strong>Methods: </strong>Participants (N=10) were veterans undergoing total knee arthroplasty within the Veterans Health Administration provided with the CPMRx app to self-manage their pain during their 7-day at-home recovery following surgery. CPMRx uses scientifically validated tools to help clinicians understand how a patient can use the least amount of medication while getting the most benefit. The suite of software includes a mobile app for patients that includes a behavioral health intervention and a clinical decision support tool for health care providers that provides feedback about pain and medication use trends. Patients filled out paper questionnaires regarding acceptability at their postoperative follow-up appointment.</p><p><strong>Results: </strong>Overall, quantitative measures of acceptability were high. The average rating for the amount of time required to use the app was 4.9 of 5 (5=\"very little\"), and the average rating for ease of use was 4.4 of 5 (5=\"very easy\"). Open-ended questions also revealed that most participants found ease of use to be high. Demand and engagement were high as well with a mean number of mobile app entries of 34.1 (SD 20.1) during the postoperative period. There were no reported technological or logistical issues with the mobile app. Participants took an average of 25.13 (SD 14.37) opioid tablets to manage their postoperative pain.</p><p><strong>Conclusions: </strong>Results of this study revealed that the use of a mobile app for pain and medication management during postoperative recovery was both feasible and acceptable in older veterans undergoing total knee arthroplasty within the Veterans Health Administration. The wide variation in opioid consumption across participants revea","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e50116"},"PeriodicalIF":0.0,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10620635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dashboard of Short-Term Postoperative Patient Outcomes for Anesthesiologists: Development and Preliminary Evaluation. 麻醉师术后短期患者结果仪表板:开发和初步评估。
JMIR perioperative medicine Pub Date : 2023-09-19 DOI: 10.2196/47398
Rama Syamala Sreepada, Ai Ching Chang, Nicholas C West, Jonath Sujan, Brendan Lai, Andrew K Poznikoff, Rebecca Munk, Norbert R Froese, James C Chen, Matthias Görges
{"title":"Dashboard of Short-Term Postoperative Patient Outcomes for Anesthesiologists: Development and Preliminary Evaluation.","authors":"Rama Syamala Sreepada,&nbsp;Ai Ching Chang,&nbsp;Nicholas C West,&nbsp;Jonath Sujan,&nbsp;Brendan Lai,&nbsp;Andrew K Poznikoff,&nbsp;Rebecca Munk,&nbsp;Norbert R Froese,&nbsp;James C Chen,&nbsp;Matthias Görges","doi":"10.2196/47398","DOIUrl":"https://doi.org/10.2196/47398","url":null,"abstract":"<p><strong>Background: </strong>Anesthesiologists require an understanding of their patients' outcomes to evaluate their performance and improve their practice. Traditionally, anesthesiologists had limited information about their surgical outpatients' outcomes due to minimal contact post discharge. Leveraging digital health innovations for analyzing personal and population outcomes may improve perioperative care. BC Children's Hospital's postoperative follow-up registry for outpatient surgeries collects short-term outcomes such as pain, nausea, and vomiting. Yet, these data were previously not available to anesthesiologists.</p><p><strong>Objective: </strong>This quality improvement study aimed to visualize postoperative outcome data to allow anesthesiologists to reflect on their care and compare their performance with their peers.</p><p><strong>Methods: </strong>The postoperative follow-up registry contains nurse-reported postoperative outcomes, including opioid and antiemetic administration in the postanesthetic care unit (PACU), and family-reported outcomes, including pain, nausea, and vomiting, within 24 hours post discharge. Dashboards were iteratively co-designed with 5 anesthesiologists, and a department-wide usability survey gathered anesthesiologists' feedback on the dashboards, allowing further design improvements. A final dashboard version has been deployed, with data updated weekly.</p><p><strong>Results: </strong>The dashboard contains three sections: (1) 24-hour outcomes, (2) PACU outcomes, and (3) a practice profile containing individual anesthesiologist's case mix, grouped by age groups, sex, and surgical service. At the time of evaluation, the dashboard included 24-hour data from 7877 cases collected from September 2020 to February 2023 and PACU data from 8716 cases collected from April 2021 to February 2023. The co-design process and usability evaluation indicated that anesthesiologists preferred simpler designs for data summaries but also required the ability to explore details of specific outcomes and cases if needed. Anesthesiologists considered security and confidentiality to be key features of the design and most deemed the dashboard information useful and potentially beneficial for their practice.</p><p><strong>Conclusions: </strong>We designed and deployed a dynamic, personalized dashboard for anesthesiologists to review their outpatients' short-term postoperative outcomes. This dashboard facilitates personal reflection on individual practice in the context of peer and departmental performance and, hence, the opportunity to evaluate iterative practice changes. Further work is required to establish their effect on improving individual and department performance and patient outcomes.</p>","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e47398"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10548316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Warning Scores to Support Continuous Wireless Vital Sign Monitoring for Complication Prediction in Patients on Surgical Wards: Retrospective Observational Study. 早期预警评分支持连续无线生命体征监测用于外科病房患者并发症预测:回顾性观察研究。
JMIR perioperative medicine Pub Date : 2023-08-30 DOI: 10.2196/44483
Mathilde C van Rossum, Robin E M Bekhuis, Ying Wang, Johannes H Hegeman, Ellis C Folbert, Miriam M R Vollenbroek-Hutten, Cornelis J Kalkman, Ewout A Kouwenhoven, Hermie J Hermens
{"title":"Early Warning Scores to Support Continuous Wireless Vital Sign Monitoring for Complication Prediction in Patients on Surgical Wards: Retrospective Observational Study.","authors":"Mathilde C van Rossum,&nbsp;Robin E M Bekhuis,&nbsp;Ying Wang,&nbsp;Johannes H Hegeman,&nbsp;Ellis C Folbert,&nbsp;Miriam M R Vollenbroek-Hutten,&nbsp;Cornelis J Kalkman,&nbsp;Ewout A Kouwenhoven,&nbsp;Hermie J Hermens","doi":"10.2196/44483","DOIUrl":"https://doi.org/10.2196/44483","url":null,"abstract":"<p><strong>Background: </strong>Wireless vital sign sensors are increasingly being used to monitor patients on surgical wards. Although early warning scores (EWSs) are the current standard for the identification of patient deterioration in a ward setting, their usefulness for continuous monitoring is unknown.</p><p><strong>Objective: </strong>This study aimed to explore the usability and predictive value of high-rate EWSs obtained from continuous vital sign recordings for early identification of postoperative complications and compares the performance of a sensor-based EWS alarm system with manual intermittent EWS measurements and threshold alarms applied to individual vital sign recordings (single-parameter alarms).</p><p><strong>Methods: </strong>Continuous vital sign measurements (heart rate, respiratory rate, blood oxygen saturation, and axillary temperature) collected with wireless sensors in patients on surgical wards were used for retrospective simulation of EWSs (sensor EWSs) for different time windows (1-240 min), adopting criteria similar to EWSs based on manual vital signs measurements (nurse EWSs). Hourly sensor EWS measurements were compared between patients with (event group: 14/46, 30%) and without (control group: 32/46, 70%) postoperative complications. In addition, alarms were simulated for the sensor EWSs using a range of alarm thresholds (1-9) and compared with alarms based on nurse EWSs and single-parameter alarms. Alarm performance was evaluated using the sensitivity to predict complications within 24 hours, daily alarm rate, and false discovery rate (FDR).</p><p><strong>Results: </strong>The hourly sensor EWSs of the event group (median 3.4, IQR 3.1-4.1) was significantly higher (P<.004) compared with the control group (median 2.8, IQR 2.4-3.2). The alarm sensitivity of the hourly sensor EWSs was the highest (80%-67%) for thresholds of 3 to 5, which was associated with alarm rates of 2 (FDR=85%) to 1.2 (FDR=83%) alarms per patient per day respectively. The sensitivity of sensor EWS-based alarms was higher than that of nurse EWS-based alarms (maximum=40%) but lower than that of single-parameter alarms (87%) for all thresholds. In contrast, the (false) alarm rates of sensor EWS-based alarms were higher than that of nurse EWS-based alarms (maximum=0.6 alarm/patient/d; FDR=80%) but lower than that of single-parameter alarms (2 alarms/patient/d; FDR=84%) for most thresholds. Alarm rates for sensor EWSs increased for shorter time windows, reaching 70 alarms per patient per day when calculated every minute.</p><p><strong>Conclusions: </strong>EWSs obtained using wireless vital sign sensors may contribute to the early recognition of postoperative complications in a ward setting, with higher alarm sensitivity compared with manual EWS measurements. Although hourly sensor EWSs provide fewer alarms compared with single-parameter alarms, high false alarm rates can be expected when calculated over shorter time spans. Further studies are r","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e44483"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing Alcohol Use Before and After Surgery: Qualitative Study of Two Treatment Approaches. 手术前后减少酒精使用:两种治疗方法的定性研究
JMIR perioperative medicine Pub Date : 2023-07-26 DOI: 10.2196/42532
Lyndsay Chapman, Tom Ren, Jake Solka, Angela R Bazzi, Brian Borsari, Michael J Mello, Anne C Fernandez
{"title":"Reducing Alcohol Use Before and After Surgery: Qualitative Study of Two Treatment Approaches.","authors":"Lyndsay Chapman,&nbsp;Tom Ren,&nbsp;Jake Solka,&nbsp;Angela R Bazzi,&nbsp;Brian Borsari,&nbsp;Michael J Mello,&nbsp;Anne C Fernandez","doi":"10.2196/42532","DOIUrl":"https://doi.org/10.2196/42532","url":null,"abstract":"<p><strong>Background: </strong>High-risk alcohol use is a common preventable risk factor for postoperative complications, admission to intensive care, and longer hospital stays. Short-term abstinence from alcohol use (2 to 4 weeks) prior to surgery is linked to a lower likelihood of postoperative complications.</p><p><strong>Objective: </strong>The study aimed to explore the acceptability and feasibility of 2 brief counseling approaches to reduce alcohol use in elective surgical patients with high-risk alcohol use in the perioperative period.</p><p><strong>Methods: </strong>A semistructured interview study was conducted with a group of \"high responders\" (who reduced alcohol use ≥50% postbaseline) and \"low responders\" (who reduced alcohol use by ≤25% postbaseline) after their completion of a pilot trial to explore the acceptability and perceived impacts on drinking behaviors of the 2 counseling interventions delivered remotely by phone or video call. Interview transcripts were analyzed using thematic analysis.</p><p><strong>Results: </strong>In total, 19 participants (10 high responders and 9 low responders) from the parent trial took part in interviews. Three main themes were identified: (1) the intervention content was novel and impactful, (2) the choice of intervention modality enhanced participant engagement in the intervention, and (3) factors external to the interventions also influenced alcohol use.</p><p><strong>Conclusions: </strong>The findings support the acceptability of both high- and low-intensity brief counseling approaches. Elective surgical patients are interested in receiving alcohol-focused education, and further research is needed to test the effectiveness of these interventions in reducing drinking before and after surgery.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT03929562; https://clinicaltrials.gov/ct2/show/NCT03929562.</p>","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e42532"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9977848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction of Pelvic Organ Prolapse Postsurgical Outcome Using Biomaterial-Induced Blood Cytokine Levels: Machine Learning Approach. 使用生物材料诱导的血液细胞因子水平预测盆腔器官脱垂术后结果:机器学习方法。
JMIR perioperative medicine Pub Date : 2023-05-31 DOI: 10.2196/40402
Mihyun Lim Waugh, Nicholas Boltin, Lauren Wolf, Jane Goodwin, Patti Parker, Ronnie Horner, Matthew Hermes, Thomas Wheeler, Richard Goodwin, Melissa Moss
{"title":"Prediction of Pelvic Organ Prolapse Postsurgical Outcome Using Biomaterial-Induced Blood Cytokine Levels: Machine Learning Approach.","authors":"Mihyun Lim Waugh,&nbsp;Nicholas Boltin,&nbsp;Lauren Wolf,&nbsp;Jane Goodwin,&nbsp;Patti Parker,&nbsp;Ronnie Horner,&nbsp;Matthew Hermes,&nbsp;Thomas Wheeler,&nbsp;Richard Goodwin,&nbsp;Melissa Moss","doi":"10.2196/40402","DOIUrl":"https://doi.org/10.2196/40402","url":null,"abstract":"<p><strong>Background: </strong>Pelvic organ prolapse (POP) refers to symptomatic descent of the vaginal wall. To reduce surgical failure rates, surgical correction can be augmented with the insertion of polypropylene mesh. This benefit is offset by the risk of mesh complication, predominantly mesh exposure through the vaginal wall. If mesh placement is under consideration as part of prolapse repair, patient selection and counseling would benefit from the prediction of mesh exposure; yet, no such reliable preoperative method currently exists. Past studies indicate that inflammation and associated cytokine release is correlated with mesh complication. While some degree of mesh-induced cytokine response accompanies implantation, excessive or persistent cytokine responses may elicit inflammation and implant rejection.</p><p><strong>Objective: </strong>Here, we explore the levels of biomaterial-induced blood cytokines from patients who have undergone POP repair surgery to (1) identify correlations among cytokine expression and (2) predict postsurgical mesh exposure through the vaginal wall.</p><p><strong>Methods: </strong>Blood samples from 20 female patients who previously underwent surgical intervention with transvaginal placement of polypropylene mesh to correct POP were collected for the study. These included 10 who experienced postsurgical mesh exposure through the vaginal wall and 10 who did not. Blood samples incubated with inflammatory agent lipopolysaccharide, with sterile polypropylene mesh, or alone were analyzed for plasma levels of 13 proinflammatory and anti-inflammatory cytokines using multiplex assay. Data were analyzed by principal component analysis (PCA) to uncover associations among cytokines and identify cytokine patterns that correlate with postsurgical mesh exposure through the vaginal wall. Supervised machine learning models were created to predict the presence or absence of mesh exposure and probe the number of cytokine measurements required for effective predictions.</p><p><strong>Results: </strong>PCA revealed that proinflammatory cytokines interferon gamma, interleukin 12p70, and interleukin 2 are the largest contributors to the variance explained in PC 1, while anti-inflammatory cytokines interleukins 10, 4, and 6 are the largest contributors to the variance explained in PC 2. Additionally, PCA distinguished cytokine correlations that implicate prospective therapies to improve postsurgical outcomes. Among machine learning models trained with all 13 cytokines, the artificial neural network, the highest performing model, predicted POP surgical outcomes with 83% (15/18) accuracy; the same model predicted POP surgical outcomes with 78% (14/18) accuracy when trained with just 7 cytokines, demonstrating retention of predictive capability using a smaller cytokine group.</p><p><strong>Conclusions: </strong>This preliminary study, incorporating a sample size of just 20 participants, identified correlations among cytokines and demo","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e40402"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9638311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Safety of Perioperative Medication Through the Lens of Digital Health and Artificial Intelligence. 从数字健康和人工智能的角度看围手术期用药患者安全。
JMIR perioperative medicine Pub Date : 2023-05-31 DOI: 10.2196/34453
Jiancheng Ye
{"title":"Patient Safety of Perioperative Medication Through the Lens of Digital Health and Artificial Intelligence.","authors":"Jiancheng Ye","doi":"10.2196/34453","DOIUrl":"https://doi.org/10.2196/34453","url":null,"abstract":"<p><p>Perioperative medication has made significant contributions to enhancing patient safety. Nevertheless, administering medication during this period still poses considerable safety concerns, with many errors being detected only after causing significant physiological disturbances. The intricacy of medication administration in the perioperative setting poses specific challenges to patient safety. To address these challenges, implementing potential strategies and interventions is critical. One such strategy is raising awareness and revising educational curricula regarding drug safety in the operating room. Another crucial strategy is recognizing the importance of redundancy and multiple checks in the operating room as a hallmark of medication safety, which is not a common practice. Digital health technologies and artificial intelligence (AI) also offer the potential to improve perioperative medication safety. Computerized physician order entry systems, electronic medication administration records, and barcode medication administration systems have been proven to reduce medication errors and improve patient safety. By implementing these strategies and interventions, health care professionals can enhance the safety of perioperative medication administration and improve patient outcomes.</p>","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e34453"},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10267793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9638306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
i-Anemia: The impact of decision support in preoperative management of anemia (Preprint) i-贫血:决策支持在贫血术前管理中的影响(预印本)
JMIR perioperative medicine Pub Date : 2023-05-20 DOI: 10.2196/49186
Gaëtan Mignanelli, Richard Boyer, Nicolas Bonifas, Emmanuel Rineau, Yassine Moussali, Morgan Le Guen
{"title":"i-Anemia: The impact of decision support in preoperative management of anemia (Preprint)","authors":"Gaëtan Mignanelli, Richard Boyer, Nicolas Bonifas, Emmanuel Rineau, Yassine Moussali, Morgan Le Guen","doi":"10.2196/49186","DOIUrl":"https://doi.org/10.2196/49186","url":null,"abstract":"BACKGROUND\u0000Major surgery on patients with anemia has demonstrated an increased risk of perioperative blood transfusions and postoperative morbidity and mortality. Recent studies have shown that integrating preoperative anemia treatment as a component of perioperative blood management may reduce blood product utilization and improve outcomes in both cardiac and noncardiac surgery. However, outpatient management of anemia falls outside of daily practice for most anesthesiologists and is probably weakly understood.\u0000\u0000\u0000OBJECTIVE\u0000We conducted a simulated case survey with anesthesiologists to accomplish the following aims: (1) evaluate the baseline knowledge of the preoperative optimization of anemia and (2) determine the impact of real-time clinical decision support on anemia management.\u0000\u0000\u0000METHODS\u0000We sent a digital survey (i-Anemia) to members of the French Society of Anaesthesia and Critical Care. The i-Anemia survey contained 7 simulated case vignettes, each describing a patient's brief clinical history and containing up to 3 multiple-choice questions related to preoperative anemia management (12 questions in total). The cases concerned potential situations of preoperative anemia and were created and validated with a committee of patient blood management experts. Correct answers were determined by the current guidelines or by expert consensus. Eligible participants were randomly assigned to control or decision support groups. In the decision support group, the primary outcome measured was the correct response rate.\u0000\u0000\u0000RESULTS\u0000Overall, 1123 participants were enrolled and randomly divided into control (n=568) and decision support (n=555) groups. Among them, 763 participants fully responded to the survey. We obtained a complete response rate of 65.6% (n=364) in the group receiving cognitive aid and 70.2% (n=399) in the group without assistance. The mean duration of response was 10.2 (SD 6.8) minutes versus 7.8 (SD 5) minutes for the decision support and control groups, respectively (P<.001). The score significantly improved with cognitive aid (mean 10.3 out of 12, SD 2.1) in comparison to standard care (mean 6.2 out of 12, SD 2.1; P<.001).\u0000\u0000\u0000CONCLUSIONS\u0000Management strategies to optimize preoperative anemia are not fully known and applied by anesthesiologists in daily practice despite their clinical importance. However, adding a decision support tool can significantly improve patient care by reminding practitioners of current recommendations.","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135542300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remote Home Monitoring of Continuous Vital Sign Measurements by Wearables in Patients Discharged After Colorectal Surgery: Observational Feasibility Study. 可穿戴设备在结直肠癌术后出院患者连续生命体征监测中的远程家庭监测:观察性可行性研究
JMIR perioperative medicine Pub Date : 2023-05-05 DOI: 10.2196/45113
Jobbe P L Leenen, Vera Ardesch, Gijsbert Patijn
{"title":"Remote Home Monitoring of Continuous Vital Sign Measurements by Wearables in Patients Discharged After Colorectal Surgery: Observational Feasibility Study.","authors":"Jobbe P L Leenen,&nbsp;Vera Ardesch,&nbsp;Gijsbert Patijn","doi":"10.2196/45113","DOIUrl":"https://doi.org/10.2196/45113","url":null,"abstract":"<p><strong>Background: </strong>Hospital stays after colorectal surgery are increasingly being reduced by enhanced recovery and early discharge protocols. As a result, postoperative complications may frequently manifest after discharge in the home setting, potentially leading to emergency room presentations and readmissions. Virtual care interventions after hospital discharge may capture clinical deterioration at an early stage and hold promise for the prevention of readmissions and overall better outcomes. Recent technological advances have enabled continuous vital sign monitoring by wearable wireless sensor devices. However, the potential of these devices for virtual care interventions for patients discharged after colorectal surgery is currently unknown.</p><p><strong>Objective: </strong>We aimed to determine the feasibility of a virtual care intervention consisting of continuous vital sign monitoring with wearable wireless sensors and teleconsultations for patients discharged after colorectal surgery.</p><p><strong>Methods: </strong>In a single-center observational cohort study, patients were monitored at home for 5 consecutive days after discharge. Daily vital sign trend assessments and telephone consultations were performed by a remote patient-monitoring department. Intervention performance was evaluated by analyzing vital sign trend assessments and telephone consultation reports. Outcomes were categorized as \"no concern,\" \"slight concern,\" or \"serious concern.\" Serious concern prompted contact with the surgeon on call. In addition, the quality of the vital sign data was determined, and the patient experience was evaluated.</p><p><strong>Results: </strong>Among 21 patients who participated in this study, 104 of 105 (99%) measurements of vital sign trends were successful. Of these 104 vital sign trend assessments, 68% (n=71) did not raise any concern, 16% (n=17) were unable to be assessed because of data loss, and none led to contacting the surgeon. Of 62 of 63 (98%) successfully performed telephone consultations, 53 (86%) did not raise any concerns and only 1 resulted in contacting the surgeon. A 68% agreement was found between vital sign trend assessments and telephone consultations. Overall completeness of the 2347 hours of vital sign trend data was 46.3% (range 5%-100%). Patient satisfaction score was 8 (IQR 7-9) of 10.</p><p><strong>Conclusions: </strong>A home monitoring intervention of patients discharged after colorectal surgery was found to be feasible, given its high performance and high patient acceptability. However, the intervention design needs further optimization before the true value of remote monitoring for early discharge protocols, prevention of readmissions, and overall patient outcomes can be adequately determined.</p>","PeriodicalId":73557,"journal":{"name":"JMIR perioperative medicine","volume":"6 ","pages":"e45113"},"PeriodicalIF":0.0,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10199380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9866400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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